Ezio Laconi

Ezio Laconi

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Ezio Laconi

Ezio Laconi

Publications by authors named "Ezio Laconi"

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40Publications

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Cancer as a disease of old age: changing mutational and microenvironmental landscapes.

Br J Cancer 2020 Feb 11. Epub 2020 Feb 11.

Department of Biochemistry and Molecular Genetics, Integrated Department of Immunology, Department of Pediatrics, Department of Medicine (Section of Hematology), University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1038/s41416-019-0721-1DOI Listing
February 2020

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape.

Aging (Albany NY) 2019 06;11(11):3851-3863

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.18632/aging.102021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594823PMC
June 2019

Development versus Evolution in Cancer Biology.

Trends Cancer 2018 05 7;4(5):342-348. Epub 2018 Apr 7.

Unit of Experimental Medicine, Department of Biomedical Sciences, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.03.007DOI Listing
May 2018

Evidence of Amniotic Epithelial Cell Differentiation toward Hepatic Sinusoidal Endothelial Cells.

Cell Transplant 2018 01;27(1):23-30

1 Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1177/0963689717727541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434484PMC
January 2018

A GC-MS untargeted metabolomics analysis in the plasma and liver of rats lacking dipeptidyl-peptidase type IV enzyme activity.

J Physiol Biochem 2017 Nov 11;73(4):575-582. Epub 2017 Sep 11.

Dipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Via Porcell 4, 09124, Cagliari, Italy.

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http://dx.doi.org/10.1007/s13105-017-0588-7DOI Listing
November 2017

Glucose-6-phosphate dehydrogenase deficiency is associated with lower fibrosis score in non-progressive HBsAg-positive subjects.

J Gastrointestin Liver Dis 2017 09;26(3):319-320

Department of Biomedical Sciences, Unit of Experimental Medicine, Università degli Studi di Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.15403/jgld.2014.1121.263.froDOI Listing
September 2017

Regenerative Medicine: Shedding Light on the Link between Aging and Cancer.

Cell Transplant 2017 09;26(9):1530-1537

1 Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1177/0963689717721224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680953PMC
September 2017

Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment.

Oncotarget 2017 May;8(22):36020-36032

Department of Biomedical Sciences, Unit of Experimental Medicine University of Cagliari-Italy, Cagliari, Italy.

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http://dx.doi.org/10.18632/oncotarget.16421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482635PMC
May 2017

Hyperplasia hypertrophy in tissue regeneration after extensive liver resection.

World J Gastroenterol 2017 Mar;23(10):1764-1770

Fabio Marongiu, Michela Marongiu, Antonella Contini, Monica Serra, Erika Cadoni, Riccardo Murgia, Ezio Laconi, Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.

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http://dx.doi.org/10.3748/wjg.v23.i10.1764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352916PMC
March 2017

Aging promotes neoplastic disease through effects on the tissue microenvironment.

Aging (Albany NY) 2016 12;8(12):3390-3399

Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari, 09124, Cagliari, Italy.

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http://dx.doi.org/10.18632/aging.101128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270675PMC
December 2016

Gas-phase fragmentation of the N-oxide and N-hydroxylated derivatives of retrorsine using liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Rapid Commun Mass Spectrom 2015 Oct;29(19):1733-48

Chemistry Department, Memorial University of Newfoundland, Saint John's, Canada.

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http://dx.doi.org/10.1002/rcm.7276DOI Listing
October 2015

Cell-autonomous decrease in proliferative competitiveness of the aged hepatocyte.

J Hepatol 2015 Jun 21;62(6):1341-8. Epub 2015 Jan 21.

University of Cagliari, Department of Biomedical Sciences, Unit of Experimental Medicine, Cagliari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.01.015DOI Listing
June 2015

Rat-derived amniotic epithelial cells differentiate into mature hepatocytes in vivo with no evidence of cell fusion.

Stem Cells Dev 2015 Jun 6;24(12):1429-35. Epub 2015 Mar 6.

1Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

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https://www.liebertpub.com/doi/10.1089/scd.2014.0532
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http://dx.doi.org/10.1089/scd.2014.0532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486142PMC
June 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Identification and characterization of mesenchymal-epithelial progenitor-like cells in normal and injured rat liver.

Am J Pathol 2015 Jan 6;185(1):110-28. Epub 2014 Nov 6.

Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278240PMC
January 2015

Hepatocyte senescence induced by radiation and partial hepatectomy in rat liver.

Int J Radiat Biol 2014 Oct 25;90(10):876-83. Epub 2014 Jun 25.

Department of Biomedical Sciences, University of Cagliari , Italy.

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http://dx.doi.org/10.3109/09553002.2014.922714DOI Listing
October 2014

Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium.

Cell Tissue Res 2014 May 1;356(2):333-40. Epub 2014 Apr 1.

Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari School of Medicine, Via Porcell 4, 3rd Floor, Cagliari, 09124, Italy.

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http://dx.doi.org/10.1007/s00441-014-1800-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015059PMC
May 2014

Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma.

Aging (Albany NY) 2014 Jan;6(1):26-34

Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari, 09124 Cagliari, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927807PMC
http://dx.doi.org/10.18632/aging.100631DOI Listing
January 2014

Normal hepatocyte transplantation delays the emergence of chemically induced preneoplastic nodules in rat liver.

Cell Transplant 2012 22;21(4):671-7. Epub 2011 Sep 22.

Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari, Cagliari, Italy.

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http://journals.sagepub.com/doi/full/10.3727/096368911X60097
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http://dx.doi.org/10.3727/096368911X600975DOI Listing
June 2013

Cancer as a disease of tissue pattern formation.

Prog Histochem Cytochem 2012 Oct 15;47(3):175-207. Epub 2012 Sep 15.

Department of Biomedical Sciences, Unit of Experimental Medicine, University of Cagliari-School of Medicine, Via Porcell 4, 3(rd) floor, 09126-Cagliari, Italy.

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http://dx.doi.org/10.1016/j.proghi.2012.08.001DOI Listing
October 2012

Hepatocyte senescence in vivo following preconditioning for liver repopulation.

Hepatology 2012 Aug 11;56(2):760-8. Epub 2012 Jun 11.

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1002/hep.25698DOI Listing
August 2012

Transplanted hepatocytes: wiped out or washed out?

J Hepatol 2012 Apr 19;56(4):996-7. Epub 2011 Sep 19.

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http://dx.doi.org/10.1016/j.jhep.2011.09.004DOI Listing
April 2012

The growth pattern of transplanted normal and nodular hepatocytes.

Histochem Cell Biol 2011 Jun 29;135(6):581-91. Epub 2011 Apr 29.

Department of Biomedical Sciences and Biotechnology, Section of Experimental Pathology, University of Cagliari, Via Porcell, 4, 09125, Cagliari, Italy.

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http://dx.doi.org/10.1007/s00418-011-0813-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106155PMC
June 2011

Repopulation by endogenous hepatocytes does not reconstitute liver mass in rats treated with retrorsine.

Cell Transplant 2008 ;17(12):1415-21

Department of Biomedical Sciences and Biotechnology, Section of Experimental Pathology, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.3727/096368908787648128DOI Listing
July 2009

Cancer development at tissue level.

Semin Cancer Biol 2008 Oct 26;18(5):303-4. Epub 2008 Mar 26.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X0800024
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http://dx.doi.org/10.1016/j.semcancer.2008.03.002DOI Listing
October 2008

The microenvironments of multistage carcinogenesis.

Semin Cancer Biol 2008 Oct 1;18(5):322-9. Epub 2008 Apr 1.

Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Università di Cagliari, 09125 Cagliari, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2008.03.019DOI Listing
October 2008

Liver repopulation and carcinogenesis: two sides of the same coin?

Am J Pathol 2008 Apr 5;172(4):857-64. Epub 2008 Mar 5.

Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Università di Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.2353/ajpath.2008.070910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276408PMC
April 2008

The evolving concept of tumor microenvironments.

Authors:
Ezio Laconi

Bioessays 2007 Aug;29(8):738-44

Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Università di Cagliari, 09125 Cagliari, Italy.

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http://dx.doi.org/10.1002/bies.20606DOI Listing
August 2007

Liver repopulation by transplanted hepatocytes and risk of hepatocellular carcinoma.

Transplantation 2006 Nov;82(10):1319-23

Dipartimento di Scienze e Tecnologie Biomediche, Università di Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1097/01.tp.0000228239.78290.13DOI Listing
November 2006

Aging is associated with increased clonogenic potential in rat liver in vivo.

Aging Cell 2006 Oct 15;5(5):373-7. Epub 2006 Aug 15.

Department of Biomedical Sciences and Biotechnology, Section of Experimental Pathology, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1111/j.1474-9726.2006.00230.xDOI Listing
October 2006

PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.

Anticancer Res 2006 Mar-Apr;26(2A):995-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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May 2006

Cyclin D1 is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine.

J Hepatol 2005 Sep;43(3):485-90

Section of Experimental Pathology, Department of Biomedical Sciences and Biotechnology, University of Cagliari, Via Porcell, 4, 09125 Cagliari, Italy.

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http://dx.doi.org/10.1016/j.jhep.2005.03.029DOI Listing
September 2005

Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.

Carcinogenesis 2003 Dec 11;24(12):1977-84. Epub 2003 Sep 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/carcin/bgg159DOI Listing
December 2003

Principles of hepatocyte repopulation.

Semin Cell Dev Biol 2002 Dec;13(6):433-8

Dipartimento di Scienze Biomediche e Biotecnologie, Università di Cagliari, c/o Oncology Hospital "A. Businco", Via Jenner, 09125, Cagliari, Italy.

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http://dx.doi.org/10.1016/s1084952102001313DOI Listing
December 2002