Publications by authors named "Eugene I Hwang"

31Publications

Considerations when treating high-grade pediatric glioma patients with immunotherapy.

Expert Rev Neurother 2020 Nov 21. Epub 2020 Nov 21.

Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Research Center, University of California San Francisco , San Francisco, CA, USA.

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http://dx.doi.org/10.1080/14737175.2020.1855144DOI Listing
November 2020

Pediatric diffuse leptomeningeal glioneuronal tumor: Two clinical cases of successful targeted therapy.

Pediatr Blood Cancer 2020 Dec 25;67(12):e28478. Epub 2020 Aug 25.

Center for Neuroscience and Behavioral Medicine, Brain Tumor Institute, Washington, District of Columbia.

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http://dx.doi.org/10.1002/pbc.28478DOI Listing
December 2020

Immunotherapy Approaches for Pediatric CNS Tumors and Associated Neurotoxicity.

Pediatr Neurol 2020 06 27;107:7-15. Epub 2020 Jan 27.

Children's National Medical Center, Brain Tumor Institute, Washington, District of Columbia; Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Washington, District of Columbia.

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http://dx.doi.org/10.1016/j.pediatrneurol.2020.01.004DOI Listing
June 2020

Molecularly Targeted Agents in the Therapy of Pediatric Brain Tumors.

Paediatr Drugs 2020 Feb;22(1):45-54

Department of Pediatric Hematology-Oncology, Center for Cancer and Immunology Research and Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.

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http://dx.doi.org/10.1007/s40272-019-00369-zDOI Listing
February 2020

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.

J Clin Oncol 2018 Oct 17:JCO2017764720. Epub 2018 Oct 17.

Eugene I. Hwang and Roger J. Packer, Children's National Medical Center, Washington, DC; Marcel Kool, Lukas Chavez, Sebastian Brabetz, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; David Capper, Andreas von Deimling, and Stefan M. Pfister, University Hospital Heidelberg; Stefan M. Pfister, National Center for Tumor Diseases, Heidelberg; David Capper, Charité Medical University, Berlin, Germany; Peter C. Burger, Johns Hopkins University, Baltimore, MD; Chris Williams-Hughes, Children's Oncology Group, Littleton, CO; Catherine Billups, Yimei Li, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Linda Heier, Weill Cornell Medical College, New York, NY; Alok Jaju, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Jeff Michalski, Washington University School of Medicine, St. Louis, MO; Sarah Leary and James M. Olson, Seattle Children's Hospital and Research Institute; Sarah Leary and James M. Olson, Fred Hutchinson Cancer Research Center, Seattle, WA; Tianni Zhou, California State University, Long Beach, Long Beach, CA; Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Ian F. Pollack, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2017.76.4720DOI Listing
October 2018

Case-based review: pediatric medulloblastoma.

Neurooncol Pract 2017 Sep 11;4(3):138-150. Epub 2017 Aug 11.

Division of Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, 550 16th Street, 4th Floor, San Francisco, CA 94158 (C.K., S.M.); Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010 (R.P.); Brain Tumor Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010 (R.P., E.H.); Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's National Health Systems, 111 Michigan Avenue NW, Washington, DC 20010 (R.P., E.H.); Department of Radiation Oncology, University of California, 1825 4th Street, San Francisco, San Francisco, CA 94158 (D.R., S.B.); Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143 (C.R., S.M.); Dana-Farber/Boston Children's Cancer and Blood Disorders Center, 450 Brookline Avenue, Boston, MA 02215 (P.B.); Department of Pediatrics, Harvard Medical School, Boston, MA 02215 (P.B.); Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142 (P.B.); Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Avenue, M551, Box 0102 San Francisco, CA 94143 (D.S.); Department of Radiology, University of California, San Francisco, 550 Parnassus Avenue, M327, San Francisco, CA 94143 (M.A., S.C.); Department of Neurology, Neurosurgery and Pediatrics, University of California, San Francisco, 550 Sandler Neurosciences, 625 Nelson Rising Lane, 402B, Box 0434, San Francisco, CA 94158 (S.M.).

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http://dx.doi.org/10.1093/nop/npx011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909805PMC
September 2017

Alexander Disease.

J Child Neurol 2017 02 10;32(2):184-187. Epub 2016 Oct 10.

1 Division of Neurology, Center for Neuroscience and Behavioral Medicine, Children's National Health System, Washington, DC, USA.

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http://dx.doi.org/10.1177/0883073816673263DOI Listing
February 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.

J Pediatr Hematol Oncol 2016 05;38(4):249-60

Departments of †Genetics **Pediatrics ‡Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Hanover, NH *Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda §Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center ∥Division of Pediatric Oncology, Johns Hopkins School of Medicine, Bloomberg Children's Hospital, Baltimore, MD ¶The Brain Tumor Institute #Division of Hematology-Oncology, Children's National Medical Center, Washington, DC.

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http://dx.doi.org/10.1097/MPH.0000000000000551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003110PMC
May 2016

The Role of NG2 Proteoglycan in Glioma.

Transl Oncol 2016 Feb;9(1):57-63

Research Center for Genetic Medicine, Children's National Health System, 111 Michigan Ave. NW, Washington, DC 20010, USA; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800061PMC
February 2016

Anaplastic Ependymoma in a Child With Sickle Cell Anemia: A Case Report Highlighting Treatment Challenges for Young Children With Central Nervous System Tumors and Underlying Vasculopathy.

Pediatr Blood Cancer 2016 Mar 21;63(3):547-50. Epub 2015 Oct 21.

Brain Tumor Institute, Children's National Health System, Washington, District of Columbia.

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http://dx.doi.org/10.1002/pbc.25809DOI Listing
March 2016

Experimental Therapeutic Trial Design for Pediatric Brain Tumors.

J Child Neurol 2016 10 9;31(12):1421-32. Epub 2015 Sep 9.

Department of Pediatric Hematology-Oncology, Children's National Medical Center, Washington, DC, USA Gilbert Family Neurofibromatosis Institute, Centers for Cancer and Immunology Research & Neuroscience Research, Children's National Medical Center, Washington, DC, USA

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http://dx.doi.org/10.1177/0883073815604221DOI Listing
October 2016

Handheld optical coherence tomography during sedation in young children with optic pathway gliomas.

JAMA Ophthalmol 2014 Mar;132(3):265-71

The Gilbert Family Neurofibromatosis Institute, Children's National Medical Center, Washington, DC2Department of Neurology, Children's National Medical Center, Washington, DC6Department of Oncology, Children's National Medical Center, Washington, DC7The B.

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http://dx.doi.org/10.1001/jamaophthalmol.2013.7649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445404PMC
March 2014

Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab.

JAMA Ophthalmol 2014 Jan;132(1):111-4

Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Washington, DC2The Gilbert Family Neurofibromatosis Institute, Children's National Medical Center, Washington, DC3Division of Neurology, Children's National Medical Cente.

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http://dx.doi.org/10.1001/jamaophthalmol.2013.5819DOI Listing
January 2014

Sluggish cognitive tempo in survivors of pediatric brain tumors.

J Neurooncol 2013 Aug 10;114(1):71-8. Epub 2013 May 10.

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1007/s11060-013-1149-8DOI Listing
August 2013

Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas.

Pediatr Blood Cancer 2013 May 13;60(5):776-82. Epub 2012 Sep 13.

Division of Oncology, Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1002/pbc.24297DOI Listing
May 2013