Fabio Zuccotto

Fabio Zuccotto

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Fabio Zuccotto

Fabio Zuccotto

Publications by authors named "Fabio Zuccotto"

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25Publications

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A platform for target prediction of phenotypic screening hit molecules.

J Mol Graph Model 2020 Mar 24;95:107485. Epub 2019 Oct 24.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2019.107485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983931PMC
March 2020

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS One 2019 31;14(5):e0217828. Epub 2019 May 31.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544269PMC
January 2020

The Q Site of Cytochrome is a Promiscuous Drug Target in and .

ACS Infect Dis 2020 Jan 30. Epub 2020 Jan 30.

Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.9b00426DOI Listing
January 2020

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

ACS Infect Dis 2018 10 10;4(10):1439-1447. Epub 2018 Sep 10.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee . DDI 5EH , U.K.

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http://dx.doi.org/10.1021/acsinfecdis.8b00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189874PMC
October 2018

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Proc Natl Acad Sci U S A 2018 09 5;115(38):9616-9621. Epub 2018 Sep 5.

The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1807915115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156652PMC
September 2018

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments.

Chem Biol Drug Des 2018 03 12;91(3):655-667. Epub 2017 Dec 12.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/cbdd.13129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836963PMC
March 2018

Prediction of Drug Penetration in Tuberculosis Lesions.

ACS Infect Dis 2016 08 6;2(8):552-63. Epub 2016 Jul 6.

Public Health Research Institute Centre, New Jersey Medical School, Rutgers , 225 Warren Street, Newark, New Jersey 07103, United States.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.6b00051
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http://dx.doi.org/10.1021/acsinfecdis.6b00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028112PMC
August 2016

Structure-based optimization of potent PDK1 inhibitors.

Bioorg Med Chem Lett 2010 Jul 8;20(14):4095-9. Epub 2010 Jun 8.

Nerviano Medical Sciences Srl, Viale Pasteur 10, 20014 Nerviano, Milano, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X100071
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http://dx.doi.org/10.1016/j.bmcl.2010.05.070DOI Listing
July 2010

Through the "gatekeeper door": exploiting the active kinase conformation.

J Med Chem 2010 Apr;53(7):2681-94

Department of Chemical Core Technologies, Nerviano Medical Sciences, Oncology, Viale Pasteur 10, Nerviano 20014, Italy.

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http://dx.doi.org/10.1021/jm901443hDOI Listing
April 2010

Pharmacophore features distributions in different classes of compounds.

Authors:
Fabio Zuccotto

J Chem Inf Comput Sci 2003 Sep-Oct;43(5):1542-52

Inpharmatica Ltd, Molecular Design, 60 Charlotte Street, London, W1T 2NU, United Kingdom.

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http://dx.doi.org/10.1021/ci034068kDOI Listing
July 2004

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.

Bioorg Med Chem 2003 Nov;11(22):4693-711

Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF Cardiff, UK.

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http://dx.doi.org/10.1016/j.bmc.2003.08.012DOI Listing
November 2003