Fabrice Lejeune

Fabrice Lejeune

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Fabrice Lejeune

Fabrice Lejeune

Publications by authors named "Fabrice Lejeune"

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19Publications

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Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability.

Oncogenesis 2018 Sep 19;7(9):70. Epub 2018 Sep 19.

Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS 938, SIRIC CURAMUS, Equipe Instabilité des Microsatellites et Cancer, Equipe Labellisée par la Ligue Contre le Cancer, Centre de Recherche Saint Antoine, Paris, F-75012, France.

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http://dx.doi.org/10.1038/s41389-018-0079-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143633PMC
September 2018

Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins.

J Cell Sci 2017 Sep 25;130(18):3009-3022. Epub 2017 Jul 25.

Univ. Lille, UMR8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, 59000 Lille, France

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http://dx.doi.org/10.1242/jcs.198176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612172PMC
September 2017

Nonsense-mediated mRNA decay at the crossroads of many cellular pathways.

Authors:
Fabrice Lejeune

BMB Rep 2017 Apr;50(4):175-185

University Lille, UMR8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies; CNRS, UMR 8161, 3Institut Pasteur de Lille, F-59000 Lille, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437961PMC
http://dx.doi.org/10.5483/bmbrep.2017.50.4.015DOI Listing
April 2017

Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.

Proc Natl Acad Sci U S A 2011 Jul 27;108(28):11572-7. Epub 2011 Jun 27.

Cibles Therapeutiques, Institut National de la Santé et de la Recherche Médicale U940, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France.

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http://dx.doi.org/10.1073/pnas.1104104108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136330PMC
July 2011

Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies.

J Cell Biol 2007 Sep;178(7):1145-60

Centre National de la Recherche Scientifique, Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier F-34293, France.

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http://dx.doi.org/10.1083/jcb.200611086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064650PMC
September 2007

Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails.

Mol Cell Biol 2006 Apr;26(8):3085-97

Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712, Rochester, NY 14642.

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http://dx.doi.org/10.1128/MCB.26.8.3085-3097.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1446973PMC
April 2006

CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.

Nat Struct Mol Biol 2005 Oct 25;12(10):893-901. Epub 2005 Sep 25.

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/nsmb995DOI Listing
October 2005

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells.

Curr Opin Cell Biol 2005 Jun;17(3):309-15

Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA.

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http://dx.doi.org/10.1016/j.ceb.2005.03.002DOI Listing
June 2005

Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA.

Prog Nucleic Acid Res Mol Biol 2004 ;78:37-88

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, C.U. Strasbourg, France.

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http://dx.doi.org/10.1016/S0079-6603(04)78002-2DOI Listing
March 2005

eIF4G is required for the pioneer round of translation in mammalian cells.

Nat Struct Mol Biol 2004 Oct 7;11(10):992-1000. Epub 2004 Sep 7.

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, New York, 14642 USA.

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http://dx.doi.org/10.1038/nsmb824DOI Listing
October 2004

Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells.

Methods Mol Biol 2004 ;257:115-24

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, NY, USA.

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http://dx.doi.org/10.1385/1-59259-750-5:115DOI Listing
April 2004

The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex.

Genes Dev 2004 Apr 1;18(7):745-54. Epub 2004 Apr 1.

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1101/gad.1170204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387415PMC
April 2004

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.

Mol Cell 2003 Sep;12(3):675-87

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 712, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00349-6DOI Listing
September 2003

The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8, ASF/SF2, and SRp20.

J Biol Chem 2003 Aug 24;278(35):32943-53. Epub 2003 Jun 24.

INSERM U463, Institut de Biologie-CHR, 9 Quai Moncousu, 44093 Nantes Cedex 1, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301090200
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http://dx.doi.org/10.1074/jbc.M301090200DOI Listing
August 2003

The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.

EMBO J 2002 Jul;21(13):3536-45

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1093/emboj/cdf345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126094PMC
July 2002