Publications by authors named "Esmaeil Salimi"

4 Publications

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Development of bioactive sodium alginate/sulfonated polyether ether ketone/hydroxyapatite nanocomposites: Synthesis and in-vitro studies.

Authors:
Esmaeil Salimi

Carbohydr Polym 2021 Sep 23;267:118236. Epub 2021 May 23.

Faculty of Chemical and Materials Engineering, Shahrood University of Technology, P. O. Box: 3619995161, Shahrood, Iran. Electronic address:

Developing bioactive composites to fill bone cavities caused by disease, injury or surgery still remains a challenge. The aim of this research was to develop a new nanostructured sodium alginate/sulfonated polyether ether ketone/nano-hydroxyapatite (Alg/SPEEK/HA) biocomposite via a simple chemical precipitation strategy. Structural analysis was carried out using X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FTIR). Thermogravimetric analysis (TGA) was used to compare the HA content of the composites. The in-vitro bioactivity of the composites with different content of HA was investigated by immersing the specimens in the simulated body fluid (SBF) for 15 days. The presence of HA in the composite structure gave rise to the precipitation of an apatite layer on the surface, which was increased by increase in the content of HA. The formation of the HA layer on the composite surface was scrutinized via FESEM and EDX analysis. Transmission electron microscopy (TEM) images exhibited the presence of HA nanoparticles with less than 30 nm in size. The in-vitro cytotoxicity evaluation was also carried out using MG-63 cells via the MTT assay, which revealed that the cytocompatibility of all specimens was increased with raising the HA content. However, the higher concentration (100 μg/ml) of the composites displayed some toxicity against MG-63 cells. These findings, therefore, proposed that the achieved novel nanocomposites could be regarded as promising materials to serve as bone filler.
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http://dx.doi.org/10.1016/j.carbpol.2021.118236DOI Listing
September 2021

Preparation and in-vitro evaluation of β-CD/HA nanocomposite as a potential carrier for hydrophobic drugs.

J Biomater Appl 2021 Aug 25;36(2):246-251. Epub 2021 Apr 25.

Faculty of chemical and materials engineering, Shahrood University of Technology, Shahrood, Islamic Republic of Iran.

This study aimed to provide a new drug delivery system for hydrophobic compounds. Dexamethasone (DEX) was employed as a hydrophobic model drug, which incorporated into the network of hydroxyapatite (HA)/Cyclodextrin (β-CD) nanocomposite. Phase analysis, chemical bonding, morphology, and drug release was evaluated using XRD, FTIR, FESEM, and UV-vis spectroscopy, respectively. XRD patterns showed the formation of the crystalline structure and FTIR analysis showed the chemical bonding between organic and inorganic phases. FESEM images accompanied by EDX analysis confirmed the presence of HA nano-flakes. Release of DEX loaded β-CD/HA was measured to be around 4.6% and 18.7% in pH5.3 and pH 7.4, respectively. In conclusion, the prepared system could be a potential pH sensitive carrier for sustainable release of water-insoluble drugs.
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http://dx.doi.org/10.1177/08853282211012289DOI Listing
August 2021

Self-emulsifying drug delivery systems changing their zeta potential via a flip-flop mechanism.

Int J Pharm 2018 Oct 24;550(1-2):200-206. Epub 2018 Aug 24.

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria. Electronic address:

To overcome the mucus layer and cell membrane barrier, self-emulsifying drug delivery systems (SEDDS) exhibiting negative zeta potential, switching to positive values when having reached the cell membrane is a promising approach. Accordingly, a novel conjugate was synthesized by covalent attachment of phosphotyrosine to octadecylamine, which was incorporated into SEDDS. Generated system presented an average diameter of 32 nm and zeta potential of around -12 mV when being diluted 1:100 in 100 mM HEPES buffer pH 7.5 containing 5 mM MgCl and 0.2 mM ZnCl. Incubation of SEDDS with isolated intestinal alkaline phosphatase (IAP) resulting in enzymatic cleavage of phosphate ester moiety caused a shift in zeta potential up to +5.3 mV. As non-toxicity of the developed SEDDS diluted 1:1000 in 25 mM HEPES buffer pH 7.5 containing 5% glucose was observed on Caco-2 cells by employing resazurin assay, this system may provide an inspiring strategy for future zeta potential changing drug delivery systems to master the mucus and membrane barrier.
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http://dx.doi.org/10.1016/j.ijpharm.2018.08.046DOI Listing
October 2018

Anti-thrombogenicity and permeability of polyethersulfone hollow fiber membrane with sulfonated alginate toward blood purification.

Int J Biol Macromol 2018 Sep 30;116:364-377. Epub 2018 Apr 30.

Polymerization Engineering Department, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965/115, Tehran, Iran.

The main aim of this study was to evaluate the suitability of sulfonated alginate as a modifying agent to enhance the hemocompatibility of self-fabricated polyethersulfone (PES) hollow fiber membrane for blood detoxification. Sodium alginate was sulfonated with a degree of 0.6 and immobilized on the membrane via surface amination and using glutaraldehyde as cross-linking agent. Coating layer not only improved the membrane surface hydrophilicity, but also induced -39.2 mV negative charges on the surface. Water permeability of the modified membrane was enhanced from 67 to 95 L/m·h·bar and flux recovery ratio increased more than 2-fold. Furthermore, the modified membrane presented higher platelet adhesion resistance (reduced by more than 90%) and prolonged coagulation time (35 s for APTT and 14 s for PT) in comparison with the pristine PES hollow fiber membrane, which verified the improved anti-thrombogenicity of the modified membrane. On the other hand, obtained membrane after 3 h coating could remove up-to 60% of the uremic toxins. According to the obtained data, sulfonated alginate can be a promising modifying agent for the future blood-contacting membrane and specially blood purification issues.
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http://dx.doi.org/10.1016/j.ijbiomac.2018.04.137DOI Listing
September 2018
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