Evan L Brittain

Evan L Brittain

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Evan L Brittain

Evan L Brittain

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Echocardiographic Detection of Occult Diastolic Dysfunction in Pulmonary Hypertension After Fluid Challenge.

J Am Heart Assoc 2019 Sep 31;8(17):e012504. Epub 2019 Aug 31.

Division of Cardiology Department of Medicine Vanderbilt University Medical Center Nashville TN.

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http://dx.doi.org/10.1161/JAHA.119.012504DOI Listing
September 2019

Moment on the Lips, a Lifetime on the Lungs?: Improving Models of Group 2 Pulmonary Hypertension.

Circ Res 2019 Aug 1;125(4):467-469. Epub 2019 Aug 1.

Divison of Allergy, Pulmonary and Critical Care Medicine (A.R.H.), Vanderbilt University Medical Center, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315478DOI Listing
August 2019

Editorial commentary: Pulmonary hypertension in left heart disease: Definitions, data sources, and the road ahead.

Trends Cardiovasc Med 2019 05 20;29(4):218-219. Epub 2018 Sep 20.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN and Vanderbilt Translational and Clinical Cardiovascular Research Center, 2525 West End Ave. Suite 300, Nashville, TN 37203, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2018.09.013DOI Listing
May 2019

Early intervention: should we conduct therapeutic trials for mild pulmonary hypertension before onset of symptoms?

Pulm Circ 2019 Apr-Jun;9(2):2045894019845615

1 Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894019844994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469279PMC
April 2019

Echocardiographic evaluation of diastolic function in the setting of pulmonary hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894019826043. Epub 2019 Feb 5.

Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894019826043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366003PMC
February 2019

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894018823528. Epub 2018 Dec 18.

5 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018823528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329033PMC
December 2018

Features Associated With Discordance Between Pulmonary Arterial Wedge Pressure and Left Ventricular End Diastolic Pressure in Clinical Practice: Implications for Pulmonary Hypertension Classification.

Chest 2018 11 24;154(5):1099-1107. Epub 2018 Aug 24.

Division of Cardiovascular Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.08.1033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224703PMC
November 2018

Reduced free-living activity levels in pulmonary arterial hypertension patients.

Pulm Circ 2019 Jan-Mar;9(1):2045894018814182. Epub 2018 Nov 13.

1 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018814182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432689PMC
November 2018

Adverse physiologic effects of Western diet on right ventricular structure and function: role of lipid accumulation and metabolic therapy.

Pulm Circ 2019 Jan-Mar;9(1):2045894018817741. Epub 2018 Nov 19.

3 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018817741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295706PMC
November 2018

The relationship between pulmonary artery wedge pressure and pulmonary blood volume derived from contrast echocardiography: A proof-of-concept study.

Echocardiography 2018 09 14;35(9):1266-1270. Epub 2018 May 14.

Department of Epidemiology and Cancer Control, St Jude Children's, Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/echo.14023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168381PMC
September 2018

Mild Pulmonary Hypertension Is Associated With Increased Mortality: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2018 09;7(18):e009729

1 Providence Veterans Affairs Medical Center Warren Alpert Medical School of Brown University Providence RI.

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http://dx.doi.org/10.1161/JAHA.118.009729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222957PMC
September 2018

Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension.

Pulm Circ 2018 Oct-Dec;8(4):2045894018800544. Epub 2018 Aug 24.

1 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018800544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134494PMC
August 2018

Update in Pulmonary Vascular Disease 2016 and 2017.

Am J Respir Crit Care Med 2018 07;198(1):13-23

5 Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1164/rccm.201801-0062UPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034126PMC
July 2018

Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years.

Am J Cardiol 2018 06 13;121(12):1552-1557. Epub 2018 Mar 13.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.amjcard.2018.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975107PMC
June 2018

Lack of a Tricuspid Regurgitation Doppler Signal and Pulmonary Hypertension by Invasive Measurement.

J Am Heart Assoc 2018 06 30;7(13). Epub 2018 Jun 30.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN

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http://dx.doi.org/10.1161/JAHA.118.009362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064901PMC
June 2018

Redefining pulmonary hypertension.

Lancet Respir Med 2018 03 18;6(3):168-170. Epub 2017 Dec 18.

Department of Medicine, University of Pittsburgh Medical Center and Pittsburgh Heart, Lung, Blood, and Vascular Medical Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/S2213-2600(17)30498-8DOI Listing
March 2018

A Metabolic Basis for Endothelial-to-Mesenchymal Transition.

Mol Cell 2018 02 8;69(4):689-698.e7. Epub 2018 Feb 8.

Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA; Aging Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816688PMC
February 2018

Racial differences in patients referred for right heart catheterization and risk of pulmonary hypertension.

Pulm Circ 2018 Apr-Jun;8(2):2045894018764273. Epub 2018 Feb 26.

3 12328 Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018764273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858628PMC
February 2018

Autonomic Nervous System in Pulmonary Arterial Hypertension: Time to Rest and Digest.

Circulation 2018 02;137(9):925-927

Division of Cardiovascular Medicine (E.L.B.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830155PMC
February 2018

The transpulmonary ratio of endothelin 1 is elevated in patients with preserved left ventricular ejection fraction and combined pre- and post-capillary pulmonary hypertension.

Pulm Circ 2018 Jan-Mar;8(1):2045893217745019. Epub 2017 Dec 18.

1 12328 Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045893217745019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764145PMC
December 2017

End-Tidal Carbon Dioxide as a Prognostic Feature in Pulmonary Arterial Hypertension.

Ann Am Thorac Soc 2017 Jun;14(6):896-902

3 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1513/AnnalsATS.201612-951OCDOI Listing
June 2017

Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis.

Amyloid 2016 Dec 4;23(4):242-248. Epub 2016 Nov 4.

a Department of Medicine, Division of Cardiovascular Medicine , Vanderbilt University School of Medicine , Nashville , TN , USA.

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http://dx.doi.org/10.1080/13506129.2016.1242480DOI Listing
December 2016

Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension.

J Am Coll Cardiol 2016 Dec;68(23):2525-2536

Vanderbilt Center for Translational and Clinical Cardiovascular Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.jacc.2016.09.942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157701PMC
December 2016

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.

Am J Respir Crit Care Med 2016 09;194(6):719-28

1 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1164/rccm.201507-1444OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027228PMC
September 2016

Integration of complex data sources to provide biologic insight into pulmonary vascular disease (2015 Grover Conference Series).

Pulm Circ 2016 Sep;6(3):251-60

Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; and Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019078PMC
http://dx.doi.org/10.1086/686995DOI Listing
September 2016

Hemodynamic evidence of vascular remodeling in combined post- and precapillary pulmonary hypertension.

Pulm Circ 2016 Sep;6(3):313-21

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019084PMC
http://dx.doi.org/10.1086/688516DOI Listing
September 2016

Severity of pulmonary hypertension and obesity are not associated with worse functional outcomes after pulmonary thromboendarterectomy.

Pulm Circ 2016 Jun;6(2):174-80

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1086/685736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869921PMC
June 2016

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.

Circulation 2016 May 22;133(20):1936-44. Epub 2016 Mar 22.

From Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (E.L.B.); Vanderbilt Translational and Clinical Cardiovascular Center, Vanderbilt University Medical Center, Nashville, TN (E.L.B.); Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.T., J.P.F., N.P., J.D.W., M.F., M.E.P., J.H.N., A.R.H.); Vanderbilt University Institute of Imaging Science, Nashville, TN (H.Z.); Department of Biochemistry; Vanderbilt University, Nashville, TN (M.W.C.); Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston (D.G.L., R.E.G.); Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (G.D.L., R.E.G.); Broad Institute of MIT and Harvard, Cambridge, MA (R.E.G.); Division of Medical Genetics and Genomic Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN (R.H.); and Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN (E.D.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870107PMC
May 2016

Feasibility and Diagnostic Potential of Pulmonary Transit Time Measurement by Contrast Echocardiography: A Pilot Study.

Echocardiography 2015 Oct 13;32(10):1564-71. Epub 2015 Feb 13.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1111/echo.12906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536186PMC
October 2015

Effect of acute arteriolar vasodilation on capacitance and resistance in pulmonary arterial hypertension.

Chest 2015 Apr;147(4):1080-1085

Pulmonary Circulation Center, Divisions of Pulmonary and Critical Care Medicine and Cardiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692153895
Publisher Site
http://dx.doi.org/10.1378/chest.14-1461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388116PMC
April 2015

Prognostic value of acute vasodilator response in pulmonary arterial hypertension: beyond the "classic" responders.

J Heart Lung Transplant 2015 Mar 4;34(3):312-8. Epub 2014 Nov 4.

Division of Cardiovascular Medicine Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2014.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380573PMC
March 2015

Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension.

Chest 2014 Dec;146(6):1478-1485

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical School, Nashville, TN.

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http://dx.doi.org/10.1378/chest.14-0809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251612PMC
December 2014

Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension.

Pulm Circ 2014 Jun;4(2):311-8

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1086/675994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070784PMC
June 2014

Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension.

PLoS One 2013 4;8(10):e76461. Epub 2013 Oct 4.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076461PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790694PMC
May 2014

One generation's "junk" is another's treasure: the emerging role of microRNAs as therapeutic targets.

J Heart Lung Transplant 2014 Mar 27;33(3):233-4. Epub 2013 Dec 27.

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.healun.2013.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837650PMC
March 2014

High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension.

Circ Heart Fail 2014 Jan 2;7(1):116-22. Epub 2013 Dec 2.

Division of Allergy, Pulmonary and Critical Care Medicine and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN; and Division of Cardiology, Wake Forest Baptist Medical Center, Winston-Salem, NC.

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.113
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934572PMC
January 2014

Acute improvement in right ventricular function after treatment of presumed massive pulmonary embolism with thrombolytics.

Pulm Circ 2012 Oct;2(4):522-4

Divisions of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.4103/2045-8932.105042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555424PMC
October 2012

Right ventricular plasticity and functional imaging.

Pulm Circ 2012 Jul;2(3):309-26

Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.4103/2045-8932.101407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487300PMC
July 2012