Ezio Giorda

B Cell Pathophysiology Unit, Immunology Research Area, Bambino Gesù Children's Hospital IRCCS, 00146 Rome, Italy; Diagnostic Immunology Unit, Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy. Electronic address:

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March 2020

Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis.

Authors:

Rita Carsetti Antonio Di Sabatino Maria Manuela Rosado Simona Cascioli Eva Piano Mortari Cinzia Milito Ola Grimsholm Alaitz Aranburu Ezio Giorda Francesco Paolo Tinozzi Federica Pulvirenti Giuseppe Donato Francesco Morini Pietro Bagolan Gino Roberto Corazza Isabella Quinti

Front Immunol 2019 8;10:2937. Epub 2020 Jan 8.

Department of Molecular Medicine, Sapienza University, Rome, Italy.

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November 2020

Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells.

Authors:

Vinicia A Polito Rosaria Cristantielli Gerrit Weber Francesca Del Bufalo Tamascia Belardinilli Claudia M Arnone Andrea Petretto Laura Antonucci Ezio Giorda Nicola Tumino Angela Pitisci Biagio De Angelis Concetta Quintarelli Franco Locatelli Ignazio Caruana

Front Immunol 2019 22;10:2717. Epub 2019 Nov 22.

Department of Paediatric Haematology and Oncology, Cellular and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

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November 2020

A Lipophilic 4-Phenylbutyric Acid Derivative That Prevents Aggregation and Retention of Misfolded Proteins.

Authors:

Salome Azoulay-Ginsburg Laura Trobiani Andrea Setini Flores Lietta Favaloro Ezio Giorda Avi Jacob Hagit Hauschner Laura Levy Gianluca Cestra Antonella De Jaco Arie Gruzman

Chemistry 2020 Feb 27;26(8):1834-1845. Epub 2020 Jan 27.

Department of Chemistry, Bar-Ilan University, Ramat-Gan, 5290002, Israel.

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February 2020

Dysregulated miR-155 and miR-125b Are Related to Impaired B-cell Responses in Down Syndrome.

Authors:

Chiara Farroni Emiliano Marasco Valentina Marcellini Ezio Giorda Diletta Valentini Stefania Petrini Valentina D'Oria Marco Pezzullo Simona Cascioli Marco Scarsella Alberto G Ugazio Giovanni C De Vincentiis Ola Grimsholm Rita Carsetti

Front Immunol 2018 20;9:2683. Epub 2018 Nov 20.

B cell Pathophysiology Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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October 2019

RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.

Authors:

Angelamaria Rizzo Martina Di Giovangiulio Carmine Stolfi Eleonora Franzè Hans-Joerg Fehling Rita Carsetti Ezio Giorda Alfredo Colantoni Angela Ortenzi Massimo Rugge Claudia Mescoli Giovanni Monteleone Massimo C Fantini

Cancer Immunol Res 2018 09 10;6(9):1082-1092. Epub 2018 Jul 10.

Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.

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September 2018

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.

Proc Natl Acad Sci U S A 2018 07 25;115(28):E6546-E6555. Epub 2018 Jun 25.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00161 Rome, Italy;

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July 2018

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.

Authors:

Concetta Quintarelli Domenico Orlando Iolanda Boffa Marika Guercio Vinicia Assunta Polito Andrea Petretto Chiara Lavarello Matilde Sinibaldi Gerrit Weber Francesca Del Bufalo Ezio Giorda Marco Scarsella Stefania Petrini Daria Pagliara Franco Locatelli Biagio De Angelis Ignazio Caruana

Oncoimmunology 2018;7(6):e1433518. Epub 2018 Mar 15.

Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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March 2018

Spleen development is modulated by neonatal gut microbiota.

Authors:

M Manuela Rosado Alaitz Aranburu Marco Scarsella Simona Cascioli Ezio Giorda Federica Del Chierico Stefano Levi Mortera Eva Piano Mortari Stefania Petrini Lorenza Putignani Rita Carsetti

Immunol Lett 2018 07 30;199:1-15. Epub 2018 Apr 30.

B Cell Physiopathology Unit, Immunology Research Area, Bambino Gesù Children Hospital, Rome, Italy.

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July 2018

Osteosarcoma-derived extracellular vesicles induce a tumor-like phenotype in normal recipient cells.

Authors:

Enrica Urciuoli Ezio Giorda Marco Scarsella Stefania Petrini Barbara Peruzzi

J Cell Physiol 2018 08 7;233(8):6158-6172. Epub 2018 Mar 7.

Multifactorial Diseases Unit-Research Laboratories, Bambino Gesù Children's Hospital, Rome, Italy.

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August 2018

Switched Memory B Cells Are Increased in Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis and Their Change Over Time Is Related to Response to Tumor Necrosis Factor Inhibitors.

Authors:

Emiliano Marasco Angela Aquilani Simona Cascioli Gian Marco Moneta Ivan Caiello Chiara Farroni Ezio Giorda Valentina D'Oria Denise Pires Marafon Silvia Magni-Manzoni Rita Carsetti Fabrizio De Benedetti

Arthritis Rheumatol 2018 04 25;70(4):606-615. Epub 2018 Mar 25.

Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.

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April 2018

Identification of GAD65 AA 114-122 reactive 'memory-like' NK cells in newly diagnosed Type 1 diabetic patients by HLA-class I pentamers.

Authors:

Valentina Perri Elena Gianchecchi Loredana Cifaldi Marsha Pellegrino Ezio Giorda Marco Andreani Marco Cappa Alessandra Fierabracci

PLoS One 2017 13;12(12):e0189615. Epub 2017 Dec 13.

Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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January 2018

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.

Cell Rep 2017 07;20(4):846-853

Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146 Rome, Italy. Electronic address:

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July 2017

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.

Cell Death Differ 2017 05 24;24(5):889-902. Epub 2017 Mar 24.

Liver Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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May 2017

Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events.

Authors:

Alaitz Aranburu Eva Piano Mortari Anwar Baban Ezio Giorda Simona Cascioli Valentina Marcellini Marco Scarsella Sara Ceccarelli Sandro Corbelli Nicoletta Cantarutti Rita De Vito Alessandro Inserra Luciana Nicolosi Arnalda Lanfranchi Fulvio Porta Caterina Cancrini Andrea Finocchi Rita Carsetti

Eur J Immunol 2017 02 14;47(2):327-344. Epub 2016 Dec 14.

B Cell Physiopathology Unit, Immunology Research Area, Ospedale Pediatrico Bambino, Gesù IRCSS, Roma, Italy.

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February 2017

B-cell activation with CD40L or CpG measures the function of B-cell subsets and identifies specific defects in immunodeficient patients.

Authors:

Emiliano Marasco Chiara Farroni Simona Cascioli Valentina Marcellini Marco Scarsella Ezio Giorda Eva Piano Mortari Lucia Leonardi Alessia Scarselli Diletta Valentini Caterina Cancrini Marzia Duse Ola Grimsholm Rita Carsetti

Eur J Immunol 2017 01 25;47(1):131-143. Epub 2016 Nov 25.

B Cell Physiopathology Unit, Immunology Research Area, Ospedale Pediatrico Bambino Gesù IRCSS, Roma, Italy.

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January 2017

Altered B cell homeostasis and Toll-like receptor 9-driven response in patients affected by autoimmune polyglandular syndrome Type 1: Altered B cell phenotype and dysregulation of the B cell function in APECED patients.

Authors:

Valentina Perri Elena Gianchecchi Riccardo Scarpa Mariella Valenzise Maria Manuela Rosado Ezio Giorda Antonino Crinò Marco Cappa Susi Barollo Silvia Garelli Corrado Betterle Alessandra Fierabracci

Immunobiology 2017 02 9;222(2):372-383. Epub 2016 Sep 9.

Immuno-Infectivology and Clinical Trials Research Area, Children's Hospital Bambino Gesù, Rome, Italy. Electronic address:

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February 2017

Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich's ataxia.

Authors:

Emanuela Piermarini Daniele Cartelli Anna Pastore Giulia Tozzi Claudia Compagnucci Ezio Giorda Jessica D'Amico Stefania Petrini Enrico Bertini Graziella Cappelletti Fiorella Piemonte

Hum Mol Genet 2016 10 11;25(19):4288-4301. Epub 2016 Aug 11.

Unit of Muscular and Neurodegenerative Diseases

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October 2016

Effects of exposure to gradient magnetic fields emitted by nuclear magnetic resonance devices on clonogenic potential and proliferation of human hematopoietic stem cells.

Authors:

Maria Grazia Iachininoto Vincenzo Camisa Lucia Leone Rosanna Pinto Vanni Lopresto Caterina Merla Ezio Giorda Rita Carsetti Salvatore Zaffina Maria Vittoria Podda Luciana Teofili Claudio Grassi

Bioelectromagnetics 2016 May 15;37(4):201-11. Epub 2016 Mar 15.

Institute of Human Physiology, Università Cattolica, Rome, Italy.

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May 2016

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.

Authors:

Federica Verginelli Laura Adesso Isabelle Limon Anna Alisi Marie Gueguen Nadia Panera Ezio Giorda Lavinia Raimondi Roberta Ciarapica Antonio F Campese Isabella Screpanti Stefano Stifani Jan Kitajewski Lucio Miele Rossella Rota Franco Locatelli

Oncotarget 2015 Dec;6(41):43216-29

Department of Oncohematology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.

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December 2015

Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus.

Authors:

Valentina Perri Benedetta Russo Antonino Crinò Riccardo Schiaffini Ezio Giorda Marco Cappa Maria Manuela Rosado Alessandra Fierabracci

Int J Mol Sci 2015 Sep 18;16(9):22584-605. Epub 2015 Sep 18.

Immunology and Pharmacotherapy Area, Children's Hospital Bambino Gesù, Viale S. Paolo 15, 00146 Rome, Italy.

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September 2015

High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells.

Authors:

Maria Ausiliatrice Puglisi Carlo Cenciarelli Valentina Tesori Marianna Cappellari Maurizio Martini Angela Maria Di Francesco Ezio Giorda Rita Carsetti Lucia Ricci-Vitiani Antonio Gasbarrini

J Pathol 2015 Aug 12;236(4):479-90. Epub 2015 May 12.

Department of Internal Medicine and Gastroenterology, Gemelli Hospital, Rome, Italy.

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August 2015

Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes.

Authors:

Andrea Del Fattore Rosa Luciano Luisa Pascucci Bianca Maria Goffredo Ezio Giorda Margherita Scapaticci Alessandra Fierabracci Maurizio Muraca

Cell Transplant 2015 18;24(12):2615-27. Epub 2015 Feb 18.

Regenerative Medicine, Bambino Gesù Children's Hospital, Rome, Italy.

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October 2016

Hematopoietic activity in putative mouse primordial germ cell populations.

Authors:

Maria Lucia Scaldaferri Francesca Gioia Klinger Donatella Farini Anna Di Carlo Rita Carsetti Ezio Giorda Massimo De Felici

Mech Dev 2015 May 12;136:53-63. Epub 2015 Feb 12.

Department of Biomedicine and Prevention, Section of Histology and Embryology, University of Rome "Tor Vergata", Rome, Italy. Electronic address:

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May 2015

Sialylation of N-linked glycans influences the immunomodulatory effects of IgM on T cells.

Authors:

Manuela Colucci Henning Stöckmann Alessia Butera Andrea Masotti Antonella Baldassarre Ezio Giorda Stefania Petrini Pauline M Rudd Roberto Sitia Francesco Emma Marina Vivarelli

J Immunol 2015 Jan 24;194(1):151-7. Epub 2014 Nov 24.

Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital-Scientific Institute, 00165 Rome, Italy;

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January 2015

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