Publications by authors named "Faisal Osra"

4 Publications

  • Page 1 of 1

Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies.

Bioorg Chem 2021 Oct 27;115:105209. Epub 2021 Jul 27.

Department of Chemistry, Umm Al-Qura University, Makkah, Saudi Arabia.

A series of semicarbazone, thiosemicarbazone, thiazole, and oxazole derivatives were designed, synthesized, and examined for monoamine oxidase inhibition using two isoforms, i.e., MAO-A and MAO-B. Among all the analogues, 3c and 3j possessed substantial activity against MAO-A with IC values of 5.619 ± 1.04 µM and 0.5781 ± 0.1674 µM, respectively. Whereas 3d and 3j were active against monoamine oxidase B with the IC values of 9.952 ± 1.831 µM and 3.5 ± 0.7 µM, respectively. Other derivatives active against MAO-B were 3c and 3g with the IC values of 17.67 ± 5.6 µM and 37.18 ± 2.485 µM. Moreover, molecular docking studies were achieved for the most potent compound (3j) contrary to human MAO-A and MAO-B. Kinetic studies were also performed for the most potent analogue to evaluate its mode of interaction with MAO-A and MAO-B.
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http://dx.doi.org/10.1016/j.bioorg.2021.105209DOI Listing
October 2021

An overview of viruses discovered over the last decades and drug development for the current pandemic.

Eur J Pharmacol 2021 Jan 19;890:173746. Epub 2020 Nov 19.

Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.

Since the discovery of the yellow fever virus in 1901, thus far, two hundred nineteen viral species are recognized as human pathogens. Each year, the number of viruses causing infections in humans increases, triggering epidemics and pandemics, such as the current COVID-19 pandemic. Pointing to bats as the natural host, in 2019, a genome highly identical to a bat coronavirus (COVID-19) spread all over the world, and the World Health Organization (WHO) officially confirmed it as a pandemic. The virus mainly spreads through the respiratory tract, uses angiotensin-converting enzyme 2 (ACE2) as a receptor, and is characterized by symptoms of fever, cough, and fatigue. Antivirals and vaccines have provided improvements in some cases, but the discovery of a new and diverse variety of viruses with outbreaks has posed a challenge in timely treatments for medical scientists. Currently, few specific antiviral strategies are being used, and many of the effective antiviral drugs and reported active molecules are under vital exploration. In this review, with the details of viral diseases, we summarize the current attempts in drug development, epidemiology, and the latest treatments and scientific advancements to combat the COVID-19 epidemic. Moreover, we discuss ways to reduce epidemics and pandemics in the near future.
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http://dx.doi.org/10.1016/j.ejphar.2020.173746DOI Listing
January 2021

A facile polymerisation of magnetic coal to enhanced phosphate removal from solution.

J Environ Manage 2019 Oct 26;247:356-362. Epub 2019 Jun 26.

Department of Civil and Environmental Engineering Syracuse University, NY, USA.

Globally, there are increased threats to available freshwater resources due to pollution, climate change, and increased demand from population growth. Phosphorus is one of the essential nutrients required for animal and plant growth. However, when it is released into freshwater resources in excess amounts, it can become a pollutant through eutrophication. This study aimed to enhance the removal of phosphate from water using modified coal. The coal was magnetised by in-situ synthesis using a precipitation technique. To obtain functional groups and mechanical stability, magnetised coal particles were coated with polyaniline, via the polymerisation of aniline to form Magnetised Unburnt Coal Polyaniline (MUC-PANI). The properties of MUC-PANI were investigated using TGA, BET, XRD, Raman spectroscopy, SEM, and FTIR. TGA reviewed MUC-PANI as 58% magnetised coal and 42% polyaniline, while the specific surface area increased from 30.0 to 42.2 m/g after modification. SEM indicated a cauliflower structure on the surface of MUC-PANI due to the successful polymerisation of polyaniline. The FTIR spectrum showed successful adsorption of phosphate due to the formation of incipient peak at1008 cm. The adsorption kinetic data are better fitted to the Elovich model. The Langmuir adsorption capacity of MUC-PANI is 147.1 mg PO/g at 25 °C and pH 5.0 (initial concentration 10-200 mg/L, dose 0.8 g/L). MUC-PANI is a cost-efficient compound for removal of phosphate because it is made from readily available coal.
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http://dx.doi.org/10.1016/j.jenvman.2019.06.088DOI Listing
October 2019

Landfill site selection in Makkah using geographic information system and analytical hierarchy process.

Waste Manag Res 2020 Mar 1;38(3):245-253. Epub 2019 Mar 1.

Department of Civil and Environmental Engineering and Construction, University of Nevada, Las Vegas, NV, USA.

Municipal solid waste is a problem to developed and developing cities in the world. If municipal solid waste is not managed well, it can be a source of numerous contaminants to water, air, and soil. Although landfill is at the bottom in terms of priorities of municipal solid waste management techniques, its applicability cannot be neglected in developing economies. Landfill site selection is a hard puzzle comprised of political, social, economic, and environmental factors. Makkah, Saudi Arabia, is targeting 30 million pilgrims by 2030, putting the city in a difficult circumstance: More pilgrims, more municipal solid waste. The current dump site, Kakia, is expected to be full by 2020; thus, there is a need to locate a new landfill site. In 20 years, Makkah is expected to produce 44 million tonnes of municipal solid waste, which requires approximately a 7.5 m × 5,874,000 square meter landfill capacity. In this study, a geographic information system, analytical hierarchy process, vertical electrical sounding, and ground-penetrating radar are applied to select the best new landfill site for Makkah. By combining these techniques, there are three suitable site locations: (39°36 ́38.45 ́ ́E: 21°18 ́26.46 ́ ́N), (39°37 ́54.07 ́ ́E: 21°19 ́35.25 ́ ́N), and (39°44 ́04.45 ́ ́E: 21°13 ́08.93 ́ ́N). These sites have a considerable depth to water table of 12 m. Therefore, the city of Makkah should use these findings to establish a sanitary landfill.
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http://dx.doi.org/10.1177/0734242X19833153DOI Listing
March 2020
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