Eunice L Kwak

Eunice L Kwak

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Eunice L Kwak

Eunice L Kwak

Publications by authors named "Eunice L Kwak"

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Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer.

Future Oncol 2020 Jan 28;16(1):4289-4301. Epub 2019 Nov 28.

Department of Medical Oncology & Therapeutics Research, The City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.2217/fon-2019-0653DOI Listing
January 2020

Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype.

J Natl Cancer Inst 2017 09;109(9)

Department of Radiation Oncology, Department of Pathology, Division of Biostatistics, Department of Medicine, Division of Medical Oncology, Department of Medicine, Department of Radiology, and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx031DOI Listing
September 2017

What's the Best Way to Treat GE Junction Tumors? Approach Like Gastric Cancer.

Ann Surg Oncol 2016 11 26;23(12):3780-3785. Epub 2016 Jul 26.

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-016-5426-6DOI Listing
November 2016

Case 35-2016. A 62-Year-Old Man with Dysphagia.

N Engl J Med 2016 11;375(20):1983-1991

From the Departments of Medicine (E.L.K., D.G.F.), Radiation Oncology (T.S.H.), Radiology (A.K.), and Pathology (J.K.L.), Massachusetts General Hospital, and the Departments of Medicine (E.L.K., D.G.F.), Radiation Oncology (T.S.H.), Radiology (A.K.), and Pathology (J.K.L.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1610714DOI Listing
November 2016

The Impact of Positive Margins on Outcome Among Patients With Gastric Cancer Treated With Radiation.

Am J Clin Oncol 2016 06;39(3):243-7

Departments of *Radiation Oncology ∥Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute Departments of †Radiation Oncology ‡Medical Oncology §Surgical Oncology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/COC.0000000000000047DOI Listing
June 2016

A matter of timing: is there a role for radiation in locally advanced pancreatic cancer, and if so, when?

Am Soc Clin Oncol Educ Book 2012 :238-42

From the Departments of Radiation Oncology and Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.14694/EdBook_AM.2012.32.238DOI Listing
April 2016

The impact of neoadjuvant therapy for gastroesophageal adenocarcinoma on postoperative morbidity and mortality.

J Surg Oncol 2016 Apr 21;113(5):560-4. Epub 2016 Jan 21.

Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24179DOI Listing
April 2016

Predictors of Lymph Node Metastasis in Western Early Gastric Cancer.

J Gastrointest Surg 2016 Mar 18;20(3):531-8. Epub 2015 Sep 18.

Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11605-015-2945-6DOI Listing
March 2016

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.

J Clin Oncol 2016 Feb 14;34(5):460-8. Epub 2015 Dec 14.

Theodore S. Hong, Jennifer Y. Wo, Beow Y. Yeap, Erin I. McDonnell, Lawrence S. Blaszkowsky, Eunice L. Kwak, Jill N. Allen, Jeffrey W. Clark, Lipika Goyal, Janet E. Murphy, John A. Wolfgang, Lorraine C. Drapek, Ronald S. Arellano, John T. Mullen, Sam S. Yoon, Kenneth K. Tanabe, Cristina R. Ferrone, David P. Ryan, Thomas F. DeLaney, and Andrew X. Zhu, Massachusetts General Hospital, Harvard Medical School; Harvey J. Mamon, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Edgar Ben-Josef, University of Pennsylvania Hospital, Philadelphia, PA; and Milind M. Javle and Christopher H. Crane, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://jco.ascopubs.org/content/early/2015/12/11/JCO.2015.64
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http://jco.ascopubs.org/content/suppl/2015/12/14/JCO.2015.64
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.64.2710
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http://dx.doi.org/10.1200/JCO.2015.64.2710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872014PMC
February 2016

Adjuvant Therapy Completion Rates in Patients with Gastric Cancer Undergoing Perioperative Chemotherapy Versus a Surgery-First Approach.

J Gastrointest Surg 2016 Jan 22;20(1):172-9; discussion 179. Epub 2015 Sep 22.

Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11605-015-2954-5DOI Listing
January 2016

Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

J Clin Oncol 2015 Dec 21;33(34):4023-31. Epub 2015 Sep 21.

Ryan B. Corcoran, Eunice L. Kwak, and David P. Ryan, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; Chloe E. Atreya, Adil Daud, and Alan P. Venook, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco; Omid Hamid, Angeles Clinic and Research Institute, Los Angeles, CA; Gerald S. Falchook, Sarah Cannon Research Institute at HealthONE, Denver; Wells A. Messersmith, University of Colorado Cancer Center and University of Colorado, Aurora, CO; Johanna C. Bendell, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; Razelle Kurzrock and Scott Kopetz, University of Texas, MD Anderson Cancer Center, Houston, TX; Mariaelena Pierobon, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA; Peng Sun, Elizabeth Cunningham, Shonda Little, Keith Orford, Monica Motwani, and Yuchen Bai, GlaxoSmithKline, Philadelphia, PA; and Kiran Patel, Incyte, Wilmington, DE.

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http://jco.ascopubs.org/content/33/34/4023.full.pdf
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http://jco.ascopubs.org/content/suppl/2015/09/21/JCO.2015.63
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.2471
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http://dx.doi.org/10.1200/JCO.2015.63.2471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669588PMC
December 2015

Familial Gastric Cancers.

Oncologist 2015 Dec 30;20(12):1365-77. Epub 2015 Sep 30.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679084PMC
December 2015

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

N Engl J Med 2015 Jul;373(5):428-37

From Memorial Sloan Kettering Cancer Center (W.D.T., J.H.H.) and Weill Cornell Medical College (W.D.T.) - both in New York; University of California, Los Angeles, Medical Center, Los Angeles (Z.A.W., B.C., A.S.S.), Plexxikon, Berkeley (P.N.I., C.Z., J.Z., G.H., Y.Z., E.A.B., G.V., L.S., P.S., H.N., M.J.K., A.M., G.T., R.S., C.G., B.L.W., P.H., K.N., H.H.H., P.S.L., S.T.-S., G.B.), and Stanford University School of Medicine, Stanford (M.R.) - all in California; Evergreen Hematology and Oncology, Spokane, WA (S.P.A.); University of Pennsylvania School of Medicine, Philadelphia (A.P.S.); Rocky Mountain Cancer Centers, Denver (A.L.C.); Dana-Farber Cancer Institute (G.I.S., A.J.W.) and Massachusetts General Hospital (E.L.K.) - both in Boston; Vanderbilt University Medical Center, Nashville (V.L.K., I.P.); Virginia G. Piper Cancer Center at Scottsdale Healthcare-Translational Genomics Research Institute (TGen), Scottsdale, AZ (D.D.V.H., G.J.W., R.K.R.); and Spire Sciences, Boca Raton, FL (C.P.).

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http://dx.doi.org/10.1056/NEJMoa1411366DOI Listing
July 2015

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

Int J Cancer 2015 Apr 29;136(8):1967-75. Epub 2014 Sep 29.

Division of Medical Oncology, University of Colorado Denver and University of Colorado Cancer Center, Aurora, CO; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.29225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323738PMC
April 2015

Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic disease.

Cancer Chemother Pharmacol 2015 Apr 28;75(4):701-9. Epub 2015 Jan 28.

Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232-6307, USA,

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http://dx.doi.org/10.1007/s00280-015-2682-2DOI Listing
April 2015

Adjuvant therapy for gastric cancers: more answers or more questions?

Ann Surg Oncol 2014 Oct 20;21(11):3367-8. Epub 2014 May 20.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,

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http://dx.doi.org/10.1245/s10434-014-3778-3DOI Listing
October 2014

Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors.

Clin Cancer Res 2014 Jan 28;20(1):233-45. Epub 2013 Oct 28.

Authors' Affiliations: Dana-Farber Cancer Institute; Massachusetts General Hospital; Beth Israel Deaconess Medical Center, Boston, Massachusetts; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Mary Crowley Cancer Research Centers, Dallas, Texas; Exelixis Inc., South San Francisco, California; and Sanofi, Cambridge, Massachusetts, and Vitry-sur-Seine, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1777DOI Listing
January 2014

Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors.

J Clin Oncol 2014 Jan 9;32(2):68-75. Epub 2013 Dec 9.

Leena Gandhi, Sara M. Tolaney, James M. Cleary, and Geoffrey I. Shapiro, Dana-Farber Cancer Institute; Eunice L. Kwak, Massachusetts General Hospital; Shuchi S. Pandya, Beth Israel Deaconess Medical Center, Boston; Anna Berkenblit and Mizue Krygowski, Aveo Pharmaceuticals; Revathi Ananthakrishnan and Kathleen W. Turnbull, Inventiv Health, Cambridge, MA; Rastislav Bahleda, Antoine Hollebecque, and Jean-Charles Soria, Insitut Gussav Roussy, Villejuif, France; Richat Abbas and Yali Liang, Pfizer, Collegeville, PA.

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http://ascopubs.org/doi/10.1200/JCO.2012.47.2787
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http://dx.doi.org/10.1200/JCO.2012.47.2787DOI Listing
January 2014

Noncurative gastrectomy for gastric adenocarcinoma should only be performed in highly selected patients.

Ann Surg Oncol 2013 Oct 14;20(11):3512-8. Epub 2013 Jun 14.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-013-3024-4DOI Listing
October 2013

Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation.

Cancer 2013 Aug 14;119(16):3043-51. Epub 2013 Jun 14.

Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/cncr.28120DOI Listing
August 2013

Targeted therapies with chemoradiation in esophageal cancer: development and future directions.

Semin Radiat Oncol 2013 Jan;23(1):31-7

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10534296120008
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http://dx.doi.org/10.1016/j.semradonc.2012.09.004DOI Listing
January 2013

Targeted inhibition in tumors with ALK dependency.

Lung Cancer (Auckl) 2013 9;4:1-8. Epub 2013 Jan 9.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.2147/LCTT.S16313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217435PMC
January 2013

Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy.

Int J Radiat Oncol Biol Phys 2012 Jan 20;82(1):153-8. Epub 2010 Nov 20.

Department of Radiation Oncology, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.09.030DOI Listing
January 2012

Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.

J Thorac Oncol 2010 Dec;5(12):2044-6

Division of Hematology-Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of Irvine Medical Center, Orange, California 92868-3298, USA.

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http://dx.doi.org/10.1097/JTO.0b013e318200f9ffDOI Listing
December 2010

Case records of the Massachusetts General Hospital. Case 19-2009. A 63-year-old woman with carcinoma of the gastroesophageal junction.

N Engl J Med 2009 Jun;360(25):2656-64

Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital.

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http://dx.doi.org/10.1056/NEJMcpc0900638DOI Listing
June 2009

MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.

Clin Cancer Res 2008 Jun;14(12):4010-5

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4187DOI Listing
June 2008

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

Nature 2007 Dec;450(7173):1235-9

Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature06385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090667PMC
December 2007

Targeted agents: the rules of combination.

Clin Cancer Res 2007 Sep;13(18 Pt 1):5232-7

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1385DOI Listing
September 2007

Hereditary colorectal cancer syndromes: an overview.

Clin Colorectal Cancer 2007 Jan;6(5):340-4

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.3816/CCC.2007.n.002DOI Listing
January 2007

Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.

Cancer Res 2006 Feb;66(4):1923-8

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865171PMC
February 2006

Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer.

Gynecol Oncol 2005 Jul;98(1):124-8

Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, CNY-7, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ygyno.2005.04.007DOI Listing
July 2005