Ewan Pearson

Ewan Pearson

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Ewan Pearson

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Visit-to-Visit HbA Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes.

Authors:
Sheyu Li Imola Nemeth Louise Donnelly Simona Hapca Kaixin Zhou Ewan R Pearson

Diabetes Care 2020 Feb 14;43(2):426-432. Epub 2019 Nov 14.

Division of Population Health and Genomics, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, Scotland, U.K.

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http://dx.doi.org/10.2337/dc19-0823DOI Listing
February 2020

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals.

Authors:
Laura J McCreight Andrea Mari Lucy Coppin Nicola Jackson A Margot Umpleby Ewan R Pearson

Diabetologia 2020 Feb 22;63(2):444-447. Epub 2019 Nov 22.

Division of Population Health and Genomics, University of Dundee, Ninewells Hospital, Dundee, DD19SY, UK.

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http://dx.doi.org/10.1007/s00125-019-05042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946719PMC
February 2020

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.

Authors:
Abirami Veluchamy Lucia Ballerini Veronique Vitart Katharina E Schraut Mirna Kirin Harry Campbell Peter K Joshi Devanjali Relan Sarah Harris Ellie Brown Suraj S Vaidya Baljean Dhillon Kaixin Zhou Ewan R Pearson Caroline Hayward Ozren Polasek Ian J Deary Thomas MacGillivray James F Wilson Emanuele Trucco Colin N A Palmer Alexander S F Doney

Arterioscler Thromb Vasc Biol 2019 Dec 10;39(12):2542-2552. Epub 2019 Oct 10.

From the Division of Population Health and Genomics (A.V., E.R.P., C.N.A.P., A.S.F.D.), University of Dundee, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.119.312552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882544PMC
December 2019

Drug-drug-gene interactions and adverse drug reactions.

Authors:
Mustafa Adnan Malki Ewan Robert Pearson

Pharmacogenomics J 2019 Dec 3. Epub 2019 Dec 3.

Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41397-019-0122-0DOI Listing
December 2019

Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes.

Authors:
Tanja Dujic Tamer Bego Maja Malenica Zelija Velija-Asimi Emma Ahlqvist Leif Groop Ewan R Pearson Adlija Causevic Sabina Semiz

Bosn J Basic Med Sci 2019 Nov 8;19(4):368-374. Epub 2019 Nov 8.

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

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http://dx.doi.org/10.17305/bjbms.2019.4181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868489PMC
November 2019

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation.

Authors:
Csilla Sipeky Adrián Llerena Vangelis G Manolopoulos Ewan Pearson Vid Mlakar Lucia Gozzo Maurizio Simmaco Paolo Marchetti Marzia Del Re Sanja Stankovic Urs Meyer Ingolf Cascorbi Magnus Ingelman-Sundberg Guilherme Suarez-Kurtz Janja Marc Theodora Katsila Markus Paulmichl Charity Nofziger Marc Ansari Filippo Drago Ron Hn van Schaik

Pharmacogenomics 2019 10;20(15):1063-1069

Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.

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http://dx.doi.org/10.2217/pgs-2019-0095DOI Listing
October 2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.

Authors:
Robert W Koivula Ian M Forgie Azra Kurbasic Ana Viñuela Alison Heggie Giuseppe N Giordano Tue H Hansen Michelle Hudson Anitra D M Koopman Femke Rutters Maritta Siloaho Kristine H Allin Søren Brage Caroline A Brorsson Adem Y Dawed Federico De Masi Christopher J Groves Tarja Kokkola Anubha Mahajan Mandy H Perry Simone P Rauh Martin Ridderstråle Harriet J A Teare E Louise Thomas Andrea Tura Henrik Vestergaard Tom White Jerzy Adamski Jimmy D Bell Joline W Beulens Søren Brunak Emmanouil T Dermitzakis Philippe Froguel Gary Frost Ramneek Gupta Torben Hansen Andrew Hattersley Bernd Jablonka Jane Kaye Markku Laakso Timothy J McDonald Oluf Pedersen Jochen M Schwenk Imre Pavo Andrea Mari Mark I McCarthy Hartmut Ruetten Mark Walker Ewan Pearson Paul W Franks

Diabetologia 2019 09 15;62(9):1601-1615. Epub 2019 Jun 15.

Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, CRC, Skåne University Hospital Malmö, Building 91, Level 10, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-019-4906-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677872PMC
September 2019

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years.

Authors:
Anita Lynam Timothy McDonald Anita Hill John Dennis Richard Oram Ewan Pearson Michael Weedon Andrew Hattersley Katharine Owen Beverley Shields Angus Jones

BMJ Open 2019 Sep 26;9(9):e031586. Epub 2019 Sep 26.

The Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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http://dx.doi.org/10.1136/bmjopen-2019-031586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773323PMC
September 2019

Diabetes: Is There a Future for Pharmacogenomics Guided Treatment?

Authors:
Ewan R Pearson

Clin Pharmacol Ther 2019 Aug;106(2):329-337

Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cpt.1484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771467PMC
August 2019

Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017.

Authors:
John M Dennis William E Henley Andrew P McGovern Andrew J Farmer Naveed Sattar Rury R Holman Ewan R Pearson Andrew T Hattersley Beverley M Shields Angus G Jones

Diabetes Obes Metab 2019 07 4;21(7):1576-1584. Epub 2019 Apr 4.

Institute of Biomedical and Clinical Science, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1111/dom.13687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618851PMC
July 2019

Type 2 diabetes: a multifaceted disease.

Authors:
Ewan R Pearson

Diabetologia 2019 07 3;62(7):1107-1112. Epub 2019 Jun 3.

Population Health & Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://link.springer.com/10.1007/s00125-019-4909-y
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http://dx.doi.org/10.1007/s00125-019-4909-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560016PMC
July 2019

Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by ) and Organic Cation Transporter 1 (OCT1) (Encoded by ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.

Authors:
Adem Y Dawed Kaixin Zhou Nienke van Leeuwen Anubha Mahajan Neil Robertson Robert Koivula Petra J M Elders Simone P Rauh Angus G Jones Reinhard W Holl Julia C Stingl Paul W Franks Mark I McCarthy Leen M 't Hart Ewan R Pearson

Diabetes Care 2019 06 18;42(6):1027-1033. Epub 2019 Mar 18.

Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/dc18-2182DOI Listing
June 2019

Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study.

Authors:
Nisha Shah Victoria Coathup Harriet Teare Ian Forgie Giuseppe Nicola Giordano Tue Haldor Hansen Lenka Groeneveld Michelle Hudson Ewan Pearson Hartmut Ruetten Jane Kaye

Genet Med 2019 05 28;21(5):1131-1138. Epub 2018 Sep 28.

HeLEX Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41436-018-0299-7DOI Listing
May 2019

Motivations for data sharing-views of research participants from four European countries: A DIRECT study.

Authors:
Nisha Shah Victoria Coathup Harriet Teare Ian Forgie Giuseppe Nicola Giordano Tue Haldor Hansen Lenka Groeneveld Michelle Hudson Ewan Pearson Hartmut Ruetten Jane Kaye

Eur J Hum Genet 2019 May 30;27(5):721-729. Epub 2019 Jan 30.

HeLEX Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41431-019-0344-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461907PMC
May 2019

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study.

Authors:
Stuart J McGurnaghan Liam Brierley Thomas M Caparrotta Paul M McKeigue Luke A K Blackbourn Sarah H Wild Graham P Leese Rory J McCrimmon John A McKnight Ewan R Pearson John R Petrie Naveed Sattar Helen M Colhoun

Diabetologia 2019 04 10;62(4):621-632. Epub 2019 Jan 10.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00125-018-4806-9DOI Listing
April 2019

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study.

Authors:
Andrew P McGovern John M Dennis Beverley M Shields Andrew T Hattersley Ewan R Pearson Angus G Jones

BMC Med 2019 04 12;17(1):79. Epub 2019 Apr 12.

University of Exeter Medical School, The Institute of Clinical and Biological Sciences, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1186/s12916-019-1307-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460517PMC
April 2019

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.

Authors:
Anita L Grubb Timothy J McDonald Femke Rutters Louise A Donnelly Andrew T Hattersley Richard A Oram Colin N A Palmer Amber A van der Heijden Fiona Carr Petra J M Elders Mike N Weedon Roderick C Slieker Leen M 't Hart Ewan R Pearson Beverley M Shields Angus G Jones

Diabetes Care 2019 02 23;42(2):208-214. Epub 2018 Oct 23.

National Institute for Health Research Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, U.K.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-043
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http://dx.doi.org/10.2337/dc18-0431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828553PMC
February 2019

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes.

Authors:
Kashyap A Patel Michael N Weedon Beverley M Shields Ewan R Pearson Andrew T Hattersley Timothy J McDonald

Diabetes Care 2019 02 8;42(2):e16-e17. Epub 2018 Nov 8.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-037
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http://dx.doi.org/10.2337/dc18-0373DOI Listing
February 2019

Differential Association of Genetic Risk of Coronary Artery Disease With Development of Heart Failure With Reduced Versus Preserved Ejection Fraction.

Authors:
Ify R Mordi Ewan R Pearson Colin N A Palmer Alexander S F Doney Chim C Lang

Circulation 2019 02;139(7):986-988

Division of Molecular and Clinical Medicine (I.R.M.,C.C.L.), University of Dundee, UK.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420119PMC
February 2019

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension.

Authors:
Yingjie Ji Andrianos M Yiorkas Francesca Frau Dennis Mook-Kanamori Harald Staiger E Louise Thomas Naeimeh Atabaki-Pasdar Archie Campbell Jessica Tyrrell Samuel E Jones Robin N Beaumont Andrew R Wood Marcus A Tuke Katherine S Ruth Anubha Mahajan Anna Murray Rachel M Freathy Michael N Weedon Andrew T Hattersley Caroline Hayward Jürgen Machann Hans-Ulrich Häring Paul Franks Renée de Mutsert Ewan Pearson Norbert Stefan Timothy M Frayling Karla V Allebrandt Jimmy D Bell Alexandra I Blakemore Hanieh Yaghootkar

Diabetes 2019 01 23;68(1):207-219. Epub 2018 Oct 23.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, U.K.

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http://dx.doi.org/10.2337/db18-0708DOI Listing
January 2019

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin.

Authors:
Maggie H Shepherd Beverley M Shields Michelle Hudson Ewan R Pearson Christopher Hyde Sian Ellard Andrew T Hattersley Kashyap A Patel

Diabetologia 2018 12 18;61(12):2520-2527. Epub 2018 Sep 18.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD, Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-018-4728-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223847PMC
December 2018

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach.

Authors:
John M Dennis Beverley M Shields Angus G Jones Ewan R Pearson Andrew T Hattersley William E Henley

Clin Epidemiol 2018 14;10:1869-1877. Epub 2018 Dec 14.

Health Statistics Group, University of Exeter Medical School, Exeter, UK,

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http://dx.doi.org/10.2147/CLEP.S179555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298877PMC
December 2018

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Authors:
Cristina Cosentino Sanna Toivonen Esteban Diaz Villamil Mohamed Atta Jean-Luc Ravanat Stéphane Demine Andrea Alex Schiavo Nathalie Pachera Jean-Philippe Deglasse Jean-Christophe Jonas Diego Balboa Timo Otonkoski Ewan R Pearson Piero Marchetti Décio L Eizirik Miriam Cnop Mariana Igoillo-Esteve

Nucleic Acids Res 2018 11;46(19):10302-10318

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1093/nar/gky839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212784PMC
November 2018

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

Authors:
Diana L Cousminer Emma Ahlqvist Rajashree Mishra Mette K Andersen Alessandra Chesi Mohammad I Hawa Asa Davis Kenyaita M Hodge Jonathan P Bradfield Kaixin Zhou Vanessa C Guy Mikael Åkerlund Mette Wod Lars G Fritsche Henrik Vestergaard James Snyder Kurt Højlund Allan Linneberg Annemari Käräjämäki Ivan Brandslund Cecilia E Kim Daniel Witte Elin Pettersen Sørgjerd David J Brillon Oluf Pedersen Henning Beck-Nielsen Niels Grarup Richard E Pratley Michael R Rickels Adrian Vella Fernando Ovalle Olle Melander Ronald I Harris Stephen Varvel Valdemar E R Grill Hakon Hakonarson Philippe Froguel John T Lonsdale Didac Mauricio Nanette C Schloot Kamlesh Khunti Carla J Greenbaum Bjørn Olav Åsvold Knud B Yderstræde Ewan R Pearson Stanley Schwartz Benjamin F Voight Torben Hansen Tiinamaija Tuomi Bernhard O Boehm Leif Groop R David Leslie Struan F A Grant

Diabetes Care 2018 11 25;41(11):2396-2403. Epub 2018 Sep 25.

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http://dx.doi.org/10.2337/dc18-1032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196829PMC
November 2018

Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?

Authors:
Ruth L M Cordiner Ewan R Pearson

Diabetes Obes Metab 2018 Nov 24. Epub 2018 Nov 24.

University of Dundee, School of Medicine, Dundee, UK.

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http://dx.doi.org/10.1111/dom.13596DOI Listing
November 2018

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register.

Authors:
Stephanie H Read Merel van Diepen Helen M Colhoun Nynke Halbesma Robert S Lindsay John A McKnight David A McAllister Ewan R Pearson John R Petrie Sam Philip Naveed Sattar Mark Woodward Sarah H Wild

Diabetes Care 2018 09 12;41(9):2010-2018. Epub 2018 Jul 12.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.

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http://dx.doi.org/10.2337/dc18-0578DOI Listing
September 2018

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data.

Authors:
John M Dennis William E Henley Michael N Weedon Mike Lonergan Lauren R Rodgers Angus G Jones William T Hamilton Naveed Sattar Salim Janmohamed Rury R Holman Ewan R Pearson Beverley M Shields Andrew T Hattersley

Diabetes Care 2018 09 2;41(9):1844-1853. Epub 2018 Aug 2.

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http://dx.doi.org/10.2337/dc18-0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591127PMC
September 2018

The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project.

Authors:
Harriet J A Teare Federico de Masi Karina Banasik Anna Barnett Sanna Herrgard Bernd Jablonka Jacqueline W M Postma Timothy J McDonald Ian Forgie Piotr J Chmura Emil K Rydzka Ramneek Gupta Soren Brunak Ewan Pearson Jane Kaye

Life Sci Soc Policy 2018 Sep 4;14(1):20. Epub 2018 Sep 4.

HeLEX Centre, University of Oxford, Ewert House, Banbury Road, Oxford, OX2 7DD, UK.

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http://dx.doi.org/10.1186/s40504-018-0083-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123336PMC
September 2018

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.

Authors:
Pamela Bowman Åsta Sulen Fabrizio Barbetti Jacques Beltrand Pernille Svalastoga Ethel Codner Ellen H Tessmann Petur B Juliusson Torild Skrivarhaug Ewan R Pearson Sarah E Flanagan Tarig Babiker Nicholas J Thomas Maggie H Shepherd Sian Ellard Iwar Klimes Magdalena Szopa Michel Polak Dario Iafusco Andrew T Hattersley Pål R Njølstad

Lancet Diabetes Endocrinol 2018 08 4;6(8):637-646. Epub 2018 Jun 4.

KG Jebsen Centre for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Paediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1016/S2213-8587(18)30106-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058077PMC
August 2018

The search for predictive metabolic biomarkers for incident T2DM.

Authors:
Ewan Pearson Jerzy Adamski

Nat Rev Endocrinol 2018 08;14(8):444-446

Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41574-018-0045-xDOI Listing
August 2018

Pharmacokinetics of metformin in patients with gastrointestinal intolerance.

Authors:
Laura J McCreight Tore B Stage Paul Connelly Mike Lonergan Flemming Nielsen Cornelia Prehn Jerzy Adamski Kim Brøsen Ewan R Pearson

Diabetes Obes Metab 2018 07 23;20(7):1593-1601. Epub 2018 Mar 23.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, UK.

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http://dx.doi.org/10.1111/dom.13264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033038PMC
July 2018

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies.

Authors:
Matthew Marzetti Tracy Brunton Laura McCreight Ewan Pearson Stephen Docherty Stephen J Gandy

Br J Radiol 2018 Jul 17;91(1087):20180025. Epub 2018 May 17.

1 NHS Tayside Medical Physics, Ninewells Hospital , Dundee , UK.

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http://dx.doi.org/10.1259/bjr.20180025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221768PMC
July 2018

Genetic Variants in and Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.

Authors:
Daniel M Rotroff Sook Wah Yee Kaixin Zhou Skylar W Marvel Hetal S Shah John R Jack Tammy M Havener Monique M Hedderson Michiaki Kubo Mark A Herman He Gao Josyf C Mychaleckyi Howard L McLeod Alessandro Doria Kathleen M Giacomini Ewan R Pearson Michael J Wagner John B Buse Alison A Motsinger-Reif

Diabetes 2018 07 12;67(7):1428-1440. Epub 2018 Apr 12.

Bioinformatics Research Center, North Carolina State University, Raleigh, NC

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http://dx.doi.org/10.2337/db17-1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014560PMC
July 2018

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

Authors:
Beverley M Shields Timothy J McDonald Richard Oram Anita Hill Michelle Hudson Pia Leete Ewan R Pearson Sarah J Richardson Noel G Morgan Andrew T Hattersley

Diabetes Care 2018 07 7;41(7):1486-1492. Epub 2018 Jun 7.

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http://dx.doi.org/10.2337/dc18-0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027962PMC
July 2018

Pharmacogenetics and target identification in diabetes.

Authors:
Ewan R Pearson

Curr Opin Genet Dev 2018 06 24;50:68-73. Epub 2018 Feb 24.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.02.005DOI Listing
June 2018

Lp-PLA activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study.

Authors:
Moneeza K Siddiqui Gwen Kennedy Fiona Carr Alexander S F Doney Ewan R Pearson Andrew D Morris Toby Johnson Megan M McLaughlin Rachel E Williams Colin N A Palmer

Diabetologia 2018 06 6;61(6):1344-1353. Epub 2018 Apr 6.

Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee School of Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-018-4601-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447502PMC
June 2018

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS).

Authors:
Harry L Hébert Bridget Shepherd Keith Milburn Abirami Veluchamy Weihua Meng Fiona Carr Louise A Donnelly Roger Tavendale Graham Leese Helen M Colhoun Ellie Dow Andrew D Morris Alexander S Doney Chim C Lang Ewan R Pearson Blair H Smith Colin N A Palmer

Int J Epidemiol 2018 04;47(2):380-381j

Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics.

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http://dx.doi.org/10.1093/ije/dyx140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913637PMC
April 2018

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy.

Authors:
John M Dennis Beverley M Shields Anita V Hill Bridget A Knight Timothy J McDonald Lauren R Rodgers Michael N Weedon William E Henley Naveed Sattar Rury R Holman Ewan R Pearson Andrew T Hattersley Angus G Jones

Diabetes Care 2018 04 31;41(4):705-712. Epub 2018 Jan 31.

National Institute for Health Research Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/dc17-1827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591121PMC
April 2018

Rates of glycaemic deterioration in a real-world population with type 2 diabetes.

Authors:
Louise A Donnelly Kaixin Zhou Alex S F Doney Chris Jennison Paul W Franks Ewan R Pearson

Diabetologia 2018 03 19;61(3):607-615. Epub 2017 Dec 19.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK, Scotland.

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http://dx.doi.org/10.1007/s00125-017-4519-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448965PMC
March 2018

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

Authors:
Laura J Corbin Vanessa Y Tan David A Hughes Kaitlin H Wade Dirk S Paul Katherine E Tansey Frances Butcher Frank Dudbridge Joanna M Howson Momodou W Jallow Catherine John Nathalie Kingston Cecilia M Lindgren Michael O'Donavan Stephen O'Rahilly Michael J Owen Colin N A Palmer Ewan R Pearson Robert A Scott David A van Heel John Whittaker Tim Frayling Martin D Tobin Louise V Wain George Davey Smith David M Evans Fredrik Karpe Mark I McCarthy John Danesh Paul W Franks Nicholas J Timpson

Nat Commun 2018 02 19;9(1):711. Epub 2018 Feb 19.

MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-018-03109-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818506PMC
February 2018

Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia: A GoDARTS Study.

Authors:
Tanja Dujic Kaixin Zhou Louise A Donnelly Graham Leese Colin N A Palmer Ewan R Pearson

Diabetes Obes Metab 2018 01 25;20(1):211-214. Epub 2017 Aug 25.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/dom.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724509PMC
January 2018

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

Authors:
Sophie Molnos Simone Wahl Mark Haid E Marelise W Eekhoff René Pool Anna Floegel Joris Deelen Daniela Much Cornelia Prehn Michaela Breier Harmen H Draisma Nienke van Leeuwen Annemarie M C Simonis-Bik Anna Jonsson Gonneke Willemsen Wolfgang Bernigau Rui Wang-Sattler Karsten Suhre Annette Peters Barbara Thorand Christian Herder Wolfgang Rathmann Michael Roden Christian Gieger Mark H H Kramer Diana van Heemst Helle K Pedersen Valborg Gudmundsdottir Matthias B Schulze Tobias Pischon Eco J C de Geus Heiner Boeing Dorret I Boomsma Anette G Ziegler P Eline Slagboom Sandra Hummel Marian Beekman Harald Grallert Søren Brunak Mark I McCarthy Ramneek Gupta Ewan R Pearson Jerzy Adamski Leen M 't Hart

Diabetologia 2018 Jan 25;61(1):117-129. Epub 2017 Oct 25.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-017-4436-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448944PMC
January 2018

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.

Authors:
Valborg Gudmundsdottir Helle Krogh Pedersen Karla Viviani Allebrandt Caroline Brorsson Nienke van Leeuwen Karina Banasik Anubha Mahajan Christopher J Groves Martijn van de Bunt Adem Y Dawed Andreas Fritsche Harald Staiger Annemarie M C Simonis-Bik Joris Deelen Mark H H Kramer Axel Dietrich Thomas Hübschle Gonneke Willemsen Hans-Ulrich Häring Eco J C de Geus Dorret I Boomsma Elisabeth M W Eekhoff Jorge Ferrer Mark I McCarthy Ewan R Pearson Ramneek Gupta Søren Brunak Leen M 't Hart

PLoS One 2018 2;13(1):e0189886. Epub 2018 Jan 2.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749727PMC
January 2018

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

Authors:
Moneeza K Siddiqui Cyrielle Maroteau Abirami Veluchamy Aleksi Tornio Roger Tavendale Fiona Carr Ngu-Uma Abelega Dan Carr Katyrzyna Bloch Par Hallberg Qun-Ying Yue Ewan R Pearson Helen M Colhoun Andrew D Morris Eleanor Dow Jacob George Munir Pirmohamed Paul M Ridker Alex S F Doney Ana Alfirevic Mia Wadelius Anke-Hilse Maitland-van der Zee Daniel I Chasman Colin N A Palmer

Eur Heart J 2017 12;38(48):3569-3575

Pat McPherson Centre for Pharmacogenetics & Pharmacogenomics, Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY, UK.

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http://dx.doi.org/10.1093/eurheartj/ehx467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837247PMC
December 2017

Clarifying the relationship between metformin, acute kidney injury and lactic acidosis.

Authors:
Samira Bell Enrique Soto-Pedre Paul Connelly Shona Livingstone Ewan Pearson

Nat Rev Nephrol 2017 12;14(1):70

Division of Molecular & Clinical Medicine, Level 5, Mailbox 12, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1038/nrneph.2017.172DOI Listing
December 2017

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.

Authors:
Paul J Connelly Mike Lonergan Enrique Soto-Pedre Louise Donnelly Kaixin Zhou Ewan R Pearson

Diabetes Obes Metab 2017 11 5;19(11):1579-1586. Epub 2017 Jul 5.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/dom.12978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655780PMC
November 2017

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.

Authors:
Adem Y Dawed Ashfaq Ali Kaixin Zhou Ewan R Pearson Paul W Franks

Diabetologia 2017 Nov 25;60(11):2231-2239. Epub 2017 Aug 25.

Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4404-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448905PMC
November 2017

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).

Authors:
Enrique Soto-Pedre Moneeza K Siddiqui Alex S Doney Colin N A Palmer Ewan R Pearson Graham P Leese

Pharmacogenet Genomics 2017 Oct;27(10):356-362

aDivision of Molecular and Clinical Medicine, School of Medicine bCentre for Pharmacogenetics and Pharmacogenomics cMedicines Monitoring Unit (MEMO) and Hypertension Research Centre (HRC) dDepartment of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

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October 2017

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study.

Authors:
Peter Eibich Amelia Green Andrew T Hattersley Christopher Jennison Mike Lonergan Ewan R Pearson Alastair M Gray

Diabetes Ther 2017 Oct 6;8(5):1031-1045. Epub 2017 Sep 6.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s13300-017-0296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630552PMC
October 2017

The mechanisms of action of metformin.

Authors:
Graham Rena D Grahame Hardie Ewan R Pearson

Diabetologia 2017 09 3;60(9):1577-1585. Epub 2017 Aug 3.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-017-4342-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552828PMC
September 2017

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study.

Authors:
Simone P Rauh Martijn W Heymans Anitra D M Koopman Giel Nijpels Coen D Stehouwer Barbara Thorand Wolfgang Rathmann Christa Meisinger Annette Peters Tonia de Las Heras Gala Charlotte Glümer Oluf Pedersen Henna Cederberg Johanna Kuusisto Markku Laakso Ewan R Pearson Paul W Franks Femke Rutters Jacqueline M Dekker

PLoS One 2017 10;12(2):e0171816. Epub 2017 Feb 10.

Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302787PMC
August 2017

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.

Authors:
Andrew R Wood Anna Jonsson Anne U Jackson Nan Wang Nienke van Leewen Nicholette D Palmer Sayuko Kobes Joris Deelen Lorena Boquete-Vilarino Jussi Paananen Alena Stančáková Dorret I Boomsma Eco J C de Geus Elisabeth M W Eekhoff Andreas Fritsche Mark Kramer Giel Nijpels Annemarie Simonis-Bik Timon W van Haeften Anubha Mahajan Michael Boehnke Richard N Bergman Jaakko Tuomilehto Francis S Collins Karen L Mohlke Karina Banasik Christopher J Groves Mark I McCarthy Ewan R Pearson Andrea Natali Andrea Mari Thomas A Buchanan Kent D Taylor Anny H Xiang Anette P Gjesing Niels Grarup Hans Eiberg Oluf Pedersen Yii-Derr Chen Markku Laakso Jill M Norris Ulf Smith Lynne E Wagenknecht Leslie Baier Donald W Bowden Torben Hansen Mark Walker Richard M Watanabe Leen M 't Hart Robert L Hanson Timothy M Frayling

Diabetes 2017 08 10;66(8):2296-2309. Epub 2017 May 10.

Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K.

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http://dx.doi.org/10.2337/db16-1452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521867PMC
August 2017

Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients.

Authors:
Beverley M Shields Maggie Shepherd Michelle Hudson Timothy J McDonald Kevin Colclough Jaime Peters Bridget Knight Chris Hyde Sian Ellard Ewan R Pearson Andrew T Hattersley

Diabetes Care 2017 08;40(8):1017-1025

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/dc17-0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570522PMC
August 2017

Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia.

Authors:
Moneeza Kalhan Siddiqui Abirami Veluchamy Cyrielle Maroteau Roger Tavendale Fiona Carr Ewan Pearson Helen Colhoun Andrew D Morris Jacob George Alexander Doney Munir Pirmohamed Ana Alfirevic Mia Wadelius Anke H Maitland van der Zee Paul M Ridker Daniel I Chasman Colin N A Palmer

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (M.K.S., A.V., C.M., R.T., F.C., E.P., J.G., A.D., C.N.A.P.); Centre for Genomic and Experimental Medicine (H.C.) and Usher Institute of Population Health Sciences and Informatics (A.D.M.), University of Edinburgh, United Kingdom; Institute of Translational Medicine, University of Liverpool, United Kingdom (M.P., A.A.); Department of Medical Sciences, Clinical Pharmacology and Science of Life Laboratory, Uppsala University, Sweden (M.W.); Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, The Netherlands (A.H.M.v.d.Z.); Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands (A.H.M.v.d.Z.); Brigham and Women's Hospital and Harvard Medical School, Boston, MA (P.M.R., D.I.C.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001737DOI Listing
August 2017

Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes.

Authors:
David Preiss Adem Dawed Paul Welsh Alison Heggie Angus G Jones Jacqueline Dekker Robert Koivula Tue H Hansen Caitlin Stewart Rury R Holman Paul W Franks Mark Walker Ewan R Pearson Naveed Sattar

Diabetes Obes Metab 2017 03 28;19(3):356-363. Epub 2016 Dec 28.

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1111/dom.12826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330429PMC
March 2017

Quantifying the extent to which index event biases influence large genetic association studies.

Authors:
Hanieh Yaghootkar Michael P Bancks Sam E Jones Aaron McDaid Robin Beaumont Louise Donnelly Andrew R Wood Archie Campbell Jessica Tyrrell Lynne J Hocking Marcus A Tuke Katherine S Ruth Ewan R Pearson Anna Murray Rachel M Freathy Patricia B Munroe Caroline Hayward Colin Palmer Michael N Weedon James S Pankow Timothy M Frayling Zoltán Kutalik

Hum Mol Genet 2017 03;26(5):1018-1030

Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne 1010, Switzerland.

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http://dx.doi.org/10.1093/hmg/ddw433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661557PMC
March 2017

Erratum to: Methods for evaluating medical tests and biomarkers.

Authors:
Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Mariska Leeflang Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Penny Whiting Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Richard Riley Joie Ensor Kym Snell Brian Willis Thomas Debray Karel Moons Jon Deeks Gary Collins Lavinia Ferrante di Ruffano Brian Willis Clare Davenport Sue Mallett Sian Taylor-Phillips Chris Hyde Jon Deeks Sue Mallett Stuart A Taylor Gauraang Batnagar Sian Taylor-Phillips Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Jon Deeks Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Chris Hyde Zhivko Zhelev Harriet Hunt Lavinia Ferrante di Ruffano Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Mariska Leeflang Aeliko Zwinderman Patrick Bossuyt Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Jon Deeks Lucinda Billingham Alice Sitch Sue Mallett Jon Deeks Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jon Deeks Alice Sitch Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Patrick Bossuyt Johannes Reitsma Karel Moons Gary Collins Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Doug Altman Laure Wynants Yvonne Vergouwe Sabine Van Huffel Dirk Timmerman Ben Van Calster Romin Pajouheshnia Rolf Groenwold Karen Moons Johannes Reitsma Linda Peelen Ben Van Calster Daan Nieboer Yvonne Vergouwe Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Sian Taylor-Phillips Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Alice Sitch Peymane Adab Bernard G Francq Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Sian Taylor-Phillips Rachel Court Aileen Clarke Joris de Groot Christiana Naaktgeboren Hans Reitsma Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke Patrick Bossuyt George Hanna Jie Ma Doug Altman Gary Collins K G M Carl Moons Joris A H de Groot Sue Mallett Doug G Altman Johannes B Reitsma Gary S Collins Karel G M Moons Douglas G Altman Johannes B Reitsma Gary S Collins Adina Najwa Kamarudin Ruwanthi Kolamunnage-Dona Trevor Cox Melody Ni Jeremy Huddy Simone Borsci George Hanna Teresa Pérez M Carmen Pardo Angel Candela-Toha Alfonso Muriel Javier Zamora Sabina Sanghera Syed Mohiuddin Richard Martin Jenny Donovan Joanna Coast Mikyung Kelly Seo John Cairns Elizabeth Mitchell Alison Smith Judy Wright Peter Hall Michael Messenger Nicola Calder Nyantara Wickramasekera Karen Vinall-Collier Andrew Lewington Romin Pajouheshnia Johanna Damen Rolf Groenwold Karel Moons Linda Peelen Michael Messenger David Cairns Alison Smith Michelle Hutchinson Judy Wright Peter Hall Nicola Calder Cathie Sturgeon Liz Mitchel Rebecca Kift Sofia Christakoudi Manohursingh Rungall Paula Mobillo Rosa Montero Tjir-Li Tsui Sui Phin Kon Beatriz Tucker Steven Sacks Chris Farmer Terry Strom Paramit Chowdhury Irene Rebollo-Mesa Maria Hernandez-Fuentes Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Johanna A A G Damen Lotty Hooft Ewoud Schuit Thomas P A Debray Gary S Collins Ioanna Tzoulaki Camille M Lassale George C M Siontis Virginia Chiocchia Corran Roberts Michael Maia Schlüssel Stephen Gerry James A Black Pauline Heus Yvonne T van der Schouw Linda M Peelen Karel G M Moons Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Jie Ma Doug Altman Gary Collins Graeme Spence David McCartney Ann van den Bruel Daniel Lasserson Gail Hayward Werner Vach Antoinette de Jong Coreline Burggraaff Otto Hoekstra Josée Zijlstra Henrica de Vet Harriet Hunt Chris Hyde Sara Graziadio Joy Allen Louise Johnston Rachel O'Leary Michael Power Joy Allen Sara Graziadio Louise Johnson Rachel O'Leary Michael Power Ray Waters John Simpson Louise Johnston Joy Allen Sara Graziadio Rachel O'Leary Ray Waters Michael Power Sue Mallett Thomas R Fanshawe Peter Phillips Andrew Plumb Emma Helbren Steve Halligan Stuart A Taylor Alastair Gale Sue Mallett Peggy Sekula Douglas G Altman Willi Sauerbrei Sue Mallett Thomas R Fanshawe Julia R Forman Susan J Dutton Yemisi Takwoingi Elizabeth M Hensor Thomas E Nichols Bethany Shinkins Yaling Yang Lucy Abel Lavinia Ferrante Di Ruffano Thomas Fanshawe Emmanuelle Kempf Raphael Porcher Jennifer de Beyer Karel Moons Douglas Altman Hans Reitsma Sally Hopewell Willi Sauerbrei Gary Collins John Dennis Beverley Shields Angus Jones William Henley Ewan Pearson Andrew Hattersley Pauline Heus Johanna A A G Damen Romin Pajouheshnia Rob J P M Scholten Johannes B Reitsma Gary S Collins Douglas G Altman Karel G M Moons Lotty Hooft Beverley Shields John Dennis Angus Jones William Henley Ewan Pearson Andrew Hattersley Fueloep Scheibler Anne Rummer Sibylle Sturtz Robert Großelfinger Katie Banister Craig Ramsay Augusto Azuara-Blanco Jonathan Cook Charles Boachie Jennifer Burr Manjula Kumarasamy Rupert Bourne Ijeoma Uchegbu Simone Borsci Jennifer Murphy George Hanna Ijeoma Uchegbu Alex Carter Jen Murphy Melody Ni Joachim Marti Julie Eatock Ijeoma Uchegbu Julie Robotham Maria Dudareva Mark Gilchrist Alison Holmes Ijeoma Uchegbu Simone Borsci Phillip Monaghan Sarah Lord Andrew StJohn Sverre Sandberg Christa Cobbaert Lieselotte Lennartz Wilma Verhagen-Kamerbeek Christoph Ebert Patrick Bossuyt Andrea Horvath Kevin Jenniskens Christiana Naaktgeboren Johannes Reitsma Karel Moons Joris de Groot Chris Hyde Jaime Peters Bogdan Grigore Jaime Peters Chris Hyde Chris Hyde Obi Ukoumunne Jaime Peters Zhivko Zhelev Brooke Levis Andrea Benedetti Alexander W Levis John P A Ioannidis Ian Shrier Pim Cuijpers Simon Gilbody Lorie A Kloda Dean McMillan Scott B Patten Russell J Steele Roy C Ziegelstein Charles H Bombardier Flavia de Lima Osório Jesse R Fann Dwenda Gjerdingen Femke Lamers Manote Lotrakul Sonia R Loureiro Bernd Löwe Juwita Shaaban Lesley Stafford Henk C P M van Weert Mary A Whooley Linda S Williams Karin A Wittkampf Albert S Yeung Brett D Thombs Jaime Peters Chris Cooper James Buchanan Tom Nieto Claire Smith Olga Tucker Janine Dretzke Andrew Beggs Nirmala Rai Clare Davenport Sue Bayliss Simon Stevens Kym Snell Sue Mallet Jon Deeks Sudha Sundar Emma Hall Nuria Porta David Lorente Estelles Johann de Bono

Diagn Progn Res 2017 30;1:11. Epub 2017 Mar 30.

278The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s41512-017-0011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460744PMC
March 2017

Defining drug response for stratified medicine.

Authors:
Mike Lonergan Stephen J Senn Christine McNamee Ann K Daly Robert Sutton Andrew Hattersley Ewan Pearson Munir Pirmohamed

Drug Discov Today 2017 01 3;22(1):173-179. Epub 2016 Nov 3.

Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3GL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.10.016DOI Listing
January 2017

CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.

Authors:
Adem Y Dawed Louise Donnelly Roger Tavendale Fiona Carr Graham Leese Colin N A Palmer Ewan R Pearson Kaixin Zhou

Diabetes Care 2016 Nov 6;39(11):1902-1908. Epub 2016 Jun 6.

Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland

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http://dx.doi.org/10.2337/dc15-2464DOI Listing
November 2016

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.

Authors:
Maggie Shepherd Beverley Shields Suzanne Hammersley Michelle Hudson Timothy J McDonald Kevin Colclough Richard A Oram Bridget Knight Christopher Hyde Julian Cox Katherine Mallam Christopher Moudiotis Rebecca Smith Barbara Fraser Simon Robertson Stephen Greene Sian Ellard Ewan R Pearson Andrew T Hattersley

Diabetes Care 2016 Nov 6;39(11):1879-1888. Epub 2016 Jun 6.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/dc16-0645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018394PMC
November 2016

Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.

Authors:
Tanja Dujic Kaixin Zhou Roger Tavendale Colin N A Palmer Ewan R Pearson

Diabetes Care 2016 Nov 4;39(11):1896-1901. Epub 2016 Aug 4.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, U.K.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-070
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http://dx.doi.org/10.2337/dc16-0706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122449PMC
November 2016

Statistical power considerations in genotype-based recall randomized controlled trials.

Authors:
Naeimeh Atabaki-Pasdar Mattias Ohlsson Dmitry Shungin Azra Kurbasic Erik Ingelsson Ewan R Pearson Ashfaq Ali Paul W Franks

Sci Rep 2016 11 25;6:37307. Epub 2016 Nov 25.

Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.

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http://dx.doi.org/10.1038/srep37307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122840PMC
November 2016

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

Authors:
Kaixin Zhou Sook Wah Yee Eric L Seiser Nienke van Leeuwen Roger Tavendale Amanda J Bennett Christopher J Groves Ruth L Coleman Amber A van der Heijden Joline W Beulens Catherine E de Keyser Linda Zaharenko Daniel M Rotroff Mattijs Out Kathleen A Jablonski Ling Chen Martin Javorský Jozef Židzik Albert M Levin L Keoki Williams Tanja Dujic Sabina Semiz Michiaki Kubo Huan-Chieh Chien Shiro Maeda John S Witte Longyang Wu Ivan Tkáč Adriaan Kooy Ron H N van Schaik Coen D A Stehouwer Lisa Logie Calum Sutherland Janis Klovins Valdis Pirags Albert Hofman Bruno H Stricker Alison A Motsinger-Reif Michael J Wagner Federico Innocenti Leen M 't Hart Rury R Holman Mark I McCarthy Monique M Hedderson Colin N A Palmer Jose C Florez Kathleen M Giacomini Ewan R Pearson

Nat Genet 2016 09 8;48(9):1055-1059. Epub 2016 Aug 8.

School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/ng.3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007158PMC
September 2016

Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

Authors:
Angus G Jones Mike Lonergan William E Henley Ewan R Pearson Andrew T Hattersley Beverley M Shields

PLoS One 2016 6;11(4):e0152428. Epub 2016 Apr 6.

NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822872PMC
August 2016

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.

Authors:
Hanieh Yaghootkar Luca A Lotta Jessica Tyrrell Roelof A J Smit Sam E Jones Louise Donnelly Robin Beaumont Archie Campbell Marcus A Tuke Caroline Hayward Katherine S Ruth Sandosh Padmanabhan J Wouter Jukema Colin C Palmer Andrew Hattersley Rachel M Freathy Claudia Langenberg Nicholas J Wareham Andrew R Wood Anna Murray Michael N Weedon Naveed Sattar Ewan Pearson Robert A Scott Timothy M Frayling

Diabetes 2016 08 26;65(8):2448-60. Epub 2016 Apr 26.

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-1671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386140PMC
August 2016

Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design.

Authors:
Jagdeep S S Singh Amir Fathi Keeran Vickneson Ify Mordi Mohapradeep Mohan J Graeme Houston Ewan R Pearson Allan D Struthers Chim C Lang

Cardiovasc Diabetol 2016 Jul 15;15:97. Epub 2016 Jul 15.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

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July 2016

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.

Authors:
Kaixin Zhou Helle Krogh Pedersen Adem Y Dawed Ewan R Pearson

Nat Rev Endocrinol 2016 Jun 11;12(6):337-46. Epub 2016 Apr 11.

School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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June 2016

Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents.

Authors:
Adem Yesuf Dawed Kaixin Zhou Ewan Robert Pearson

Pharmgenomics Pers Med 2016 6;9:17-29. Epub 2016 Apr 6.

Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, Scotland, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827904PMC
April 2016

Metformin and the gastrointestinal tract.

Authors:
Laura J McCreight Clifford J Bailey Ewan R Pearson

Diabetologia 2016 Mar 16;59(3):426-35. Epub 2016 Jan 16.

Pearson Group, Division of Cardiovascular and Diabetes Medicine, School of Medicine, University of Dundee, Ninewells Hospital, Mailbox 12, Level 5, Dundee, DD1 9SY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742508PMC
March 2016

Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database.

Authors:
Andrew J Farmer Lauren R Rodgers Mike Lonergan Beverley Shields Michael N Weedon Louise Donnelly Rury R Holman Ewan R Pearson Andrew T Hattersley

Diabetes Care 2016 Feb 17;39(2):258-263. Epub 2015 Dec 17.

Department of Diabetes and Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894467PMC
February 2016

Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population.

Authors:
Ewan R Pearson

Diabetes 2015 Dec;64(12):3993-5

Division of Cardiovascular & Diabetes Medicine, School of Medicine, University of Dundee, Dundee, Scotland

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December 2015

Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study.

Authors:
Kaixin Zhou Louise A Donnelly Andrew D Morris Paul W Franks Chris Jennison Colin Na Palmer Ewan R Pearson

Diabetes Care 2014 1;37(3):718-724. Epub 2013 Nov 1.

Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, DD1 9SY.

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August 2015

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

Authors:
Tanja Dujic Kaixin Zhou Louise A Donnelly Roger Tavendale Colin N A Palmer Ewan R Pearson

Diabetes 2015 May 15;64(5):1786-93. Epub 2014 Dec 15.

Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, Scotland, U.K.

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May 2015

Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors.

Authors:
Richard A Oram Timothy J McDonald Beverley M Shields Michelle M Hudson Maggie H Shepherd Suzanne Hammersley Ewan R Pearson Andrew T Hattersley

Diabetes Care 2015 Feb 17;38(2):323-8. Epub 2014 Dec 17.

National Institute for Health Research, Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, U.K.

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February 2015

Pharmacogenetics of oral antidiabetic drugs.

Authors:
Matthijs L Becker Ewan R Pearson Ivan Tkáč

Int J Endocrinol 2013 13;2013:686315. Epub 2013 Nov 13.

Department of Epidemiology, Erasmus MC, 3015 CE Rotterdam, The Netherlands ; Pharmacy Foundation of Haarlem Hospitals, 2035 RC Haarlem, The Netherlands.

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June 2014

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

Authors:
Robert W Koivula Alison Heggie Anna Barnett Henna Cederberg Tue H Hansen Anitra D Koopman Martin Ridderstråle Femke Rutters Henrik Vestergaard Ramneek Gupta Sanna Herrgård Martijn W Heymans Mandy H Perry Simone Rauh Maritta Siloaho Harriet J A Teare Barbara Thorand Jimmy Bell Søren Brunak Gary Frost Bernd Jablonka Andrea Mari Tim J McDonald Jacqueline M Dekker Torben Hansen Andrew Hattersley Markku Laakso Oluf Pedersen Veikko Koivisto Hartmut Ruetten Mark Walker Ewan Pearson Paul W Franks

Diabetologia 2014 Jun 4;57(6):1132-42. Epub 2014 Apr 4.

Department of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 10, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.

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June 2014

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Authors:
Kaixin Zhou Louise Donnelly Jian Yang Miaoxin Li Harshal Deshmukh Natalie Van Zuydam Emma Ahlqvist Chris C Spencer Leif Groop Andrew D Morris Helen M Colhoun Pak C Sham Mark I McCarthy Colin N A Palmer Ewan R Pearson

Lancet Diabetes Endocrinol 2014 Jun 19;2(6):481-7. Epub 2014 Mar 19.

Medical Research Institute, University of Dundee, Dundee, UK. Electronic address:

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June 2014

Zinc transport and diabetes risk.

Authors:
Ewan Pearson

Nat Genet 2014 Apr;46(4):323-4

Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, UK.

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April 2014

Glycemic exposure and blood pressure influencing progression and remission of diabetic retinopathy: a longitudinal cohort study in GoDARTS.

Authors:
Yiyuan Liu Minghui Wang Andrew D Morris Alex S F Doney Graham P Leese Ewan R Pearson Colin N A Palmer

Diabetes Care 2013 Dec 29;36(12):3979-84. Epub 2013 Oct 29.

Corresponding author: Colin N.A. Palmer,

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December 2013

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.

Authors:
Louise A Donnelly Natalie R van Zuydam Kaixin Zhou Roger Tavendale Fiona Carr Anke H Maitland-van der Zee Maarten Leusink Anthonius de Boer Pieter A Doevendans Folkert W Asselbergs Andrew D Morris Ewan R Pearson Olaf H Klungel Alex S F Doney Colin N A Palmer

Pharmacogenet Genomics 2013 Oct;23(10):518-25

aMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee bWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK cDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University dDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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October 2013

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.

Authors:
Leen M 't Hart Andreas Fritsche Giel Nijpels Nienke van Leeuwen Louise A Donnelly Jacqueline M Dekker Marjan Alssema Joao Fadista Françoise Carlotti Anette P Gjesing Colin N A Palmer Timon W van Haeften Silke A Herzberg-Schäfer Annemarie M C Simonis-Bik Jeanine J Houwing-Duistermaat Quinta Helmer Joris Deelen Bruno Guigas Torben Hansen Fausto Machicao Gonneke Willemsen Robert J Heine Mark H H Kramer Jens J Holst Eelco J P de Koning Hans-Ulrich Häring Oluf Pedersen Leif Groop Eco J C de Geus P Eline Slagboom Dorret I Boomsma Elisabeth M W Eekhoff Ewan R Pearson Michaela Diamant

Diabetes 2013 Sep 14;62(9):3275-81. Epub 2013 May 14.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.

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September 2013

Molecular mechanism of action of metformin: old or new insights?

Authors:
Graham Rena Ewan R Pearson Kei Sakamoto

Diabetologia 2013 Sep 9;56(9):1898-906. Epub 2013 Jul 9.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

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September 2013

Insights from genome-wide association studies of drug response.

Authors:
Kaixin Zhou Ewan R Pearson

Annu Rev Pharmacol Toxicol 2013 16;53:299-310. Epub 2012 Oct 16.

Medical Research Institute, University of Dundee, Scotland, United Kingdom DD1 9SY.

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July 2013

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects.

Authors:
Paul W Franks Ewan Pearson Jose C Florez

Diabetes Care 2013 May;36(5):1413-21

Department of Clinical Science, Lund University, Malmö, Sweden.

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May 2013

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Authors:
Momoko Horikoshi Hanieh Yaghootkar Dennis O Mook-Kanamori Ulla Sovio H Rob Taal Branwen J Hennig Jonathan P Bradfield Beate St Pourcain David M Evans Pimphen Charoen Marika Kaakinen Diana L Cousminer Terho Lehtimäki Eskil Kreiner-Møller Nicole M Warrington Mariona Bustamante Bjarke Feenstra Diane J Berry Elisabeth Thiering Thiemo Pfab Sheila J Barton Beverley M Shields Marjan Kerkhof Elisabeth M van Leeuwen Anthony J Fulford Zoltán Kutalik Jing Hua Zhao Marcel den Hoed Anubha Mahajan Virpi Lindi Liang-Kee Goh Jouke-Jan Hottenga Ying Wu Olli T Raitakari Marie N Harder Aline Meirhaeghe Ioanna Ntalla Rany M Salem Karen A Jameson Kaixin Zhou Dorota M Monies Vasiliki Lagou Mirna Kirin Jani Heikkinen Linda S Adair Fowzan S Alkuraya Ali Al-Odaib Philippe Amouyel Ehm Astrid Andersson Amanda J Bennett Alexandra I F Blakemore Jessica L Buxton Jean Dallongeville Shikta Das Eco J C de Geus Xavier Estivill Claudia Flexeder Philippe Froguel Frank Geller Keith M Godfrey Frédéric Gottrand Christopher J Groves Torben Hansen Joel N Hirschhorn Albert Hofman Mads V Hollegaard David M Hougaard Elina Hyppönen Hazel M Inskip Aaron Isaacs Torben Jørgensen Christina Kanaka-Gantenbein John P Kemp Wieland Kiess Tuomas O Kilpeläinen Norman Klopp Bridget A Knight Christopher W Kuzawa George McMahon John P Newnham Harri Niinikoski Ben A Oostra Louise Pedersen Dirkje S Postma Susan M Ring Fernando Rivadeneira Neil R Robertson Sylvain Sebert Olli Simell Torsten Slowinski Carla M T Tiesler Anke Tönjes Allan Vaag Jorma S Viikari Jacqueline M Vink Nadja Hawwa Vissing Nicholas J Wareham Gonneke Willemsen Daniel R Witte Haitao Zhang Jianhua Zhao James F Wilson Michael Stumvoll Andrew M Prentice Brian F Meyer Ewan R Pearson Colin A G Boreham Cyrus Cooper Matthew W Gillman George V Dedoussis Luis A Moreno Oluf Pedersen Maiju Saarinen Karen L Mohlke Dorret I Boomsma Seang-Mei Saw Timo A Lakka Antje Körner Ruth J F Loos Ken K Ong Peter Vollenweider Cornelia M van Duijn Gerard H Koppelman Andrew T Hattersley John W Holloway Berthold Hocher Joachim Heinrich Chris Power Mads Melbye Mònica Guxens Craig E Pennell Klaus Bønnelykke Hans Bisgaard Johan G Eriksson Elisabeth Widén Hakon Hakonarson André G Uitterlinden Anneli Pouta Debbie A Lawlor George Davey Smith Timothy M Frayling Mark I McCarthy Struan F A Grant Vincent W V Jaddoe Marjo-Riitta Jarvelin Nicholas J Timpson Inga Prokopenko Rachel M Freathy

Nat Genet 2013 Jan 2;45(1):76-82. Epub 2012 Dec 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762PMC
January 2013

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

Authors:
Colin N A Palmer Cristina Maglio Carlo Pirazzi Maria Antonella Burza Martin Adiels Lindsay Burch Louise A Donnelly Helen Colhoun Alexander S Doney John F Dillon Ewan R Pearson Mark McCarthy Andrew T Hattersley Tim Frayling Andrew D Morris Markku Peltonen Per-Arne Svensson Peter Jacobson Jan Borén Lars Sjöström Lena M S Carlsson Stefano Romeo

PLoS One 2012 18;7(6):e39362. Epub 2012 Jun 18.

Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377675PMC
December 2012

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.

Authors:
Tim J McDonald Jane McEneny Ewan R Pearson Gaya Thanabalasingham Magdalena Szopa Beverley M Shields Sian Ellard Katharine R Owen Maciej T Malecki Andrew T Hattersley Ian S Young

Clin Chim Acta 2012 May 14;413(9-10):927-32. Epub 2012 Feb 14.

NIHR Clinical Research Facility, Peninsula College or Medicine and Dentistry, University of Exeter, Exeter, UK.

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May 2012

The role of ATM in response to metformin treatment and activation of AMPK.

Authors:
Kaixin Zhou Celine Bellenguez Calum Sutherland Grahame Hardie Colin Palmer Peter Donnelly Ewan Pearson

Nat Genet 2012 Mar 28;44(4):361-2. Epub 2012 Mar 28.

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March 2012

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology.

Authors:
John R Petrie Ewan R Pearson Calum Sutherland

Biochem Pharmacol 2011 Feb 25;81(4):471-7. Epub 2010 Nov 25.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G11 6TA, United Kingdom.

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February 2011

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Authors:
Kaixin Zhou Celine Bellenguez Chris C A Spencer Amanda J Bennett Ruth L Coleman Roger Tavendale Simon A Hawley Louise A Donnelly Chris Schofield Christopher J Groves Lindsay Burch Fiona Carr Amy Strange Colin Freeman Jenefer M Blackwell Elvira Bramon Matthew A Brown Juan P Casas Aiden Corvin Nicholas Craddock Panos Deloukas Serge Dronov Audrey Duncanson Sarah Edkins Emma Gray Sarah Hunt Janusz Jankowski Cordelia Langford Hugh S Markus Christopher G Mathew Robert Plomin Anna Rautanen Stephen J Sawcer Nilesh J Samani Richard Trembath Ananth C Viswanathan Nicholas W Wood Lorna W Harries Andrew T Hattersley Alex S F Doney Helen Colhoun Andrew D Morris Calum Sutherland D Grahame Hardie Leena Peltonen Mark I McCarthy Rury R Holman Colin N A Palmer Peter Donnelly Ewan R Pearson

Nat Genet 2011 Feb 26;43(2):117-20. Epub 2010 Dec 26.

Biomedical Research Institute, University of Dundee, Dundee, UK.

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February 2011

Generation, validation and humanisation of a novel insulin resistant cell model.

Authors:
Lisa Logie Antonio J Ruiz-Alcaraz Christopher J Schofield Hari S Hundal Giora Z Feuerstein Jeffrey D Brady Daniel Crowther Anna M Tommasi Christal E Grierson Bridget Shepherd Andrew D Morris Michael K Hansen Ewan Pearson Calum Sutherland

Biochem Pharmacol 2010 Oct 23;80(7):1042-9. Epub 2010 Jun 23.

Biomedical Research Institute, University of Dundee, United Kingdom.

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October 2010

Desktop software to identify patients eligible for recruitment into a clinical trial: using SARMA to recruit to the ROAD feasibility trial.

Authors:
Shaun Treweek Ewan Pearson Natalie Smith Ron Neville Paul Sargeant Brian Boswell Frank Sullivan

Inform Prim Care 2010 ;18(1):51-8

Clinical and Population Sciences and Education, University of Dundee, Dundee, UK.

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June 2010

Insulin resistance before and after parathyroidectomy in patients with primary hyperparathyroidism--a pilot study.

Authors:
Andrew Rudman Ewan R Pearson David Smith Rajeev Srivastava Michael J Murphy Graham P Leese

Endocr Res 2010 May;35(2):85-93

University of Dundee, Dundee, UK.

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May 2010

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.

Authors:
John R B Perry Michael N Weedon Claudia Langenberg Anne U Jackson Valeriya Lyssenko Thomas Sparsø Gudmar Thorleifsson Harald Grallert Luigi Ferrucci Marcello Maggio Giuseppe Paolisso Mark Walker Colin N A Palmer Felicity Payne Elizabeth Young Christian Herder Narisu Narisu Mario A Morken Lori L Bonnycastle Katharine R Owen Beverley Shields Beatrice Knight Amanda Bennett Christopher J Groves Aimo Ruokonen Marjo Riitta Jarvelin Ewan Pearson Laura Pascoe Ele Ferrannini Stefan R Bornstein Heather M Stringham Laura J Scott Johanna Kuusisto Peter Nilsson Malin Neptin Anette P Gjesing Charlotta Pisinger Torsten Lauritzen Annelli Sandbaek Mike Sampson Ele Zeggini Cecilia M Lindgren Valgerdur Steinthorsdottir Unnur Thorsteinsdottir Torben Hansen Peter Schwarz Thomas Illig Markku Laakso Kari Stefansson Andrew D Morris Leif Groop Oluf Pedersen Michael Boehnke Inês Barroso Nicholas J Wareham Andrew T Hattersley Mark I McCarthy Timothy M Frayling

Hum Mol Genet 2010 Feb 18;19(3):535-44. Epub 2009 Nov 18.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798726PMC
February 2010

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Authors:
Kaixin Zhou Louise A Donnelly Charlotte H Kimber Peter T Donnan Alex S F Doney Graham Leese Andrew T Hattersley Mark I McCarthy Andrew D Morris Colin N A Palmer Ewan R Pearson

Diabetes 2009 Jun 31;58(6):1434-9. Epub 2009 Mar 31.

Dundee Diabetes Genetics Group, Biomedical Research Institute, University of Dundee, Dundee, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682689PMC
June 2009

The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study.

Authors:
Alex S F Doney Jennifer Dannfald Charlotte H Kimber Louise A Donnelly Ewan Pearson Andrew D Morris Colin N A Palmer

Circ Cardiovasc Genet 2009 Jun 30;2(3):255-9. Epub 2009 Mar 30.

Diabetes Research Group, Biomedical Research Institute, University of Dundee, Dundee, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045745PMC
June 2009

Pharmacogenetics in diabetes.

Authors:
Ewan R Pearson

Curr Diab Rep 2009 Apr;9(2):172-81

Biomedical Research Institute, Ninewells Hospital and Medical School, Ninewells Avenue, Dundee, DD1 9SY, UK.

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April 2009

Pharmacogenetics and future strategies in treating hyperglycaemia in diabetes.

Authors:
Ewan R Pearson

Front Biosci (Landmark Ed) 2009 Jan 1;14:4348-62. Epub 2009 Jan 1.

Biomedical Research Institute, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland.

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January 2009

Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2) gene.

Authors:
Thais Della Manna Claudilene Battistim Vanessa Radonsky Roberta D Savoldelli Durval Damiani Fernando Kok Ewan R Pearson Sian Ellard Andrew T Hattersley André F Reis

Arq Bras Endocrinol Metabol 2008 Nov;52(8):1350-5

Instituto da Criança, Hospital das Clínicas, Universidade de São Paulo, SP, Brasil.

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November 2008

Recent advances in the genetics of diabetes.

Authors:
Ewan R Pearson

Prim Care Diabetes 2008 Jun 12;2(2):67-72. Epub 2008 Feb 12.

Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee DD19SY, United Kingdom.

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June 2008