Publications by authors named "F Xu"

9,748 Publications

Comparative analysis of 5 inspection techniques for the application in the diagnosis and treatment of osteoarticular tuberculosis.

Int J Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, No. 28 Baofeng Road, Qiaokou District, Wuhan City, Hubei Province, China. Electronic address:

Objective: To evaluate 5 inspection techniques in the diagnosis and treatment of osteoarticular tuberculosis.

Methods: We collected the microbiological samples from a total of 284 patients during the period from August 2017 to December 2019 in Wuhan Pulmonary Hospital. The specimens were examined by AFB smear microscopy. Mycobacterial cultures, PCR, T-spot and X-pert rapid molecular detection.

Results: The diagnostic sensitivity of Xpert technology was 96.8% (116/120), a specificity of 96.8% (58/60), the Youden index was 0.936, and the area under the ROC curve is 0.967. The sensitivity and specificity of PCR were 84.2% (104/128) and 95.2% (76/80). The area under the ROC curve is 0.881. T-spot had a detection sensitivity of 75.0% (12/16), a specificity of 85.0% (17/20). AFP smear microscopy had a sensitivity of 60.0% (75/125), the specificity was 95.8% (152/159). Tuberculosis culture sensitivity 58.1% (72/124) specificity 96.2% (73/76) . The sensitivity and specificity of Xpert MTB/RIF for detecting RIF resistance were 100% (2/2) and 97.3% (73/75), respectively.

Conclusion: The Xpert MTB/RIF technique had a good diagnostic value. It also had high therapeutic guidance in the diagnosis of rifampicin resistance.
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http://dx.doi.org/10.1016/j.ijid.2021.09.019DOI Listing
September 2021

Role of Neonatal Behavioral Neurological Assessment combined with magnetic resonance diffusion tensor imaging in evaluating white matter development in preterm infants.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):916-921

Department of Neonatology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China (Xu F-L, Email: com).

Objectives: To study the correlation of fractional anisotropy (FA) on magnetic resonance diffusion tensor imaging with Neonatal Behavioral Neurological Assessment (NBNA) score in preterm infants, and to study the role of FA in evaluating white matter development from the perspective of imaging.

Methods: A prospective study was performed for 98 preterm infants who were admitted to the Neonatal Intensive Care Unit of the Third Affiliated Hospital of Zhengzhou University within 24 hours after birth from October 2016 to January 2020. According to the results of NBNA, they were divided into an abnormal group with 51 infants (NBNA score <37) and a normal group with 47 infants (NBNA score ≥37). The FA values of 10 regions of interest were collected and compared between the two groups. The correlations of FA value and umbilical arterial blood gas pH value with the NBNA score were analyzed.

Results: Compared with the normal group, the abnormal group had significantly lower FA value of the posterior limb of the internal capsule and umbilical arterial blood pH (<0.05). The FA value of the posterior limb of the internal capsule and umbilical arterial blood pH were positively correlated with the NBNA score (=0.584 and 0.604 respectively, <0.001), and the FA value of the posterior limb of the internal capsule was positively correlated with umbilical arterial blood pH (=0.426, <0.05).

Conclusions: The FA value of the posterior limb of the internal capsule can quantitatively reflect white matter development in preterm infants and is correlated with the NBNA score. The combination of the two indices can help to evaluate white matter development in preterm infants more accurately and objectively. .
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http://dx.doi.org/10.7499/j.issn.1008-8830.2106005DOI Listing
September 2021

Clinical features and prognosis of severe meconium aspiration syndrome with acute respiratory distress syndrome.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):903-908

Department of Neonatology, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan, Guangdong 523325, China (Email: com).

Objectives: To study the clinical features and prognosis of neonates with severe meconium aspiration syndrome (MAS) and acute respiratory distress syndrome (ARDS).

Methods: A retrospective analysis was performed on the medical data of 60 neonates with severe MAS who were admitted from January 2017 to December 2019. According to the presence or absence of ARDS, they were divided into two groups: ARDS (=45) and non-ARDS (=15). Clinical features and prognosis were compared between the two groups.

Results: Among the 60 neonates with severe MAS, 45 (75%) developed ARDS. Arterial blood gas analysis showed that the ARDS group had a significantly higher median oxygenation index within 1 hour after birth than the non-ARDS group (4.7 vs 2.1, <0.05), while there was no significant difference between the two groups in white blood cell count, C-reactive protein (CRP), and interleukin-6 (IL-6) on admission and the peak values of procalcitonin, CRP, and IL-6 during hospitalization (>0.05). The ARDS group had a significantly higher incidence rate of shock than the non-ARDS group (84% vs 47%, <0.05). There was no significant difference between the two groups in the incidence rates of persistent pulmonary hypertension, pneumothorax, pulmonary hemorrhage, hypoxic-ischemic encephalopathy, intracranial hemorrhage, and disseminated intravascular coagulation (>0.05). The ARDS group required a longer median duration of mechanical ventilation than the non-ARDS group (53 hours vs 3 hours, <0.05). In the ARDS group, 43 neonates (96%) were cured and 2 neonates (4%) died. In the non-ARDS group, all 15 neonates (100%) were cured.

Conclusions: Neonates with severe MAS and ARDS tend to develop respiratory distress earlier, require a longer duration of mechanical ventilation, and have a higher incidence rate of shock. During the management of children with severe MAS, it is recommended to closely monitor oxygenation index, give timely diagnosis and treatment of ARDS, evaluate tissue perfusion, and actively prevent and treat shock. .
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http://dx.doi.org/10.7499/j.issn.1008-8830.2106121DOI Listing
September 2021

High BTBD7 expression positive is correlated with SLUG-predicted poor prognosis in hormone receptor-negative breast cancer.

Ann Transl Med 2021 Aug;9(15):1252

Department of Rheumatology, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.

Background: Hormone receptor-negative breast cancer (HRNBC), which includes triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer, is prone to metastasis and has a poor prognosis. BTB/POZ domain-containing protein 7 (Btbd7) is thought to regulate SLUG and the epithelial-mesenchymal transition (EMT) process. However, the role of Btbd7 in HRNBC is unclear.

Methods: Expression of BTBD7 and SLUG in HRNBC tumor tissue and normal adjacent tissue (NAT) as well as breast cancer cells were characterized by immunohistochemistry and immunofluorescence. MDA-MA-231 cells was transfected with BTBD7 siRNA and detected by qRT-PCR and western blot. Expression levels of Slug and EMT related proteins were detected western blot analysis. cell invasion assays were used to analyse cell invasion ability of MDA-MA-231. GO and KEGG analyses was used to analysis the gene function.

Results: The total positive rate of BTBD7 expression in HRNBC tumor tissue was 66.7%, which was higher than that in NAT (52.1%) and benign breast lesion tissues (20%). Co-expression of SLUG and BTBD7 proteins could be found in HRNBC tissue and MDA-MA-231 cells. silencing significantly up-regulated the epithelial marker E-cadherin, down-regulated the mesenchymal markers α-SMA and SLUG and suppressed the invasion abilities of MDA-MA-231 cells. GO and KEGG analyses based on 322 DEGs showed that may be associated with generic transcription in breast cancer.

Conclusions: The study data indicated that BTBD7 was inversely associated with SLUG expression. Higher BTBD7 was associated with poor clinicopathologic features and prognosis in HRNBC patients. silencing inhibited EMT through regulation of SLUG expression. might act as a potential molecular target for gene therapy in HRNBC patients.
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http://dx.doi.org/10.21037/atm-21-3409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421947PMC
August 2021

Impact of tillage and crop establishment methods on rice yields in a rice-ratoon rice cropping system in Southwest China.

Sci Rep 2021 Sep 16;11(1):18421. Epub 2021 Sep 16.

Rice and Sorghum Research Institute, Sichuan Academy of Agricultural Sciences/Key Laboratory of Southwest Rice Biology and Genetic Breeding, Ministry of Agriculture, Deyang, 618000, China.

Simplified cultivation methods for rice production offer considerable social, economic, and environmental benefits. However, limited information is available on yield components of rice grown using simplified cultivation methods in a rice-ratoon rice cropping system. A field experiment using two hybrid and two inbred rice cultivars was conducted to compare four cultivation methods (conventional tillage and transplanting, CTTP; conventional tillage and direct seeding, CTDS; no-tillage and transplanting, NTTP; no-tillage and direct seeding, NTDS) in a rice-ratoon rice system from 2017 to 2020. Main season yields for CTDS and NTDS were higher than for CTTP by 6.1% and 2.8%, respectively; whereas ratoon season yields for CTDS and NTDS were equal to or higher than for CTTP. Annual grain yields for CTDS and NTDS were higher than for CTTP by 4.4% and 3.2%, respectively. The higher CTDS and NTDS yields were associated with higher panicle numbers per m and biomass production. Rice hybrids had higher yields than inbred cultivars by 15.8-19.3% for main season and by 15.6-19.4% for ratoon season, which was attributed to long growth duration, high grain weight and biomass production. Our results suggest that CTTP can be replaced by CTDS and NTDS to maintain high grain yields and save labor costs. Developing cultivars with high grain weight could be a feasible approach to achieve high rice yields in the rice-ratoon rice cropping system in southwest China.
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http://dx.doi.org/10.1038/s41598-021-98057-xDOI Listing
September 2021
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