Publications by authors named "F Benhadou"

34 Publications

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects.

Int J Dermatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Dermatology, Liverpool Hospital, University of New South Wales, Sydney, NSW, Australia.

Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.
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http://dx.doi.org/10.1111/ijd.15910DOI Listing
September 2021

Unilateral Nevoid Telangiectasia in a Healthy Man.

Case Rep Dermatol 2021 May-Aug;13(2):330-335. Epub 2021 Jun 23.

Department of Dermatology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.

We report the case of a healthy 26-year-old man presenting telangiectatic macules on the left thorax and arm since childhood. The main diagnostic hypothesis were unilateral nevoid telangiectasia (UNT), hereditary benign telangiectasia, atrial myxoma, segmental serpiginous angioma, circumscribed neviform angiokeratoma, and nevus vascularis mixtus. The diagnosis retained was UNT characterized by congenital or acquired telangiectasia distributed asymmetrically along the upper extremities, or the third or fourth cervical dermatomes. The congenital form is extremely rare, predominant in men, and persists in adulthood. The acquired form is most frequent, affects preferentially women, usually appears at puberty or during pregnancy and tends to disappear. Estrogen excess triggers the formation of telangiectasia. UNT is rarely associated with liver or thyroid disorder. Pulsed-dye lasers and normalization of estrogen are proposed as therapeutic options. We report a rare diagnosis of UNT in a young man with no other underlying condition. We would like to highlight that in the presence of unilateral telangiectasia, a complete clinical examination must be performed to rule out signs of hyperestrogenism in man, ocular or neurological abnormalities, a blood test to exclude pregnancy, hepatic and thyroid dysfunctions, and ultrasonography in case of suspicion of atrial myxoma.
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http://dx.doi.org/10.1159/000514941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299370PMC
June 2021

Tuberculosis Risk Stratification of Psoriatic Patients Before Anti-TNF-α Treatment.

Front Immunol 2021 3;12:672894. Epub 2021 Jun 3.

Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Psoriasis is a skin inflammatory condition for which significant progress has been made in its management by the use of targeted biological drugs. Detection of latent infection (LTBI) is mandatory before starting biotherapy that is associated with reactivation risk. Together with evaluation of TB risk factors and chest radiographs, tuberculin skin tests (TST) and/or blood interferon-γ-release assays (IGRA), like the QuantiFERON (QFT), are usually performed to diagnose infection. Using this approach, 14/49 psoriatic patients prospectively included in this study were identified as LTBI (14 TST, induration size ≥ 10mm, 8 QFT), and 7/14 received prophylactic anti-TB treatment, the other 7 reporting past-treatment. As the specificity and sensitivity of these tests were challenged, we evaluated the added value of an IGRA in response to a mycobacterial antigen associated with latency, the heparin-binding haemagglutinin (HBHA). All but one TST patient had a positive HBHA-IGRA, indicating higher sensitivity than the QFT. The HBHA-IGRA was also positive for 12/35 TSTQFT patients. Measurement for 15 psoriatic patients (12 with HBHA-IGRA) of 8 chemokines in addition to IFN-γ revealed a broad array of HBHA-induced chemokines for TSTQFT and TSTQFT patients, compared to a more restricted pattern for TSTQFT patients. This allowed us to define subgroups within psoriatic patients characterized by different immune responses to antigens that may be associated to different risk levels of reactivation of the infection. This approach may help in prioritizing patients who should receive prophylactic anti-TB treatment before starting biotherapies in order to reduce their number.
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http://dx.doi.org/10.3389/fimmu.2021.672894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209474PMC
June 2021

Factors Determining Affected Sites in Hidradenitis Suppurativa.

Dermatology 2021 Feb 1:1-3. Epub 2021 Feb 1.

ResoVerneuil, Paris, France,

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http://dx.doi.org/10.1159/000513866DOI Listing
February 2021
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