Publications by authors named "Fabien Touzot"

46Publications

CRISPR gene-engineered CYBB THP-1 cell lines highlight the crucial role of NADPH-induced reactive oxygen species for regulating inflammasome activation.

J Allergy Clin Immunol 2020 Jun 15;145(6):1690-1693.e5. Epub 2020 Jan 15.

CHU Sainte Justine Research Center, Montréal, Quebec, Canada; Université de Montréal, Montréal, Quebec, Canada; Department of Immunology-Rheumatology, Department of Pediatrics, CHU Sainte Justine, Montréal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.12.913DOI Listing
June 2020

Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome.

Front Immunol 2018 24;9:2162. Epub 2018 Sep 24.

Department of Immunology-Rheumatology, Department of Pediatric, CHU Sainte Justine, Montréal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2018.02162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166634PMC
September 2019

Understanding therapeutic emergencies in acute hemolysis.

Intensive Care Med 2018 04 4;44(4):482-485. Epub 2017 Sep 4.

Medical Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00134-017-4918-6DOI Listing
April 2018

Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease.

J Allergy Clin Immunol 2017 May 1;139(5):1641-1649.e6. Epub 2016 Oct 1.

Biotherapy Department, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France; University Paris Descartes Sorbonne Paris Cité, Institut Imagine, Paris, France; Inserm UMR 1163, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.08.033DOI Listing
May 2017

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

J Allergy Clin Immunol 2017 02 16;139(2):597-606.e4. Epub 2016 Jul 16.

Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292996PMC
February 2017

Specific T cells for the treatment of cytomegalovirus and/or adenovirus in the context of hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2016 09 30;138(3):920-924.e3. Epub 2016 Apr 30.

Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immunology and Pediatric Hematology Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Human Lymphohematopoiesis-INSERM UMR1163, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.032DOI Listing
September 2016

Reply.

J Allergy Clin Immunol 2016 08 20;138(2):633-4. Epub 2016 May 20.

Université Paris Descartes - Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker - Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2016.02.037DOI Listing
August 2016

Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey.

J Clin Immunol 2016 Feb 6;36(2):149-59. Epub 2016 Feb 6.

Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique Hôpitaux de Paris (APHP), University Paris Descartes, 149 rue de Sevres, 75015, Paris, France.

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http://dx.doi.org/10.1007/s10875-016-0240-2DOI Listing
February 2016

An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.

J Allergy Clin Immunol 2015 Dec 26;136(6):1619-1626.e5. Epub 2015 Jul 26.

INSERM UMR 1163, Laboratory of Genome Dynamics in the Immune System, Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.06.008DOI Listing
December 2015

Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children.

J Allergy Clin Immunol 2016 Jan 17;137(1):306-309.e4. Epub 2015 Jul 17.

Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://search.proquest.com/openview/ca42ac96763a00e67aac143f
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http://linkinghub.elsevier.com/retrieve/pii/S009167491500790
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http://dx.doi.org/10.1016/j.jaci.2015.06.003DOI Listing
January 2016

Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder.

Br J Haematol 2015 Aug 4;170(4):457-71. Epub 2015 May 4.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/bjh.13442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526362PMC
August 2015

Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1.

Blood 2015 Jun 13;125(23):3563-9. Epub 2015 Apr 13.

Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France;

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http://dx.doi.org/10.1182/blood-2014-12-616003DOI Listing
June 2015

Hepatitis E virus in hematopoietic stem cell donors: Towards a systematic HEV screening of donors?

J Infect 2015 Jul 26;71(1):141-4. Epub 2015 Feb 26.

Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, AP-HP, Hôpital Necker - Enfants malades, Paris, France; Institut Imagine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; EA08, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jinf.2015.02.008DOI Listing
July 2015

Stem cell transplantation for primary immunodeficiencies: the European experience.

Curr Opin Allergy Clin Immunol 2014 Dec;14(6):516-20

aBiotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris bBiotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, Assistance Publique-Hôpitaux de Paris, INSERM cParis Descartes - Sorbonne Paris Cité University, Imagine Institute dINSERM UMR 1163, Laboratory of Human Lymphohematopoiesis eImmunology and Pediatric Hematology Department, Assistance Publique-Hôpitaux de Paris fCollège de France, Paris, France.

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http://dx.doi.org/10.1097/ACI.0000000000000119DOI Listing
December 2014

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

N Engl J Med 2014 Oct;371(15):1407-17

From the Departments of Biotherapy (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.) and Immunology and Pediatric Hematology (S.B., G.C., D.M., B.N., C.P., F.T., A.F.) and the Centre d'Étude des Déficits Immunitaires (C.P.), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), the Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique, 8258-INSERM Unité 1022, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), Imagine Institute, Paris Descartes-Sorbonne Paris Cité University (S.B., J. Blondeau, L.C., D.M., B.N., C.P., E.S., A.F., M.C.), INSERM Unités Mixtes de Recherche 1163, Laboratory of Human Lymphohematopoiesis (J. Blondeau, L.C., E.S., F.T., A.F., M.C.), Groupe Immunoscope, Immunology Department, Institut Pasteur (A.L.), and Collège de France (A.F.) - all in Paris; Division of Hematology-Oncology (S.-Y.P., H.B., D.G., C.E.H., G.H., L.E.L., W.B.L., D.A.W.) and Division of Immunology (L.D.N.), Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute (S.-Y.P., D.G., L.E.L., W.B.L., D.A.W.), Harvard Medical School (S.-Y.P., M.A., L.E.L., W.B.L., J.R., L.E.S., A.T., L.D.N., D.A.W.), Center for Human Cell Therapy, Program in Cellular and Molecular Medicine, Boston Children's Hospital (M.A., J.R., L.E.S., A.T.), Division of Hematologic Malignancies, Dana-Farber Cancer Institute (J.R.), and the Manton Center for Orphan Disease Research (L.D.N.) - all in Boston; Great Ormond Street Hospital for Children NHS Foundation Trust (H.B.G., J.X.-B., A.J.T.) and Section of Molecular and Cellular Immunology, University College London Institute of Child Health (H.B.G., K.F.B., A.

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http://dx.doi.org/10.1056/NEJMoa1404588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274995PMC
October 2014

CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study.

J Allergy Clin Immunol 2015 May 3;135(5):1303-9.e1-3. Epub 2014 Oct 3.

Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2014.08.019DOI Listing
May 2015

Circulating endothelial cells as markers of endothelial dysfunction during hematopoietic stem cell transplantation for pediatric primary immunodeficiency.

J Allergy Clin Immunol 2014 Nov 16;134(5):1203-6. Epub 2014 Jul 16.

Service d'Hématologie Biologique, Hôpital George Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749140080
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http://dx.doi.org/10.1016/j.jaci.2014.05.039DOI Listing
November 2014

Gene therapy for inherited immunodeficiency.

Expert Opin Biol Ther 2014 Jun 8;14(6):789-98. Epub 2014 Mar 8.

U768 INSERM , Paris , France.

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http://dx.doi.org/10.1517/14712598.2014.895811DOI Listing
June 2014

Temporal and spatial compartmentalization of drug-resistant cytomegalovirus (CMV) in a child with CMV meningoencephalitis: implications for sampling in molecular diagnosis.

J Clin Microbiol 2013 Dec 9;51(12):4266-9. Epub 2013 Oct 9.

Unité d'immunologie, hématologie et rhumatologie pédiatrique, Assistance publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, Paris, France.

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http://dx.doi.org/10.1128/JCM.02411-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838023PMC
December 2013

Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies.

J Infect Dis 2012 Oct 7;206(8):1269-74. Epub 2012 Aug 7.

Unité d'Immunologie, Hématologie et Rhumatologie Pédiatriques, AP-HP, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1093/infdis/jis498DOI Listing
October 2012

[Dyskeratosis congenita: short telomeres are not the rule].

Med Sci (Paris) 2012 Jun-Jul;28(6-7):618-24. Epub 2012 Jul 16.

Equipe dynamique du génome et système immunitaire, Paris, France.

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http://dx.doi.org/10.1051/medsci/2012286015DOI Listing
October 2012