Publications by authors named "Eugenie S Kleinerman"

100Publications

[I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [I]MIBG in neuroblastoma.

Nucl Med Biol 2020 Sep 28;90-91:49-54. Epub 2020 Sep 28.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2020.09.004DOI Listing
September 2020

Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1258:189-197

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-3-030-43085-6_13DOI Listing
January 2020

The Fas/FasL Signaling Pathway: Its Role in the Metastatic Process and as a Target for Treating Osteosarcoma Lung Metastases.

Adv Exp Med Biol 2020 ;1258:177-187

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Children's Cancer Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-3-030-43085-6_12DOI Listing
January 2020

Neuronal Repressor REST Controls Ewing Sarcoma Growth and Metastasis by Affecting Vascular Pericyte Coverage and Vessel Perfusion.

Cancers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Department of Pediatrics, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3390/cancers12061405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352345PMC
May 2020

Anthracycline-Induced Cardiotoxicity: Causes, Mechanisms, and Prevention.

Adv Exp Med Biol 2020 ;1257:181-192

Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-3-030-43032-0_15DOI Listing
August 2020

Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions.

Oncoimmunology 2020 12;9(1):1747677. Epub 2020 Apr 12.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2020.1747677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153823PMC
April 2020

Knock down of Fas-Associated Protein with Death Domain (FADD) Sensitizes Osteosarcoma to TNFα-induced Cell Death.

J Cancer 2020 14;11(7):1657-1667. Epub 2020 Jan 14.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054.

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http://dx.doi.org/10.7150/jca.38721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052864PMC
January 2020

Vascular modulation through exercise improves chemotherapy efficacy in Ewing sarcoma.

Pediatr Blood Cancer 2019 09 28;66(9):e27835. Epub 2019 May 28.

Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27835
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http://dx.doi.org/10.1002/pbc.27835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646082PMC
September 2019

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines.

J Adolesc Young Adult Oncol 2019 06 22;8(3):385-386. Epub 2019 Feb 22.

2 Department of Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1089/jayao.2018.0141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909714PMC
June 2019

Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases.

Cancer Med 2018 06 7;7(6):2654-2664. Epub 2018 May 7.

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cam4.1518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010882PMC
June 2018

Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing.

Sarcoma 2018 21;2018:3143096. Epub 2018 Jan 21.

The University of Texas MD Anderson Cancer Center, Division of Pediatrics, 1515 Holcombe Blvd., Unit 0853, Houston, TX 77030, USA.

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http://dx.doi.org/10.1155/2018/3143096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828535PMC
January 2018

miR-20a Regulates FAS Expression in Osteosarcoma Cells by Modulating Promoter Activity and Can be Therapeutically Targeted to Inhibit Lung Metastases.

Mol Cancer Ther 2018 01 27;17(1):130-139. Epub 2017 Oct 27.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752589PMC
January 2018

Diet and exercise interventions for pediatric cancer patients during therapy: tipping the scales for better outcomes.

Pediatr Res 2018 01 25;83(1-1):50-56. Epub 2017 Oct 25.

Department of Pediatrics Research, Center for Energy Balance in Cancer Prevention and Survivorship, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1038/pr.2017.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865395PMC
January 2018

Effect of entinostat on NK cell-mediated cytotoxicity against osteosarcoma cells and osteosarcoma lung metastasis.

Oncoimmunology 2017 11;6(8):e1333214. Epub 2017 Jul 11.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1333214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593704PMC
July 2017

Interferon Gamma Induces Changes in Natural Killer (NK) Cell Ligand Expression and Alters NK Cell-Mediated Lysis of Pediatric Cancer Cell Lines.

Front Immunol 2017 6;8:391. Epub 2017 Apr 6.

Center for Childhood Cancer and Blood Disorders, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382194PMC
April 2017

Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8 T Cells and Histone Acetyltransferases.

Cancer Immunol Res 2017 04 21;5(4):300-311. Epub 2017 Feb 21.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382872PMC
April 2017

Osteosarcoma Overview.

Rheumatol Ther 2017 Jun 8;4(1):25-43. Epub 2016 Dec 8.

Division of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/s40744-016-0050-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443719PMC
June 2017

Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo.

Clin Cancer Res 2016 08 15;22(15):3876-83. Epub 2016 Mar 15.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970873PMC
August 2016

Osteosarcoma: the state of affairs dictates a change. What do we know?

Adv Exp Med Biol 2014 ;804:vii-viii

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September 2014

Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases.

Adv Exp Med Biol 2014 ;804:203-17

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Children's Cancer Hospital, 1515 Holcombe - MOD1.002, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/978-3-319-04843-7_11
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http://dx.doi.org/10.1007/978-3-319-04843-7_11DOI Listing
September 2014

Aerosol interleukin-2 induces natural killer cell proliferation in the lung and combination therapy improves the survival of mice with osteosarcoma lung metastasis.

Pediatr Blood Cancer 2014 Aug 9;61(8):1362-8. Epub 2014 Mar 9.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.25019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144337PMC
August 2014

CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors.

Mol Cancer 2014 Feb 24;13:34. Epub 2014 Feb 24.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1186/1476-4598-13-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938086PMC
February 2014

Universal marker and detection tool for human sarcoma circulating tumor cells.

Cancer Res 2014 Mar 21;74(6):1645-50. Epub 2014 Jan 21.

Authors' Affiliations: Departments of Pediatrics and Surgical Oncology; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center; and UTMD Graduate School of Biomedical Sciences, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959622PMC
March 2014

EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology.

Cancer 2014 Feb 10;120(4):579-88. Epub 2014 Jan 10.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.28555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969734PMC
February 2014

Blocking SDF-1α/CXCR4 downregulates PDGF-B and inhibits bone marrow-derived pericyte differentiation and tumor vascular expansion in Ewing tumors.

Mol Cancer Ther 2014 Feb 26;13(2):483-91. Epub 2013 Nov 26.

Corresponding Author: Eugenie S. Kleinerman, Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston TX 77030.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926209PMC
February 2014

Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.

Pediatr Blood Cancer 2014 Apr 18;61(4):618-26. Epub 2013 Oct 18.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.24801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154381PMC
April 2014

Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts.

Pediatr Blood Cancer 2013 Apr 19;60(4):575-9. Epub 2012 Dec 19.

Division of Pediatrics, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/pbc.24412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883385PMC
April 2013

Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression.

Curr Cancer Drug Targets 2013 Jan;13(1):48-56

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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January 2013

miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.

Cancer Res 2012 Feb 20;72(4):908-16. Epub 2011 Dec 20.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288434PMC
February 2012

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells.

Cancer 2012 Apr 25;118(8):2106-16. Epub 2011 Aug 25.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1002/cncr.26488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262942PMC
April 2012

SDF-1α induces PDGF-B expression and the differentiation of bone marrow cells into pericytes.

Mol Cancer Res 2011 Nov 12;9(11):1462-70. Epub 2011 Sep 12.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219839PMC
November 2011

Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents.

Sarcoma 2011 16;2011:165837. Epub 2011 Jun 16.

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1155/2011/165837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137951PMC
November 2011

Epigenetic regulation of apoptosis and cell cycle in osteosarcoma.

Sarcoma 2011 27;2011:679457. Epub 2010 Dec 27.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1155/2011/679457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021878PMC
July 2011

Bone marrow cells participate in tumor vessel formation that supports the growth of Ewing's sarcoma in the lung.

Angiogenesis 2011 May 24;14(2):125-33. Epub 2010 Dec 24.

Division of Pediatrics, Unit 87, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10456-010-9196-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087863PMC
May 2011

Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation.

Blood 2011 Jan 13;117(2):719-26. Epub 2010 Oct 13.

The Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1182/blood-2010-05-284869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031490PMC
January 2011

Platelet-derived growth factor receptor beta inhibition increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity: imatinib and TRAIL dual therapy.

Cancer 2010 Aug;116(16):3892-902

Department of Pediatrics-Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.25107DOI Listing
August 2010

Aerosol therapy for the treatment of osteosarcoma lung metastases: targeting the Fas/FasL pathway and rationale for the use of gemcitabine.

J Aerosol Med Pulm Drug Deliv 2010 Aug;23(4):189-96

Children's Cancer Hospital, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1089/jamp.2009.0812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133834PMC
August 2010

The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases.

Cancer Treat Res 2009 ;152:497-508

Division of Pediatrics, Children's Cancer Hospital, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit #87, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1007/978-1-4419-0284-9_29DOI Listing
October 2010

Vasculogenesis driven by bone marrow-derived cells is essential for growth of Ewing's sarcomas.

Cancer Res 2010 Feb 2;70(4):1334-43. Epub 2010 Feb 2.

Division of Pediatrics and Department of Immunology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874750PMC
February 2010

Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.

Clin Cancer Res 2010 Feb 26;16(3):848-56. Epub 2010 Jan 26.

Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818539PMC
February 2010

VEGF165 promotes the osteolytic bone destruction of ewing's sarcoma tumors by upregulating RANKL.

Oncol Res 2009 ;18(2-3):117-25

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875875PMC
http://dx.doi.org/10.3727/096504009789954627DOI Listing
January 2010

Fas expression in metastatic osteosarcoma cells is not regulated by CpG island methylation.

Oncol Res 2009 ;18(1):31-9

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929182PMC
http://dx.doi.org/10.3727/096504009789745638DOI Listing
April 2010

Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors.

Cancer 2009 Jan;115(1):13-22

Division of Pediatrics, The University of Texas M. D. Anderson Cancer, Department of Cancer Biology, Houston, Texas. 77030, USA.

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http://dx.doi.org/10.1002/cncr.24013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652505PMC
January 2009

COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.

J Pediatr Hematol Oncol 2008 Jul;30(7):507-12

Department of Pediatrics, Children's Cancer Hospital, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1097/MPH.0b013e31816e238cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771732PMC
July 2008

VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells.

J Exp Ther Oncol 2008 ;7(2):89-97

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562636PMC
January 2009

Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma.

Mol Cancer Ther 2008 Jul;7(7):1807-16

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Unit 87, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556989PMC
July 2008

Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels.

Mol Cancer Res 2008 Jun;6(6):929-36

Division of Pediatrics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 87, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441901PMC
June 2008

VEGF165 expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature.

Angiogenesis 2008 16;11(3):257-67. Epub 2008 Mar 16.

Division of Pediatrics, Unit 87, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10456-008-9109-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587248PMC
December 2008

The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.

Mol Cancer Res 2008 Jan;6(1):119-26

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929177PMC
January 2008

Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.

J Pediatr Hematol Oncol 2007 Dec;29(12):815-21

Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1097/MPH.0b013e3181581506DOI Listing
December 2007

VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.

Mol Cancer Res 2007 Nov;5(11):1125-32

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Unit 87, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0174DOI Listing
November 2007

Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis.

Antimicrob Agents Chemother 2008 Feb 5;52(2):716-8. Epub 2007 Nov 5.

The Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.

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http://dx.doi.org/10.1128/AAC.00760-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224773PMC
February 2008

Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma.

Mol Cancer Res 2007 Oct;5(10):991-9

Division of Pediatrics Research, Unit 853, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0007DOI Listing
October 2007

Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy.

Clin Cancer Res 2007 Aug;13(16):4867-73

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0133DOI Listing
August 2007

EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.

Cancer Res 2007 Jul;67(14):6675-84

Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4140DOI Listing
July 2007

Early lymphocyte recovery as a prognostic indicator for high-risk Ewing sarcoma.

J Pediatr Hematol Oncol 2007 Jan;29(1):48-52

Department of Biostatistics and Mathematics, University of Texas M.D. Anderson Cancer Center/Children's Cancer Hospital, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1097/MPH.0b013e31802d3e3eDOI Listing
January 2007

Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature.

Int J Cancer 2006 Aug;119(4):839-46

Division of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/ijc.21916DOI Listing
August 2006

Intranasal interleukin-12 gene therapy enhanced the activity of ifosfamide against osteosarcoma lung metastases.

Cancer 2006 Mar;106(6):1382-8

Division of Pediatrics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/cncr.21744DOI Listing
March 2006

Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity.

Mol Cancer Res 2005 Dec;3(12):685-91

Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0092DOI Listing
December 2005

Fas expression in lung metastasis from osteosarcoma patients.

J Pediatr Hematol Oncol 2005 Nov;27(11):611-5

Division of Pediatrics, Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, and Division of Pediatrics Hematology/Oncology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1097/01.mph.0000188112.42576.dfDOI Listing
November 2005

Zoledronic acid inhibits primary bone tumor growth in Ewing sarcoma.

Cancer 2005 Oct;104(8):1713-20

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.21383DOI Listing
October 2005

Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells.

Clin Exp Metastasis 2004 ;21(8):747-53

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1007/s10585-005-0599-6DOI Listing
August 2005

E1A specifically enhances sensitivity to topoisomerase IIalpha targeting anticancer drug by up-regulating the promoter activity.

Mol Cancer Res 2005 May;3(5):271-5

Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Unit 87, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-04-0179DOI Listing
May 2005

A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model.

Clin Cancer Res 2005 Apr;11(7):2662-9

Division of Pediatrics and Departments of Cancer Biology and Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1206DOI Listing
April 2005

Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.

Int J Cancer 2005 Sep;116(3):458-63

Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/ijc.21011DOI Listing
September 2005

Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo.

Clin Cancer Res 2005 Mar;11(5):2008-17

Division of Pediatrics, Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0777DOI Listing
March 2005

Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma.

Cancer Res 2005 Feb;65(4):1124-8

Division of Pediatrics and Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-2128DOI Listing
February 2005

Increased Fas expression reduces the metastatic potential of human osteosarcoma cells.

Clin Cancer Res 2004 Dec;10(23):8114-9

Division of Pediatrics, Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0353DOI Listing
December 2004

Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway.

Clin Cancer Res 2004 Jan;10(2):777-83

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.ccr-1245-02DOI Listing
January 2004

E1A gene therapy inhibits angiogenesis in a Ewing's sarcoma animal model.

Mol Cancer Ther 2003 Dec;2(12):1313-9

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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December 2003

Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastases.

Clin Cancer Res 2003 Aug;9(9):3462-8

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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August 2003

Alpha 4 integrin increases anoikis of human osteosarcoma cells.

J Cell Biochem 2003 Apr;88(5):1038-47

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/jcb.10465DOI Listing
April 2003

Vasculogenesis Plays a Role in the Growth of Ewing's Sarcoma in Vivo.

Clin Cancer Res 2002 Nov;8(11):3622-7

Division of Pediatrics and Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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November 2002

Nude mouse lung metastases models of osteosarcoma and Ewing's sarcoma for evaluating new therapeutic strategies.

Methods Mol Med 2003 ;74:495-505

Division of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1385/1-59259-323-2:495DOI Listing
April 2003

Aerosol gene therapy for metastatic lung cancer using PEI-p53 complexes.

Methods Mol Med 2003 ;75:607-18

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1385/1-59259-324-0:607DOI Listing
May 2003

Fas expression inversely correlates with metastatic potential in osteosarcoma cells.

Oncol Rep 2002 Jul-Aug;9(4):823-7

Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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January 2003

Adenovirus-E1A gene therapy enhances the in vivo sensitivity of Ewing's sarcoma to VP-16.

Cancer Gene Ther 2002 May;9(5):407-13

Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700449DOI Listing
May 2002

Eradication of osteosarcoma lung metastasis using intranasal gemcitabine.

Anticancer Drugs 2002 Feb;13(2):155-61

Department of Pediatric, University of Texas MD Anderson Cancer Center, Houston, TX 77030-4095, USA.

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http://dx.doi.org/10.1097/00001813-200202000-00007DOI Listing
February 2002

Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector.

Cancer Gene Ther 2002 Mar;9(3):260-6

Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700432DOI Listing
March 2002