Fabrizio Thorel

Fabrizio Thorel

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Fabrizio Thorel

Fabrizio Thorel

Publications by authors named "Fabrizio Thorel"

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A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.

Cell Metab 2019 Mar 31;29(3):755-768.e5. Epub 2019 Jan 31.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183069
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http://dx.doi.org/10.1016/j.cmet.2018.11.014DOI Listing
March 2019

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Nature 2019 03 13;567(7746):43-48. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41586-019-0942-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624841PMC
March 2019

Dnmt1 activity is dispensable in δ-cells but is essential for α-cell homeostasis.

Int J Biochem Cell Biol 2017 07 22;88:226-235. Epub 2017 Jan 22.

Department of Genetic Medicine & Development, Faculty of Medicine, University of Geneva, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland; Centre facultaire du diabète, University of Geneva, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494274PMC
July 2017

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Cell Metab 2017 03 16;25(3):622-634. Epub 2017 Feb 16.

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358097PMC
March 2017

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.

Cell Rep 2017 03;18(13):3192-3203

Endocrinology, Diabetes, and Metabolism, University Hospital Basel, 4031 Basel, Switzerland; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.005DOI Listing
March 2017

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Elife 2016 04 19;5. Epub 2016 Apr 19.

Department of Genetic Medicine and Development of the Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.7554/eLife.13828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871705PMC
April 2016

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

Diabetes 2015 Apr 12;64(4):1284-98. Epub 2014 Nov 12.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN Department of Medicine, Vanderbilt University, Nashville, TN Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN

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http://dx.doi.org/10.2337/db14-1195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375083PMC
April 2015

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.

Diabetologia 2015 Feb 22;58(2):304-12. Epub 2014 Nov 22.

Department of Genetic Medicine and Development, University of Geneva, Geneva, CMU, 1 rue Michel-Servet, CH-1211, Geneva 4, Switzerland,

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http://dx.doi.org/10.1007/s00125-014-3442-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287680PMC
February 2015

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

Nature 2014 Oct 20;514(7523):503-7. Epub 2014 Aug 20.

Department of Genetic Medicine &Development, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland.

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http://dx.doi.org/10.1038/nature13633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209186PMC
October 2014

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Cell Metab 2013 Sep;18(3):431-44

Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890693PMC
September 2013

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.

PLoS Genet 2013 31;9(1):e1003274. Epub 2013 Jan 31.

Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561089PMC
May 2013

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Diabetes 2011 Nov 16;60(11):2872-82. Epub 2011 Sep 16.

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.2337/db11-0876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198058PMC
November 2011

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Mol Endocrinol 2011 Nov 29;25(11):1904-14. Epub 2011 Sep 29.

Department of Cellular and Molecular Medicine, The University of California, San Diego, USA.

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http://dx.doi.org/10.1210/me.2011-1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198960PMC
November 2011

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

Genes Dev 2011 Aug;25(16):1680-5

Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1101/gad.16875711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165933PMC
August 2011

Progenitor cell domains in the developing and adult pancreas.

Cell Cycle 2011 Jun 15;10(12):1921-7. Epub 2011 Jun 15.

Departments of Pediatrics and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154415PMC
http://dx.doi.org/10.4161/cc.10.12.16010DOI Listing
June 2011

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Nature 2010 Apr 4;464(7292):1149-54. Epub 2010 Apr 4.

Department of Cell Physiology & Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/nature08894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877635PMC
April 2010

Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.

Gastroenterology 2009 Jan 9;136(1):309-319.e9. Epub 2008 Oct 9.

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.

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http://dx.doi.org/10.1053/j.gastro.2008.10.015DOI Listing
January 2009

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.

Development 2007 Aug 27;134(15):2719-25. Epub 2007 Jun 27.

Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/dev.02875DOI Listing
August 2007

The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificity.

J Biol Chem 2005 Feb 7;280(8):7030-7. Epub 2004 Dec 7.

Department of Microbiology and Molecular Medicine, University Medical Centre, 1211 Geneva, Switzerland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M412228200
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http://dx.doi.org/10.1074/jbc.M412228200DOI Listing
February 2005

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG.

J Biol Chem 2003 May 18;278(21):19500-8. Epub 2003 Mar 18.

Institute of Molecular Cancer Research, University of Zürich, August Forel Strasse 7, CH-8008 Zürich, Switzerland.

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http://dx.doi.org/10.1074/jbc.M213155200DOI Listing
May 2003

The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity.

J Invest Dermatol 2002 Feb;118(2):344-51

Department of Genetics and Microbiology, Centre Médical Universitaire (CMU), Geneva, Switzerland.

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http://dx.doi.org/10.1046/j.0022-202x.2001.01673.xDOI Listing
February 2002