Publications by authors named "Ester Fernandez-Salas"

22Publications

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.

J Med Chem 2020 07 24;63(13):7252-7267. Epub 2020 Jun 24.

Rogel Cancer Center, Departments of Internal Medicine and Pharmacology, Medical School, and Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.

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July 2020

Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment.

Neoplasia 2020 02 10;22(2):111-119. Epub 2020 Jan 10.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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February 2020

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Angew Chem Int Ed Engl 2018 02 15;57(6):1601-1605. Epub 2018 Jan 15.

Comprehensive Cancer and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI, 48109, USA.

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February 2018

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

J Med Chem 2018 01 24;61(2):462-481. Epub 2017 Mar 24.

University of Michigan Comprehensive Cancer Center, and Departments of ‡Internal Medicine, §Pathology, ∥Pharmaceutical Sciences, ⊥Medicinal Chemistry, and #Pharmacology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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January 2018

Role of BET proteins in castration-resistant prostate cancer.

Drug Discov Today Technol 2016 Mar 30;19:29-38. Epub 2016 Jul 30.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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March 2016

Elucidation of Resistance Mechanisms to Second-Generation ALK Inhibitors Alectinib and Ceritinib in Non-Small Cell Lung Cancer Cells.

Neoplasia 2016 Mar;18(3):162-71

University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

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March 2016

A Highly Specific Monoclonal Antibody for Botulinum Neurotoxin Type A-Cleaved SNAP25.

Toxins (Basel) 2015 Jun 24;7(7):2354-70. Epub 2015 Jun 24.

Department of Biological Sciences, Allergan, Irvine, CA 92612, USA.

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June 2015

Septin dynamics are essential for exocytosis.

J Biol Chem 2015 Feb 9;290(9):5280-97. Epub 2015 Jan 9.

From the Departments of Physiology and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073,

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February 2015

Botulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassay.

PLoS One 2012 21;7(11):e49516. Epub 2012 Nov 21.

Department of Biological Sciences, Allergan Inc., Irvine, California, United States of America.

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May 2013

CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.

Carcinogenesis 2012 May 1;33(5):986-95. Epub 2012 Mar 1.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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May 2012

Is the light chain subcellular localization an important factor in botulinum toxin duration of action?

Mov Disord 2004 Mar;19 Suppl 8:S23-34

Neurotoxin Research Program, Department of Biological Sciences, Allergan Inc, Irvine, California 92612, USA.

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March 2004

Plasma membrane localization signals in the light chain of botulinum neurotoxin.

Proc Natl Acad Sci U S A 2004 Mar 24;101(9):3208-13. Epub 2004 Feb 24.

Neurotoxin Research Program, Department of Biological Sciences, Allergan Inc., 2525 Dupont Drive, Irvine, CA 92612-1599, USA.

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March 2004