Fabrizio De Benedetti

Fabrizio De Benedetti

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Fabrizio De Benedetti

Publications by authors named "Fabrizio De Benedetti"

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Translating IL-6 biology into effective treatments.

Nat Rev Rheumatol 2020 06 23;16(6):335-345. Epub 2020 Apr 23.

Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1038/s41584-020-0419-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178926PMC
June 2020

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.

N Engl J Med 2020 05;382(19):1811-1822

From the Department of Pediatrics, Sapienza, University of Rome (F.L.), and the Department of Pediatric Hematology-Oncology (F.L.) and Division of Rheumatology (F.D.B.), IRCCS Bambino Gesù Children's Hospital, Rome, Pediatric Hematology-Oncology, Woman and Child Hospital, Azienda Ospedaliera Universitaria Integrata, Verona (S.C.), the Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, Monza Brianza per il Bambino e la sua Mamma Foundation, Monza (C.R.), the Clinic of Pediatric Hematology-Oncology, University Hospital of Padova, Padua (M.-C.P.), and the Division of Pediatric Onco-Hematology, Regina Margherita Hospital, Turin (F.F.) - all in Italy; the Divisions of Immunobiology and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics (M.B.J.), and the Division of Rheumatology (A.G.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (M.B.J.) - all in Cincinnati; the Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston (C.A.); the Department of Hematology, Great Ormond Street Hospital for Children, London (A.R.); the Department of Pediatric Hematology-Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston (B.D.); the Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora (T.P.G.); the Departments of Pediatric Hematology-Oncology and Hematology and Oncology, Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid (J.S.), and the Department of Pediatric Hematology and Oncology, Hospital Universitari Vall d'Hebron, Barcelona (J.-L.D.D.); the Department of Pediatric Hematology and Oncology, University Children's Hospital, Muenster, Germany (M.A.); the Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ (M.H.); NovImmune, Plan-les-Ouates, Switzerland (G.L., M.B., C.M.); and MnS Modelling and Simulation, Dinant, Belgium (P.J.).

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http://dx.doi.org/10.1056/NEJMoa1911326DOI Listing
May 2020

Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle.

Oxid Med Cell Longev 2019 16;2019:3018584. Epub 2019 Nov 16.

DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Via A. Scarpa 14, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2019/3018584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881749PMC
April 2020

The activating p.Ser466Arg change in STAT1 causes a peculiar phenotype with features of interferonopathies.

Clin Genet 2019 12 4;96(6):585-589. Epub 2019 Sep 4.

Dipartimento Pediatrie Specialistiche, U. O. Reumatologia, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.1111/cge.13632DOI Listing
December 2019

Is fibrodysplasia ossificans progressiva an interleukin-1 driven auto-inflammatory syndrome?

Pediatr Rheumatol Online J 2019 Dec 21;17(1):84. Epub 2019 Dec 21.

Pediatric Rheumatology Unit, Department of Pediatrics, Meir Medical Center, 59 Tchernichovsky St., 4428164, Kfar Saba, Israel.

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http://dx.doi.org/10.1186/s12969-019-0386-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925442PMC
December 2019

Different responses of PC12 cells to different pro-nerve growth factor protein variants.

Neurochem Int 2019 10 3;129:104498. Epub 2019 Jul 3.

Institute of Translational Pharmacology, Consiglio Nazionale Delle Ricerche (CNR), Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2019.104498DOI Listing
October 2019

NLRP2 Regulates Proinflammatory and Antiapoptotic Responses in Proximal Tubular Epithelial Cells.

Front Cell Dev Biol 2019 24;7:252. Epub 2019 Oct 24.

Department of Laboratories, Immuno-Rheumatology Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.3389/fcell.2019.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822264PMC
October 2019

Interleukin-18 in pediatric rheumatic diseases.

Curr Opin Rheumatol 2019 09;31(5):421-427

Division of Rheumatology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.1097/BOR.0000000000000634DOI Listing
September 2019

Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency.

J Rheumatol 2019 05 15;46(5):523-526. Epub 2019 Jan 15.

From the Division of Rheumatology, and the Unit of Medical Genetics, Laboratory of Cytogenetics and Molecular Genetics, Institute for Research and Health Care (IRCCS), Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180045
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http://dx.doi.org/10.3899/jrheum.180045DOI Listing
May 2019

Patients with juvenile idiopathic arthritis become adults: the role of transitional care.

Clin Exp Rheumatol 2018 Nov-Dec;36(6):1086-1094. Epub 2018 Apr 13.

Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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March 2019

Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial.

J Rheumatol 2018 08 1;45(8):1173-1179. Epub 2018 Jul 1.

From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children's Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children's Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children's Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK.

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http://dx.doi.org/10.3899/jrheum.170326DOI Listing
August 2018

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.

J Rheumatol 2018 07 1;45(7):956-961. Epub 2018 May 1.

From the Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Institute for Research and Health Care (IRCCS), Rome, Italy.

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http://dx.doi.org/10.3899/jrheum.170794DOI Listing
July 2018

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

N Engl J Med 2018 05;378(20):1908-1919

From the Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Rome (F.D.B.), Clinica Pediatrica e Reumatologia, Unità Operativa Semplice Dipartimentale di Malattie Autoinfiammatorie e Immunodeficienze, IRCCS, Istituto G. Gaslini, Genoa (M.G.), the Pediatric Clinic, University of Brescia and Spedali Civili, Brescia (M.C.), and the Amyloidosis Research and Treatment Center, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Pavia (L.O.) - all in Italy; the Division of Pediatric Rheumatology, Hospital Sant Joan de Déu, Universitat de Barcelona (J.A.), and the Internal Medicine Department, Autoimmune and Systemic Diseases Unit, Hospital Vall d'Hebron (S.B.-R.), Barcelona, and the Pediatric Rheumatology Unit, Hospital Universitario y Politécnico La Fe, Valencia (I.C.P.) - all in Spain; the Rheumatology Unit, Hadassah-Hebrew University Hospital (E.B.-C.), and the Pediatric Rheumatology Unit, Shaare Zedek Medical Center (P.J.H.), Jerusalem, and Heller Institute of Medical Research and Medicine Faculty, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (A.L.) - all in Israel; the Division of Pediatrics, University Medical Center Utrecht, Utrecht (J.F.), and the Radboud Expertise Center for Immunodeficiency and Autoinflammation, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (A. Simon) - both in the Netherlands; the Departments of Pediatrics and Medicine, University of California at San Diego and Rady Children's Hospital San Diego, San Diego (H.M.H.); the Department of Pediatric Rheumatology, Centre de Référence des Maladies Auto-inflammatoires et de l'Amylose Inflammatoire, Centre Hospitalier Universitaire (CHU) de Bicêtre, Assistance Publique-Hopitaux de Paris (APHP), Université de Paris Sud (I.K.-P.), and Paris-Descartes University, Imagine Institute, Unité d'Immuno-Hématologie et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, APHP (P.Q.), Paris; the National Amyloidosis Centre, University College London Division of Medicine, Royal Free Campus (H.J.L.), and University College London, Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust (P.B.), London; the Department of Pediatrics, Hacettepe University, Ankara (S.O.), and the Department of Pediatric Rheumatology, Cerrahpasa Medical School (O.K.), and Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology (A.G.), Istanbul University, Istanbul - all in Turkey; the Department of Pediatrics, Division of Pediatric Rheumatology, Cleveland Clinic, Cleveland (A.Z.); the Department of Infectious Diseases and General Internal Medicine, CHU Sart-Tilman, University of Liège, Liege (M.M.), and the Department of Infectious Diseases and Immunity, Jessa Hospital, University of Hasselt, Hasselt (J.V.H.) - both in Belgium; the Department of Clinical Immunology, Center for Pediatric Hematology, Oncology, and Immunology, Moscow (A. Shcherbina); Pediatric Rheumatology of Western Switzerland, University of Lausanne, Lausanne, (M.H.), and Novartis, Basel (K.L., A. Speziale, G.J.) - both in Switzerland; the Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan (R.H.); and the Department of Pediatrics, Semmelweis Egyetem, Budapest, Hungary (T.C.).

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http://dx.doi.org/10.1056/NEJMoa1706314DOI Listing
May 2018

Haematological involvement associated with a mild autoinflammatory phenotype, in two patients carrying the E250K mutation of PSTPIP1.

Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):113-115. Epub 2017 Jun 19.

Division of Rheumatology, Department of Paediatric Medicine, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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February 2018

Inflammatory events during food protein-induced enterocolitis syndrome reactions.

Pediatr Allergy Immunol 2017 08 22;28(5):464-470. Epub 2017 Jun 22.

Division of Allergy, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.1111/pai.12723DOI Listing
August 2017

Anakinra in a Cohort of Children with Chronic Nonbacterial Osteomyelitis.

J Rheumatol 2017 08 15;44(8):1231-1238. Epub 2017 Jun 15.

From the Division of Rheumatology, and the Nuclear Medicine Unit, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy.

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http://dx.doi.org/10.3899/jrheum.160690DOI Listing
August 2017

Systemic juvenile idiopathic arthritis: New insights into pathogenesis and cytokine directed therapies.

Best Pract Res Clin Rheumatol 2017 08 21;31(4):505-516. Epub 2018 Mar 21.

Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza Sant'Onofrio, 4, 00165, Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.berh.2018.02.002DOI Listing
August 2017

NGF and Its Receptors in the Regulation of Inflammatory Response.

Int J Mol Sci 2017 May 11;18(5). Epub 2017 May 11.

Division of Rheumatology and Immuno-Rheumatology Research Laboratories, Bambino Gesù Children's Hospital, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms18051028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454940PMC
May 2017

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome.

Pediatr Rheumatol Online J 2017 Jan 17;15(1). Epub 2017 Jan 17.

Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.

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http://dx.doi.org/10.1186/s12969-016-0130-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240371PMC
January 2017

Macrophage activation syndrome in the era of biologic therapy.

Nat Rev Rheumatol 2016 May 24;12(5):259-68. Epub 2016 Mar 24.

Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Piazza Sant'Onofrio, 4, Rome, Italy.

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http://dx.doi.org/10.1038/nrrheum.2015.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851441PMC
May 2016

A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.

J Immunol 2016 Mar 15;196(6):2492-503. Epub 2016 Feb 15.

Division of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35233; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294;

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http://dx.doi.org/10.4049/jimmunol.1501284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779709PMC
March 2016

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice.

Hum Mol Genet 2015 Nov 6;24(21):6041-53. Epub 2015 Aug 6.

Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM and Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome 00161, Italy

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http://dx.doi.org/10.1093/hmg/ddv323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599671PMC
November 2015

The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods.

Brain Res 2015 Oct 15;1624:455-468. Epub 2015 Aug 15.

Institute of Translational Pharmacology-CNR, via del Fosso del Cavaliere 100, 00133 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.08.005DOI Listing
October 2015

Anakinra in Systemic Juvenile Idiopathic Arthritis: A Single-center Experience.

J Rheumatol 2015 Aug 1;42(8):1523-7. Epub 2015 Jun 1.

From the Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.M. Pardeo, MD; D. Pires Marafon, MD; A. Insalaco, MD; C. Bracaglia, MD; R. Nicolai, MD; V. Messia, MD; F. De Benedetti, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children's Hospital, IRCCS.

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http://dx.doi.org/10.3899/jrheum.141567DOI Listing
August 2015

IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases.

PLoS One 2014 1;9(10):e107886. Epub 2014 Oct 1.

Division of Rheumatology, Bambino Gesù Children's Hospital, Rome, Italy; Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182736PMC
June 2015

Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade.

EBioMedicine 2015 Apr 26;2(4):285-93. Epub 2015 Feb 26.

Institute Pasteur-Cenci Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, 00161, Italy ; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome 00161, Italy.

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http://dx.doi.org/10.1016/j.ebiom.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485902PMC
April 2015

A novel mutation in the CIAS1/NLRP3 gene associated with an unexpected phenotype of cryopyrin-associated periodic syndromes.

Clin Exp Rheumatol 2014 Jan-Feb;32(1):123-5. Epub 2013 Oct 11.

Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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October 2014

Wolman disease associated with hemophagocytic lymphohistiocytosis: attempts for an explanation.

Eur J Pediatr 2014 Oct 21;173(10):1391-4. Epub 2014 May 21.

Division of Metabolism, Department of Pediatric Medicine, Bambino Gesu' Children's Hospital, IRCCS, Piazza S. Onofrio 4, Rome, 00165, Italy.

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http://link.springer.com/10.1007/s00431-014-2338-y
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http://dx.doi.org/10.1007/s00431-014-2338-yDOI Listing
October 2014

Kikuchi-Fujimoto disease in patient with systemic phacomatosis pigmentovascularis.

Blood Coagul Fibrinolysis 2014 Oct;25(7):783-5

aUniversity Department of Pediatrics bRare Diseases and Medical Genetics Unit, Department of Pediatric Medicine cDivision of Rheumatology, Department of Pediatric Medicine dUnit of Pathology, Bambino Gesù" Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.1097/MBC.0000000000000129DOI Listing
October 2014

Renal involvement in hypocomplementaemic urticarial vasculitis syndrome: a report of three paediatric cases.

Rheumatology (Oxford) 2014 Aug 12;53(8):1409-13. Epub 2014 Mar 12.

Department of Pediatrics, Azienda Ospedaliero-Universitaria Sant'Orsola-Malpighi, Bologna, Department of Pediatric Medicine, IRCCS Ospedale Pediatrico Bambin Gesù, Roma and Department of Pediatrics, Ospedale degli Infermi, Rimini, Italy.

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http://dx.doi.org/10.1093/rheumatology/keu023DOI Listing
August 2014

Nerve growth factor downregulates inflammatory response in human monocytes through TrkA.

J Immunol 2014 Apr 28;192(7):3345-54. Epub 2014 Feb 28.

Research Laboratories, Unit of Rheumatology, Bambino Gesù Children's Hospital, 00165 Rome, Italy;

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http://dx.doi.org/10.4049/jimmunol.1300825DOI Listing
April 2014

Monocytes and macrophages as biomarkers for the diagnosis of megalencephalic leukoencephalopathy with subcortical cysts.

Mol Cell Neurosci 2013 Sep 10;56:307-21. Epub 2013 Jul 10.

Confocal Microscopy Core Facility, Research Center, Bambino Gesù Children's Hospital, IRCCS, P.zza S. Onofrio 4, 00165 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2013.07.001DOI Listing
September 2013

Reaching the threshold: a multilayer pathogenesis of macrophage activation syndrome.

J Rheumatol 2013 Jun 15;40(6):761-7. Epub 2013 Apr 15.

Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.3899/jrheum.121233DOI Listing
June 2013

Acute rheumatic fever with chorea.

Arch Dis Child 2013 Mar 24;98(3):203. Epub 2012 Nov 24.

Rare Diseases and Medical Genetics Unit, Department of Pediatric Medicine, Bambino Gesù Children's Hospital, Piazza S. Onofrio, 4, Rome 00135, Italy.

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http://adc.bmj.com/cgi/doi/10.1136/archdischild-2012-302732
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http://dx.doi.org/10.1136/archdischild-2012-302732DOI Listing
March 2013

Tocilizumab for systemic juvenile idiopathic arthritis.

N Engl J Med 2013 03;368(13):1256-7

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http://dx.doi.org/10.1056/NEJMc1301017DOI Listing
March 2013

Safety and efficacy of etanercept in a cohort of patients with juvenile idiopathic arthritis under 4 years of age.

J Rheumatol 2012 Jun 15;39(6):1287-90. Epub 2012 May 15.

Division of Rheumatology, Department of Pediatric Medicine, Ospedale Pediatrico Bambino GesùIRCCS, Rome, Italy.

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http://dx.doi.org/10.3899/jrheum.111555DOI Listing
June 2012

Rituximab in a childhood-onset idiopathic refractory chronic inflammatory demyelinating polyneuropathy.

Eur J Paediatr Neurol 2012 May 7;16(3):301-3. Epub 2011 Sep 7.

Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neurosciences, IRCCS Bambino Gesù Pediatric Children's Hospital, P.zza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1016/j.ejpn.2011.08.002DOI Listing
May 2012

c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling.

Nat Commun 2012 Jan 17;3:630. Epub 2012 Jan 17.

Department of Experimental Medicine, University of L'Aquila, Via Vetoio - Coppito 2, L'Aquila 67100, Italy.

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http://dx.doi.org/10.1038/ncomms1651DOI Listing
January 2012

Role of mannose-binding lectin in nosocomial sepsis in critically ill neonates.

Hum Immunol 2010 Nov 21;71(11):1084-8. Epub 2010 Aug 21.

Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01988859100048
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http://dx.doi.org/10.1016/j.humimm.2010.08.012DOI Listing
November 2010

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.

Rheumatology (Oxford) 2010 Mar 17;49(3):441-9. Epub 2009 Dec 17.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kep418DOI Listing
March 2010