Publications by authors named "Eva Surmacz"

54Publications

Editorial: Adiponectin: Friend or Foe? Toward Understanding the Complexities of Adiponectin Biology and Challenges in Pharmaceutical Development.

Front Endocrinol (Lausanne) 2020 29;11:343. Epub 2020 May 29.

Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.3389/fendo.2020.00343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272668PMC
May 2020

Corrigendum: Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models.

Front Mol Biosci 2016 18;3:75. Epub 2016 Nov 18.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fmolb.2016.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114862PMC
November 2016

Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models.

Front Mol Biosci 2016 13;3:67. Epub 2016 Oct 13.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fmolb.2016.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062870PMC
October 2016

Molecular targeting of obesity pathways in cancer.

Horm Mol Biol Clin Investig 2015 May;22(2):53-62

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http://dx.doi.org/10.1515/hmbci-2015-0007DOI Listing
May 2015

Optimization of adiponectin-derived peptides for inhibition of cancer cell growth and signaling.

Biopolymers 2015 May;104(3):156-66

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA, 19122.

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http://dx.doi.org/10.1002/bip.22627DOI Listing
May 2015

Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors.

J Neuroimmune Pharmacol 2014 Jun 23;9(3):388-98. Epub 2014 Feb 23.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, 70808, USA.

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http://link.springer.com/10.1007/s11481-014-9529-1
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http://dx.doi.org/10.1007/s11481-014-9529-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351715PMC
June 2014

The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor.

Amino Acids 2014 Apr 24;46(4):873-82. Epub 2013 Dec 24.

Department of Biology, Temple University, 1900 North 12th Street, Philadelphia, PA, 19122, USA,

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http://dx.doi.org/10.1007/s00726-013-1650-6DOI Listing
April 2014

Leptin and adiponectin: emerging therapeutic targets in breast cancer.

Authors:
Eva Surmacz

J Mammary Gland Biol Neoplasia 2013 Dec 18;18(3-4):321-32. Epub 2013 Oct 18.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, 1900 N12th Street, BioLife Bldg. Rm 425, Philadelphia, PA, 19122, USA,

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http://dx.doi.org/10.1007/s10911-013-9302-8DOI Listing
December 2013

Exploring leptin antagonism in ophthalmic cell models.

PLoS One 2013 3;8(10):e76437. Epub 2013 Oct 3.

Sbarro Institute for Cancer Research and Molecular Medicine, Biotechnology Center, Temple University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076437PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789671PMC
July 2014

Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity.

Peptides 2013 Jun 6;44:127-34. Epub 2013 Apr 6.

Temple University, Sbarro Institute for Cancer Reserach and Molecular Medicine, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1016/j.peptides.2013.03.027DOI Listing
June 2013

Metformin inhibits leptin-induced growth and migration of glioblastoma cells.

Oncol Lett 2012 Nov 3;4(5):1077-1081. Epub 2012 Aug 3.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA ;

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http://dx.doi.org/10.3892/ol.2012.843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499461PMC
November 2012

Targeting the leptin receptor: a potential new mode of treatment for breast cancer.

Expert Rev Anticancer Ther 2011 Aug;11(8):1147-50

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http://dx.doi.org/10.1586/era.11.109DOI Listing
August 2011

Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.

BMC Cancer 2011 Jul 19;11:303. Epub 2011 Jul 19.

Sbarro Institute for Cancer Research and Molecular Medicine, Biotechnology Center, Temple University, 1900 N 12th street, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1186/1471-2407-11-303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146945PMC
July 2011

Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.

Eur J Cancer 2011 Jul 23;47(10):1578-84. Epub 2011 Feb 23.

Department of Biology, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1016/j.ejca.2011.01.018DOI Listing
July 2011

Leptin-based therapeutics.

Expert Rev Endocrinol Metab 2010 Nov;5(6):875-889

a Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1586/eem.10.61DOI Listing
November 2010

Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells.

Endocr Relat Cancer 2010 Sep 16;17(3):823-33. Epub 2010 Aug 16.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1677/ERC-10-0083DOI Listing
September 2010

miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.

J Cell Physiol 2010 Jul;224(1):242-9

Section of Medical Oncology, Department of Surgical and Oncological Sciences, Palermo University, Palermo, Italy.

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http://dx.doi.org/10.1002/jcp.22126DOI Listing
July 2010

Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.

Brain Pathol 2010 Mar 6;20(2):481-9. Epub 2009 Aug 6.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1111/j.1750-3639.2009.00323.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864337PMC
March 2010

Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.

J Cell Physiol 2009 Oct;221(1):189-94

Department of Surgical and Oncological Sciences, Section of Medical Oncology, Università di Palermo, Palermo, Italy.

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http://dx.doi.org/10.1002/jcp.21843DOI Listing
October 2009

Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells.

Int J Cancer 2009 Sep;125(5):1038-44

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1002/ijc.24372DOI Listing
September 2009

Agonists and partial antagonists acting on the leptin--leptin receptor interface.

Adv Exp Med Biol 2009 ;611:497-8

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1007/978-0-387-73657-0_215DOI Listing
June 2009

Insulin-dependent leptin expression in breast cancer cells.

Cancer Res 2008 Jun;68(12):4919-27

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, USA.

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http://cancerres.aacrjournals.org/content/68/12/4919.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-0642DOI Listing
June 2008

Development of a pharmacologically improved peptide agonist of the leptin receptor.

Biochim Biophys Acta 2008 Oct 21;1783(10):1745-54. Epub 2008 May 21.

Temple University, Sbarro Institute of Cancer Research and Molecular Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2008.05.007DOI Listing
October 2008

Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells.

Breast Cancer Res Treat 2009 May 4;115(2):297-306. Epub 2008 Jun 4.

Department Farmaco-Biologico, University of Calabria, Arcavacata di Rende (CS) 87036, Italy.

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http://dx.doi.org/10.1007/s10549-008-0079-1DOI Listing
May 2009

Is BRCA1-5083del19, identified in breast cancer patients of Sicilian origin, a Calabrian founder mutation?

Breast Cancer Res Treat 2009 Jan 29;113(1):67-70. Epub 2008 Jan 29.

Department of Oncology, Section of Medical Oncology, Regional Reference Center for the Biomolecular Characterization and Genetic Screening of Hereditary Tumors, Università di Palermo, Via del Vespro 127, 90127 Palermo, Italy.

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http://dx.doi.org/10.1007/s10549-008-9906-7DOI Listing
January 2009

Overexpression of the obesity hormone leptin in human colorectal cancer.

J Clin Pathol 2007 Aug;60(8):902-6

Department of Pathology, Medical University of Bialystok, Bialystok, Poland.

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http://dx.doi.org/10.1136/jcp.2006.041004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994494PMC
August 2007

Crosstalk between IGF signaling and steroid hormone receptors in breast cancer.

Curr Pharm Des 2007 ;13(7):705-17

Department of Pharmaco-Biology, University of Calabria, Arcavacata di Rende CS 87036.

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http://dx.doi.org/10.2174/138161207780249182DOI Listing
April 2007

Obesity hormone leptin: a new target in breast cancer?

Authors:
Eva Surmacz

Breast Cancer Res 2007 ;9(1):301

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1186/bcr1638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851379PMC
May 2007

BRCA1 genetic testing in 106 breast and ovarian cancer families from Southern Italy (Sicily): a mutation analyses.

Breast Cancer Res Treat 2007 Nov 13;105(3):267-76. Epub 2007 Jan 13.

Interdepartmental Center of Clinical Oncology, Regional Reference Center for the Biomolecular Characterization and Genetic Screening of Hereditary Tumors, Università di Palermo, Via del Vespro 127, 90127, Palermo, Italy.

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http://link.springer.com/content/pdf/10.1007/s10549-006-9456
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http://link.springer.com/10.1007/s10549-006-9456-9
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http://dx.doi.org/10.1007/s10549-006-9456-9DOI Listing
November 2007

Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells.

J Biol Chem 2007 Feb 13;282(6):3498-506. Epub 2006 Dec 13.

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia Pennsylvania 19122, USA.

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http://dx.doi.org/10.1074/jbc.M606244200DOI Listing
February 2007

Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.

Clin Cancer Res 2006 Mar;12(5):1447-53

Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1913DOI Listing
March 2006

RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells.

J Cell Biochem 2006 May;98(2):440-50

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1002/jcb.20817DOI Listing
May 2006

Leptin and cancer.

J Cell Physiol 2006 Apr;207(1):12-22

Department of Pharmaco-Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy.

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http://dx.doi.org/10.1002/jcp.20472DOI Listing
April 2006

Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.

J Biol Chem 2005 Aug 20;280(33):29912-20. Epub 2005 Jun 20.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M504516200DOI Listing
August 2005

Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.

Oncogene 2004 Dec;23(57):9269-79

Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and McGill University, Departments of Oncology and Medicine, Montreal, Quebec, Canada.

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http://www.nature.com/articles/1208104
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http://dx.doi.org/10.1038/sj.onc.1208104DOI Listing
December 2004

Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

Clin Cancer Res 2004 Oct;10(19):6466-75

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-04-0203DOI Listing
October 2004

IGF-I receptor, cell-cell adhesion, tumour development and progression.

J Mol Histol 2004 Mar;35(3):247-53

Department of Cellular Biology and Faculty of Pharmacy, University of Calabria, 87030 Rende, Italy.

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http://dx.doi.org/10.1023/b:hijo.0000032356.98363.a2DOI Listing
March 2004

Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.

Oncogene 2004 Sep;23(45):7517-26

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/sj.onc.1208014DOI Listing
September 2004

Expression of ERalpha, ERbeta and Ki-67 in primary tumors and lymph node metastases in breast cancer.

Oncol Rep 2004 Apr;11(4):753-9

Department of Clinical Pathology, Medical University of Bialystok, 15-269 Bialystok, Poland.

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April 2004

Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor.

Authors:
Eva Surmacz

Oncogene 2003 Sep;22(42):6589-97

Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St., BLSB 631, Philadelphia, PA 19107, USA.

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http://www.nature.com/articles/1206772
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http://dx.doi.org/10.1038/sj.onc.1206772DOI Listing
September 2003

Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells.

Oncogene 2003 Jun;22(26):4007-16

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/sj.onc.1206436DOI Listing
June 2003

Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression.

J Cell Physiol 2003 Feb;194(2):108-16

Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://doi.wiley.com/10.1002/jcp.10207
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http://dx.doi.org/10.1002/jcp.10207DOI Listing
February 2003