Publications by authors named "Ewa Styczeń-Binkowska"

2 Publications

  • Page 1 of 1

The Gene Influences Cellular Pathways in the Neuronal Differentiation of Human Neural Progenitor Cells.

Front Cell Neurosci 2019 30;13:391. Epub 2019 Aug 30.

Department of Molecular Carcinogenesis, Medical University of Łódź, Łódź, Poland.

The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis and migration processes. Moreover, genetic aberrations in induce severe neuropathological phenotypes in humans and rodents. The aim of the present study was to investigate in detail the impact of on human neural progenitor cell (hNPC) maintenance and how depletion of disturbs signaling pathways playing a pivotal role in neuronal differentiation and central nervous system (CNS) organogenesis. hNPC with a silenced gene exhibited lowered mitochondrial redox potential, enhanced adhesion to fibronectin and extracellular matrix protein mixture, downregulation of MMP2/9 expression and impaired 3D growth. Global transcriptome analysis using cap analysis of gene expression (CAGE) found that downregulation significantly changes the expression of multiple genes engaged in cytoskeleton organization, adhesion, cell signaling and chromatin remodeling. The massive changes in gene expression caused by silencing may strongly affect the differentiation and migration of neurons in organogenesis, brain injury, cancerogenesis or neurodifferentiation. gene appears to be an important regulator of neural tissue architecture and function.
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http://dx.doi.org/10.3389/fncel.2019.00391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730490PMC
August 2019

Alteration of WWOX in human cancer: a clinical view.

Exp Biol Med (Maywood) 2015 Mar 13;240(3):305-14. Epub 2015 Feb 13.

Department of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, Poland

WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.
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http://dx.doi.org/10.1177/1535370214561953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935223PMC
March 2015