Dr. Falin Qu, PhD - Tangdu Hospital

Dr. Falin Qu

PhD

Tangdu Hospital

China

ORCID logohttps://orcid.org/0000-0002-6497-0634

Dr. Falin Qu, PhD - Tangdu Hospital

Dr. Falin Qu

PhD

Introduction

Primary Affiliation: Tangdu Hospital - China

Education

Dec 2014
The Fourth Military Medical University
PhD./General Surgery
Jun 2011
The Fourth Military Medical University
M.S./General Surgery
Jun 2005
The Fourth Military Medical University
M.D./Medicine

Publications

14Publications

389Reads

2Profile Views

A functional polymorphism of SSBP1 gene predicts prognosis and response to chemotherapy in resected gastric cancer patients

DOI: 10.18632/oncotarget.22864

Oncotarget

Growing evidence has indicated that single-stranded DNA-binding proteins 1 (SSBP1) is involved in tumor initiation and progression. However, effects of single nucleotide polymorphisms (SNPs) in SSBP1 gene on gastric cancer (GC) prognosis are still unknown. In present study, two functional SNPs from SSBP1 were selected and genotyped in a large cohorts of 1030 resected GC patients (326 in the training set, 704 in the validation set) to explore the association of SNPs with patients’ survival. The rs6976500 G allele (CG/GG) genotypes were found significantly associated with both worse overall survival (OS) and recurrence-free survival (RFS) in the training and the independent validation set when compared to C allele genotype, which reaching a more robust statistical significance in the pooled analysis. Furthermore, integration of rs6976500 genotypes and TNM stage significantly improved the prognosis prediction models based on TNM stage alone. In addition, only carriers with at least one G allele of rs6976500 gained significant survival benefit from FOLFOX-based ACT. Mechanistically, SNP rs6976500 G allele genotype could significantly decrease promoter transcriptional activity and markedly reduce expression level of SSBP1 compared with the C allele genotype in GC cells. This was further substantiated by immunohistochemical assay in 70 GC tissue samples. Our study presents the first evidence that SNP rs6976500 G allele genotypes might contribute to GC prognosis by attenuating SSBP1 promoter activity and gene expression, and provides the guidance in refining therapeutic decisions of GC patients. Further exploration on its function is needed to clarify the exact biological mechanism behind.

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December 2017
11 Reads

Prognostic Significance of Tag SNP rs1045411 in HMGB1 of the Aggressive Gastric Cancer in a Chinese Population.

PLoS One 2016 26;11(4):e0154378. Epub 2016 Apr 26.

Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710032, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154378PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845981PMC
March 2017
26 Reads
3.234 Impact Factor

High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients.

Oncotarget 2016 Apr;7(16):22834-45

State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, The Fourth Military Medical University, Xi'an 710032, China.

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http://dx.doi.org/10.18632/oncotarget.8071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008404PMC
April 2016
71 Reads
6.360 Impact Factor

Genetic polymorphisms in circadian negative feedback regulation genes predict overall survival and response to chemotherapy in gastric cancer patients.

Sci Rep 2016 Mar 1;6:22424. Epub 2016 Mar 1.

Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.

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http://dx.doi.org/10.1038/srep22424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772484PMC
March 2016
8 Reads
5.080 Impact Factor

Leukocyte mitochondrial DNA content: a novel biomarker associated with prognosis and therapeutic outcome in colorectal cancer.

Carcinogenesis 2015 May 30;36(5):543-52. Epub 2015 Mar 30.

State Key Laboratory of Cancer Biology, Experimental Teaching Center of Basic Medicine,

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http://dx.doi.org/10.1093/carcin/bgv042DOI Listing
May 2015
52 Reads
5.334 Impact Factor

Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients.

Mol Oncol 2015 Mar 3;9(3):727-39. Epub 2014 Dec 3.

Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528698PMC
March 2015
18 Reads
5.331 Impact Factor

Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case-control study.

BMC Cancer 2014 Sep 19;14:680. Epub 2014 Sep 19.

State Key Laboratory of Cancer Biology & Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.

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http://dx.doi.org/10.1186/1471-2407-14-680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177174PMC
September 2014
3 Reads
3.362 Impact Factor

Association between leukocyte telomere length and glioma risk: a case-control study.

Neuro Oncol 2014 Apr 22;16(4):505-12. Epub 2013 Dec 22.

Department of Oncology, First Affiliated Hospital of Chengdu Medical College, Chengdu, China (S.W., H.J.); State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Xi'an, China (Y.C., F.Q., X.H., J.X.); Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China (S.H.); National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, China (T.J.); Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania (S.W.).

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http://dx.doi.org/10.1093/neuonc/not240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956352PMC
April 2014
112 Reads
5.562 Impact Factor

Short leukocyte telomere length predicts poor prognosis and indicates altered immune functions in colorectal cancer patients.

Ann Oncol 2014 Apr 7;25(4):869-76. Epub 2014 Mar 7.

State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an.

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http://dx.doi.org/10.1093/annonc/mdu016DOI Listing
April 2014
14 Reads
7.040 Impact Factor

Genetic variations in stem cell-related genes and colorectal cancer prognosis.

J Gastrointest Cancer 2012 Dec;43(4):584-93

Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Room 1015, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s12029-012-9388-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721524PMC
December 2012
13 Reads

Functional polymorphisms of circadian positive feedback regulation genes and clinical outcome of Chinese patients with resected colorectal cancer.

Cancer 2012 Feb 19;118(4):937-46. Epub 2011 Jul 19.

Department of General Surgery, Tangdu Hospital, Xi'an, China.

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http://dx.doi.org/10.1002/cncr.26348DOI Listing
February 2012
19 Reads
4.890 Impact Factor

Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2012 Jan 25;21(1):217-27. Epub 2011 Oct 25.

State Key Laboratory of Cancer Biology, Cell Engineering Research Center & Department of Cell Biology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253954PMC
January 2012
5 Reads
4.125 Impact Factor

GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.

Eur J Cancer 2011 Jul 12;47(11):1699-707. Epub 2011 Mar 12.

State Key Laboratory of Cancer Biology, Cell Engineering Research Centre, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.

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http://dx.doi.org/10.1016/j.ejca.2011.02.004DOI Listing
July 2011
12 Reads
5.420 Impact Factor

Association between mitochondrial DNA content in leukocytes and colorectal cancer risk: a case-control analysis.

Cancer 2011 Jul 18;117(14):3148-55. Epub 2011 Jan 18.

Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1002/cncr.25906DOI Listing
July 2011
36 Reads
4.890 Impact Factor

Top co-authors

Jinliang Xing
Jinliang Xing

Fourth Military Medical University

9
Xianli He
Xianli He

Tangdu Hospital

8
Guoqiang Bao
Guoqiang Bao

Tangdu Hospital

7
Feng Zhou
Feng Zhou

School of Chemistry and Materials Science

5
Hushan Yang
Hushan Yang

Sidney Kimmel Cancer Center

5
Yibing Chen
Yibing Chen

Fourth Military Medical University

4
Zhinan Chen
Zhinan Chen

State Key Laboratory of Cancer Biology

3
Shaogui Wan
Shaogui Wan

Thomas Jefferson University

3
Gang Ji
Gang Ji

Fourth Military Medical University

3
Ronald E Myers
Ronald E Myers

Thomas Jefferson University

3