Espen Melum

Espen Melum

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Espen Melum

Espen Melum

Publications by authors named "Espen Melum"

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62Publications

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Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

Nat Protoc 2019 06 20;14(6):1884-1925. Epub 2019 May 20.

Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41596-019-0168-0DOI Listing
June 2019

Genetic markers associated with long-term cardiovascular outcome in kidney transplant recipients.

Am J Transplant 2019 May 18;19(5):1444-1451. Epub 2018 Dec 18.

Norwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://doi.wiley.com/10.1111/ajt.15191
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http://dx.doi.org/10.1111/ajt.15191DOI Listing
May 2019

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF innate T cells in the human liver.

Eur J Immunol 2018 08 25;48(8):1329-1335. Epub 2018 May 25.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.201747334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733416PMC
August 2018

Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree.

Am J Physiol Gastrointest Liver Physiol 2018 03 6;314(3):G349-G359. Epub 2017 Dec 6.

Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet , Oslo , Norway.

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http://dx.doi.org/10.1152/ajpgi.00124.2017DOI Listing
March 2018

Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation.

Front Immunol 2017 30;8:765. Epub 2017 Jun 30.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.3389/fimmu.2017.00765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491939PMC
June 2017

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation.

J Hepatol 2017 02 5;66(2):382-389. Epub 2016 Oct 5.

Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Centre and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Division of Surgery, Inflammatory Medicine and Transplantation, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250551PMC
February 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer.

J Immunol 2017 02 4;198(4):1729-1739. Epub 2017 Jan 4.

Center for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, 0318 Oslo, Norway;

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http://dx.doi.org/10.4049/jimmunol.1600061DOI Listing
February 2017

The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.

Physiol Rep 2017 Feb;5(4)

Norwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway

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http://dx.doi.org/10.14814/phy2.13117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328767PMC
February 2017

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.

J Hepatol 2017 01 17;66(1):116-122. Epub 2016 Sep 17.

Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.09.002DOI Listing
January 2017

Prognostic biomarkers and surrogate end points in PSC.

Liver Int 2016 12;36(12):1748-1751

Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1111/liv.13216DOI Listing
December 2016

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires.

Hepatology 2016 May 30;63(5):1608-19. Epub 2015 Sep 30.

Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.28116DOI Listing
May 2016

Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation.

Scand J Gastroenterol 2015 11;50(9):1127-34. Epub 2015 Apr 11.

Department of Emergencies and Critical Care, Oslo University Hospital , Oslo , Norway.

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http://www.tandfonline.com/doi/full/10.3109/00365521.2015.10
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http://dx.doi.org/10.3109/00365521.2015.1027262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673540PMC
March 2016

Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.

Gut 2015 Dec 3;64(12):1889-97. Epub 2014 Nov 3.

Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/gutjnl-2014-308541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512923PMC
December 2015

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.

PLoS One 2014 18;9(12):e114486. Epub 2014 Dec 18.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270690PMC
December 2015

The biliary epithelium presents antigens to and activates natural killer T cells.

Hepatology 2015 Oct 20;62(4):1249-59. Epub 2015 May 20.

Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1002/hep.27840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589438PMC
October 2015

Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway.

Transplant Direct 2015 Oct 19;1(9):e39. Epub 2015 Oct 19.

Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Section of Gastroenterology, Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1097/TXD.0000000000000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946487PMC
October 2015

Low use of surveillance and early diagnosis of hepatocellular carcinoma in Norway--a population-based cohort study.

Cancer Epidemiol 2014 Dec;38(6):741-7

Department of Infectious Diseases, Medical Division, Akershus University Hospital, Lørenskog, Norway.

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http://dx.doi.org/10.1016/j.canep.2014.10.005DOI Listing
December 2014

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease.

Liver Int 2014 Nov 7;34(10):1488-95. Epub 2014 Mar 7.

Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1111/liv.12492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128902PMC
November 2014

Characterization of animal models for primary sclerosing cholangitis (PSC).

J Hepatol 2014 Jun 19;60(6):1290-303. Epub 2014 Feb 19.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517670PMC
June 2014

Update on primary sclerosing cholangitis genetics.

Curr Opin Gastroenterol 2014 May;30(3):310-9

aDivision of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet bDivision of Cancer Medicine, Surgery and Transplantation, K.G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo cDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1097/MOG.0000000000000052DOI Listing
May 2014

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.

World J Gastroenterol 2014 Apr;20(14):3986-4000

Bjarte Fosby, Sigrid Næss, Johannes R Hov, Kirsten M Boberg, Espen Melum, Tom H Karlsen, Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, N-0424 Oslo, Norway.

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http://dx.doi.org/10.3748/wjg.v20.i14.3986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983454PMC
April 2014

Analyzing antigen recognition by Natural Killer T cells.

Methods Mol Biol 2013 ;960:557-572

Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-218-6_41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708615PMC
June 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort.

Eur J Gastroenterol Hepatol 2012 Aug;24(8):890-6

Department of Infectious Diseases, Medical Division, Akershus University Hospital, Lørenskog, Norway.

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http://dx.doi.org/10.1097/MEG.0b013e3283546efdDOI Listing
August 2012

Genetics in primary sclerosing cholangitis.

Best Pract Res Clin Gastroenterol 2011 Dec;25(6):713-26

Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S15216918110008
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http://dx.doi.org/10.1016/j.bpg.2011.09.010DOI Listing
December 2011

SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels.

BMC Bioinformatics 2010 Dec 17;11:600. Epub 2010 Dec 17.

Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Norway.

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http://dx.doi.org/10.1186/1471-2105-11-600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022629PMC
December 2010

Association to the Glypican-5 gene in multiple sclerosis.

J Neuroimmunol 2010 Sep 6;226(1-2):194-7. Epub 2010 Aug 6.

Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jneuroim.2010.07.003DOI Listing
September 2010

HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas.

Clin Endocrinol (Oxf) 2010 Aug 13;73(2):229-35. Epub 2010 Mar 13.

Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital and University of Oslo, Oslo, Norway.

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http://doi.wiley.com/10.1111/j.1365-2265.2010.03805.x
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http://dx.doi.org/10.1111/j.1365-2265.2010.03805.xDOI Listing
August 2010

SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region.

Hum Mutat 2010 Jul;31(7):875-85

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://doi.wiley.com/10.1002/humu.21276
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http://dx.doi.org/10.1002/humu.21276DOI Listing
July 2010

The utility of genome-wide association studies in hepatology.

Hepatology 2010 May;51(5):1833-42

Medical Department, Oslo University Hospital, Norwegian Primary Sclerosing Cholangitis Research Center, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1002/hep.23564DOI Listing
May 2010

Genome-wide association studies--a summary for the clinical gastroenterologist.

World J Gastroenterol 2009 Nov;15(43):5377-96

Medical Department, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778094PMC
http://dx.doi.org/10.3748/wjg.15.5377DOI Listing
November 2009

Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms.

Hepatology 2008 Jan;47(1):90-6

Medical Department, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.

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http://dx.doi.org/10.1002/hep.21964DOI Listing
January 2008

Liver TX for hepatitis C cirrhosis in a low prevalence population: risk factors and status at evaluation.

Scand J Gastroenterol 2006 May;41(5):592-6

Section of Gastroenterology and Hepatology, Department of Medicine, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1080/00365520500347113DOI Listing
May 2006