Eunok Im

Eunok Im

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Eunok Im

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Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells.

Oncol Lett 2019 Sep 25;18(3):3256-3264. Epub 2019 Jul 25.

College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.3892/ol.2019.10664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704326PMC
September 2019

Effects of Harvest Time on Phytochemical Constituents and Biological Activities of Berry Extracts.

Molecules 2019 Sep 13;24(18). Epub 2019 Sep 13.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Korea.

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http://dx.doi.org/10.3390/molecules24183343DOI Listing
September 2019

Pten gene deletion in intestinal epithelial cells enhances susceptibility to Salmonella Typhimurium infection in mice.

J Microbiol 2019 Sep 25. Epub 2019 Sep 25.

Department of Biological Sciences, Oakland University, Rochester, Michigan, 48309, USA.

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http://dx.doi.org/10.1007/s12275-019-9320-3DOI Listing
September 2019

Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.

Biochim Biophys Acta Mol Basis Dis 2018 12 26;1864(12):3668-3678. Epub 2018 Sep 26.

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183036
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http://dx.doi.org/10.1016/j.bbadis.2018.09.031DOI Listing
December 2018

Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease.

Carbohydr Polym 2018 Oct 26;198:434-442. Epub 2018 Jun 26.

College of Pharmacy, Pusan National University, Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2018.06.107DOI Listing
October 2018

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Feb 7;1863(2):105-116. Epub 2017 Nov 7.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 469241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.11.002DOI Listing
February 2018

Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses.

Biochem Pharmacol 2018 01 23;147:119-127. Epub 2017 Nov 23.

Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733702PMC
January 2018

Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.

Aging Cell 2017 10 30;16(5):1026-1034. Epub 2017 Jun 30.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, 46241, Korea.

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http://dx.doi.org/10.1111/acel.12629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595700PMC
October 2017

Analysis of endogenous lipids during intestinal wound healing.

PLoS One 2017 11;12(8):e0183028. Epub 2017 Aug 11.

College of Pharmacy, Pusan National University, Busan, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183028PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553895PMC
October 2017

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model.

Int J Oncol 2017 Aug 27;51(2):715-723. Epub 2017 Jun 27.

Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2017.4058DOI Listing
August 2017

The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.

Autophagy 2017 Jul 2;13(7):1113-1129. Epub 2017 Jun 2.

a Molecular Inflammation Research Center for Aging Intervention (MRCA) , College of Pharmacy, Pusan National University , Busan , South Korea.

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http://dx.doi.org/10.1080/15548627.2017.1319040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529074PMC
July 2017

Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson's disease.

Brain Res 2017 05 18;1663:184-193. Epub 2017 Mar 18.

Department of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.03.018DOI Listing
May 2017

Endocannabinoids in the gastrointestinal tract.

Am J Physiol Gastrointest Liver Physiol 2016 10 18;311(4):G655-G666. Epub 2016 Aug 18.

College of Pharmacy, Pusan National University, Busan, Korea; and

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http://dx.doi.org/10.1152/ajpgi.00294.2015DOI Listing
October 2016

Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells.

Int J Oncol 2015 Dec 13;47(6):2226-32. Epub 2015 Oct 13.

Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2015.3200DOI Listing
December 2015

Profiling age-related epigenetic markers of stomach adenocarcinoma in young and old subjects.

Cancer Inform 2015 20;14:47-54. Epub 2015 Apr 20.

Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan, Republic of Korea. ; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.4137/CIN.S16912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406278PMC
May 2015

Multi-facets of Corticotropin-releasing Factor in Modulating Inflammation and Angiogenesis.

Authors:
Eunok Im

J Neurogastroenterol Motil 2015 Jan;21(1):25-32

College of Pharmacy, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.5056/jnm14076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288099PMC
January 2015

Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.

Gastroenterology 2014 Sep 29;147(3):667-679.e10. Epub 2014 May 29.

Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143453PMC
September 2014

Anti-inflammatory effects of betaine on AOM/DSS‑induced colon tumorigenesis in ICR male mice.

Int J Oncol 2014 Sep 24;45(3):1250-6. Epub 2014 Jun 24.

Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609‑735, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2014.2515DOI Listing
September 2014

Corticotropin-releasing Hormone and Its Biological Diversity toward Angiogenesis.

Authors:
Eunok Im

Intest Res 2014 Apr 29;12(2):96-102. Epub 2014 Apr 29.

Department of Pharmacy, Pusan National University College of Pharmacy, Busan, Korea.

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http://dx.doi.org/10.5217/ir.2014.12.2.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204709PMC
April 2014

Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice.

Int J Oncol 2013 Nov 4;43(5):1652-8. Epub 2013 Sep 4.

Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2013.2086DOI Listing
November 2013

PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment.

FASEB J 2013 Jan 4;27(1):243-54. Epub 2012 Oct 4.

Division of Digestive Diseases, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California 90095, USA.

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http://www.fasebj.org/doi/10.1096/fj.12-217596
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http://dx.doi.org/10.1096/fj.12-217596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528317PMC
January 2013

Toll-like receptor 5 engagement induces interleukin-17C expression in intestinal epithelial cells.

J Interferon Cytokine Res 2012 Dec 20;32(12):583-91. Epub 2012 Sep 20.

School of Pharmacy, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1089/jir.2012.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514012PMC
December 2012

Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid.

Diabetes 2012 May 13;61(5):1225-33. Epub 2012 Mar 13.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db11-1189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331768PMC
May 2012

Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents.

Gastroenterology 2011 May 26;140(5):1586-96.e6. Epub 2011 Jan 26.

Center for Ulcer Research and Education/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.01.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150547PMC
May 2011

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells.

J Biol Chem 2010 Nov 20;285(48):37570-8. Epub 2010 Sep 20.

Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M110.158394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988362PMC
November 2010

The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition.

Int J Cancer 2010 Aug;127(4):780-90

Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/ijc.25011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420487PMC
August 2010

TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5.

J Biol Chem 2010 Jul 7;285(28):21382-90. Epub 2010 May 7.

Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M110.115022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898416PMC
July 2010

Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.

Gastroenterology 2010 Jun 3;138(7):2457-67, 2467.e1-5. Epub 2010 Mar 3.

Section of Inflammatory Bowel Disease and Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883634PMC
June 2010

The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8.

Am J Physiol Gastrointest Liver Physiol 2009 Nov;297(5):G999-G1008

Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.

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http://www.physiology.org/doi/10.1152/ajpgi.00204.2009
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777460PMC
http://dx.doi.org/10.1152/ajpgi.00204.2009DOI Listing
November 2009

Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice.

J Nutr 2009 Oct 12;139(10):1848-54. Epub 2009 Aug 12.

Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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https://academic.oup.com/jn/article/139/10/1848/4670307
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http://dx.doi.org/10.3945/jn.109.108613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744608PMC
October 2009

Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer.

Gastroenterology 2008 Aug 23;135(2):518-28. Epub 2008 Apr 23.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667819PMC
August 2008

Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway.

J Biol Chem 2007 Oct 7;282(40):29122-9. Epub 2007 Aug 7.

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M702637200DOI Listing
October 2007

PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis.

Expert Opin Ther Targets 2007 Apr;11(4):443-51

Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1517/14728222.11.4.443 DOI Listing
April 2007

The role of cathepsins in ocular physiology and pathology.

Exp Eye Res 2007 Mar 7;84(3):383-8. Epub 2006 Aug 7.

Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.exer.2006.05.017DOI Listing
March 2007

Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids.

Curr Cancer Drug Targets 2006 Dec;6(8):681-9

Division of Pharmacy (Brain Korea 21 Program), Pusan National University, Research Institute for Drug Development, Busan 609-735, South Korea.

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December 2006

New insights regarding vessel regression.

Cell Cycle 2006 Sep 15;5(18):2057-9. Epub 2006 Sep 15.

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.4161/cc.5.18.3210DOI Listing
September 2006

Regulating angiogenesis at the level of PtdIns-4,5-P2.

EMBO J 2006 May 20;25(10):2075-82. Epub 2006 Apr 20.

Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462986PMC
May 2006

Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases.

Cancer Lett 2006 Feb 26;232(2):214-25. Epub 2005 Apr 26.

Department of Pharmacy and Pusan Cancer Research Center, Pusan National University, Busan 609-735, South Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350500180
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http://dx.doi.org/10.1016/j.canlet.2005.02.030DOI Listing
February 2006

Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-kappaB-dependent process in human cervical carcinoma cells.

Cancer Lett 2005 Nov 18;229(1):49-57. Epub 2005 Jan 18.

Department of Pharmacy and Pusan Cancer Research Center, Pusan National University, Busan 609-735, South Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350400968
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http://dx.doi.org/10.1016/j.canlet.2004.11.055DOI Listing
November 2005

Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells.

Mol Carcinog 2005 Nov;44(3):162-73

Department of Pharmacy and Pusan Cancer Research Center, Pusan National University, Busan, South Korea.

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http://dx.doi.org/10.1002/mc.20084DOI Listing
November 2005

Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells.

Cancer Lett 2005 Sep;227(2):153-62

Department of Pharmacy, College of Pharmacy, and Research Institute for Drug Development, Pusan National University, Busan 609-735, South Korea.

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http://dx.doi.org/10.1016/j.canlet.2005.01.011DOI Listing
September 2005

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

Proc Natl Acad Sci U S A 2005 Sep 12;102(38):13610-5. Epub 2005 Sep 12.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.0502174102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224619PMC
September 2005

Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling.

Nutr Cancer 2005 ;51(1):110-6

Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA.

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http://dx.doi.org/10.1207/s15327914nc5101_15DOI Listing
August 2005

Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.

Mol Biol Cell 2005 Aug 18;16(8):3488-500. Epub 2005 May 18.

Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1091/mbc.e04-11-1029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182291PMC
August 2005

Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells.

J Nutr 2004 Feb;134(2):483-6

Arizona Cancer Center, Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1093/jn/134.2.483DOI Listing
February 2004

Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis.

Biochim Biophys Acta 2002 Jun;1583(1):108-16

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 53792-8550, USA.

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http://dx.doi.org/10.1016/s1388-1981(02)00190-7DOI Listing
June 2002