Publications by authors named "F Zhang"

27,083 Publications

Investigations of specialised metabolites of endophyte Diaporthe destruens hosted in Illigera orbiculata C. Y. Wu.

Phytochemistry 2022 Aug 12:113357. Epub 2022 Aug 12.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China; College of Pharmacy, Dali University, Dali, 671003, People's Republic of China. Electronic address:

A chemical investigation of the endophytic fungus Diaporthe destruens from the Hernandiaceae plant Illigera orbiculata C. Y. Wu collected from southern Yunnan Province, China, led to the isolation of six undescribed compounds, including two azaphilone analogs, which are a pair of epimers (13R-hydroxy-chermesinone A and 13S-hydroxy-chermesinone A); a pyrrole derivative (1-(4-(methoxymethyl)-1H-pyrrol-3-yl)ethan-1-one); an isoindolone derivative (4-hydroxy-6-methoxyisoindolin-1-one); a benzylbenzene derivative (destruensine A) and a conjectural fragment of polyketide ((2R,4R)-2-(methoxymethyl)pentane-1,4-diol) along with nine known compounds. Their structures were elucidated by spectroscopic methods and HRESIMS, and the absolute configurations were further confirmed by electronic circular dichroism (ECD) and chemical derivatization. The antimicrobial activities, anti-acetylcholinesterase activities, antiproliferation, and NO production inhibitory effects of compounds 1-15 were evaluated.
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http://dx.doi.org/10.1016/j.phytochem.2022.113357DOI Listing
August 2022

The Selective Function of Quantum Biological Electron Transfer between DNA Bases and Metal Ions in DNA Replication.

J Phys Chem Lett 2022 Aug 15:7779-7787. Epub 2022 Aug 15.

Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, School of Optical-Electrical Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Metal ions play vital roles in the electron transfer between biological molecules in humans, animals, and plants. However, the electron transfer between metal ions and nucleic acids and its impact on DNA-ion binding during DNA replication has been ignored. Here, we present a long-range quantum biological electron transfer (QBET) between DNA bases and metal ions and its selective function of DNA-ion binding in DNA replication. We discover biophysical DNA-ion binding and create biological filters that allow selective DNA replication by dual modulators of the valence and concentration of metal ions. QBET-based DNA replication filters provide powerful tools for ultrasensitive polymerase chain reaction (PCR) to selectively amplify target sequences with a discrete concentration window of metal ions; for example, Au exhibits a concentration window that is approximately 3 orders of magnitude lower than that of Na. DNA-ion filters provide new perspectives into metal ion-mediated QBET in DNA replication and hold great potential in life sciences and medical applications.
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http://dx.doi.org/10.1021/acs.jpclett.2c01877DOI Listing
August 2022

Low Serum Soluble Transferrin Receptor Levels Are Associated with Poor Prognosis in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Biol Trace Elem Res 2022 Aug 15. Epub 2022 Aug 15.

Department of Medical Technology, Anhui Medical College, Hefei, 230601, Anhui, China.

Iron metabolism disorder is closely related to acute-on-chronic liver failure (ACLF). This study was conducted to analyze the serum levels of soluble transferrin receptor (sTfR) in hepatitis B virus (HBV)-related ACLF and to evaluate the predictive value of sTfR for the short-term prognosis of HBV-ACLF. A total of 359 patients, including 139 with HBV-ACLF, 103 with chronic hepatitis B (CHB), and 117 healthy controls (HCs), participated in this study. We measured serum levels of ferritin, transferrin, and sTfR using nephelometry and performed data analysis using SPSS software. Ferritin levels were significantly higher in HBV-ACLF patients (both P < 0.001), while transferrin and sTfR were significantly lower (all P < 0.001) than in patients with CHB and HCs. Spearman correlation analysis demonstrated that serum sTfR significantly correlated with the alanine aminotransferase (ALT) (r = -0.366, P < 0.001), aspartate aminotransferase (AST) (r = -0.322, P < 0.001), total bilirubin (TBIL) (r = -0.222, P = 0.009), alpha fetoprotein (AFP) (r = 0.329, P < 0.001), prothrombin time-international normalization ratio (PT-INR) (r = -0.428, P < 0.001), and model for end-stage liver disease (MELD) (r = -0.459, P < 0.001). Nonsurviving HBV-ACLF patients who died within 30 days had much lower serum sTfR levels than surviving patients (P < 0.001). Logistic regression analysis showed that decreased serum sTfR levels were independently associated with 30-day mortality in patients with HBV-ACLF (P = 0.003). Receiver operating characteristic (ROC) curve analysis for predicting 30-day mortality showed that the area under the curve (AUC) for serum sTfR was 0.813 (95% CI: 0.738-0.874, P < 0.001). This was similar to that of the MELD score (AUC = 0.812, 95% CI: 0.737-0.873, P < 0.001). Serum sTfR combined with MELD score significantly improved the predictive capacity for 30-day mortality in patients with HBV-ACLF (AUC = 0.871, 95% CI: 0.803-0.922, P < 0.001). Kaplan-Meier analysis revealed that the overall cumulative 30-day mortality rate was significantly higher in patients with serum sTfR levels ≤ 0.55 mg/L compared to those with serum sTfR levels > 0.55 mg/L (P < 0.001).
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http://dx.doi.org/10.1007/s12011-022-03385-2DOI Listing
August 2022

[Recent progress in the diagnosis and treatment of cold agglutinin disease].

Authors:
J Q Liu F K Zhang

Zhonghua Xue Ye Xue Za Zhi 2022 Jun;43(6):524-528

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2022.06.015DOI Listing
June 2022

Analysis of Bone Loss around Cemented and Biologic Prostheses after Hemiarthroplasty.

Dis Markers 2022 5;2022:7366576. Epub 2022 Aug 5.

The Department of Orthopedic Surgery, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 215028 Jiangsu, China.

Objective: To perform hemiarthroplasty (HA) on elderly patients with femoral neck fractures using cemented and biologic prostheses and then compare the bone loss around the two types of prostheses after surgery.

Methods: A total of 60 patients aged over 75 years (with a mean age of 83.5 years) and suffering from femoral neck fracture (Garden types III and IV) from January 2018 to December 2020 were selected; they were randomly divided into group A ( = 30, cemented prostheses) and group B ( = 30, biologic prostheses) and received HA. At 1 month, 6 months, and 12 months after surgery, Harris Hip Scale (HHS) was adopted for patient evaluation, and patients' bone mineral density (BMD) of the 7 Gruen zones around the prostheses was measured by dual-energy X-ray absorptiometry (DEXA scan).

Results: Both groups achieved satisfactory results postoperatively, and the Harris scores of the hips increased gradually over time, which were better in group A than in group B. Gruen zones in group A showed a slower trend of decreasing BMD than group B, and the differences were significant at zones 2, 3, and 4 ( < 0.05).

Conclusion: For elderly patients with femoral neck fractures, selecting cemented prosthesis for HA better recovers the hip function and has a low rate of bone loss around the prosthesis.
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http://dx.doi.org/10.1155/2022/7366576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374543PMC
August 2022
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