Evan T Keller

Evan T Keller

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Evan T Keller

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Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA.

Mol Carcinog 2019 Oct 3;58(10):1886-1896. Epub 2019 Jul 3.

School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.

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http://dx.doi.org/10.1002/mc.23082DOI Listing
October 2019

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis.

J Exp Med 2019 Sep 23. Epub 2019 Sep 23.

Department of Urology, Medical School, University of Michigan, Ann Arbor, MI

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http://dx.doi.org/10.1084/jem.20190158DOI Listing
September 2019

Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone.

J Cancer Res Clin Oncol 2019 Aug 6;145(8):1999-2012. Epub 2019 Jun 6.

Key Laboratory of Longevity and Aging-Related Diseases, Guangxi Medical University, Ministry of Education, Nanning, 530021, Guangxi, China.

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http://dx.doi.org/10.1007/s00432-019-02950-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658578PMC
August 2019

Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.

Oncogene 2019 Aug 29. Epub 2019 Aug 29.

Program for Skeletal Disease and Tumor Microenvironment, Center for Cancer and Cell Biology, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1038/s41388-019-0977-1DOI Listing
August 2019

SNV identification from single-cell RNA sequencing data.

Hum Mol Genet 2019 Aug 27. Epub 2019 Aug 27.

Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1093/hmg/ddz207DOI Listing
August 2019

Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications.

Eur Urol 2018 12 20;74(6):741-753. Epub 2018 Jul 20.

Michigan Center for Translational Pathology, Michigan Medicine, Ann Arbor, MI, USA; Department of Pathology, Michigan Medicine, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA; Department of Urology, Michigan Medicine, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.06.047DOI Listing
December 2018

Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer.

Cancer Lett 2018 11 3;436:96-108. Epub 2018 Aug 3.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA; Section of Urology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA; College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278836PMC
November 2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling.

J Biomed Res 2018 Sep;32(5):343-353

Key Laboratory of Longevity and Aging-related Diseases, Guangxi Medical University, Ministry of Education, Nanning, Guangxi 530021, China.

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http://dx.doi.org/10.7555/JBR.32.20180035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163113PMC
September 2018

Crosstalk Between Androgen-sensitive and Androgen-insensitive Prostate Cancer Cells.

Anticancer Res 2018 04;38(4):2045-2055

Integrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

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http://dx.doi.org/10.21873/anticanres.12444DOI Listing
April 2018

Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.

Oncotarget 2018 Mar 5;9(22):16185-16196. Epub 2018 Mar 5.

Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.

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http://dx.doi.org/10.18632/oncotarget.24609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882326PMC
March 2018

Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone Metastasis.

Calcif Tissue Int 2018 02 1;102(2):152-162. Epub 2017 Nov 1.

Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1007/s00223-017-0350-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807175PMC
February 2018

Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis.

J Pathol 2017 10 29;243(2):208-219. Epub 2017 Aug 29.

Department of Immunology, Key Laboratory of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, PR China.

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http://dx.doi.org/10.1002/path.4940DOI Listing
October 2017

Abituzumab Targeting of αV-Class Integrins Inhibits Prostate Cancer Progression.

Mol Cancer Res 2017 07 17;15(7):875-883. Epub 2017 Mar 17.

Department of Urology, University of Michigan, Ann Arbor, Michigan.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-16-0447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541673PMC
July 2017

Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance.

Mol Cancer Res 2017 04 13;15(4):457-466. Epub 2017 Jan 13.

Department of Urology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380553PMC
April 2017

Immune mediators in the tumor microenvironment of prostate cancer.

Chin J Cancer 2017 Mar 14;36(1):29. Epub 2017 Mar 14.

Department of Urology and Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1186/s40880-017-0198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351274PMC
March 2017

Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling.

Chin J Cancer 2017 Mar 29;36(1):35. Epub 2017 Mar 29.

Center for Translational Medicine, Guangxi Medical University, 12th Floor, Medical Science Research Building, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, P. R. China.

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http://dx.doi.org/10.1186/s40880-017-0203-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372329PMC
March 2017

Metformin targets multiple signaling pathways in cancer.

Chin J Cancer 2017 Jan 26;36(1):17. Epub 2017 Jan 26.

Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, 530021, Guangxi, P. R. China.

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http://dx.doi.org/10.1186/s40880-017-0184-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270304PMC
January 2017

Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling.

Sci Rep 2017 01 30;7:41656. Epub 2017 Jan 30.

Center for Translational Medicine, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China.

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http://dx.doi.org/10.1038/srep41656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278538PMC
January 2017

Providing prostate cancer survivorship care in Japan: Implications from the USA care model.

Int J Urol 2016 11 13;23(11):906-915. Epub 2016 Sep 13.

Department of Urology, University of Michigan Health System, Ann Arbor, Michigan, USA.

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http://doi.wiley.com/10.1111/iju.13186
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http://dx.doi.org/10.1111/iju.13186DOI Listing
November 2016

Raman microscopy of bladder cancer cells expressing green fluorescent protein.

J Biomed Opt 2016 11;21(11):115001

University of Michigan, Department of Chemistry, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.

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http://dx.doi.org/10.1117/1.JBO.21.11.115001DOI Listing
November 2016

IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker.

Oncotarget 2016 Oct;7(42):68140-68150

Key Laboratory of Longevity and Aging-related Diseases, Ministry of Education, Guangxi Medical University, Nanning, Guangxi, China.

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http://dx.doi.org/10.18632/oncotarget.11886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356544PMC
October 2016

Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation.

Nat Cell Biol 2016 09 1;18(9):917-29. Epub 2016 Aug 1.

Division of Molecular Medicine &Genetics, Department of Internal Medicine and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/ncb3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007193PMC
September 2016

A review on the diagnosis and treatment of hepatocellular carcinoma with a focus on the role of Wnts and the dickkopf family of Wnt inhibitors.

J Hepatocell Carcinoma 2014 6;1:1-7. Epub 2014 Mar 6.

Key Laboratory of Longevity and Ageing-Related Diseases, Ministry of Education, Nanning, Guangxi, People's Republic of China; Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, People's Republic of China; Department of Urology, School of Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2147/JHC.S44537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918262PMC
August 2016

Exosome-derived microRNAs contribute to prostate cancer chemoresistance.

Int J Oncol 2016 Aug 3;49(2):838-46. Epub 2016 Jun 3.

Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education, Nanning, Guangxi, P.R. China.

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http://dx.doi.org/10.3892/ijo.2016.3560DOI Listing
August 2016

Skp2 is associated with paclitaxel resistance in prostate cancer cells.

Oncol Rep 2016 Jul 13;36(1):559-66. Epub 2016 May 13.

Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education, Nanning, Guangxi 530021, P.R. China.

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http://dx.doi.org/10.3892/or.2016.4809DOI Listing
July 2016

Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model.

PLoS One 2014 23;9(6):e100394. Epub 2014 Jun 23.

Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067356PMC
November 2015

Translational progress on tumor biomarkers.

Thorac Cancer 2015 Nov 27;6(6):665-71. Epub 2015 Jul 27.

Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China ; Center for Translational Medicine, Guangxi Medical University Nanning, China ; Department of Urology and Pathology, School of Medicine, University of Michigan Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1111/1759-7714.12294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632916PMC
November 2015

Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer.

Clin Cancer Res 2015 Oct 22;21(20):4619-29. Epub 2015 Jul 22.

Department of Urology, University of Michigan, Ann Arbor, Michigan. Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609279PMC
October 2015

Wnt3a: functions and implications in cancer.

Chin J Cancer 2015 Sep 14;34(12):554-62. Epub 2015 Sep 14.

Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China.

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http://dx.doi.org/10.1186/s40880-015-0052-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593336PMC
September 2015

Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases.

Cancer Res 2015 Jun 8;75(11):2151-8. Epub 2015 Apr 8.

Department of Urology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452392PMC
June 2015

Survey of Raf kinase inhibitor protein (RKIP) in multiple cancer types.

Crit Rev Oncog 2014 ;19(6):455-68

Department of Urology, School of Medicine, University of Michigan, 1500 E. Medical Center Dr., Room 5308 CCGCB, Ann Arbor, MI 48105, USA; Center for Translational Medicine, Guangxi Medical University, Nanning, China.

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February 2015

Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow.

Mol Cancer Res 2015 Jan 19;13(1):197-207. Epub 2014 Aug 19.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297714PMC
January 2015

Targeting the Notch signaling pathway in cancer therapeutics.

Thorac Cancer 2014 11 23;5(6):473-86. Epub 2014 Oct 23.

Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China; Center for Translational Medicine, Guangxi Medical University Nanning, China; Department of Urology and Pathology, School of Medicine, University of Michigan Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1111/1759-7714.12143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704338PMC
November 2014

Osteocytes serve as a progenitor cell of osteosarcoma.

J Cell Biochem 2014 Aug;115(8):1420-9

Department of Urology, University of Michigan, Ann Arbor, Michigan, 48109, USA.

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http://dx.doi.org/10.1002/jcb.24793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733535PMC
August 2014

Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis.

J Biol Chem 2014 Aug 8;289(35):24560-72. Epub 2014 Jul 8.

From the Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109,

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http://dx.doi.org/10.1074/jbc.M114.571620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148880PMC
August 2014

Recent advances in bone-targeted therapies of metastatic prostate cancer.

Cancer Treat Rev 2014 Jul 16;40(6):730-8. Epub 2014 Apr 16.

Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042838PMC
July 2014

SOD3 acts as a tumor suppressor in PC-3 prostate cancer cells via hydrogen peroxide accumulation.

Anticancer Res 2014 Jun;34(6):2821-31

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.

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http://ar.iiarjournals.org/content/34/6/2821.full.pdf
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June 2014

Detection and isolation of human disseminated tumor cells in the murine bone marrow stem cell niche.

Methods Mol Biol 2013 ;1035:207-15

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/978-1-62703-508-8_18DOI Listing
March 2014

Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions.

Clin Cancer Res 2014 Feb 4;20(3):617-30. Epub 2013 Oct 4.

Authors' Affiliations: Departments of Urology and Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan; and Exelixis Inc., South San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946460PMC
February 2014

Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and bone.

Mol Cancer Res 2013 Dec 2;11(12):1597-610. Epub 2013 Oct 2.

Department of Urology, University of Michigan, 5308 CCGC, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-8940.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0332-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869871PMC
December 2013

Prostate cancer: radium-223: a new treatment option for bone-metastatic CRPC.

Nat Rev Urol 2013 Nov 15;10(11):630-1. Epub 2013 Oct 15.

Division of Hematology/Oncology, Department of Internal Medicine, C353 Med Inn Building, SPC 5848, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5848, USA.

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http://dx.doi.org/10.1038/nrurol.2013.232DOI Listing
November 2013

Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone.

Anticancer Res 2013 Oct;33(10):4453-61

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.

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October 2013

Mechanisms of Metastatic Tumor Dormancy.

J Clin Med 2013 Sep 23;2(3):136-50. Epub 2013 Sep 23.

Department of Urology, University of Michigan Medical School, 5111 CCGC1500 E. Medical Center, Ann Arbor, MI 48109-0940, USA.

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http://dx.doi.org/10.3390/jcm2030136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470233PMC
September 2013

Wnt and Wnt inhibitors in bone metastasis.

Bonekey Rep 2012 4;1:101. Epub 2012 Jul 4.

Department of Urology, University of Michigan , Ann Arbor, MI, USA .

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http://dx.doi.org/10.1038/bonekey.2012.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727776PMC
August 2013

Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin β1.

Prostate 2013 Aug 26;73(11):1159-70. Epub 2013 Mar 26.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1002/pros.22664DOI Listing
August 2013

Stromal cells in tumor microenvironment and breast cancer.

Cancer Metastasis Rev 2013 Jun;32(1-2):303-15

Shanghai Ruijin Hospital, Comprehensive Breast Health Center, Shanghai, China.

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http://dx.doi.org/10.1007/s10555-012-9415-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432936PMC
June 2013

A novel canine model for prostate cancer.

Prostate 2013 Jun 17;73(9):952-9. Epub 2013 Jan 17.

Department of Urology, University of Michigan, Ann Arbor, Michigan 48109-5940, USA.

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http://dx.doi.org/10.1002/pros.22642DOI Listing
June 2013

Transcriptional regulation of RKIP expression by androgen in prostate cells.

Cell Physiol Biochem 2012 23;30(6):1340-50. Epub 2012 Oct 23.

University of Michigan Comprehensive Cancer Center and Department of Urology, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1159/000343323DOI Listing
May 2013

MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.

Dev Cell 2013 May 16;25(4):402-16. Epub 2013 May 16.

Division of Molecular Medicine & Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.devcel.2013.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736823PMC
May 2013

Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer.

Prostate 2012 Dec 1;72(16):1789-801. Epub 2012 May 1.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Ishikawa, Japan.

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http://dx.doi.org/10.1002/pros.22533DOI Listing
December 2012

Raf kinase inhibitor protein (RKIP) in cancer.

Cancer Metastasis Rev 2012 Dec;31(3-4):615-20

Department of Urology, University of Michigan, RM 5308 Cancer Center, 1500 East Medical Center Dr, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1007/s10555-012-9365-9DOI Listing
December 2012

Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.

Mol Cancer Res 2012 Mar 12;10(3):282-92. Epub 2012 Jan 12.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307952PMC
March 2012

Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.

Oncoimmunology 2012 Mar;1(2):152-161

Department of Surgery; University of Michigan; Ann Arbor, MI USA ; Department of Surgery; Central Laboratory; Union Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan, China.

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http://dx.doi.org/10.4161/onci.1.2.18480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376984PMC
March 2012

The PCa Tumor Microenvironment.

Cancer Microenviron 2011 Dec 5;4(3):283-97. Epub 2011 Jul 5.

Department of Urology, University of Michigan, RM 5308 CC, Ann Arbor, MI, 48109-8940, USA.

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http://dx.doi.org/10.1007/s12307-011-0073-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234329PMC
December 2011

Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone.

Authors:
Evan T Keller

Asian J Androl 2011 Jul 30;13(4):622-3. Epub 2011 May 30.

Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1038/aja.2011.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739614PMC
July 2011

ALDH activity indicates increased tumorigenic cells, but not cancer stem cells, in prostate cancer cell lines.

In Vivo 2011 Jan-Feb;25(1):69-76

Department of Urology, University of Michigan Medical School, 5111 CCGC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0940, USA.

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May 2011

The first Tianjin, China forum on tumor microenvironment.

Cancer Res 2011 Jan 11;71(2):310-3. Epub 2011 Jan 11.

Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075440PMC
January 2011

Role of Raf Kinase Inhibitor Protein in Pathophysiology of Prostate Cancer.

Authors:
Evan T Keller

For Immunopathol Dis Therap 2011 ;2(1):89-94

Department of Urology, University of Michigan, 1500 E. Medical Center Dr., Room 5308 CCGCB, Ann Arbor, MI 48105.

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http://dx.doi.org/10.1615/ForumImmunDisTher.v2.i1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187718PMC
January 2011

CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer.

Prostate 2010 Jan;70(1):48-60

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

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http://dx.doi.org/10.1002/pros.21037DOI Listing
January 2010

Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone.

Endocr Relat Cancer 2009 Dec 16;16(4):1139-55. Epub 2009 Jul 16.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Takaramachi, Kanazawa City, Japan.

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https://erc.bioscientifica.com/view/journals/erc/16/4/1139.x
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http://dx.doi.org/10.1677/ERC-09-0070DOI Listing
December 2009

A bioluminescent orthotopic mouse model of human osteosarcoma that allows sensitive and rapid evaluation of new therapeutic agents In vivo.

In Vivo 2009 Sep-Oct;23(5):661-8

Department of Urology/Surgery, University of Michigan, Ann Arbor, MI, USA.

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November 2009

Expression of PGK1 by prostate cancer cells induces bone formation.

Mol Cancer Res 2009 Oct 13;7(10):1595-604. Epub 2009 Oct 13.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771860PMC
October 2009

Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes.

Prostate 2009 Aug;69(11):1222-34

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan.

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http://dx.doi.org/10.1002/pros.20975DOI Listing
August 2009

EGFR ligand switch in late stage prostate cancer contributes to changes in cell signaling and bone remodeling.

Prostate 2009 Apr;69(5):528-37

Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109-0654, USA.

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http://dx.doi.org/10.1002/pros.20903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766509PMC
April 2009

Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression.

Cancer Res 2008 Dec;68(23):9663-70

Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100895PMC
December 2008

Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer.

Int J Radiat Oncol Biol Phys 2008 Sep;72(1):153-60

Department of Urology, University of Michigan Health System, Ann Arbor, MI 48109-0940, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2008.04.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597029PMC
September 2008

Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells.

Comp Biochem Physiol A Mol Integr Physiol 2008 Jul 7;150(3):307-14. Epub 2008 Apr 7.

Departments of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109-0940, USA.

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http://dx.doi.org/10.1016/j.cbpa.2008.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2507762PMC
July 2008

Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation.

Bone 2008 Apr 15;42(4):806-18. Epub 2007 Dec 15.

Department of Biomedical Engineering, University of Michigan College of Engineering, USA.

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http://dx.doi.org/10.1016/j.bone.2007.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677418PMC
April 2008

New trends in the treatment of bone metastasis.

J Cell Biochem 2007 Dec;102(5):1095-102

Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1002/jcb.21540DOI Listing
December 2007