Eugene R Bleecker

Eugene R Bleecker

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Eugene R Bleecker

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Tiotropium Respimat® add-on therapy to inhaled corticosteroids in patients with symptomatic asthma improves clinical outcomes regardless of baseline characteristics.

Respir Med 2019 Oct - Nov;158:97-109. Epub 2019 Sep 30.

University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis and Groningen Research Institute for Asthma and COPD, Groningen, Netherlands.

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http://dx.doi.org/10.1016/j.rmed.2019.09.014DOI Listing
August 2020

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study.

Thorax 2020 Jun 1. Epub 2020 Jun 1.

Department of Internal Medicine, Pulmonary Section, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

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http://dx.doi.org/10.1136/thoraxjnl-2019-214496DOI Listing
June 2020

Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.

J Allergy Clin Immunol Pract 2020 Apr 19. Epub 2020 Apr 19.

University of Groningen, University Medical Center Groningen, and Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jaip.2020.04.013DOI Listing
April 2020

Disease Burden and Long-Term Risk of Persistent Very Poorly Controlled Asthma: TENOR II.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2243-2253. Epub 2020 Mar 12.

Departments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, Calif.

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http://dx.doi.org/10.1016/j.jaip.2020.02.040DOI Listing
March 2020

Efficacy of once-daily tiotropium Respimat in adults with asthma at GINA Steps 2-5.

Pulm Pharmacol Ther 2020 02 23;60:101881. Epub 2019 Dec 23.

Genomics and Precision Medicine, University of Arizona College of Medicine, Tucson, AZ, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2019.101881DOI Listing
February 2020

COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Authors:
Katherine E Lowe Elizabeth A Regan Antonio Anzueto Erin Austin John H M Austin Terri H Beaty Panayiotis V Benos Christopher J Benway Surya P Bhatt Eugene R Bleecker Sandeep Bodduluri Jessica Bon Aladin M Boriek Adel Re Boueiz Russell P Bowler Matthew Budoff Richard Casaburi Peter J Castaldi Jean-Paul Charbonnier Michael H Cho Alejandro Comellas Douglas Conrad Corinne Costa Davis Gerard J Criner Douglas Curran-Everett Jeffrey L Curtis Dawn L DeMeo Alejandro A Diaz Mark T Dransfield Jennifer G Dy Ashraf Fawzy Margaret Fleming Eric L Flenaugh Marilyn G Foreman Spyridon Fortis Hirut Gebrekristos Sarah Grant Philippe A Grenier Tian Gu Abhya Gupta MeiLan K Han Nicola A Hanania Nadia N Hansel Lystra P Hayden Craig P Hersh Brian D Hobbs Eric A Hoffman James C Hogg John E Hokanson Karin F Hoth Albert Hsiao Stephen Humphries Kathleen Jacobs Francine L Jacobson Ella A Kazerooni Victor Kim Woo Jin Kim Gregory L Kinney Harald Koegler Sharon M Lutz David A Lynch Neil R MacIntye Barry J Make Nathaniel Marchetti Fernando J Martinez Diego J Maselli Anne M Mathews Meredith C McCormack Merry-Lynn N McDonald Charlene E McEvoy Matthew Moll Sarah S Molye Susan Murray Hrudaya Nath John D Newell Mariaelena Occhipinti Matteo Paoletti Trisha Parekh Massimo Pistolesi Katherine A Pratte Nirupama Putcha Margaret Ragland Joseph M Reinhardt Stephen I Rennard Richard A Rosiello James C Ross Harry B Rossiter Ingo Ruczinski Raul San Jose Estepar Frank C Sciurba Jessica C Sieren Harjinder Singh Xavier Soler Robert M Steiner Matthew J Strand William W Stringer Ruth Tal-Singer Byron Thomashow Gonzalo Vegas Sánchez-Ferrero John W Walsh Emily S Wan George R Washko J Michael Wells Chris H Wendt Gloria Westney Ava Wilson Robert A Wise Andrew Yen Kendra Young Jeong Yun Edwin K Silverman James D Crapo

Chronic Obstr Pulm Dis 2019 Nov;6(5):384-399

National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.15326/jcopdf.6.5.2019.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846PMC
November 2019

Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

N Engl J Med 2019 09;381(13):1227-1239

From National Jewish Health (M.E.W., R.C., J.T.O.), Denver, and University of Colorado School of Medicine (M.E.W., S.J.S., R.C., F.H., J.T.O.) and Children's Hospital Colorado (S.J.S.), Aurora - all in Colorado; Wake Forest School of Medicine (V.E.O., W.C.M., S.P.P.), Winston-Salem, North Carolina Clinical Research (C.F.L.), Raleigh, and Duke University Medical Center (N.L., L.Q.), Durham - all in North Carolina; Ann and Robert H. Lurie Children's Hospital of Chicago (J.A.P., R.G.R.), University of Illinois at Chicago (J.A.K., H.K.), Rush University Medical Center (J.M.), University of Chicago (E.N., J.S., S. White), and Northwestern University Feinberg School of Medicine (L.J.S.) - all in Chicago; Penn State University (V.C., S.J.K., D.M.), Hershey, and Allegheny General Hospital (D.G.) and University of Pittsburgh Medical Center (S. Wenzel), Pittsburgh - all in Pennsylvania; Nemours Children's Health System, Jacksonville (J.J.L., K.V.B., J.L.), and University of South Florida Morsani College of Medicine, Tampa (J.-C.C.) - both in Florida; University of Arizona Health Sciences, Tucson (E.R.B., M.K., F.M., D.A.M.); Washington University School of Medicine, St. Louis (L.B.B., A.B., M.C.); University of California, San Francisco (UCSF), San Francisco (M.B., M.D.C., S.C.L., D.L.) and UCSF Benioff Children's Hospital, Oakland (M.B., D.L.) - both in California; Brigham and Women's Hospital and Harvard Medical School (J.-C.C., N.G., E.I.) and Boston Children's Hospital (W.P., W.S.) - all in Boston; University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland (J.F.C., K.R.); University of Wisconsin-Madison, Madison (L.D., D.J.J., R.F.L., C.A.S.) and Aurora Sinai Medical Center, Milwaukee (L.S.-V.) - both in Wisconsin; Columbia University Irving Medical Center, New York, (E.D.); Emory University, Atlanta (A.M.F.); and University of New Mexico, Albuquerque (H.R.).

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http://dx.doi.org/10.1056/NEJMoa1905560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026584PMC
September 2019

Strength in numbers: The quest for asthma genes.

J Allergy Clin Immunol 2019 08 20;144(2):413-415. Epub 2019 Jun 20.

Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, Ariz; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, Ariz.

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http://dx.doi.org/10.1016/j.jaci.2019.06.007DOI Listing
August 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.

JCI Insight 2019 03 7;4(5). Epub 2019 Mar 7.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

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https://insight.jci.org/articles/view/122475
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http://dx.doi.org/10.1172/jci.insight.122475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483602PMC
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

J Allergy Clin Immunol 2019 01 7;143(1):104-113.e14. Epub 2018 Mar 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.12.1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128784PMC
January 2019

Clinical Issues in Severe Asthma: Consensus and Controversies on the Road to Precision Medicine.

Chest 2018 10;154(4):982-983

Allergy, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, PA.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183222
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http://dx.doi.org/10.1016/j.chest.2018.08.1022DOI Listing
October 2018

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780PMC
August 2018

Genome-wide association study of lung function and clinical implication in heavy smokers.

BMC Med Genet 2018 08 1;19(1):134. Epub 2018 Aug 1.

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA.

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http://dx.doi.org/10.1186/s12881-018-0656-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090900PMC
August 2018

Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control.

Chest 2018 02 26;153(2):378-386. Epub 2017 Oct 26.

Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00123692173291
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http://dx.doi.org/10.1016/j.chest.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815875PMC
February 2018

Biomarkers for severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Dec;140(6):1509-1518

Respiratory Medicine Unit and Oxford Respiratory BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.10.005DOI Listing
December 2017

Effects of bronchoscopy on lung function in asthmatics.

J Asthma 2017 Oct 5;54(8):866-871. Epub 2017 Jan 5.

a Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine , Winston-Salem , NC , USA.

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http://dx.doi.org/10.1080/02770903.2016.1276587DOI Listing
October 2017

Characterisation of asthma subgroups associated with circulating YKL-40 levels.

Eur Respir J 2017 10 12;50(4). Epub 2017 Oct 12.

Section of Pulmonary, Critical Care Medicine and Sleep and Dept of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA

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http://dx.doi.org/10.1183/13993003.00800-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967238PMC
October 2017

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

N Engl J Med 2017 09;377(10):911-922

From the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill (M.K., A.A.F., A.C., G.R., R.C., C.W.D., C.M.D., N.E.A., W.H.A., A.G.H., W.K.O., R.C.B.), and the Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem (E.R.B., A.T.H.) - both in North Carolina; the Department of Medicine, Columbia University Medical Center, and the Department of Epidemiology, Mailman School of Public Health at Columbia University (R.G.B.), and the Department of Medicine, Weill Cornell Medical College (F.M.), New York; the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco Medical Center, San Francisco (S.A.C., P.G.W.); the Department of Medicine and Physiology, David Geffen School of Medicine, University of California, Los Angeles (C.B.C.); the Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor (M.K.H.); the Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore (N.N.H.); the Department of Radiology, Division of Physiologic Imaging, University of Iowa Hospitals and Clinics, Iowa City (E.A.H.); and the Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, Veterans Affairs Medical Center, Salt Lake City (R.E.K., R.P.).

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http://dx.doi.org/10.1056/NEJMoa1701632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706541PMC
September 2017

Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.

Am J Respir Crit Care Med 2017 06;195(11):1449-1463

1 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Asthma Institute at UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201607-1407OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470748PMC
June 2017

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Apr 7;139(4):1167-1175.e2. Epub 2016 Oct 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.08.008DOI Listing
April 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone.

N Engl J Med 2016 Sep;375(9):850-60

From Wake Forest School of Medicine, Winston-Salem, NC (S.P.P., E.R.B.); University of Genoa, Genoa, Italy (G.W.C.); Hallym University, Seoul, South Korea (Y.B.P.); Centro de Investigacion y Atencion Integral, Durango, Mexico (R.R.); AstraZeneca, Macclesfield, United Kingdom (S.H.); AstraZeneca Research and Development, Gothenburg, Sweden (H.F., C.J.); and AstraZeneca, Gaithersburg, MD (U.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1511190DOI Listing
September 2016

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.

Lancet Respir Med 2016 07 10;4(7):549-556. Epub 2016 May 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2213-2600(16)30031-5DOI Listing
July 2016

Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II.

J Allergy Clin Immunol Pract 2015 Jul-Aug;3(4):566-75.e1. Epub 2015 May 21.

Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

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http://dx.doi.org/10.1016/j.jaip.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500672PMC
April 2016

Asthma Is More Severe in Older Adults.

PLoS One 2015 22;10(7):e0133490. Epub 2015 Jul 22.

Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511639PMC
April 2016

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.

Am J Physiol Lung Cell Mol Physiol 2015 Jul 22;309(2):L129-38. Epub 2015 May 22.

Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, North Carolina;

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http://dx.doi.org/10.1152/ajplung.00288.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504976PMC
July 2015