Publications Authored by Eunice L Kwak

Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer.

Authors:

Jeffrey W Clark D Ross Camidge Eunice L Kwak Robert G Maki Geoffrey I Shapiro Isan Chen Weiwei Tan Sophia Randolph James G Christensen Mark Ozeck Yiyun Tang Keith D Wilner Ravi Salgia

Future Oncol 2020 Jan 28;16(1):4289-4301. Epub 2019 Nov 28.

Department of Medical Oncology & Therapeutics Research, The City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.2217/fon-2019-0653	DOI Listing

January 2020

A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer.

Authors:

Lipika Goyal Surendra Pal Chaudhary Eunice L Kwak Thomas A Abrams Amanda N Carpenter Brian M Wolpin Raymond C Wadlow Jill N Allen Rebecca Heist Nadine Jackson McCleary Jennifer A Chan Wolfram Goessling Deborah Schrag Kimmie Ng Peter C Enzinger David P Ryan Jeffrey W Clark

Invest New Drugs 2020 Jan 2. Epub 2020 Jan 2.

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10637-019-00889-y	DOI Listing

January 2020

Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Nat Med 2019 Dec;25(12):1949

Cancer Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-019-0698-6	DOI Listing

December 2019

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Nat Med 2019 09 9;25(9):1415-1421. Epub 2019 Sep 9.

Cancer Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-019-0561-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741444	PMC

September 2019

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.

JAMA Oncol 2019 Jul;5(7):1020-1027

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2019.0892	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547247	PMC

July 2019

Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors.

Authors:

David S Hong Patricia LoRusso Omid Hamid Filip Janku Muaiad Kittaneh Daniel V T Catenacci Emily Chan Tanios Bekaii-Saab Shirish M Gadgeel Robert D Loberg Benny M Amore Yuying C Hwang Rui Tang Gataree Ngarmchamnanrith Eunice L Kwak

Clin Cancer Res 2019 Apr 13;25(8):2403-2413. Epub 2018 Nov 13.

Hematology/Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107	Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-1341	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892342	PMC

April 2019

Tolerability and Long-term Outcomes of Dose-Painted Neoadjuvant Chemoradiation to Regions of Vessel Involvement in Borderline or Locally Advanced Pancreatic Cancer.

Authors:

Jennifer Y Wo Andrzej Niemierko David P Ryan Lawrence S Blaszkowsky Jeffrey W Clark Eunice L Kwak Keith D Lillemoe Lorraine N Drapek Andrew X Zhu Jill N Allen Jason E Faris Janet E Murphy Ryan Nipp Carlos Fernandez-Del Castillo Cristina R Ferrone Theodore S Hong

Am J Clin Oncol 2018 07;41(7):656-661

Departments of Radiation Oncology.

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http://dx.doi.org/10.1097/COC.0000000000000349	DOI Listing

July 2018

Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.

Authors:

Janet E Murphy Jennifer Y Wo David P Ryan Wenqing Jiang Beow Y Yeap Lorraine C Drapek Lawrence S Blaszkowsky Eunice L Kwak Jill N Allen Jeffrey W Clark Jason E Faris Andrew X Zhu Lipika Goyal Keith D Lillemoe Thomas F DeLaney Carlos Fernández-Del Castillo Cristina R Ferrone Theodore S Hong

JAMA Oncol 2018 07;4(7):963-969

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamaoncol.2018.0329	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145728	PMC

July 2018

Intraoperative Radiotherapy in the Era of Intensive Neoadjuvant Chemotherapy and Chemoradiotherapy for Pancreatic Adenocarcinoma.

Authors:

Florence K Keane Jennifer Y Wo Cristina R Ferrone Jeffrey W Clark Lawrence S Blaszkowsky Jill N Allen Eunice L Kwak David P Ryan Keith D Lillemoe Carlos Fernandez-Del Castillo Theodore S Hong

Am J Clin Oncol 2018 06;41(6):607-612

Departments of Radiation Oncology.

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http://dx.doi.org/10.1097/COC.0000000000000336	DOI Listing

June 2018

Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis.

Authors:

Sophia C Kamran Jeffrey W Clark Hui Zheng Darrell R Borger Lawrence S Blaszkowsky Jill N Allen Eunice L Kwak Jennifer Y Wo Aparna R Parikh Ryan D Nipp Janet E Murphy Lipika Goyal Andrew X Zhu A John Iafrate Ryan B Corcoran David P Ryan Theodore S Hong

Cancer Med 2018 May 17. Epub 2018 May 17.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/cam4.1558	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051212	PMC

May 2018

Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in Colorectal Cancer.

Cancer Discov 2018 04 5;8(4):417-427. Epub 2018 Feb 5.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1227	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882515	PMC

April 2018

A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies.

Authors:

Dejan Juric Johann S de Bono Patricia M LoRusso John Nemunaitis Elisabeth I Heath Eunice L Kwak Teresa Macarulla Mercadé Elena Geuna Maria Jose de Miguel-Luken Chirag Patel Keisuke Kuida Serap Sankoh Eric H Westin Fabian Zohren Yaping Shou Josep Tabernero

Clin Cancer Res 2017 Sep 10;23(17):5015-5023. Epub 2017 May 10.

Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2888	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858996	PMC

September 2017

Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype.

J Natl Cancer Inst 2017 09;109(9)

Department of Radiation Oncology, Department of Pathology, Division of Biostatistics, Department of Medicine, Division of Medical Oncology, Department of Medicine, Department of Radiology, and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx031	DOI Listing

September 2017

Long-term outcomes and toxicities of a large cohort of anal cancer patients treated with dose-painted IMRT per RTOG 0529.

Authors:

Devarati Mitra Theodore S Hong Nora Horick Brent Rose Lorraine N Drapek Lawrence S Blaszkowsky Jill N Allen Eunice L Kwak Janet E Murphy Jeffrey W Clark David P Ryan James C Cusack Liliana G Bordeianou David L Berger Jennifer Y Wo

Adv Radiat Oncol 2017 Apr-Jun;2(2):110-117. Epub 2017 Feb 6.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.adro.2017.01.009	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514246	PMC

February 2017

What's the Best Way to Treat GE Junction Tumors? Approach Like Gastric Cancer.

Authors:

John T Mullen Eunice L Kwak Theodore S Hong

Ann Surg Oncol 2016 11 26;23(12):3780-3785. Epub 2016 Jul 26.

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-016-5426-6	DOI Listing

November 2016

Case 35-2016. A 62-Year-Old Man with Dysphagia.

Authors:

Eunice L Kwak Theodore S Hong David G Forcione Avinash Kambadakone Jochen K Lennerz

N Engl J Med 2016 11;375(20):1983-1991

From the Departments of Medicine (E.L.K., D.G.F.), Radiation Oncology (T.S.H.), Radiology (A.K.), and Pathology (J.K.L.), Massachusetts General Hospital, and the Departments of Medicine (E.L.K., D.G.F.), Radiation Oncology (T.S.H.), Radiology (A.K.), and Pathology (J.K.L.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1610714	DOI Listing

November 2016

A protein and mRNA expression-based classification of gastric cancer.

Authors:

Namrata Setia Agoston T Agoston Hye S Han John T Mullen Dan G Duda Jeffrey W Clark Vikram Deshpande Mari Mino-Kenudson Amitabh Srivastava Jochen K Lennerz Theodore S Hong Eunice L Kwak Gregory Y Lauwers

Mod Pathol 2016 07 1;29(7):772-84. Epub 2016 Apr 1.

Pathology Service, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2016.55	DOI Listing

July 2016

The Impact of Positive Margins on Outcome Among Patients With Gastric Cancer Treated With Radiation.

Authors:

Jonathan D Schoenfeld Jennifer Y Wo Harvey J Mamon Eunice L Kwak John T Mullen Peter Z Enzinger Lawrence S Blaskowsky David P Ryan Theodore S Hong

Am J Clin Oncol 2016 06;39(3):243-7

Departments of *Radiation Oncology ∥Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute Departments of †Radiation Oncology ‡Medical Oncology §Surgical Oncology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/COC.0000000000000047	DOI Listing

June 2016

A matter of timing: is there a role for radiation in locally advanced pancreatic cancer, and if so, when?

Authors:

Theodore S Hong Jennifer Y Wo Eunice L Kwak

Am Soc Clin Oncol Educ Book 2012 :238-42

From the Departments of Radiation Oncology and Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.14694/EdBook_AM.2012.32.238	DOI Listing

April 2016

The impact of neoadjuvant therapy for gastroesophageal adenocarcinoma on postoperative morbidity and mortality.

Authors:

Eva Fuentes Rima Ahmad Theodore S Hong Jeffrey W Clark Eunice L Kwak David W Rattner John T Mullen

J Surg Oncol 2016 Apr 21;113(5):560-4. Epub 2016 Jan 21.

Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24179	DOI Listing

April 2016

Predictors of Lymph Node Metastasis in Western Early Gastric Cancer.

Authors:

Rima Ahmad Namrata Setia Benjamin H Schmidt Theodore S Hong Jennifer Y Wo Eunice L Kwak David W Rattner Gregory Y Lauwers John T Mullen

J Gastrointest Surg 2016 Mar 18;20(3):531-8. Epub 2015 Sep 18.

Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11605-015-2945-6	DOI Listing

March 2016

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

Cancer Discov 2016 Feb 7;6(2):147-153. Epub 2015 Dec 7.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1283	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744519	PMC

February 2016

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.

J Clin Oncol 2016 Feb 14;34(5):460-8. Epub 2015 Dec 14.

Theodore S. Hong, Jennifer Y. Wo, Beow Y. Yeap, Erin I. McDonnell, Lawrence S. Blaszkowsky, Eunice L. Kwak, Jill N. Allen, Jeffrey W. Clark, Lipika Goyal, Janet E. Murphy, John A. Wolfgang, Lorraine C. Drapek, Ronald S. Arellano, John T. Mullen, Sam S. Yoon, Kenneth K. Tanabe, Cristina R. Ferrone, David P. Ryan, Thomas F. DeLaney, and Andrew X. Zhu, Massachusetts General Hospital, Harvard Medical School; Harvey J. Mamon, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Edgar Ben-Josef, University of Pennsylvania Hospital, Philadelphia, PA; and Milind M. Javle and Christopher H. Crane, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://jco.ascopubs.org/content/early/2015/12/11/JCO.2015.64	Web Search
http://jco.ascopubs.org/content/suppl/2015/12/14/JCO.2015.64	Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.64.2710	Publisher Site
http://dx.doi.org/10.1200/JCO.2015.64.2710	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872014	PMC

February 2016

Adjuvant Therapy Completion Rates in Patients with Gastric Cancer Undergoing Perioperative Chemotherapy Versus a Surgery-First Approach.

Authors:

Eva Fuentes Rima Ahmad Theodore S Hong Jeffrey W Clark Eunice L Kwak David W Rattner John T Mullen

J Gastrointest Surg 2016 Jan 22;20(1):172-9; discussion 179. Epub 2015 Sep 22.

Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11605-015-2954-5	DOI Listing

January 2016

Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

J Clin Oncol 2015 Dec 21;33(34):4023-31. Epub 2015 Sep 21.

Ryan B. Corcoran, Eunice L. Kwak, and David P. Ryan, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; Chloe E. Atreya, Adil Daud, and Alan P. Venook, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco; Omid Hamid, Angeles Clinic and Research Institute, Los Angeles, CA; Gerald S. Falchook, Sarah Cannon Research Institute at HealthONE, Denver; Wells A. Messersmith, University of Colorado Cancer Center and University of Colorado, Aurora, CO; Johanna C. Bendell, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; Razelle Kurzrock and Scott Kopetz, University of Texas, MD Anderson Cancer Center, Houston, TX; Mariaelena Pierobon, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA; Peng Sun, Elizabeth Cunningham, Shonda Little, Keith Orford, Monica Motwani, and Yuchen Bai, GlaxoSmithKline, Philadelphia, PA; and Kiran Patel, Incyte, Wilmington, DE.

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http://jco.ascopubs.org/content/33/34/4023.full.pdf	Web Search
http://jco.ascopubs.org/content/suppl/2015/09/21/JCO.2015.63	Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.2471	Publisher Site
http://dx.doi.org/10.1200/JCO.2015.63.2471	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669588	PMC

December 2015

Familial Gastric Cancers.

Authors:

Namrata Setia Jeffrey W Clark Dan G Duda Theodore S Hong Eunice L Kwak John T Mullen Gregory Y Lauwers

Oncologist 2015 Dec 30;20(12):1365-77. Epub 2015 Sep 30.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0205	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679084	PMC

December 2015

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer.

Authors:

Eunice L Kwak Leanne G Ahronian Giulia Siravegna Benedetta Mussolin Darrell R Borger Jason T Godfrey Nicholas A Jessop Jeffrey W Clark Lawrence S Blaszkowsky David P Ryan Jochen K Lennerz A John Iafrate Alberto Bardelli Theodore S Hong Ryan B Corcoran

Cancer Discov 2015 12 2;5(12):1271-81. Epub 2015 Oct 2.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0748	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670804	PMC

December 2015

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma.

Oncologist 2015 Sep 5;20(9):1019-27. Epub 2015 Aug 5.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0210	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571807	PMC

September 2015

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

N Engl J Med 2015 Jul;373(5):428-37

From Memorial Sloan Kettering Cancer Center (W.D.T., J.H.H.) and Weill Cornell Medical College (W.D.T.) - both in New York; University of California, Los Angeles, Medical Center, Los Angeles (Z.A.W., B.C., A.S.S.), Plexxikon, Berkeley (P.N.I., C.Z., J.Z., G.H., Y.Z., E.A.B., G.V., L.S., P.S., H.N., M.J.K., A.M., G.T., R.S., C.G., B.L.W., P.H., K.N., H.H.H., P.S.L., S.T.-S., G.B.), and Stanford University School of Medicine, Stanford (M.R.) - all in California; Evergreen Hematology and Oncology, Spokane, WA (S.P.A.); University of Pennsylvania School of Medicine, Philadelphia (A.P.S.); Rocky Mountain Cancer Centers, Denver (A.L.C.); Dana-Farber Cancer Institute (G.I.S., A.J.W.) and Massachusetts General Hospital (E.L.K.) - both in Boston; Vanderbilt University Medical Center, Nashville (V.L.K., I.P.); Virginia G. Piper Cancer Center at Scottsdale Healthcare-Translational Genomics Research Institute (TGen), Scottsdale, AZ (D.D.V.H., G.J.W., R.K.R.); and Spire Sciences, Boca Raton, FL (C.P.).

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http://dx.doi.org/10.1056/NEJMoa1411366	DOI Listing

July 2015

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

Authors:

Eun-Kee Song W M Tai Wells A Messersmith Stacey Bagby Alicia Purkey Kevin S Quackenbush Todd M Pitts Guoliang Wang Patrick Blatchford Rachel Yahn Jeffrey Kaplan Aik Choon Tan Chloe E Atreya Gail Eckhardt Robin K Kelley Alan Venook Eunice L Kwak David Ryan John J Arcaroli

Int J Cancer 2015 Apr 29;136(8):1967-75. Epub 2014 Sep 29.

Division of Medical Oncology, University of Colorado Denver and University of Colorado Cancer Center, Aurora, CO; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.29225	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323738	PMC

April 2015

Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic disease.

Authors:

Emily Chan Eunice L Kwak Jimmy Hwang Marja Heiskala Guillaume de La Bourdonnaye Monica Mita

Cancer Chemother Pharmacol 2015 Apr 28;75(4):701-9. Epub 2015 Jan 28.

Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232-6307, USA,

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http://dx.doi.org/10.1007/s00280-015-2682-2	DOI Listing

April 2015

First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer.

Authors:

Geoffrey I Shapiro Katherine M Bell-McGuinn Julian R Molina Johanna Bendell James Spicer Eunice L Kwak Susan S Pandya Robert Millham Gary Borzillo Kristen J Pierce Lixin Han Brett E Houk Jorge D Gallo Maria Alsina Irene Braña Josep Tabernero

Clin Cancer Res 2015 04 4;21(8):1888-95. Epub 2015 Feb 4.

Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1306	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508327	PMC

April 2015

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.

Cancer Discov 2015 Apr 11;5(4):358-67. Epub 2015 Feb 11.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1518	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390490	PMC

April 2015

Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control.

Authors:

Jennifer Y Wo Stephanie K Childs Jackie Szymonifka Harvey J Mamon David P Ryan Lawrence S Blaszkowsky Eunice L Kwak Cristina R Ferrone Jill N Allen Andrew X Zhu Brian M Wolpin Jennifer A Chan Thomas A Abrams Nadine J McCleary Carlos Fernandez-Del Castillo Theodore S Hong

Pract Radiat Oncol 2014 Mar-Apr;4(2):e117-e123. Epub 2013 Aug 9.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.prro.2013.07.006	DOI Listing

March 2015

Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer.

Ann Surg 2015 Jan;261(1):12-7

*Department of Surgery †Department of Radiation Oncology; and ‡Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/SLA.0000000000000867	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349683	PMC

January 2015

Adjuvant therapy for gastric cancers: more answers or more questions?

Authors:

Theodore S Hong Eunice L Kwak

Ann Surg Oncol 2014 Oct 20;21(11):3367-8. Epub 2014 May 20.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,

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http://dx.doi.org/10.1245/s10434-014-3778-3	DOI Listing

October 2014

A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.

Int J Radiat Oncol Biol Phys 2014 Jul 24;89(4):830-8. Epub 2014 May 24.

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://bacbuc.hd.free.fr/WebDAV/data/CEDIT/Protonth%C3%A9rap	Web Search
http://linkinghub.elsevier.com/retrieve/pii/S036030161400391	Publisher Site
http://dx.doi.org/10.1016/j.ijrobp.2014.03.034	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791180	PMC

July 2014

A phase 1 open-label, sequential dose-escalation study investigating the safety, tolerability, and pharmacokinetics of intravenous TLC388 administered to patients with advanced solid tumors.

Authors:

Sharad Ghamande Chia-Chi Lin Daniel C Cho Geoffrey I Shapiro Eunice L Kwak Michael H Silverman Yunlong Tseng Min-Wen Kuo Wendy B Mach Shu-Chi Hsu Teresa Coleman James Chih-Hsin Yang Ann-Lii Cheng Mohammad H Ghalib Imran Chuadhary Sanjay Goel

Invest New Drugs 2014 Jun 24;32(3):445-51. Epub 2013 Nov 24.

Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.

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http://link.springer.com/10.1007/s10637-013-0044-7	Publisher Site
http://dx.doi.org/10.1007/s10637-013-0044-7	DOI Listing

June 2014

Mutational analysis and clinical correlation of metastatic colorectal cancer.

Authors:

Andrea L Russo Darrell R Borger Jackie Szymonifka David P Ryan Jennifer Y Wo Lawrence S Blaszkowsky Eunice L Kwak Jill N Allen Raymond C Wadlow Andrew X Zhu Janet E Murphy Jason E Faris Dora Dias-Santagata Kevin M Haigis Leif W Ellisen Anthony J Iafrate Theodore S Hong

Cancer 2014 May 5;120(10):1482-90. Epub 2014 Feb 5.

Harvard Radiation Oncology Program, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28599	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327902	PMC

May 2014

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.

Clin Cancer Res 2014 Apr 29;20(7):1884-90. Epub 2014 Jan 29.

Authors' Affiliations: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; Agios Pharmaceuticals, Cambridge, Massachusetts; and Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2649	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107454	PMC

April 2014

Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.

Authors:

Andrea L Russo David P Ryan Darrell R Borger Jennifer Y Wo Jackie Szymonifka Wen-Yih Liang Eunice L Kwak Lawrence S Blaszkowsky Jeffrey W Clark Jill N Allen Andrew X Zhu David L Berger James C Cusack Harvey J Mamon Kevin M Haigis Theodore S Hong

J Gastrointest Cancer 2014 Mar;45(1):34-9

Harvard Radiation Oncology Program, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12029-013-9546-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361942	PMC

March 2014

Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors.

Authors:

Geoffrey I Shapiro Jordi Rodon Cynthia Bedell Eunice L Kwak Jose Baselga Irene Braña Shuchi S Pandya Christian Scheffold A Douglas Laird Linh T Nguyen Yi Xu Coumaran Egile Gerald Edelman

Clin Cancer Res 2014 Jan 28;20(1):233-45. Epub 2013 Oct 28.

Authors' Affiliations: Dana-Farber Cancer Institute; Massachusetts General Hospital; Beth Israel Deaconess Medical Center, Boston, Massachusetts; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Mary Crowley Cancer Research Centers, Dallas, Texas; Exelixis Inc., South San Francisco, California; and Sanofi, Cambridge, Massachusetts, and Vitry-sur-Seine, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1777	DOI Listing

January 2014

Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer.

Authors:

Jennifer Y Wo Harvey J Mamon Cristina R Ferrone David P Ryan Lawrence S Blaszkowsky Eunice L Kwak Yolanda D Tseng Brian N Napolitano Marek Ancukiewicz Richard S Swanson Keith D Lillemoe Carlos Fernandez-del Castillo Theodore S Hong

Radiother Oncol 2014 Jan 11;110(1):160-4. Epub 2013 Nov 11.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S01678140130053	Publisher Site
http://dx.doi.org/10.1016/j.radonc.2013.10.027	DOI Listing

January 2014

Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors.

Authors:

Leena Gandhi Rastislav Bahleda Sara M Tolaney Eunice L Kwak James M Cleary Shuchi S Pandya Antoine Hollebecque Richat Abbas Revathi Ananthakrishnan Anna Berkenblit Mizue Krygowski Yali Liang Kathleen W Turnbull Geoffrey I Shapiro Jean-Charles Soria

J Clin Oncol 2014 Jan 9;32(2):68-75. Epub 2013 Dec 9.

Leena Gandhi, Sara M. Tolaney, James M. Cleary, and Geoffrey I. Shapiro, Dana-Farber Cancer Institute; Eunice L. Kwak, Massachusetts General Hospital; Shuchi S. Pandya, Beth Israel Deaconess Medical Center, Boston; Anna Berkenblit and Mizue Krygowski, Aveo Pharmaceuticals; Revathi Ananthakrishnan and Kathleen W. Turnbull, Inventiv Health, Cambridge, MA; Rastislav Bahleda, Antoine Hollebecque, and Jean-Charles Soria, Insitut Gussav Roussy, Villejuif, France; Richat Abbas and Yali Liang, Pfizer, Collegeville, PA.

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http://ascopubs.org/doi/10.1200/JCO.2012.47.2787	Publisher Site
http://dx.doi.org/10.1200/JCO.2012.47.2787	DOI Listing

January 2014

Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer.

Authors:

Brian M Wolpin Kimmie Ng Andrew X Zhu Thomas Abrams Peter C Enzinger Nadine J McCleary Deborah Schrag Eunice L Kwak Jill N Allen Pankaj Bhargava Jennifer A Chan Wolfram Goessling Lawrence S Blaszkowsky Jeffrey G Supko Meaghan Elliot Kaori Sato Eileen Regan Jeffrey A Meyerhardt Charles S Fuchs

Oncologist 2013 11;18(4):377-8. Epub 2013 Apr 11.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2012-0378	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639523	PMC

December 2013

FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience.

Oncologist 2013 8;18(5):543-8. Epub 2013 May 8.

Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1634/theoncologist.2012-0435	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662845	PMC

December 2013

Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010.

Authors:

Sophie Cai Theodore S Hong Saveli I Goldberg Carlos Fernandez-del Castillo Sarah P Thayer Cristina R Ferrone David P Ryan Lawrence S Blaszkowsky Eunice L Kwak Christopher G Willett Keith D Lillemoe Andrew L Warshaw Jennifer Y Wo

Cancer 2013 Dec 4;119(23):4196-204. Epub 2013 Sep 4.

Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28329	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403862	PMC

December 2013

Noncurative gastrectomy for gastric adenocarcinoma should only be performed in highly selected patients.

Authors:

Benjamin Schmidt Nicole Look-Hong Ugwuji N Maduekwe Kevin Chang Theodore S Hong Eunice L Kwak Gregory Y Lauwers David W Rattner John T Mullen Sam S Yoon

Ann Surg Oncol 2013 Oct 14;20(11):3512-8. Epub 2013 Jun 14.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-013-3024-4	DOI Listing

October 2013

Preoperative cetuximab, irinotecan, cisplatin, and radiation therapy for patients with locally advanced esophageal cancer.

Authors:

Michael S Lee Harvey J Mamon Theodore S Hong Noah C Choi Panagiotis M Fidias Eunice L Kwak Jeffrey A Meyerhardt David P Ryan Raphael Bueno Dean M Donahue Michael T Jaklitsch Michael Lanuti David W Rattner Charles S Fuchs Peter C Enzinger

Oncologist 2013 21;18(3):281-7. Epub 2013 Feb 21.

Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1634/theoncologist.2012-0208	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607524	PMC

September 2013

Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation.

Authors:

Eunice L Kwak Geoffrey I Shapiro Seth M Cohen Carlos R Becerra Heinz-Josef Lenz Wen-Fang Cheng Wu-Chou Su Meghan Robohn Florence Le Maulf Maximilian T Lobmeyer Vikram K Chand A John Iafrate

Cancer 2013 Aug 14;119(16):3043-51. Epub 2013 Jun 14.

Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/cncr.28120	DOI Listing

August 2013

Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection?

Authors:

Ioannis T Konstantinidis Andrew L Warshaw Jill N Allen Lawrence S Blaszkowsky Carlos Fernandez-Del Castillo Vikram Deshpande Theodore S Hong Eunice L Kwak Gregory Y Lauwers David P Ryan Jennifer A Wargo Keith D Lillemoe Cristina R Ferrone

Ann Surg 2013 Apr;257(4):731-6

Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1097/SLA.0b013e318263da2f	DOI Listing

April 2013

Targeted therapies with chemoradiation in esophageal cancer: development and future directions.

Authors:

Theodore S Hong Jennifer Y Wo Eunice L Kwak

Semin Radiat Oncol 2013 Jan;23(1):31-7

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10534296120008	Publisher Site
http://dx.doi.org/10.1016/j.semradonc.2012.09.004	DOI Listing

January 2013

Targeted inhibition in tumors with ALK dependency.

Authors:

Eunice L Kwak Jeffrey W Clark Alice T Shaw

Lung Cancer (Auckl) 2013 9;4:1-8. Epub 2013 Jan 9.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.2147/LCTT.S16313	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217435	PMC

January 2013

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.

Lancet Oncol 2012 Oct 4;13(10):1011-9. Epub 2012 Sep 4.

University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1016/S1470-2045(12)70344-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936578	PMC

October 2012

A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.

Authors:

Jason E Faris Jamie Arnott Hui Zheng David P Ryan Thomas A Abrams Lawrence S Blaszkowsky Jeffrey W Clark Peter C Enzinger Aram F Hezel Kimmie Ng Brian M Wolpin Eunice L Kwak

Invest New Drugs 2012 Aug 29;30(4):1614-20. Epub 2011 Jul 29.

Department of Medical Oncology, Massachusetts General Hospital Cancer Center, POB 221, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s10637-011-9708-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670147	PMC

August 2012

Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy.

Authors:

Nils D Arvold Christopher G Willett Carlos Fernandez-del Castillo David P Ryan Cristina R Ferrone Jeffrey W Clark Lawrence S Blaszkowsky Vikram Deshpande Andrzej Niemierko Jill N Allen Eunice L Kwak Raymond C Wadlow Andrew X Zhu Andrew L Warshaw Theodore S Hong

Int J Radiat Oncol Biol Phys 2012 Jul 11;83(3):e337-43. Epub 2012 Mar 11.

Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2011.12.068	DOI Listing

July 2012

Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.

J Clin Oncol 2012 Jul 23;30(19):2348-53. Epub 2012 Apr 23.

South Texas Accelerated Research Therapeutics, 4383 Medical Dr, 4th Floor, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1200/JCO.2011.36.8282	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950496	PMC

July 2012

Long-term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer.

Authors:

Nils D Arvold David P Ryan Andrzej Niemierko Lawrence S Blaszkowsky Eunice L Kwak Jennifer Y Wo Jill N Allen Jeffrey W Clark Raymond C Wadlow Andrew X Zhu Carlos Fernandez-Del Castillo Theodore S Hong

Cancer 2012 Jun 21;118(12):3026-35. Epub 2011 Oct 21.

Harvard Radiation Oncology Program, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cncr.26633	DOI Listing

June 2012

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

Authors:

Darrell R Borger Kenneth K Tanabe Kenneth C Fan Hector U Lopez Valeria R Fantin Kimberly S Straley David P Schenkein Aram F Hezel Marek Ancukiewicz Hannah M Liebman Eunice L Kwak Jeffrey W Clark David P Ryan Vikram Deshpande Dora Dias-Santagata Leif W Ellisen Andrew X Zhu A John Iafrate

Oncologist 2012 16;17(1):72-9. Epub 2011 Dec 16.

Division of Hematology-Oncology, Massachusetts General Hospital, Boston 02114-2698, USA

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http://dx.doi.org/10.1634/theoncologist.2011-0386	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267826	PMC

June 2012

Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab.

Authors:

Raymond C Wadlow Aram F Hezel Thomas A Abrams Lawrence S Blaszkowsky Charles S Fuchs Matthew H Kulke Eunice L Kwak Jeffrey A Meyerhardt David P Ryan Jackie Szymonifka Brian M Wolpin Andrew X Zhu Jeffrey W Clark

Oncologist 2012 30;17(1):14. Epub 2011 Dec 30.

Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2011-0452	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267814	PMC

June 2012

ROS1 rearrangements define a unique molecular class of lung cancers.

J Clin Oncol 2012 Mar 3;30(8):863-70. Epub 2012 Jan 3.

Massachusetts General Hospital, Boston, MA 02114-2696, USA.

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http://dx.doi.org/10.1200/JCO.2011.35.6345	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295572	PMC

March 2012

Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy.

Authors:

Lisa A Kachnic Henry K Tsai John J Coen Lawrence S Blaszkowsky Kevan Hartshorn Eunice L Kwak John D Willins David P Ryan Theodore S Hong

Int J Radiat Oncol Biol Phys 2012 Jan 20;82(1):153-8. Epub 2010 Nov 20.

Department of Radiation Oncology, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.09.030	DOI Listing

January 2012

Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor.

Authors:

Andrew S Chi Tracy T Batchelor Eunice L Kwak Jeffrey W Clark Daphne L Wang Keith D Wilner David N Louis A John Iafrate

J Clin Oncol 2012 Jan 12;30(3):e30-3. Epub 2011 Dec 12.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.

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http://ascopubs.org/doi/10.1200/JCO.2011.38.4586	Publisher Site
http://dx.doi.org/10.1200/JCO.2011.38.4586	DOI Listing

January 2012

MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.

Authors:

Jochen K Lennerz Eunice L Kwak Allison Ackerman Michael Michael Stephen B Fox Kristin Bergethon Gregory Y Lauwers James G Christensen Keith D Wilner Daniel A Haber Ravi Salgia Yung-Jue Bang Jeffrey W Clark Benjamin J Solomon A John Iafrate

J Clin Oncol 2011 Dec 31;29(36):4803-10. Epub 2011 Oct 31.

Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1200/JCO.2011.35.4928	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255989	PMC

December 2011

Phase 1/2 study of everolimus in advanced hepatocellular carcinoma.

Authors:

Andrew X Zhu Thomas A Abrams Rebecca Miksad Lawrence S Blaszkowsky Jeffrey A Meyerhardt Hui Zheng Alona Muzikansky Jeffrey W Clark Eunice L Kwak Deborah Schrag Kathryn R Jors Charles S Fuchs A John Iafrate Darrell R Borger David P Ryan

Cancer 2011 Nov 27;117(22):5094-102. Epub 2011 Apr 27.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cncr.26165	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417818	PMC

November 2011

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis.

Lancet Oncol 2011 Oct 18;12(11):1004-12. Epub 2011 Sep 18.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1470-2045(11)70232-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328296	PMC

October 2011

Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification.

Authors:

Sai-Hong Ignatius Ou Eunice L Kwak Christina Siwak-Tapp Joni Dy Kristin Bergethon Jeffrey W Clark D Ross Camidge Benjamin J Solomon Robert G Maki Yung-Jue Bang Dong-Wan Kim James Christensen Weiwei Tan Keith D Wilner Ravi Salgia A John Iafrate

J Thorac Oncol 2011 May;6(5):942-6

Division of Hematology/Oncology, Department of Internal Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868-3298, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155608641532017	Publisher Site
http://dx.doi.org/10.1097/JTO.0b013e31821528d3	DOI Listing

May 2011

Phase I safety, pharmacokinetic, and pharmacodynamic study of ENMD-2076, a novel angiogenic and Aurora kinase inhibitor, in patients with advanced solid tumors.

Authors:

Jennifer R Diamond Bruno R Bastos Ryan J Hansen Daniel L Gustafson S Gail Eckhardt Eunice L Kwak Shuchi S Pandya Graham C Fletcher Todd M Pitts Gillian N Kulikowski Mark Morrow Jamie Arnott Mark R Bray Carolyn Sidor Wells Messersmith Geoffrey I Shapiro

Clin Cancer Res 2011 Feb 3;17(4):849-60. Epub 2010 Dec 3.

University of Colorado at Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2144	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867298	PMC

February 2011

Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head.

Authors:

Theodore S Hong David P Ryan Lawrence S Blaszkowsky Harvey J Mamon Eunice L Kwak Mari Mino-Kenudson Judith Adams Beow Yeap Barbara Winrich Thomas F DeLaney Carlos Fernandez-Del Castillo

Int J Radiat Oncol Biol Phys 2011 Jan 24;79(1):151-7. Epub 2010 Apr 24.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2009.10.061	DOI Listing

January 2011

Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.

Authors:

Sai-Hong Ignatius Ou Lyudmila Bazhenova D Ross Camidge Benjamin J Solomon June Herman Tatiana Kain Yung-Jue Bang Eunice L Kwak Alice T Shaw Ravi Salgia Robert G Maki Jeffrey W Clark Keith D Wilner A John Iafrate

J Thorac Oncol 2010 Dec;5(12):2044-6

Division of Hematology-Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of Irvine Medical Center, Orange, California 92868-3298, USA.

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http://dx.doi.org/10.1097/JTO.0b013e318200f9ff	DOI Listing

December 2010

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

N Engl J Med 2010 Oct;363(18):1693-703

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.1056/NEJMoa1006448	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014291	PMC

October 2010

Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

Authors:

James E Butrynski David R D'Adamo Jason L Hornick Paola Dal Cin Cristina R Antonescu Suresh C Jhanwar Marc Ladanyi Marzia Capelletti Scott J Rodig Nikhil Ramaiya Eunice L Kwak Jeffrey W Clark Keith D Wilner James G Christensen Pasi A Jänne Robert G Maki George D Demetri Geoffrey I Shapiro

N Engl J Med 2010 Oct;363(18):1727-33

Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1056/NEJMoa1007056	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014292	PMC

October 2010

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

EMBO Mol Med 2010 May;2(5):146-58

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/emmm.201000070	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377316	PMC

May 2010

Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study.

Lancet Oncol 2010 Jan 20;11(1):48-54. Epub 2009 Nov 20.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1470-2045(09)70333-X	DOI Listing

January 2010

Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.

Authors:

Alice T Shaw Beow Y Yeap Mari Mino-Kenudson Subba R Digumarthy Daniel B Costa Rebecca S Heist Benjamin Solomon Hannah Stubbs Sonal Admane Ultan McDermott Jeffrey Settleman Susumu Kobayashi Eugene J Mark Scott J Rodig Lucian R Chirieac Eunice L Kwak Thomas J Lynch A John Iafrate

J Clin Oncol 2009 Sep 10;27(26):4247-53. Epub 2009 Aug 10.

Department of Pathology, Massachusetts General Hospital, Warren 501c, 55 Fruit St, Boston, MA 02114, USA.

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http://ascopubs.org/doi/10.1200/JCO.2009.22.6993	Publisher Site
http://dx.doi.org/10.1200/JCO.2009.22.6993	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744268	PMC

September 2009

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.

J Clin Oncol 2009 Jun 26;27(18):3027-35. Epub 2009 May 26.

Division of Hematology/Oncology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2008.20.9908	Publisher Site
http://dx.doi.org/10.1200/JCO.2008.20.9908	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702235	PMC

June 2009

Case records of the Massachusetts General Hospital. Case 19-2009. A 63-year-old woman with carcinoma of the gastroesophageal junction.

Authors:

Eunice L Kwak Theodore S Hong David L Berger David G Forcione Raul N Uppot Gregory Y Lauwers

N Engl J Med 2009 Jun;360(25):2656-64

Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital.

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http://dx.doi.org/10.1056/NEJMcpc0900638	DOI Listing

June 2009

NCCN Task Force Report: mTOR inhibition in solid tumors.

Authors:

Robert A Figlin Elizabeth Brown Andrew J Armstrong Wallace Akerley Al B Benson Harold J Burstein David S Ettinger Phillip G Febbo Matthew G Fury Gary R Hudes Merrill S Kies Eunice L Kwak Robert J Morgan Joanne Mortimer Karen Reckamp Alan P Venook Frank Worden Yun Yen

J Natl Compr Canc Netw 2008 Sep;6 Suppl 5:S1-20; quiz S21-2

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September 2008

MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.

Authors:

Kofi Asomaning Amy E Reid Wei Zhou Rebecca S Heist Rihong Zhai Li Su Eunice L Kwak Lawrence Blaszkowsky Andrew X Zhu David P Ryan David C Christiani Geoffrey Liu

Clin Cancer Res 2008 Jun;14(12):4010-5

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4187	DOI Listing

June 2008

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

Authors:

Sunitha Nagrath Lecia V Sequist Shyamala Maheswaran Daphne W Bell Daniel Irimia Lindsey Ulkus Matthew R Smith Eunice L Kwak Subba Digumarthy Alona Muzikansky Paula Ryan Ulysses J Balis Ronald G Tompkins Daniel A Haber Mehmet Toner

Nature 2007 Dec;450(7173):1235-9

Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA.

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