Eugene R Bleecker

Eugene R Bleecker

UNVERIFIED PROFILE

Are you Eugene R Bleecker?   Register this Author

Register author
Eugene R Bleecker

Eugene R Bleecker

Publications by authors named "Eugene R Bleecker"

Are you Eugene R Bleecker?   Register this Author

100Publications

3324Reads

23Profile Views

Strength in numbers: The quest for asthma genes.

J Allergy Clin Immunol 2019 Aug 20;144(2):413-415. Epub 2019 Jun 20.

Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, Ariz; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, Ariz.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.06.007DOI Listing
August 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.

JCI Insight 2019 Mar 7;4(5). Epub 2019 Mar 7.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
https://insight.jci.org/articles/view/122475
Publisher Site
http://dx.doi.org/10.1172/jci.insight.122475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483602PMC
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

J Allergy Clin Immunol 2019 Jan 7;143(1):104-113.e14. Epub 2018 Mar 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.12.1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128784PMC
January 2019

Clinical Issues in Severe Asthma: Consensus and Controversies on the Road to Precision Medicine.

Chest 2018 Oct;154(4):982-983

Allergy, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, PA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692183222
Publisher Site
http://dx.doi.org/10.1016/j.chest.2018.08.1022DOI Listing
October 2018

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
August 2018

Genome-wide association study of lung function and clinical implication in heavy smokers.

BMC Med Genet 2018 08 1;19(1):134. Epub 2018 Aug 1.

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12881-018-0656-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090900PMC
August 2018

Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control.

Chest 2018 02 26;153(2):378-386. Epub 2017 Oct 26.

Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692173291
Publisher Site
http://dx.doi.org/10.1016/j.chest.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815875PMC
February 2018

Biomarkers for severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Dec;140(6):1509-1518

Respiratory Medicine Unit and Oxford Respiratory BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.10.005DOI Listing
December 2017

Effects of bronchoscopy on lung function in asthmatics.

J Asthma 2017 Oct 5;54(8):866-871. Epub 2017 Jan 5.

a Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine , Winston-Salem , NC , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02770903.2016.1276587DOI Listing
October 2017

Characterisation of asthma subgroups associated with circulating YKL-40 levels.

Eur Respir J 2017 10 12;50(4). Epub 2017 Oct 12.

Section of Pulmonary, Critical Care Medicine and Sleep and Dept of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00800-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967238PMC
October 2017

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

N Engl J Med 2017 09;377(10):911-922

From the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill (M.K., A.A.F., A.C., G.R., R.C., C.W.D., C.M.D., N.E.A., W.H.A., A.G.H., W.K.O., R.C.B.), and the Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem (E.R.B., A.T.H.) - both in North Carolina; the Department of Medicine, Columbia University Medical Center, and the Department of Epidemiology, Mailman School of Public Health at Columbia University (R.G.B.), and the Department of Medicine, Weill Cornell Medical College (F.M.), New York; the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco Medical Center, San Francisco (S.A.C., P.G.W.); the Department of Medicine and Physiology, David Geffen School of Medicine, University of California, Los Angeles (C.B.C.); the Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor (M.K.H.); the Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore (N.N.H.); the Department of Radiology, Division of Physiologic Imaging, University of Iowa Hospitals and Clinics, Iowa City (E.A.H.); and the Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, Veterans Affairs Medical Center, Salt Lake City (R.E.K., R.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1701632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706541PMC
September 2017

Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.

Am J Respir Crit Care Med 2017 06;195(11):1449-1463

1 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Asthma Institute at UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201607-1407OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470748PMC
June 2017

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Apr 7;139(4):1167-1175.e2. Epub 2016 Oct 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.08.008DOI Listing
April 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone.

N Engl J Med 2016 Sep;375(9):850-60

From Wake Forest School of Medicine, Winston-Salem, NC (S.P.P., E.R.B.); University of Genoa, Genoa, Italy (G.W.C.); Hallym University, Seoul, South Korea (Y.B.P.); Centro de Investigacion y Atencion Integral, Durango, Mexico (R.R.); AstraZeneca, Macclesfield, United Kingdom (S.H.); AstraZeneca Research and Development, Gothenburg, Sweden (H.F., C.J.); and AstraZeneca, Gaithersburg, MD (U.J.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1511190DOI Listing
September 2016

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.

Lancet Respir Med 2016 07 10;4(7):549-556. Epub 2016 May 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30031-5DOI Listing
July 2016

Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II.

J Allergy Clin Immunol Pract 2015 Jul-Aug;3(4):566-75.e1. Epub 2015 May 21.

Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500672PMC
April 2016

Asthma Is More Severe in Older Adults.

PLoS One 2015 22;10(7):e0133490. Epub 2015 Jul 22.

Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511639PMC
April 2016

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

J Allergy Clin Immunol 2015 Jul 13;136(1):51-58.e10. Epub 2015 Jan 13.

Section of Pulmonary, Critical Care and Sleep Medicine and the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749140172
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2014.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494869PMC
July 2015

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.

Am J Physiol Lung Cell Mol Physiol 2015 Jul 22;309(2):L129-38. Epub 2015 May 22.

Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, North Carolina;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00288.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504976PMC
July 2015

Fluticasone furoate-vilanterol 100-25 mcg compared with fluticasone furoate 100 mcg in asthma: a randomized trial.

J Allergy Clin Immunol Pract 2014 Sep-Oct;2(5):553-61. Epub 2014 Apr 24.

Department of Medicine, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2014.02.010DOI Listing
May 2015

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine.

Pharmgenomics Pers Med 2015 16;8:9-22. Epub 2015 Jan 16.

Center for Genomics and Personalized Medicine Research, Pulmonary Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://www.dovepress.com/asthma-pharmacogenetics-and-the-dev
Publisher Site
http://dx.doi.org/10.2147/PGPM.S52846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325626PMC
February 2015

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.

J Allergy Clin Immunol 2015 Jan 1;135(1):92-9. Epub 2014 Aug 1.

Department of Medicine, University of Pittsburgh, Pittsburgh, Pa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289095PMC
January 2015

Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways.

Am J Respir Crit Care Med 2014 Dec;190(12):1363-72

1 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Asthma Institute at UPMC, Pittsburgh, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201406-1099OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294630PMC
December 2014

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis.

J Allergy Clin Immunol 2014 Jun 9;133(6):1557-63.e5. Epub 2013 Dec 9.

Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research and the Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston-Salem, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2013.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040309PMC
June 2014

Ease of use of the ELLIPTA dry powder inhaler: data from three randomised controlled trials in patients with asthma.

NPJ Prim Care Respir Med 2014 Jun 26;24:14019. Epub 2014 Jun 26.

Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/npjpcrm.2014.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373320PMC
June 2014

Asthma genetics and personalised medicine.

Lancet Respir Med 2014 May 2;2(5):405-15. Epub 2014 May 2.

Human Development and Health, and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(14)70012-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768462PMC
May 2014

Asthma heterogeneity and severity-why is comprehensive phenotyping important?

Lancet Respir Med 2014 Jan 23;2(1):10-1. Epub 2013 Dec 23.

Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(13)70288-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029153PMC
January 2014

Clinical heterogeneity in the severe asthma research program.

Ann Am Thorac Soc 2013 Dec;10 Suppl:S118-24

1 Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, North Carolina; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.201309-307AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960988PMC
December 2013