Eva Dombi

Eva Dombi

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Eva Dombi

Eva Dombi

Publications by authors named "Eva Dombi"

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Longitudinal evaluation of peripheral nerve sheath tumors in neurofibromatosis type 1: Growth analysis of plexiform neurofibromas and distinct nodular lesions.

Neuro Oncol 2020 Mar 10. Epub 2020 Mar 10.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/neuonc/noaa053DOI Listing
March 2020

Selumetinib in Children with Inoperable Plexiform Neurofibromas.

N Engl J Med 2020 Mar 18. Epub 2020 Mar 18.

From the Pediatric Oncology Branch (A.M.G., P.L.W., E.D., P.W., S.M., M.C.R., D.C.P., A.C., J.T., O.K., J.G., B.C.W.) and the Clinical Pharmacology Program (C.J.P., W.D.F.), Center for Cancer Research, National Cancer Institute, and the Rehabilitation Medicine Department, Clinical Center (S.M.P), National Institutes of Health, Bethesda, the Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick (A.B., K.H.), the Cancer Therapy Evaluation Program (M.S., L.A.D.) and the Biostatistics and Data Management Section, Center for Cancer Research (S.M.S., D.J.V.), National Cancer Institute, National Institutes of Health, Shady Grove, and Johns Hopkins University School of Medicine, Baltimore (J.O.B.) - all in Maryland; Children's Hospital of Philadelphia, Philadelphia (M.J.F., A.C.S.); Cincinnati Children's Hospital, Cincinnati (B.W.); Children's National Hospital, Washington, DC (A.K., M.B.); and Indiana University School of Medicine, Indianapolis (D.W.C., C.Z.).

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http://dx.doi.org/10.1056/NEJMoa1912735DOI Listing
March 2020

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma.

Oncogene 2019 04 12;38(15):2876-2884. Epub 2018 Dec 12.

Department of Pediatrics, University of Cincinnati College of Medicine, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH, 45229-0713, USA.

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http://dx.doi.org/10.1038/s41388-018-0600-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461477PMC
April 2019

RUNX represses to drive neurofibromagenesis.

Sci Adv 2019 04 24;5(4):eaau8389. Epub 2019 Apr 24.

Cincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/sciadv.aau8389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482019PMC
April 2019

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.98601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413799PMC
February 2019

Volumetric MRI Analysis of Plexiform Neurofibromas in Neurofibromatosis Type 1: Comparison of Two Methods.

Acad Radiol 2018 02 31;25(2):144-152. Epub 2017 Oct 31.

Center for Cancer Research, Pediatric Oncology Branch, National Cancer Institute, 10 Center Drive, CRC Room 1-5750, Bethesda, MD 20892. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794522PMC
February 2018

Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.

N Engl J Med 2016 12;375(26):2550-2560

From the Center for Cancer Research, Pediatric Oncology Branch, Bethesda (E.D., A. Baldwin, L.J.M., P. Whitcomb, S.M., R.E., P. Wolters, J.T., J.G., A.J.S., A.G., B.C.W.) and the Cancer Therapy Evaluation Program, Shady Grove (A.L.D.), National Cancer Institute, and the National Heart, Lung, and Blood Institute (A. Brofferio), Bethesda, National Institutes of Health, and the Food and Drug Administration, Silver Spring (L.J.M., R.E.) - all in Maryland; the Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (M.J.F., J.B.B.); Children's National Health System, Washington, DC (A.K.); and Cincinnati Children's Hospital, Cincinnati (B.W., L.E.A.-S., T.A.R., J.W., E.S., N.R.).

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http://dx.doi.org/10.1056/NEJMoa1605943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508592PMC
December 2016

Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis.

Neurology 2016 Aug;87(7 Suppl 1):S31-9

From The Russell H. Morgan Department of Radiology and Radiological Science (S.A., L.M.F., M.A.J.), Sidney Kimmel Comprehensive Cancer Center (M.A.J.), and Department of Neurology (J.O.B.), Johns Hopkins University, Baltimore, MD; Khyber Medical College (M.S.K.), Peshawar, Pakistan; Department of Radiology (M.A.B., G.J.H., W.C.), Massachusetts General Hospital and Harvard Medical School, Boston; Genomic Medicine (D.G.E.), Manchester Academic Health Science Centre, The University of Manchester, UK; Department of Neurology (S.F., V.F.M.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Radiology & Orthopedic Surgery (A.C.), UT Southwestern Medical Center, Dallas, TX; Department of Diagnostic and Interventional Radiology (J.M.S.), University Hospital Hamburg-Eppendorf; Radiological Practice Altona (R.W.), Hamburg, Germany; Pediatric Oncology Branch (E.D.), National Cancer Institute, Bethesda, MD; and Department of Neurology and Cancer Center (S.R.P.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000002929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578359PMC
August 2016

Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.

J Clin Oncol 2016 05 14;34(14):1669-75. Epub 2016 Mar 14.

Jaishri O. Blakeley, Xiaobu Ye, Amanda L. Bergner, Laura M. Fayad, Shivani Ahlawat, and Michael A. Jacobs, Johns Hopkins University, Baltimore; Christopher Zalewski, National Institute on Deafness and Other Communication Disorders; Eva Dombi and Brigitte C. Widemann, National Cancer Institute, Bethesda, MD; Dan G. Duda, Alona Muzikansky, Vanessa L. Merker, Elizabeth R. Gerstner, Rakesh K. Jain, and Scott R. Plotkin, Massachusetts General Hospital; and Chris F. Halpin, Massachusetts Eye and Ear Infirmary, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2015.64.3817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872317PMC
May 2016

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.

Pediatr Blood Cancer 2015 Oct 22;62(10):1709-16. Epub 2015 Apr 22.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.25546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546559PMC
October 2015

Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.

Neuro Oncol 2015 Apr 14;17(4):596-603. Epub 2014 Oct 14.

Division of Oncology, Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute, Cincinnati, Ohio (B.W., J.P.); Division of Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (E.S.); Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (A.V.); National Cancer Institute, Pediatric Oncology Branch, Bethesda, Maryland (B.C.W, E.D., P.W.); Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama (B.K.); Department of Preventitive Medicine, University of Alabama at Birmingham, Birmingham, Alabama (A.C.); Department of Neurology, Boston Children's Hospital, Boston, Massachusetts (N.U.); Department of Neurology, Washington University, St. Louis, Missouri (D.H.G.); Children's National Health System, Center for Neuroscience and Behavioral Medicine, Washington, DC (R.J.P.); Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (M.J.F.); Division of Genetics, Primary Children's Hospital, Salt Lake City, Utah (D.V.); Division of Neurology, The University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois (J.T.).

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http://dx.doi.org/10.1093/neuonc/nou235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483073PMC
April 2015

Characterization of spinal findings in children and adults with neurofibromatosis type 1 enrolled in a natural history study using magnetic resonance imaging.

J Neurooncol 2015 Jan 8;121(1):209-15. Epub 2014 Oct 8.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA,

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http://dx.doi.org/10.1007/s11060-014-1629-5DOI Listing
January 2015

Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

Front Oncol 2014 17;4:324. Epub 2014 Nov 17.

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA.

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http://dx.doi.org/10.3389/fonc.2014.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233912PMC
December 2014

Phase 2 randomized, flexible crossover, double-blinded, placebo-controlled trial of the farnesyltransferase inhibitor tipifarnib in children and young adults with neurofibromatosis type 1 and progressive plexiform neurofibromas.

Neuro Oncol 2014 May 4;16(5):707-18. Epub 2014 Feb 4.

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland (B.W., E.D., A.G., P.W., S.M., E.F., F.B.); Cancer Therapy Evaluation Program, Investigational Drug Branch, National Cancer Institute, Bethesda, Maryland (J.W.); Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland (S.S.); Diagnostic Radiology Department, National Institutes of Health, Bethesda, Maryland (N.P.); The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.B., E.F., F.B.); Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois (S.G.); Department of Genetics, University of Alabama at Birmingham, South Birmingham, Alabama (B.K.); Expert Image Analysis LC, Potomac, Maryland (J.S.); Dana-Farber/Children's Hospital Cancer Center, Boston, Massachusetts (M.K.); Cincinnati Children's Hospital, Cincinnati, Ohio (J.P.); Children's National Medical Center, Washington, DC (A.K.); US Army Medical Research and Material Command, Fort Detrick, Maryland (W.S.); Children's Hospital of Alabama, Birmingham, Alabama (A.R.).

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http://dx.doi.org/10.1093/neuonc/nou004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984559PMC
May 2014

Puberty and plexiform neurofibroma tumor growth in patients with neurofibromatosis type I.

J Pediatr 2014 Mar 8;164(3):620-4. Epub 2013 Dec 8.

Pharmacology and Experimental Therapeutics Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1016/j.jpeds.2013.10.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943976PMC
March 2014

Achieving consensus for clinical trials: the REiNS International Collaboration.

Neurology 2013 Nov;81(21 Suppl 1):S1-5

From the Neurology Department and Cancer Center (S.R.P.), Massachusetts General Hospital, Boston, MA; Department of Neurology, Neurosurgery, and Oncology (J.O.B.), Johns Hopkins, Baltimore, MD; Pediatric Oncology Branch (E.D., P.L.W., B.C.W.), National Cancer Institute, Bethesda, MD; Division of Oncology, Department of Pediatrics (M.J.F.), The Children's Hospital of Pennsylvania, Philadelphia; Plymouth University Peninsula Schools of Medicine and Dentistry (C.O.H.), Plymouth, United Kingdom; and The Jennifer and Daniel Gilbert Neurofibromatosis Institute (K.S.W.), Children's National Medical Center, Washington, DC.

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http://dx.doi.org/10.1212/01.wnl.0000435743.49414.b6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908338PMC
November 2013

Recommendations for imaging tumor response in neurofibromatosis clinical trials.

Neurology 2013 Nov;81(21 Suppl 1):S33-40

From the Pediatric Oncology Branch (E.D., B.C.W.), National Cancer Institute, Bethesda, MD; Department of Neurology (S.L.A.-H.), The Children's Hospital at Westmead, Sydney, Australia; Department of Medical Genetics (D. B.-V.), Mayo Clinic, Rochester, MN; Neurosurgical Service (F.G.B.), Department of Radiology (G.J.H.), and Department of Neurology and Cancer Center (S.R.P.), Massachusetts General Hospital, Boston, MA; Department of Neuroradiology (S.C.), King's College Hospital, London, UK; Department of Genetic Medicine (D.G.E.), MAHSC, St Mary's Hospital, Manchester, UK; Division of Oncology (M.J.F.) and Department of Radiology (D.J.), The Children's Hospital of Philadelphia; Department of Pediatrics (M.J.F.), The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Neurosurgery (S.G.), Hôpital Beaujon, Clichy, France; Division of Pediatric Hematology/Oncology and NYU Cancer Institute (M.A.K.), NYU Langone Medical Center, New York, NY; Department of Genetics (B.R.K.), University of Alabama at Birmingham, Birmingham, AL; Department of Neurology (V.M.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (T.Y.P.), Boston Children's Hospital, Boston, MA; and Department of Pediatrics (K.R., C.-S.S.), Riley Hospital for Children, Indianapolis, IN.

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http://dx.doi.org/10.1212/01.wnl.0000435744.57038.afDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908340PMC
November 2013

Conclusions and future directions for the REiNS International Collaboration.

Neurology 2013 Nov;81(21 Suppl 1):S41-4

From the Pediatric Oncology Branch (B.C.W., E.D., P.L.W.), National Cancer Institute, Bethesda, MD; Department of Neurology, Neurosurgery, and Oncology (J.O.B.), Johns Hopkins, Baltimore, MD; Division of Oncology, Department of Pediatrics (M.J.F.), The Children's Hospital of Pennsylvania, Philadelphia; Plymouth University Peninsula Schools of Medicine and Dentistry (C.O.H.), Plymouth, United Kingdom; The Jennifer and Daniel Gilbert Neurofibromatosis Institute (K.S.W.), Children's National Medical Center, Washington, DC; and Neurology Department and Cancer Center (S.R.P.). Massachusetts General Hospital, Boston, MA.

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http://www.neurology.org/content/81/21_supplement_1/S41.full
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http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000435748.7
Publisher Site
http://dx.doi.org/10.1212/01.wnl.0000435748.79908.c5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908339PMC
November 2013

Visual outcomes in children with neurofibromatosis type 1 and orbitotemporal plexiform neurofibromas.

Am J Ophthalmol 2013 Jun 26;155(6):1089-1094.e1. Epub 2013 Feb 26.

Department of Neurology, Children's National Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.ajo.2013.01.011DOI Listing
June 2013

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.

Acta Neuropathol 2013 Jan 26;125(1):159-68. Epub 2012 Oct 26.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1007/s00401-012-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547628PMC
January 2013

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.

J Clin Invest 2013 Jan 10;123(1):340-7. Epub 2012 Dec 10.

Children’s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Ave., M.L.C. 7013, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI60578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533264PMC
January 2013

Bone mineral density in children and young adults with neurofibromatosis type 1.

Endocr Relat Cancer 2012 Dec 19;19(6):817-25. Epub 2012 Nov 19.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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https://erc.bioscientifica.com/view/journals/erc/19/6/817.xm
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http://dx.doi.org/10.1530/ERC-12-0293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132947PMC
December 2012

Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.

Pediatr Blood Cancer 2012 Feb 11;58(2):173-80. Epub 2011 Feb 11.

Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1002/pbc.23015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128176PMC
February 2012

(111)In-octreotide scintigraphy for identification of metastatic medullary thyroid carcinoma in children and adolescents.

J Clin Endocrinol Metab 2012 Feb 7;97(2):E207-12. Epub 2011 Dec 7.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1210/jc.2011-2766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275365PMC
February 2012

Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1.

Neuro Oncol 2008 Aug 17;10(4):593-8. Epub 2008 Jun 17.

Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1215/15228517-2008-011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666233PMC
August 2008

The role of [18F]-fluorodeoxyglucose positron emission tomography in predicting plexiform neurofibroma progression.

J Neurooncol 2008 Apr 11;87(2):165-71. Epub 2007 Dec 11.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://link.springer.com/10.1007/s11060-007-9501-5
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http://dx.doi.org/10.1007/s11060-007-9501-5DOI Listing
April 2008

Automated detection and volume measurement of plexiform neurofibromas in neurofibromatosis 1 using magnetic resonance imaging.

Comput Med Imaging Graph 2004 Jul;28(5):257-65

Sensor Systems, Inc., 103A Carpenter Drive, Sterling, Virginia 20864, USA.

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http://dx.doi.org/10.1016/j.compmedimag.2004.03.002DOI Listing
July 2004