Evan D Rosen

Evan D Rosen

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Evan D Rosen

Evan D Rosen

Publications by authors named "Evan D Rosen"

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Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Cell Metab 2018 10 2;28(4):631-643.e3. Epub 2018 Aug 2.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183044
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http://dx.doi.org/10.1016/j.cmet.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170693PMC
October 2018

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Diabetes 2018 10;67(10):1923-1931

Department of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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http://dx.doi.org/10.2337/db18-0537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463748PMC
October 2018

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Cell Metab 2018 May 12;27(5):1121-1137.e5. Epub 2018 Apr 12.

Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Department of Genetics, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183018
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http://dx.doi.org/10.1016/j.cmet.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932137PMC
May 2018

Dnmt3a is an epigenetic mediator of adipose insulin resistance.

Elife 2017 11 1;6. Epub 2017 Nov 1.

Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States.

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http://dx.doi.org/10.7554/eLife.30766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730374PMC
November 2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Cell Metab 2017 Oct 24;26(4):660-671.e3. Epub 2017 Aug 24.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629120PMC
October 2017

Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding.

Mol Metab 2017 10 29;6(10):1150-1160. Epub 2017 Jun 29.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA; Broad Institute, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641598PMC
October 2017

A molecular census of arcuate hypothalamus and median eminence cell types.

Nat Neurosci 2017 Mar 6;20(3):484-496. Epub 2017 Feb 6.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323293PMC
March 2017

Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo.

Cell Rep 2017 01;18(4):1048-1061

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163180
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http://dx.doi.org/10.1016/j.celrep.2016.12.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291126PMC
January 2017

Nuclear Mechanisms of Insulin Resistance.

Trends Cell Biol 2016 05 25;26(5):341-351. Epub 2016 Jan 25.

Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844850PMC
May 2016

Burning Fat by Bugging the System.

Authors:
Evan D Rosen

N Engl J Med 2016 Mar;374(9):885-7

From the Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcibr1515457DOI Listing
March 2016

Making Biological Sense of GWAS Data: Lessons from the FTO Locus.

Cell Metab 2015 Oct;22(4):538-9

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131150047
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http://dx.doi.org/10.1016/j.cmet.2015.09.018DOI Listing
October 2015

Two paths to fat.

Authors:
Evan D Rosen

Nat Cell Biol 2015 Apr;17(4):360-1

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3133DOI Listing
April 2015

Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.

Nat Cell Biol 2015 Jan 15;17(1):44-56. Epub 2014 Dec 15.

1] Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA [2] Broad Institute, Cambridge, Massachusetts 02142, USA [3] Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281178PMC
January 2015

Adipocyte-specific transgenic and knockout models.

Methods Enzymol 2014 ;537:1-16

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-411619-1.00001-XDOI Listing
September 2014

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

Proc Natl Acad Sci U S A 2014 Sep 25;111(36):13127-32. Epub 2014 Aug 25.

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142; Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114; Department of Medicine, Harvard Medical School, Boston, MA 02115; Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1410428111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246964PMC
September 2014

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Cell 2014 Jul;158(1):69-83

Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116691PMC
July 2014

Characterization of Cre recombinase models for the study of adipose tissue.

Adipocyte 2014 Jul 27;3(3):206-11. Epub 2014 Jun 27.

Department of Molecular, Cell and Developmental Biology; Yale University; New Haven, CT USA ; Section of Comparative Medicine; Yale University; New Haven, CT USA ; Yale Stem Cell Center; Yale University; New Haven, CT USA.

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http://dx.doi.org/10.4161/adip.29674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110097PMC
July 2014

A smooth muscle-like origin for beige adipocytes.

Cell Metab 2014 May 4;19(5):810-20. Epub 2014 Apr 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052772PMC
May 2014

What we talk about when we talk about fat.

Cell 2014 Jan;156(1-2):20-44

Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674130154
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http://dx.doi.org/10.1016/j.cell.2013.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934003PMC
January 2014

Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

J Cell Sci 2013 Dec 17;126(Pt 23):5432-40. Epub 2013 Sep 17.

Genes, Development and Disease Group, F-BBVA-CNIO Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.134510DOI Listing
December 2013

Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.

J Biol Chem 2013 Dec 30;288(50):35925-39. Epub 2013 Oct 30.

From the Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1074/jbc.M113.491936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861642PMC
December 2013

Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization.

Diabetes 2013 Oct 8;62(10):3394-403. Epub 2013 Jul 8.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.2337/db12-1327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781469PMC
October 2013

Regulation of early adipose commitment by Zfp521.

PLoS Biol 2012 27;10(11):e1001433. Epub 2012 Nov 27.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507953PMC
April 2013

Lessons on conditional gene targeting in mouse adipose tissue.

Diabetes 2013 Mar 15;62(3):864-74. Epub 2013 Jan 15.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-1089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581196PMC
March 2013

New insights into adipocyte-specific leptin gene expression.

Adipocyte 2012 Jul;1(3):168-172

Division of Endocrinology, Diabetes, and Metabolism; Beth Israel Deaconess Medical Center; Boston, MA USA ; Dana-Farber Cancer Institute and Department of Cell Biology; Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/adip.20574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609097PMC
July 2012

FOSL2 promotes leptin gene expression in human and mouse adipocytes.

J Clin Invest 2012 Mar 13;122(3):1010-21. Epub 2012 Feb 13.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://www.jci.org/articles/view/58431
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http://dx.doi.org/10.1172/JCI58431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322535PMC
March 2012

Identifying novel transcriptional components controlling energy metabolism.

Cell Metab 2011 Dec;14(6):739-45

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131110042
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http://dx.doi.org/10.1016/j.cmet.2011.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240865PMC
December 2011

A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance.

Am J Physiol Endocrinol Metab 2011 Nov 19;301(5):E825-35. Epub 2011 Jul 19.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1152/ajpendo.00147.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073944PMC
November 2011

Mammalian stem cells reprogramming in response to terahertz radiation.

PLoS One 2010 Dec 31;5(12):e15806. Epub 2010 Dec 31.

Department of Medicine, Endocrinology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015806PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013123PMC
December 2010

The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis.

Proc Natl Acad Sci U S A 2008 Feb 4;105(7):2421-6. Epub 2008 Feb 4.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.0707082105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268152PMC
February 2008

Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.

Mol Cell Biol 2007 Jan 23;27(2):743-57. Epub 2006 Oct 23.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01557-06
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http://dx.doi.org/10.1128/MCB.01557-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800806PMC
January 2007

FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults.

Proc Natl Acad Sci U S A 2007 Jan 17;104(4):1348-53. Epub 2007 Jan 17.

Reproductive Endocrine Unit, Division of Cardiology, and Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.0607966104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783105PMC
January 2007

Adipocyte differentiation from the inside out.

Nat Rev Mol Cell Biol 2006 Dec;7(12):885-96

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/nrm2066
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http://dx.doi.org/10.1038/nrm2066DOI Listing
December 2006

Adipocytes as regulators of energy balance and glucose homeostasis.

Nature 2006 Dec;444(7121):847-53

Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature05483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212857PMC
December 2006

Reactive oxygen species have a causal role in multiple forms of insulin resistance.

Nature 2006 Apr;440(7086):944-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA.

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http://dx.doi.org/10.1038/nature04634DOI Listing
April 2006

New drugs from fat bugs?

Authors:
Evan D Rosen

Cell Metab 2006 Jan;3(1):1-2

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.12.002DOI Listing
January 2006

The transcriptional basis of adipocyte development.

Authors:
Evan D Rosen

Prostaglandins Leukot Essent Fatty Acids 2005 Jul;73(1):31-4

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.plefa.2005.04.004DOI Listing
July 2005

Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours.

Clin Endocrinol (Oxf) 2005 May;62(5):603-6

Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

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http://doi.wiley.com/10.1111/j.1365-2265.2005.02267.x
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http://dx.doi.org/10.1111/j.1365-2265.2005.02267.xDOI Listing
May 2005

Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.

Proc Natl Acad Sci U S A 2004 Jul 9;101(29):10750-5. Epub 2004 Jul 9.

Hematology Division, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0404044101
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http://dx.doi.org/10.1073/pnas.0404044101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC490006PMC
July 2004

Energy balance: a new role for PPARalpha.

Authors:
Evan D Rosen

Curr Biol 2003 Dec;13(24):R961-3

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North 330-D, 99 Brookline Avenue, Boston, MA 02214, USA.

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http://dx.doi.org/10.1016/j.cub.2003.11.043DOI Listing
December 2003

The molecular control of adipogenesis, with special reference to lymphatic pathology.

Authors:
Evan D Rosen

Ann N Y Acad Sci 2002 Dec;979:143-58; discussion 188-96

Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04875.xDOI Listing
December 2002

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.

J Biol Chem 2002 Nov 27;277(44):41925-30. Epub 2002 Aug 27.

Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M206950200DOI Listing
November 2002