Ewan R Pearson

Ewan R Pearson

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Ewan R Pearson

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Diabetes: Is There a Future for Pharmacogenomics Guided Treatment?

Authors:
Ewan R Pearson

Clin Pharmacol Ther 2019 Aug;106(2):329-337

Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cpt.1484DOI Listing
August 2019

Type 2 diabetes: a multifaceted disease.

Authors:
Ewan R Pearson

Diabetologia 2019 Jul 3;62(7):1107-1112. Epub 2019 Jun 3.

Population Health & Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-019-4909-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560016PMC
July 2019

Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes.

Bosn J Basic Med Sci 2019 May 9. Epub 2019 May 9.

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

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http://dx.doi.org/10.17305/bjbms.2019.4181DOI Listing
May 2019

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study.

BMC Med 2019 04 12;17(1):79. Epub 2019 Apr 12.

University of Exeter Medical School, The Institute of Clinical and Biological Sciences, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1186/s12916-019-1307-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460517PMC
April 2019

Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?

Diabetes Obes Metab 2018 Nov 24. Epub 2018 Nov 24.

University of Dundee, School of Medicine, Dundee, UK.

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http://dx.doi.org/10.1111/dom.13596DOI Listing
November 2018

Pharmacokinetics of metformin in patients with gastrointestinal intolerance.

Diabetes Obes Metab 2018 07 23;20(7):1593-1601. Epub 2018 Mar 23.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, UK.

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http://dx.doi.org/10.1111/dom.13264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033038PMC
July 2018

Pharmacogenetics and target identification in diabetes.

Authors:
Ewan R Pearson

Curr Opin Genet Dev 2018 06 24;50:68-73. Epub 2018 Feb 24.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.02.005DOI Listing
June 2018

Lp-PLA activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study.

Diabetologia 2018 06 6;61(6):1344-1353. Epub 2018 Apr 6.

Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee School of Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-018-4601-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447502PMC
June 2018

Rates of glycaemic deterioration in a real-world population with type 2 diabetes.

Diabetologia 2018 03 19;61(3):607-615. Epub 2017 Dec 19.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK, Scotland.

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http://dx.doi.org/10.1007/s00125-017-4519-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448965PMC
March 2018

Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia: A GoDARTS Study.

Diabetes Obes Metab 2018 01 25;20(1):211-214. Epub 2017 Aug 25.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/dom.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724509PMC
January 2018

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.

Diabetes Obes Metab 2017 11 5;19(11):1579-1586. Epub 2017 Jul 5.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/dom.12978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655780PMC
November 2017

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.

Diabetologia 2017 Nov 25;60(11):2231-2239. Epub 2017 Aug 25.

Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4404-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448905PMC
November 2017

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).

Pharmacogenet Genomics 2017 Oct;27(10):356-362

aDivision of Molecular and Clinical Medicine, School of Medicine bCentre for Pharmacogenetics and Pharmacogenomics cMedicines Monitoring Unit (MEMO) and Hypertension Research Centre (HRC) dDepartment of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

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http://Insights.ovid.com/crossref?an=01213011-201710000-0000
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http://dx.doi.org/10.1097/FPC.0000000000000299DOI Listing
October 2017

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study.

Diabetes Ther 2017 Oct 6;8(5):1031-1045. Epub 2017 Sep 6.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s13300-017-0296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630552PMC
October 2017

The mechanisms of action of metformin.

Diabetologia 2017 09 3;60(9):1577-1585. Epub 2017 Aug 3.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-017-4342-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552828PMC
September 2017

CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.

Diabetes Care 2016 Nov 6;39(11):1902-1908. Epub 2016 Jun 6.

Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland

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http://dx.doi.org/10.2337/dc15-2464DOI Listing
November 2016

Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.

Diabetes Care 2016 Nov 4;39(11):1896-1901. Epub 2016 Aug 4.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, U.K.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-070
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http://dx.doi.org/10.2337/dc16-0706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122449PMC
November 2016

Statistical power considerations in genotype-based recall randomized controlled trials.

Sci Rep 2016 11 25;6:37307. Epub 2016 Nov 25.

Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.

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http://dx.doi.org/10.1038/srep37307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122840PMC
November 2016

Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

PLoS One 2016 6;11(4):e0152428. Epub 2016 Apr 6.

NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822872PMC
August 2016

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.

Nat Rev Endocrinol 2016 Jun 11;12(6):337-46. Epub 2016 Apr 11.

School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1038/nrendo.2016.51DOI Listing
June 2016

Metformin and the gastrointestinal tract.

Diabetologia 2016 Mar 16;59(3):426-35. Epub 2016 Jan 16.

Pearson Group, Division of Cardiovascular and Diabetes Medicine, School of Medicine, University of Dundee, Ninewells Hospital, Mailbox 12, Level 5, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-015-3844-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742508PMC
March 2016

Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population.

Authors:
Ewan R Pearson

Diabetes 2015 Dec;64(12):3993-5

Division of Cardiovascular & Diabetes Medicine, School of Medicine, University of Dundee, Dundee, Scotland

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http://dx.doi.org/10.2337/dbi15-0016DOI Listing
December 2015

Pharmacogenetics of oral antidiabetic drugs.

Int J Endocrinol 2013 13;2013:686315. Epub 2013 Nov 13.

Department of Epidemiology, Erasmus MC, 3015 CE Rotterdam, The Netherlands ; Pharmacy Foundation of Haarlem Hospitals, 2035 RC Haarlem, The Netherlands.

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http://www.hindawi.com/journals/ije/2013/686315/
Publisher Site
http://dx.doi.org/10.1155/2013/686315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845331PMC
June 2014

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.

Pharmacogenet Genomics 2013 Oct;23(10):518-25

aMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee bWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK cDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University dDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/FPC.0b013e3283642fd6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110714PMC
October 2013

Molecular mechanism of action of metformin: old or new insights?

Diabetologia 2013 Sep 9;56(9):1898-906. Epub 2013 Jul 9.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-013-2991-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737434PMC
September 2013

Insights from genome-wide association studies of drug response.

Annu Rev Pharmacol Toxicol 2013 16;53:299-310. Epub 2012 Oct 16.

Medical Research Institute, University of Dundee, Scotland, United Kingdom DD1 9SY.

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140237DOI Listing
July 2013

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Authors:
Momoko Horikoshi Hanieh Yaghootkar Dennis O Mook-Kanamori Ulla Sovio H Rob Taal Branwen J Hennig Jonathan P Bradfield Beate St Pourcain David M Evans Pimphen Charoen Marika Kaakinen Diana L Cousminer Terho Lehtimäki Eskil Kreiner-Møller Nicole M Warrington Mariona Bustamante Bjarke Feenstra Diane J Berry Elisabeth Thiering Thiemo Pfab Sheila J Barton Beverley M Shields Marjan Kerkhof Elisabeth M van Leeuwen Anthony J Fulford Zoltán Kutalik Jing Hua Zhao Marcel den Hoed Anubha Mahajan Virpi Lindi Liang-Kee Goh Jouke-Jan Hottenga Ying Wu Olli T Raitakari Marie N Harder Aline Meirhaeghe Ioanna Ntalla Rany M Salem Karen A Jameson Kaixin Zhou Dorota M Monies Vasiliki Lagou Mirna Kirin Jani Heikkinen Linda S Adair Fowzan S Alkuraya Ali Al-Odaib Philippe Amouyel Ehm Astrid Andersson Amanda J Bennett Alexandra I F Blakemore Jessica L Buxton Jean Dallongeville Shikta Das Eco J C de Geus Xavier Estivill Claudia Flexeder Philippe Froguel Frank Geller Keith M Godfrey Frédéric Gottrand Christopher J Groves Torben Hansen Joel N Hirschhorn Albert Hofman Mads V Hollegaard David M Hougaard Elina Hyppönen Hazel M Inskip Aaron Isaacs Torben Jørgensen Christina Kanaka-Gantenbein John P Kemp Wieland Kiess Tuomas O Kilpeläinen Norman Klopp Bridget A Knight Christopher W Kuzawa George McMahon John P Newnham Harri Niinikoski Ben A Oostra Louise Pedersen Dirkje S Postma Susan M Ring Fernando Rivadeneira Neil R Robertson Sylvain Sebert Olli Simell Torsten Slowinski Carla M T Tiesler Anke Tönjes Allan Vaag Jorma S Viikari Jacqueline M Vink Nadja Hawwa Vissing Nicholas J Wareham Gonneke Willemsen Daniel R Witte Haitao Zhang Jianhua Zhao James F Wilson Michael Stumvoll Andrew M Prentice Brian F Meyer Ewan R Pearson Colin A G Boreham Cyrus Cooper Matthew W Gillman George V Dedoussis Luis A Moreno Oluf Pedersen Maiju Saarinen Karen L Mohlke Dorret I Boomsma Seang-Mei Saw Timo A Lakka Antje Körner Ruth J F Loos Ken K Ong Peter Vollenweider Cornelia M van Duijn Gerard H Koppelman Andrew T Hattersley John W Holloway Berthold Hocher Joachim Heinrich Chris Power Mads Melbye Mònica Guxens Craig E Pennell Klaus Bønnelykke Hans Bisgaard Johan G Eriksson Elisabeth Widén Hakon Hakonarson André G Uitterlinden Anneli Pouta Debbie A Lawlor George Davey Smith Timothy M Frayling Mark I McCarthy Struan F A Grant Vincent W V Jaddoe Marjo-Riitta Jarvelin Nicholas J Timpson Inga Prokopenko Rachel M Freathy

Nat Genet 2013 Jan 2;45(1):76-82. Epub 2012 Dec 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.2477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762PMC
January 2013

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.

Clin Chim Acta 2012 May 14;413(9-10):927-32. Epub 2012 Feb 14.

NIHR Clinical Research Facility, Peninsula College or Medicine and Dentistry, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1016/j.cca.2012.02.005DOI Listing
May 2012

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology.

Biochem Pharmacol 2011 Feb 25;81(4):471-7. Epub 2010 Nov 25.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G11 6TA, United Kingdom.

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http://dx.doi.org/10.1016/j.bcp.2010.11.010DOI Listing
February 2011

Pharmacogenetics in diabetes.

Authors:
Ewan R Pearson

Curr Diab Rep 2009 Apr;9(2):172-81

Biomedical Research Institute, Ninewells Hospital and Medical School, Ninewells Avenue, Dundee, DD1 9SY, UK.

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April 2009

Transition from insulin to sulfonylurea in a child with diabetes due to a mutation in KCNJ11 encoding Kir6.2--initial and long-term response to sulfonylurea therapy.

Eur J Pediatr 2009 Mar 12;168(3):359-61. Epub 2008 Jun 12.

Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, University of Lübeck, Lübeck, Germany.

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http://link.springer.com/10.1007/s00431-008-0757-3
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http://dx.doi.org/10.1007/s00431-008-0757-3DOI Listing
March 2009

Pharmacogenetics and future strategies in treating hyperglycaemia in diabetes.

Authors:
Ewan R Pearson

Front Biosci (Landmark Ed) 2009 Jan 1;14:4348-62. Epub 2009 Jan 1.

Biomedical Research Institute, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland.

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January 2009

Recent advances in the genetics of diabetes.

Authors:
Ewan R Pearson

Prim Care Diabetes 2008 Jun 12;2(2):67-72. Epub 2008 Feb 12.

Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee DD19SY, United Kingdom.

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http://dx.doi.org/10.1016/j.pcd.2007.12.005DOI Listing
June 2008

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.

Diabetes 2007 Aug 22;56(8):2178-82. Epub 2007 May 22.

Division of Medicine and Therapeutics, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.2337/db07-0440DOI Listing
August 2007

Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes.

Endocrinology 2006 Jun 23;147(6):2657-63. Epub 2006 Mar 23.

Peninsula Medical School, Exeter EX2 5DW, United Kingdom.

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http://dx.doi.org/10.1210/en.2006-0152DOI Listing
June 2006

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

Hum Mol Genet 2005 Apr 17;14(7):925-34. Epub 2005 Feb 17.

Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, USA.

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http://dx.doi.org/10.1093/hmg/ddi086DOI Listing
April 2005

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Lancet 2003 Oct;362(9392):1275-81

Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK.

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http://dx.doi.org/10.1016/S0140-6736(03)14571-0DOI Listing
October 2003

Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene.

Am J Kidney Dis 2002 Dec;40(6):1325-30

Nephro-Urology Unit, Institute of Child Health, University College London and the Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, England.

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http://dx.doi.org/10.1053/ajkd.2002.36915DOI Listing
December 2002