Eun-Hye Joe

Eun-Hye Joe

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Eun-Hye Joe

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Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

Acta Neuropathol Commun 2019 May 2;7(1):68. Epub 2019 May 2.

Department of Pharmacology, and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.

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http://dx.doi.org/10.1186/s40478-019-0716-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498585PMC
May 2019

A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D synthase expression.

Neurobiol Dis 2019 Apr 4;127:482-491. Epub 2019 Apr 4.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Department of Pharmacology, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Department of Brain Science, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.003DOI Listing
April 2019

A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3.

Neurosci Lett 2018 10 29;685:144-149. Epub 2018 Aug 29.

Department of Pharmacology, Ajou University School of Medicine, South Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, South Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, South Korea; Department of Brain Science, Ajou University School of Medicine, Worldcup-ro 164, Suwon, Kyunggi-do 16499, South Korea.

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http://dx.doi.org/10.1016/j.neulet.2018.08.025DOI Listing
October 2018

Astrocytes, Microglia, and Parkinson's Disease.

Exp Neurobiol 2018 Apr 24;27(2):77-87. Epub 2018 Apr 24.

Department of Pharmacology, Ajou University School of Medicine, Suwon 16944, Korea.

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http://dx.doi.org/10.5607/en.2018.27.2.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934545PMC
April 2018

A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis.

Glia 2018 02 6;66(2):445-458. Epub 2017 Nov 6.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Suwon, Kyunggi-do, 16499, Korea.

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http://dx.doi.org/10.1002/glia.23258DOI Listing
February 2018

DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.

Proc Natl Acad Sci U S A 2018 02 31;115(7):1629-1634. Epub 2018 Jan 31.

Department of Pharmacology, Ajou University School of Medicine, 16499 Suwon, Korea;

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http://dx.doi.org/10.1073/pnas.1708754115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816138PMC
February 2018

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.

PLoS One 2016 15;11(9):e0163029. Epub 2016 Sep 15.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163029PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025236PMC
August 2017

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.

Biomed Res Int 2016 25;2016:7917128. Epub 2016 May 25.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido 15865, Republic of Korea.

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http://dx.doi.org/10.1155/2016/7917128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897664PMC
February 2017

LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2.

Exp Neurobiol 2016 Oct 26;25(5):269-276. Epub 2016 Oct 26.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Brain Science, Ajou University School of Medicine, Suwon 16499, Korea.; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.

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http://dx.doi.org/10.5607/en.2016.25.5.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081473PMC
October 2016

22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling.

Biochim Biophys Acta 2016 08 17;1859(8):1056-70. Epub 2016 May 17.

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.05.008DOI Listing
August 2016

Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.

Sci Signal 2016 08 2;9(439):ra78. Epub 2016 Aug 2.

Department of Pharmacology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1126/scisignal.aaf4850DOI Listing
August 2016

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.

Sci Rep 2016 06 27;6:28823. Epub 2016 Jun 27.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1038/srep28823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922019PMC
June 2016

PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation.

Exp Neurobiol 2016 Feb 22;25(1):14-23. Epub 2016 Feb 22.

Neuroscience Graduate Program Department of Biomedical Sciences, Ajou University School of Medicine, Suwon 16499, Korea.; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Brain Science, Ajou University School of Medicine, Suwon 16499, Korea.; Brain Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.

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http://dx.doi.org/10.5607/en.2016.25.1.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766110PMC
February 2016

Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.

Mol Neurodegener 2015 Dec 1;10:63. Epub 2015 Dec 1.

Department of Pharmacology, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, 16499, Korea.

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http://dx.doi.org/10.1186/s13024-015-0060-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666086PMC
December 2015

FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis.

Neurobiol Dis 2015 Nov 3;83:90-9. Epub 2015 Sep 3.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea; Neuroscience graduate program, Department of Biological Sciences, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.08.025DOI Listing
November 2015

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Nat Commun 2015 Sep 14;6:8255. Epub 2015 Sep 14.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Gyeonggi-do 443-380, Korea.

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http://dx.doi.org/10.1038/ncomms9255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647842PMC
September 2015

MAP kinase phosphatase-1 expression is regulated by 15-deoxy-Δ12,14-prostaglandin J2 via a HuR-dependent post-transcriptional mechanism.

Biochim Biophys Acta 2015 Jun 22;1849(6):612-25. Epub 2015 Mar 22.

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2015.03.004DOI Listing
June 2015

Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases.

Exp Neurobiol 2015 Jun 11;24(2):95-102. Epub 2015 May 11.

Department of Pharmacology, and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Korea. ; Department of Biomedical Sciences, Ajou University School of Medicine, Suwon 443-721, Korea.

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http://dx.doi.org/10.5607/en.2015.24.2.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479815PMC
June 2015

Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease.

EMBO Mol Med 2015 May;7(5):510-25

Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea Hanyang Biomedical Research Institute, Hanyang University, Seoul, Korea Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea

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http://dx.doi.org/10.15252/emmm.201404610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492814PMC
May 2015

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.

Hum Mol Genet 2015 Feb 9;24(4):1127-41. Epub 2014 Oct 9.

Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea,

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http://dx.doi.org/10.1093/hmg/ddu526DOI Listing
February 2015

Suppression of miR-155 Expression in IFN-γ-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression.

Exp Neurobiol 2014 Jun 13;23(2):148-54. Epub 2014 Jun 13.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 443-380, Korea. ; Department of Pharmacology, Ajou University School of Medicine, Suwon 443-380, Korea. ; Department of Brain Science, Ajou University School of Medicine, Suwon 443-380, Korea. ; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 443-380, Korea.

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http://dx.doi.org/10.5607/en.2014.23.2.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065828PMC
June 2014

Astrogliosis is a possible player in preventing delayed neuronal death.

Mol Cells 2014 Apr 22;37(4):345-55. Epub 2014 Apr 22.

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://www.e-sciencecentral.org/upload/molcell/pdf/molcell-3
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http://www.molcells.org/journal/view.html?doi=10.14348/molce
Publisher Site
http://dx.doi.org/10.14348/molcells.2014.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012084PMC
April 2014

The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex.

Neuroreport 2014 Jan;25(1):18-22

aDepartment of Pharmacology bNeuroscience Graduate Program, Graduate School of Biomedical Sciences cChronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, South Korea.

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http://dx.doi.org/10.1097/WNR.0000000000000022DOI Listing
January 2014

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1.

Neurobiol Dis 2013 Dec 20;60:1-10. Epub 2013 Aug 20.

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; National Research Lab of Brain Inflammation, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.nbd.2013.08.007DOI Listing
December 2013

Absence of Delayed Neuronal Death in ATP-Injected Brain: Possible Roles of Astrogliosis.

Exp Neurobiol 2013 Dec 31;22(4):308-14. Epub 2013 Dec 31.

Department of Pharmacology, Ajou University School of Medicine, Suwon 443-721, Korea. ; Neuroscience Graduate Program in Department of Biomedical Sciences, Ajou University School of Medicine, Suwon 443-721, Korea. ; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Korea. ; Brain Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Korea.

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http://dx.doi.org/10.5607/en.2013.22.4.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897692PMC
December 2013

Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β.

Neurobiol Dis 2013 Oct 10;58:249-57. Epub 2013 Jun 10.

Department of Anatomy, Ajou University School of Medicine, Suwon, South Korea.

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http://dx.doi.org/10.1016/j.nbd.2013.06.001DOI Listing
October 2013

A ratiometric two-photon fluorescent probe reveals reduction in mitochondrial H2S production in Parkinson's disease gene knockout astrocytes.

J Am Chem Soc 2013 Jul 18;135(26):9915-23. Epub 2013 Jun 18.

Division of Energy Systems Research, Ajou University, Suwon 443-749, Korea.

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http://dx.doi.org/10.1021/ja404004vDOI Listing
July 2013

Repair of astrocytes, blood vessels, and myelin in the injured brain: possible roles of blood monocytes.

Mol Brain 2013 Jun 10;6:28. Epub 2013 Jun 10.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Kyunggi-do 443-721, Korea.

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http://dx.doi.org/10.1186/1756-6606-6-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684510PMC
June 2013

Brain inflammation and microglia: facts and misconceptions.

Exp Neurobiol 2013 Jun 27;22(2):59-67. Epub 2013 Jun 27.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon 442-721, Korea. ; Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea. ; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea. ; National Research Lab of Brain Inflammation, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.5607/en.2013.22.2.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699675PMC
June 2013

Spatial and temporal correlation in progressive degeneration of neurons and astrocytes in contusion-induced spinal cord injury.

J Neuroinflammation 2012 May 25;9:100. Epub 2012 May 25.

Department of Pharmacology, Ajou University School of Medicine, san-5 Woncheon-dong Youngtong-gu, Suwon, Kyunggi-do, 442-721, Korea.

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http://dx.doi.org/10.1186/1742-2094-9-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418552PMC
May 2012

5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.

J Neuroinflammation 2012 Feb 18;9:34. Epub 2012 Feb 18.

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1186/1742-2094-9-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308915PMC
February 2012

Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury.

Exp Neurol 2012 Jan 31;233(1):312-22. Epub 2011 Oct 31.

Brain Disease Research Center, Institute for Medical Sciences, and Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.

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http://dx.doi.org/10.1016/j.expneurol.2011.10.021DOI Listing
January 2012

An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism.

Cell Signal 2011 Sep 18;23(9):1505-13. Epub 2011 May 18.

Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, South Korea.

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http://dx.doi.org/10.1016/j.cellsig.2011.05.013DOI Listing
September 2011

Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor.

J Immunol 2011 Mar 11;186(6):3701-9. Epub 2011 Feb 11.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.1000212DOI Listing
March 2011

Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra.

Exp Mol Med 2010 Dec;42(12):823-32

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015156PMC
http://dx.doi.org/10.3858/emm.2010.42.12.085DOI Listing
December 2010

Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses.

J Neurochem 2010 Dec 12;115(5):1161-71. Epub 2010 Oct 12.

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Korea Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://doi.wiley.com/10.1111/j.1471-4159.2010.07004.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2010.07004.xDOI Listing
December 2010

Enhanced phosphatidylinositol 4-phosphate 5-kinase alpha expression and PI(4,5)P2 production in LPS-stimulated microglia.

Neurochem Int 2010 Nov 24;57(5):600-7. Epub 2010 Jul 24.

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Gyeonggi, Republic of Korea.

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http://dx.doi.org/10.1016/j.neuint.2010.07.008DOI Listing
November 2010

Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.

Mol Cell 2009 Sep;35(6):806-17

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1016/j.molcel.2009.07.021DOI Listing
September 2009

Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes.

Free Radic Biol Med 2009 Jun 5;46(12):1694-702. Epub 2009 Apr 5.

Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.03.026DOI Listing
June 2009

The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1.

J Immunol 2008 Dec;181(12):8642-9

Department of Pharmacology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.181.12.8642DOI Listing
December 2008

Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex.

Glia 2008 Aug;56(10):1039-47

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.20677DOI Listing
August 2008

Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2.

Glia 2008 Jul;56(9):1028-37

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, 442-721, Korea.

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http://dx.doi.org/10.1002/glia.20676DOI Listing
July 2008

Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia.

J Neurosci Res 2008 May;86(6):1353-60

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Kyunggi-do, Korea.

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http://dx.doi.org/10.1002/jnr.21593DOI Listing
May 2008

Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements.

Biochem J 2008 Mar;410(3):605-11

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea 442-721.

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http://dx.doi.org/10.1042/BJ20071207DOI Listing
March 2008

Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain.

Glia 2007 Nov;55(15):1577-88

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.20571DOI Listing
November 2007

Gangliosides trigger inflammatory responses via TLR4 in brain glia.

Am J Pathol 2006 May;168(5):1619-30

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, 443-721, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606595PMC
http://dx.doi.org/10.2353/ajpath.2006.050924DOI Listing
May 2006

Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia.

J Biol Chem 2006 Apr 28;281(17):11872-8. Epub 2006 Feb 28.

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1074/jbc.M511706200DOI Listing
April 2006

Ionizing radiation induces astrocyte gliosis through microglia activation.

Neurobiol Dis 2006 Mar 3;21(3):457-67. Epub 2005 Oct 3.

Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea.

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http://dx.doi.org/10.1016/j.nbd.2005.08.006DOI Listing
March 2006

Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: oxidative stress acts through control of inflammation.

Biochem Biophys Res Commun 2006 Mar 31;342(1):9-18. Epub 2006 Jan 31.

Department of Pharmacology, Ajou University School of Medicine, San 5, Wonchen-Dong, Youngtong-Gu, Gyunggi-Do, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2006.01.107DOI Listing
March 2006

Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.

Neuroreport 2006 Feb;17(2):183-7

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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February 2006

Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation.

J Neurosci 2006 Feb;26(6):1880-7

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1523/JNEUROSCI.3696-05.2006DOI Listing
February 2006

PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia.

Neuroreport 2005 May;16(8):829-33

Department of Pharmacology, Ajou University School of Medicine, Suwon, 442-721 Korea.

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May 2005

Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation.

Biochem Biophys Res Commun 2005 Apr;329(1):125-31

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2005.01.110DOI Listing
April 2005

Characterization of new microglia-like cells obtained from neonatal rat brain.

Biochem Biophys Res Commun 2005 Mar;328(1):281-7

Department of Pharmacology, Ajou University School of Medicine, San 5, Wonchen-Dong, Youngtong-Gu, Gyunggi-Do, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2004.12.169DOI Listing
March 2005

Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.

Biochem Biophys Res Commun 2005 Mar;328(2):595-600

Interdisciplinary Course for Neuroscience and Technology, Ajou University School of Medicine, Suwon 442-721, South Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0500066
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2005.01.025DOI Listing
March 2005

Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.

Glia 2004 Nov;48(2):102-11

Neuroscience Graduate Program, Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.20059DOI Listing
November 2004

Gangliosides activate microglia via protein kinase C and NADPH oxidase.

Glia 2004 Nov;48(3):197-206

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.20069DOI Listing
November 2004

Rac1 contributes to maximal activation of STAT1 and STAT3 in IFN-gamma-stimulated rat astrocytes.

J Immunol 2004 Nov;173(9):5697-703

Department of Pharmacology, School of Medicine, Ajou University, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.173.9.5697DOI Listing
November 2004

Protein kinase A mediates microglial activation induced by plasminogen and gangliosides.

Exp Mol Med 2004 Oct;36(5):461-7

Department of Pharmacology, Ajou University, School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1038/emm.2004.58DOI Listing
October 2004

Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells.

J Biol Chem 2004 Sep 21;279(37):38125-33. Epub 2004 Jun 21.

Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M402085200
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http://dx.doi.org/10.1074/jbc.M402085200DOI Listing
September 2004

Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo.

Glia 2004 Apr;46(2):142-52

Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://doi.wiley.com/10.1002/glia.10357
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http://dx.doi.org/10.1002/glia.10357DOI Listing
April 2004

Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia.

J Immunol 2003 Dec;171(11):6072-9

Department of Pharmacology, Ajou University Medical School, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.171.11.6072DOI Listing
December 2003

Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells.

J Neurosci Res 2003 Sep;73(5):659-69

Research Institute, National Cancer Center, Goyang, Gyeonggi, Republic of Korea.

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http://dx.doi.org/10.1002/jnr.10706DOI Listing
September 2003

Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats.

Neurosci Lett 2003 Aug;346(3):141-4

Department of Pharmacology, Ajou University School of Medicine, Suwon, Kyunggi-do, 442-721, South Korea.

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August 2003

15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia.

J Biol Chem 2003 Apr 12;278(17):14747-52. Epub 2003 Feb 12.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea 442-721.

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http://dx.doi.org/10.1074/jbc.M210819200DOI Listing
April 2003

JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells.

J Biol Chem 2002 Oct 20;277(43):40594-601. Epub 2002 Aug 20.

Department of Pharmacology, School of Medicine, Ajou University, Suwon 442-721, Korea.

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http://dx.doi.org/10.1074/jbc.M203885200DOI Listing
October 2002

Interleukin-13 and -4 induce death of activated microglia.

Glia 2002 Jun;38(4):273-80

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.10057DOI Listing
June 2002

Prothrombin kringle-2 activates cultured rat brain microglia.

J Immunol 2002 Jun;168(11):5805-10

Department of Pharmacology, Neuroscience Graduate Program, and Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.168.11.5805DOI Listing
June 2002