Fa Liu

Fa Liu

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Fa Liu

Fa Liu

Publications by authors named "Fa Liu"

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CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor.

Diabetologia 2019 Sep 17;62(9):1727-1729. Epub 2019 May 17.

Novo Nordisk A/S Research Projects, Novo Nordisk Park, DK-2760, Måløv, Denmark.

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http://dx.doi.org/10.1007/s00125-019-4893-2DOI Listing
September 2019

The Application of Isoacyl Structural Motifs in Prodrug Design and Peptide Chemistry.

Chembiochem 2019 Aug 22;20(16):2017-2031. Epub 2019 Jul 22.

Discovery Chemistry, Novo Nordisk Research Center Seattle, 530 Fairview Ave N, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1002/cbic.201900260DOI Listing
August 2019

Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking.

Protein Pept Lett 2018 ;25(12):1149-1154

Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.

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http://dx.doi.org/10.2174/0929866525666181101103500DOI Listing
February 2019

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.

Org Lett 2018 06 6;20(12):3695-3699. Epub 2018 Jun 6.

Novo Nordisk Research Center Indianapolis , Indianapolis , Indiana 46241 , United States.

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http://dx.doi.org/10.1021/acs.orglett.8b01501DOI Listing
June 2018

Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5.

ChemMedChem 2018 04 23;13(8):852-859. Epub 2018 Mar 23.

Novo Nordisk Research Center Indianapolis, 5225 Exploration Drive, Indianapolis, IN, 46241, USA.

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http://dx.doi.org/10.1002/cmdc.201800057DOI Listing
April 2018

Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.

Acc Chem Res 2017 08 3;50(8):1855-1865. Epub 2017 Aug 3.

Novo Nordisk Research Center Indianapolis , Indianapolis, Indiana 46241, United States.

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http://dx.doi.org/10.1021/acs.accounts.7b00227DOI Listing
August 2017

Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.

J Pept Sci 2017 Jun 3;23(6):455-465. Epub 2017 May 3.

Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.

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http://doi.wiley.com/10.1002/psc.3010
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http://dx.doi.org/10.1002/psc.3010DOI Listing
June 2017

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.

J Org Chem 2017 04 27;82(7):3506-3512. Epub 2017 Mar 27.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.joc.6b03078DOI Listing
April 2017

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.

Org Lett 2017 02 26;19(3):706-709. Epub 2017 Jan 26.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.orglett.6b03876DOI Listing
February 2017

Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon.

ACS Chem Biol 2016 12 8;11(12):3412-3420. Epub 2016 Nov 8.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acschembio.6b00923DOI Listing
December 2016

Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation.

Org Lett 2016 11 18;18(21):5516-5519. Epub 2016 Oct 18.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.orglett.6b02751DOI Listing
November 2016

Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.

J Med Chem 2016 09 25;59(17):8061-7. Epub 2016 Aug 25.

Novo Nordisk Research Center , Indianapolis, Indiana 46241, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00840DOI Listing
September 2016

Influence of Carbon Nanotube Coatings on Carbon Fiber by Ultrasonically Assisted Electrophoretic Deposition on Its Composite Interfacial Property.

Polymers (Basel) 2016 Aug 17;8(8). Epub 2016 Aug 17.

Shaanxi Engineering Research Center for Digital Manufacturing Technology, Northwestern Polytechnical University, Xi'an 710072, China.

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http://dx.doi.org/10.3390/polym8080302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432207PMC
August 2016

Chemical Synthesis of Human Insulin-Like Peptide-6.

Chemistry 2016 Jul 3;22(28):9777-83. Epub 2016 Jun 3.

Department of Chemistry, Indiana University Bloomington, 800 E. Kirkwood Avenue, Bloomington, Indiana, 47405, USA.

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http://dx.doi.org/10.1002/chem.201601410DOI Listing
July 2016

Chemical synthesis of peptides within the insulin superfamily.

J Pept Sci 2016 May 22;22(5):260-70. Epub 2016 Feb 22.

Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.

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http://dx.doi.org/10.1002/psc.2863DOI Listing
May 2016

Protein chemical synthesis in drug discovery.

Authors:
Fa Liu John P Mayer

Top Curr Chem 2015 ;362:183-228

Calibrium LLC, 11711 N. Meridian Street, Carmel, IN, 46032, USA,

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http://dx.doi.org/10.1007/128_2014_598DOI Listing
September 2015

An iodine-free and directed-disulfide-bond-forming route to insulin analogues.

Org Lett 2014 Jun 26;16(11):3126-9. Epub 2014 May 26.

Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/ol501252bDOI Listing
June 2014

A synthetic route to human insulin using isoacyl peptides.

Angew Chem Int Ed Engl 2014 Apr 11;53(15):3983-7. Epub 2014 Mar 11.

Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 (USA).

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http://dx.doi.org/10.1002/anie.201310735DOI Listing
April 2014

Irreversible sortase A-mediated ligation driven by diketopiperazine formation.

J Org Chem 2014 Jan 6;79(2):487-92. Epub 2014 Jan 6.

Lilly Research Laboratories , Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/jo4024914DOI Listing
January 2014

An Fmoc compatible, O to S shift-mediated procedure for the preparation of C-terminal thioester peptides.

Authors:
Fa Liu John P Mayer

J Org Chem 2013 Oct 19;78(19):9848-56. Epub 2013 Sep 19.

Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/jo4015112DOI Listing
October 2013

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.

Bioorg Med Chem 2013 Jul 26;21(14):3996-4003. Epub 2012 May 26.

Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462889PMC
July 2013

Concise synthetic routes to human insulin.

Org Lett 2013 Feb 7;15(4):960-3. Epub 2013 Feb 7.

Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/ol400149jDOI Listing
February 2013

Naftopidil and tolterodine in the medical expulsive therapy for intramural ureteral stones: a prospective randomized study.

Urol Res 2012 Dec 25;40(6):757-62. Epub 2012 Aug 25.

Department of Urology, Affiliated Jiangning Hospital, Nanjing Medical University, Gushan Road 78, Nanjing, 211100, China.

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http://dx.doi.org/10.1007/s00240-012-0498-7DOI Listing
December 2012

Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Chembiochem 2012 Jun 8;13(9):1291-6. Epub 2012 May 8.

Chemical Biology Laboratory, Frederick National Lab, NCI, NIH, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cbic.201200206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536914PMC
June 2012

Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.

ACS Chem Biol 2012 May 14;7(5):805-10. Epub 2012 Feb 14.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1021/cb200469aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355227PMC
May 2012

Site-specific fluorescein labeling of human insulin.

J Pept Sci 2012 May 26;18(5):336-41. Epub 2012 Mar 26.

Lilly Research Laboratories, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1002/psc.2405DOI Listing
May 2012

Oxime-based linker libraries as a general approach for the rapid generation and screening of multidentate inhibitors.

Nat Protoc 2012 Mar 15;7(4):686-702. Epub 2012 Mar 15.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, National Cancer Institute-Frederick, Frederick, Maryland, USA.

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http://dx.doi.org/10.1038/nprot.2012.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727389PMC
March 2012

Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.

Biopolymers 2011 ;96(6):780-8

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/bip.21692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402909PMC
February 2012

Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues.

J Org Chem 2011 Nov 3;76(21):8885-90. Epub 2011 Oct 3.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.

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https://pubs.acs.org/doi/10.1021/jo201599c
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http://dx.doi.org/10.1021/jo201599cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211136PMC
November 2011

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.

Nat Chem Biol 2011 Jul 17;7(9):595-601. Epub 2011 Jul 17.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, USA.

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http://dx.doi.org/10.1038/nchembio.614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158281PMC
July 2011

Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.

Structure 2010 Nov;18(11):1536-47

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA.

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http://dx.doi.org/10.1016/j.str.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124085PMC
November 2010

A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.

Bioorg Med Chem Lett 2010 May 15;20(9):2813-6. Epub 2010 Mar 15.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.03.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863121PMC
May 2010

Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists.

Bioorg Med Chem Lett 2010 Jan 29;20(1):318-21. Epub 2009 Oct 29.

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health Frederick, MD 21702, United States.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818493PMC
January 2010

Preparation of orthogonally protected ()-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides.

Tetrahedron 2009 Nov;65(47):9673-9679

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 2170, U.S.A.

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http://dx.doi.org/10.1016/j.tet.2009.09.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061760PMC
November 2009

Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids.

J Med Chem 2009 Mar;52(6):1612-8

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1021/jm800789hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669314PMC
March 2009

Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription.

Virus Res 2009 Jan 13;139(1):14-21. Epub 2008 Nov 13.

Liver Cell Signal Transduction Laboratory, Metabolic Syndrome Research Center, Korea Research Institute of Bioscience and Biotechnology, Liver Research Division, Lee's Biotechnology Institute of Research and Development, Taejeon 305-606, Republic of Korea.

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http://dx.doi.org/10.1016/j.virusres.2008.09.006DOI Listing
January 2009

SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization.

Chembiochem 2008 Aug;9(12):2000-4

Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, Building 376 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cbic.200800281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581409PMC
August 2008

Protected aminooxyprolines for expedited library synthesis: application to Tsg101-directed proline-oxime containing peptides.

Bioorg Med Chem Lett 2008 Feb 7;18(3):1096-101. Epub 2007 Dec 7.

Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Building 376 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488393PMC
February 2008

Synthesis of a Homologous Series of Side Chain Extended Orthogonally-Protected Aminooxy-Containing Amino Acids.

Synthesis (Stuttg) 2008 ;15:2432-2438

Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Bldg. 376 Boyles St., Frederick, Maryland 21702, Fax 301-846-6033.

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http://dx.doi.org/10.1055/s-2008-1078600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491720PMC
January 2008

Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.

J Org Chem 2007 Dec 9;72(25):9635-42. Epub 2007 Nov 9.

Laboratory of Medicinal Chemistry, CCR, NCI, NIH, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1021/jo701831qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533429PMC
December 2007

15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain.

Cancer Res 2007 Mar;67(6):2595-602

Cancer Stem Cell Section, Laboratory of Cancer Prevention, Science Applications International Corporation-Frederick, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3043DOI Listing
March 2007

Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.

Org Biomol Chem 2007 Jan 4;5(2):367-72. Epub 2006 Dec 4.

Laboratory of Medicinal Chemistry, Bldg. 376 Boyles St., Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1039/b611887aDOI Listing
January 2007

[Studies on chemical constituents from herb of Dracocephalum moldavica].

Zhongguo Zhong Yao Za Zhi 2004 Mar;29(3):232-4

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.

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March 2004

Synthesis of a new conformation-constrained L-tyrosine analogue as a potential scaffold for SH2 domain ligands.

J Org Chem 2003 Aug;68(17):6679-84

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China.

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http://dx.doi.org/10.1021/jo0340152DOI Listing
August 2003