Publications by authors named "Evdoxia-Maria Karasavvidou"

3 Publications

  • Page 1 of 1

Optical coherence tomography biomarkers for visual acuity in patients with idiopathic epiretinal membrane.

Eur J Ophthalmol 2020 Dec 14:1120672120980951. Epub 2020 Dec 14.

Vitreoretinal and Uveitis Department, Ophthalmica Clinic, Thessaloniki, Greece.

Purpose: To investigate the correlation between outer and inner retina optical coherence tomography (OCT) biomarkers and visual acuity in patients with idiopathic epiretinal membrane (iERM) and identify which of them may be predictive of visual function.

Methods: A retrospective cross-sectional single-center study was conducted that included patients diagnosed with iERM. Spectral domain OCT images were obtained and assessed qualitatively and quantitatively. The association of OCT parameters with best corrected visual acuity was analyzed.

Results: Charts of 97 eyes of 97 patients were reviewed. Central foveal thickness, maximal retinal thickness (MRT), photoreceptor outer segment length, outer foveal thickness, ganglion cell-inner plexiform layer complex thickening, inner retinal thickness and inner retinal layer irregularity index were among the major outcome measures. OCT scans were also assessed for the presence of cotton ball sign, ellipsoid zone disruption, ectopic inner foveal layer, disorganization of retinal inner layers (DRIL), intraretinal fluid, subretinal fluid (SRF) and epimacular membrane rip. Univariate analysis showed statistically significant association between all the aforementioned parameters with worse vision, except for cotton ball sign and SRF. Multivariate analysis found that MRT and severe DRIL were strongly correlated with worse vision ( < 0.001).

Conclusion: MRT and severe DRIL should be considered as negative prognostic factors for visual acuity.
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http://dx.doi.org/10.1177/1120672120980951DOI Listing
December 2020

Optical coherence tomography angiography in uveitis.

J Ophthalmic Inflamm Infect 2019 Dec 23;9(1):21. Epub 2019 Dec 23.

Uveitis Department, Moorfields Eye Hospital, 162 City Rd, London, EC1V 2PD, UK.

Before the introduction of optical coherence tomography angiography (OCTA) in the early 2000s, dye-based angiography was considered the "gold standard" for the diagnosis and monitoring of ocular inflammation. OCTA is a novel technique, which demonstrates capillary networks based on the amount of light returned from moving blood cells, providing further information on pathophysiological changes in uveitis.The aim of this review is to describe the basic principles of OCTA and its application to ocular inflammatory disorders. It particularly emphasizes on its contribution not only in the diagnosis and management of the disease but also in the identification of possible complications, comparing it with fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA). Although the advent of OCTA has remarkably enhanced the assessment of uveitic entities, we highlight the need for further investigation in order to better understand its application to these conditions.
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http://dx.doi.org/10.1186/s12348-019-0190-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928173PMC
December 2019

Valsalva retinopathy associated with intranasal cocaine abuse: A case report.

Eur J Ophthalmol 2019 May 12;29(3):NP5-NP8. Epub 2018 Sep 12.

4 Vitreoretinal & Uveitis Department, Ophthalmica Clinic, Thessaloniki, Greece.

Introduction: The purpose of this report is to describe a case of Valsalva retinopathy in an intranasal cocaine user.

Case Report: A 49-year-old male presented with a history of sudden loss of vision and inferior visual field defect in his left eye. Clinical evaluation of the affected eye showed best corrected visual acuity of 20/25 and fundus examination revealed a preretinal hemorrhage superior to the disk with multiple intraretinal hemorrhages in and around the posterior pole. On further questioning, the patient revealed intranasal cocaine use the day before the onset of his visual symptoms. Blood tests were requested to exclude blood dyscrasias or predisposition to vascular occlusive disorders and no further treatment measures were taken. The patient was reviewed a month later when his hemorrhages had completely resolved and his visual acuity had improved to 20/20. His blood results were within normal limits.

Conclusion: Although never been reported before, Valsalva retinopathy can be associated with intranasal cocaine abuse and should be considered in the differential diagnosis of visual reduction in such population.
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http://dx.doi.org/10.1177/1120672118799627DOI Listing
May 2019