Eugenii A Rabiner

Eugenii A Rabiner

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Eugenii A Rabiner

Eugenii A Rabiner

Publications by authors named "Eugenii A Rabiner"

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Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease: an in vivo11C-BU99008 PET study.

Brain 2019 Aug 26. Epub 2019 Aug 26.

Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1093/brain/awz260DOI Listing
August 2019

Comparison of phosphodiesterase 10A and dopamine transporter levels as markers of disease burden in early Parkinson's disease.

Mov Disord 2019 Jun 3. Epub 2019 Jun 3.

Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.27733DOI Listing
June 2019

The application of positron emission tomography (PET) imaging in CNS drug development.

Brain Imaging Behav 2019 Apr;13(2):354-365

Invicro - London, Burlington Danes Building, Du Cane Road, W12 0NN, London, UK.

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http://dx.doi.org/10.1007/s11682-018-9967-0DOI Listing
April 2019

Accuracy and reliability of [C]PBR28 specific binding estimated without the use of a reference region.

Neuroimage 2019 03 27;188:102-110. Epub 2018 Nov 27.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2018.11.020DOI Listing
March 2019

The role of phosphodiesterase 4 in excessive daytime sleepiness in Parkinson's disease.

Parkinsonism Relat Disord 2019 Feb 22. Epub 2019 Feb 22.

Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.027DOI Listing
February 2019

PET Radioligands for imaging of the PDE10A in human: current status.

Neurosci Lett 2019 01 10;691:11-17. Epub 2018 Aug 10.

Invicro, Hammersmith Hospital, Du Cane Road, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2018.08.006DOI Listing
January 2019

Disease-related patterns of in vivo pathology in Corticobasal syndrome.

Eur J Nucl Med Mol Imaging 2018 12 8;45(13):2413-2425. Epub 2018 Aug 8.

Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, 125 Coldharbour Lane, Camberwell, London, SE5 9NU, UK.

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http://dx.doi.org/10.1007/s00259-018-4104-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208819PMC
December 2018

PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology.

Mov Disord 2018 12 21;33(12):1961-1965. Epub 2018 Oct 21.

Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1002/mds.27523DOI Listing
December 2018

Evaluation of C-BU99008, a PET Ligand for the Imidazoline Binding Site in Human Brain.

J Nucl Med 2018 10 9;59(10):1597-1602. Epub 2018 Mar 9.

Neuropsychopharmacology Unit, Centre for Academic Psychiatry, Division of Brain Sciences, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.2967/jnumed.118.208009DOI Listing
October 2018

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus.

J Nucl Med 2018 07 4;59(7):1125-1132. Epub 2018 Jan 4.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.2967/jnumed.117.202200DOI Listing
July 2018

First evaluation of PET-based human biodistribution and radiation dosimetry of C-BU99008, a tracer for imaging the imidazoline binding site.

EJNMMI Res 2018 Jul 30;8(1):71. Epub 2018 Jul 30.

Neuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Imperial College London, 5th Floor Burlington Danes Building, Hammersmith Hospital campus, 160 Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13550-018-0429-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066589PMC
July 2018

Imaging Synaptic Density: A Different Look at Neurologic Diseases.

J Nucl Med 2018 03 9;59(3):380-381. Epub 2017 Nov 9.

Imanova Ltd. and Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, United Kingdom

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http://dx.doi.org/10.2967/jnumed.117.198317DOI Listing
March 2018

C-PBR28 and F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis.

J Nucl Med 2017 09 16;58(9):1477-1482. Epub 2017 Mar 16.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.2967/jnumed.116.187161DOI Listing
September 2017

Loss of phosphodiesterase 4 in Parkinson disease: Relevance to cognitive deficits.

Neurology 2017 Aug 12;89(6):586-593. Epub 2017 Jul 12.

From the Neurodegeneration Imaging Group (F.N., H.W., G.P., M.P.) and Department of Neuroimaging (M.A.M., E.A.R.), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London; Imanova Ltd., Centre for Imaging Sciences (C.C., G.E.S., R.N.G., E.A.R.), and Division of Brain Sciences, Imperial College London (R.N.G), Hammersmith Hospital; and Sobell Department of Motor Neuroscience (T.F.), UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004201DOI Listing
August 2017

Imaging in Central Nervous System Drug Discovery.

Semin Nucl Med 2017 Jan 28;47(1):89-98. Epub 2016 Oct 28.

Imanova Ltd, London, United Kingdom; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.

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http://dx.doi.org/10.1053/j.semnuclmed.2016.09.001DOI Listing
January 2017

Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease.

Neurology 2016 Dec 2;87(23):2451-2456. Epub 2016 Nov 2.

From the Division of Brain Sciences (G.P., P.G.B., D.J.B., N.P.), Imperial College London; Imperial College NHS Trust (S.M.); Imanova Ltd (E.A.R.); National Parkinson Foundation International Centre of Excellence (E.A.R.), King's College London and National Institute for Health Research Biomedical Research Centre and King's College London; Institute of Neuroscience (D.J.B., N.P.), Newcastle University, UK; and Institute of Clinical Medicine (D.J.B., N.P.), University of Aarhus, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000003396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177673PMC
December 2016

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease.

Inflamm Bowel Dis 2016 11;22(11):2619-2629

*Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom; Departments of †Gastroenterology and ‡Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom; §Imanova Centre for Imaging Sciences, London, United Kingdom; ‖Centre for Neuroimaging Sciences, King's College, London, United Kingdom; ¶Centre for Medical Imaging, University College London, London, United Kingdom; **Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and ††Division of Hepatology and Gastroenterology, Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000924DOI Listing
November 2016

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers.

J Neurol Sci 2016 Sep 15;368:243-8. Epub 2016 Jul 15.

Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.07.033DOI Listing
September 2016

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis.

Biol Psychiatry 2016 07 5;80(1):62-72. Epub 2015 Dec 5.

Psychological Medicine, and Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Imanova Centre for Imaging Sciences, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918731PMC
July 2016

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

Am J Psychiatry 2016 07 19;173(7):714-21. Epub 2016 Feb 19.

From the Department of Psychosis Studies, the Neurodegeneration Imaging Group, the Department of Basic and Clinical Neuroscience, and the Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Division of Brain Sciences, Department of Medicine, and the Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London; and Imanova Ltd., Centre for Imaging Sciences, Hammersmith Hospital, London.

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http://dx.doi.org/10.1176/appi.ajp.2015.15040518DOI Listing
July 2016

Neuroinflammation in treated HIV-positive individuals: A TSPO PET study.

Neurology 2016 04 24;86(15):1425-1432. Epub 2016 Feb 24.

From the Division of Medicine, Section of Infectious Diseases (J.H.V., A.W.), Division of Brain Sciences (J.H.C., R.N.G., P.M.M.), and Centre for Immunology and Vaccinology (A.B., L.G., P.K.), Imperial College London; Division of Medicine (J.H.V.), Brighton and Sussex Medical School; Imanova Centre for Imaging Sciences (Q.G., E.A.R., N.K., C.B., R.N.G.), London; and Chelsea and Westminster Hospital (A.B., L.G., P.K.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000002485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831035PMC
April 2016

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.

Brain 2015 Oct 21;138(Pt 10):3016-29. Epub 2015 Jul 21.

1 Neurodegeneration Imaging Group, Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv214DOI Listing
October 2015

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease.

Brain 2015 Oct 25;138(Pt 10):3003-15. Epub 2015 Jul 25.

1 Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv219DOI Listing
October 2015

Does cannabis affect dopaminergic signaling in the human brain? A systematic review of evidence to date.

Eur Neuropsychopharmacol 2015 Aug 30;25(8):1201-24. Epub 2015 Mar 30.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, London SE5 8AF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.03.011DOI Listing
August 2015

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography.

Neuropharmacology 2015 May 2;92:44-8. Epub 2014 Dec 2.

Clinical Imaging Centre, GlaxoSmithKline, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.11.017DOI Listing
May 2015

PET neuroimaging: the elephant unpacks his trunk: comment on Cumming: "PET neuroimaging: the white elephant packs his trunk?".

Neuroimage 2014 Jul 31;94:408-410. Epub 2013 Dec 31.

Imanova, Centre for Imaging Sciences, London, UK; Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2013.12.042DOI Listing
July 2014

A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [¹¹C]PBR28 and [¹⁸F]PBR111 for TSPO imaging.

J Cereb Blood Flow Metab 2014 Jul 16;34(7):1162-8. Epub 2014 Apr 16.

1] Imanova, Centre for Imaging Sciences, London, UK [2] Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK [3] Department of Engineering Science, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083379PMC
July 2014

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with (18)F-PBR111 PET.

J Nucl Med 2014 Jul 5;55(7):1112-8. Epub 2014 Jun 5.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Neurosciences, GlaxoSmithKline, Brentford, United Kingdom

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http://dx.doi.org/10.2967/jnumed.113.135129DOI Listing
July 2014

In vivo imaging of cerebral dopamine D3 receptors in alcoholism.

Neuropsychopharmacology 2014 Jun 28;39(7):1703-12. Epub 2014 Jan 28.

Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/npp.2014.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023144PMC
June 2014

Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study.

J Cereb Blood Flow Metab 2014 Jun 19;34(6):989-94. Epub 2014 Mar 19.

1] Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK [2] Imanova, Centre for Imaging Sciences, London, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050243PMC
June 2014

Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.

Neuropsychopharmacology 2014 Mar 15;39(4):866-74. Epub 2013 Oct 15.

1] Department of Diagnostic Radiology, Yale PET Center, Yale University School of Medicine, New Haven, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2013.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924521PMC
March 2014

Translational PET imaging research.

Neurobiol Dis 2014 Jan 17;61:32-8. Epub 2013 Sep 17.

Merck and Co, WP-42-212, 770, Sumneytown Pike, PO Box 4, West Point, PA19486, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.08.017DOI Listing
January 2014

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).

Psychoneuroendocrinology 2013 Nov 12;38(11):2826-9. Epub 2013 Aug 12.

Division of Brain Sciences, Imperial College, London, United Kingdom; Imanova Centre for Imaging Sciences, Hammersmith Hospital Campus, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2013.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820042PMC
November 2013

Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients.

Am J Drug Alcohol Abuse 2013 Nov;39(6):433-40

Centre for Neuropsychopharmacology, Imperial College London , London , UK .

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http://dx.doi.org/10.3109/00952990.2013.846348DOI Listing
November 2013

Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.

Neuroimage 2013 Mar 30;68:119-32. Epub 2012 Nov 30.

GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2012.11.033DOI Listing
March 2013

Endogenous opioid release in the human brain reward system induced by acute amphetamine administration.

Biol Psychiatry 2012 Sep 3;72(5):371-7. Epub 2012 Mar 3.

Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2012.01.027DOI Listing
September 2012

The development, past achievements, and future directions of brain PET.

J Cereb Blood Flow Metab 2012 Jul 21;32(7):1426-54. Epub 2012 Mar 21.

PET Research Advisory Company, 8 Prestbury Road, Wilmslow, Cheshire SK9 2LJ, UK.

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http://dx.doi.org/10.1038/jcbfm.2012.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390812PMC
July 2012

Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo.

Neuroimage 2012 Apr 10;60(2):902-10. Epub 2012 Jan 10.

Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2011.12.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314937PMC
April 2012

Positron emission tomography molecular imaging for drug development.

Br J Clin Pharmacol 2012 Feb;73(2):175-86

GSK Clinical Imaging Centre, GlaxoSmithKline Research and Development Ltd, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2011.04085.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269576PMC
February 2012

A pharmacokinetic PET study of NK₁ receptor occupancy.

Eur J Nucl Med Mol Imaging 2012 Feb 13;39(2):226-35. Epub 2011 Oct 13.

GlaxoSmithKline, Clinical Pharmacology Modeling & Simulation, Stockley Park, UK.

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http://dx.doi.org/10.1007/s00259-011-1954-2DOI Listing
February 2012

Radiation dose estimates for carbon-11-labelled PET tracers.

Nucl Med Biol 2012 Feb 26;39(2):305-14. Epub 2011 Oct 26.

GlaxoSmithKline, Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, W120NN London, UK.

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http://dx.doi.org/10.1016/j.nucmedbio.2011.08.005DOI Listing
February 2012

Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain.

Neuropsychopharmacology 2011 Oct 13;36(11):2258-65. Epub 2011 Jul 13.

PET Methodology, MRC-Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1038/npp.2011.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176562PMC
October 2011

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy.

Neuroimage 2011 Jan 30;54(1):264-77. Epub 2010 Jun 30.

GlaxoSmithKline, Clinical Imaging Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2010.06.044DOI Listing
January 2011

Mixed-affinity binding in humans with 18-kDa translocator protein ligands.

J Nucl Med 2011 Jan 13;52(1):24-32. Epub 2010 Dec 13.

Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.2967/jnumed.110.079459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161826PMC
January 2011

Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.

J Cereb Blood Flow Metab 2010 Sep 28;30(9):1608-18. Epub 2010 Apr 28.

Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1038/jcbfm.2010.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949260PMC
September 2010

Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors.

J Cereb Blood Flow Metab 2010 May 23;30(5):985-93. Epub 2009 Dec 23.

Discovery Medicine, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Barcelona, Spain.

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http://dx.doi.org/10.1038/jcbfm.2009.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949183PMC
May 2010

Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET).

Int J Neuropsychopharmacol 2010 Apr 11;13(3):289-90. Epub 2010 Feb 11.

GlaxoSmithKline Clinical Imaging Centre, London, UK.

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http://dx.doi.org/10.1017/S1461145710000088DOI Listing
April 2010