Publications by authors named "Esmaeil Idani"

30 Publications

  • Page 1 of 1

Comparison of high-flow oxygenation with noninvasive ventilation in COPD exacerbation: A crossover clinical trial.

Clin Respir J 2021 Apr 22;15(4):420-429. Epub 2020 Dec 22.

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: To compare the therapeutic effects of high-flow-oxygen-Therapy (HFT) and noninvasive-ventilation (NIV) for stabilizing chronic obstructive pulmonary disease during exacerbation.

Methods: In this randomized clinical trial at Masih-Daneshvari hospital, between July 2019 and Oct 2019, 30 exacerbated-COPD-patient with PaCO 64.58 ± 11.61 mm Hg, Respiratory Rate 24.43 ± 2.75, and PH 7.31 ± 0.02 were divided into two groups, N = 15. By a simple randomized allocation, patients receive either NIV or HFT for 1 hour, and following a washout period of 30 minutes, they switched to the other treatment option. Arterial Blood Gas Parameters, as well as Respiratory Rate (RR), Dyspnea Score, Heart Rate (HR), and Oxygen Saturation (SO ), were compared before and after the intervention and between groups.

Results: Baseline patient characteristics were similar in the two groups. Pre and post-analysis revealed that in both groups, all improved significantly. After the first period, there was no difference in all parameters between groups except for SO which was significantly higher in HFT (%92.1 ± 1) than that of NIV (%89 ± 1), P = .001. Likewise, following the washout period, patients in HFT and NIV had a dyspnea score of 1.93 ± 0.7 and 2.73 ± 0.9, respectively, P = .01. No carryover-effect and was observed but the period effect was significant for some outcomes. A significant improvement in SO and HR was observed by HFT according to treatment effect by combining two periods' results. During the study, no side effects were reported.

Conclusion: In this short-term study HFT appears feasible for patients with COPD exacerbation to reduce dyspnea score and improve respiratory distress.
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http://dx.doi.org/10.1111/crj.13315DOI Listing
April 2021

Developing "Code of Ethics for Medical Professionals, Medical Council of Islamic Republic of Iran".

Arch Iran Med 2020 10 1;23(10):658-664. Epub 2020 Oct 1.

Immunology and Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: The medical profession has always been an inspiration for human societies throughout its diverse history. This position and historical authority in the field of ethics has had a different and higher status, in such a way that many of the norms of general ethics and professional ethics, especially principles, such as trust, confidentiality and respect for human dignity, have been developed by medical professionals. Developing guidelines of general and professional ethics is one of the inherent duties of the Medical Council of the Islamic Republic of Iran (IRIMC) as a professional organization. In this regard, the Supreme Council of IRIMC has approved the "Code of Ethics for Medical Professionals" and, in accordance with its legal authority, has annexed it to the disciplinary regulations of IRIMC.

Methods: A draft document, the result of extensive literature review, was discussed in 27 expert panel meetings and after receiving and endorsing the stakeholders' point of view, was approved by the IRIMC Supreme Council.

Results: The first edition of "Code of Ethics for Medical Professionals, Medical Council of Islamic Republic of Iran" was developed on July 6, 2017 by the Supreme Council of IRIMC. The guideline was set to take effect one year after its enactment. The first edition was revised and completed and final edition was adopted on August 9, 2018 by IRIMC in 13 chapters and 140 articles (original full text is available in the Supplementary file 1).

Conclusion: According to the approved decision by the Supreme Council of IRIMC on May 10, 2018, the final edition takes effect as of October 7, 2018.
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http://dx.doi.org/10.34172/aim.2020.83DOI Listing
October 2020

Effects of PM and NO on the 8-isoprostane and lung function indices of FVC and FEV in students of Ahvaz city, Iran.

Saudi J Biol Sci 2019 Mar 12;26(3):473-480. Epub 2016 Nov 12.

Department of Environmental Health Engineering, Health Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The aim of this study was to determine the correlation between PM and NO pollutants and oxidative stress marker (8-isoprostane) and lung function tests (FVC and FEV) in healthy children who were living and studying in three different areas of Ahvaz city including A: Naderi site with high traffic, A: Alavi Alley site with average traffic, and A: Ein 2 site with low traffic (a rural area on the suburb of Ahvaz). 30 students in the 12-13 year-old range were selected from each studied zone (1, 2 and 3 sites) during three months of year. Of each student, one sample was taken every two weeks to measure 8-isoprostane of exhaled breath condensate (EBC). Air pollution data were collected from three air quality monitoring stations. Also, the relationship between air pollution and 8-isoprostane as well as lung function tests were determined using generalized estimating equations (GEE). The mean concentration of PM and NO in A, A and A areas were 116, 92 and 45 (μg/m) also 77, 53 and 14 (ppb) respectively. Among all studied students, there was a significant correlation between the increase of mean concentration of PM and NO in 1-4 before sampling day, increased 8-isoprostane concentration and decreased FEV, while there was no significant correlation between them and decreased FVC. In A site, an increase in IQR (13 μg/m) PM and IQR (6.5 ppb) NO on 1-4 days before sampling was associated with 0.38 unit (95% CI: 0.11, 0.65) and 1.1 unit (95% CI: 0.85, 1.35) increase in 8-isoprostane concentration, also decreased 121 ml and 190 ml FEV, respectively. Results showed that the short-term exposure to traffic-related air pollution can decrease the values of lung function indices and increase the oxidative stress. It may adversely affect children's lungs.
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http://dx.doi.org/10.1016/j.sjbs.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408680PMC
March 2019

Prevalence of asthma and other allergic conditions in adults in Khuzestan, southwest Iran, 2018.

BMC Public Health 2019 Mar 13;19(1):303. Epub 2019 Mar 13.

Department of Epidemiology and Biostatistics, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Health information on the dimensions of asthma and allergic conditions in Khuzestan Province, as a major industrial and polluted area in Iran as and the Middle East, is inadequate. This study was performed to measure the prevalence of asthma and other allergic conditions in adults in Khuzestan Province.

Methods: This population-based cross-sectional study was carried out in 17 villages and 27 cities of Khuzestan Province during the years 2017-2018 on 20 to 65 year old respondents. Two-stage cluster sampling was used. The ECRHS (European Community Respiratory Health Survey) questionnaire was completed for individuals with additional questions regarding other allergic conditions.

Results: In the study, 5720 questionnaires were distributed of which 5708 were returned. The prevalence of current asthma was 8.5% and that of asthma-like symptoms was 19.0%. The most common symptoms of asthma were nocturnal cough (13.6%), chest tightness (12.3%) and wheezing (13.1%). The prevalence of allergic rhinitis (AR), eczema and airway hyperresponsiveness were 27.2, 10.7, and 38.7%, respectively. The prevalence of current asthma was strongly correlated with age, current location (city, village), and the smoking status of respondents (p < 0.05).

Conclusion: The prevalence of current asthma and asthma-like symptoms in Khuzestan Province is almost twice as high as in Iran. Given the high prevalence of symptoms of airway hyperresponsiveness in the entire province, it is necessary to take environmental measures to mitigate the emergence of new cases of asthma among the residents. In addition, surveillance studies are necessary to monitor the trends in the prevalence of asthma in this province.
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http://dx.doi.org/10.1186/s12889-019-6491-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417254PMC
March 2019

Forced Expiratory Flow at 25-75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms.

Tanaffos 2018 Feb;17(2):90-95

Air pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: The aim of the present study was threefold: to assess the association between baseline FEF and Airway Hyper-responsiveness (AHR), to specify whether a decrease in FEF may reflect severe hyper-responsiveness, and finally to confirm a FEF cut-off value.

Materials And Methods: In a cross sectional study in Imam Khomeini Hospital, Ahvaz, patients suffering from respiratory symptoms due the 2013 autumn rainfall with normal FEV1 and FEV1/FVC were evaluated by methacholine challenge test. Those with PD20<1000, 10002000 μg were classified as severe, moderate and mild AHR, respectively. Data were analyzed using Chi-square, Independent t-test, One-way ANOVA and Receiver Operating Characteristic (ROC) curve.

Results: Among the 234 patients, mean baseline FEF was 84.2±22.7% for 54 patients having a negative bronchial provocation test result and 70.9±19.2% for 179 patients with a positive bronchial provocation test result (P < 0.0001). No change was observed in the median PD20 among patients with a higher baseline FEF. ROC analysis showed that FEF could potentially be a predictor of AHR, but it could not confirm the cut-off value of FEF for these patients.

Conclusion: When asthma begins, AHR could be predicted by impaired FEF with normal FEV1 and FEV1/FVC. However, we could not determine a cut-off value, and no association was found between a greater impairment of FEF and a more severe AHR.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320556PMC
February 2018

Short-term effects of air pollution on respiratory mortality in Ahvaz, Iran.

Med J Islam Repub Iran 2018 8;32:30. Epub 2018 Apr 8.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Urban air pollutants may affect respiratory mortality. This study was conducted to investigate this effect in Ahvaz, one of the most polluted cities in the world. The impact of 7 major air pollutants including O3, PM10, NO2, CO, and SO2 were evaluated on respiratory mortality in different gender and age groups using a quasi-Poisson, second degree polynomial constrained, distributed lag model, with single and cumulative lag structures adjusted by trend, seasonality, temperature, relative humidity, weekdays, and holiday. Data were analyzed using the dlnm package in R x64 3.2.5 software. Significance level was set at less than 0.05. In adjusted models, for each IQR increase of O3 in the total population, the risk ratio (RR) for respiratory deaths in 0 to 14- day lags was, respectively, 1.009 (95% CI:1.001-1.016) and 1.009 (95% CI:1.002-1.017), and it was 1.021 (95% CI: 1.002-1.040) in cumulative 0 to 14- day lags. For PM10, in the total population and in adjusted models after 0 to 14- day lags and in cumulative lags of 0 to 14 for an IQR increase in the mean concentration of PM10, the RR for respiratory deaths increased significantly and was, respectively, 1.027 (95% CI:1.002-1.051), 1.029 (95% CI:1.006-1.052), and 1.065 (95% CI:1.005-1.128). NO2 showed a significant association with respiratory deaths only in the 18 to 60 year- old age group and in 9- day lags (RR= 1.318, 95% CI:1.002-1.733). Finally, the results showed that for an IQR increase in the mean concentration of CO and SO2, the adjusted RR for respiratory deaths in 9- day lags in the total population was, respectively, RR= 1.058 (95% CI:1.008-1.111) and 1.126 (95% CI:1.034-1.220). Air pollution in Ahvaz is probably causing increased respiratory mortality.
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http://dx.doi.org/10.14196/mjiri.32.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108243PMC
April 2018

Answers to the comments on "Air pollution, biological marker and lung function in children".

Environ Sci Pollut Res Int 2018 09 9;25(27):27669-27671. Epub 2018 Aug 9.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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http://dx.doi.org/10.1007/s11356-018-2905-2DOI Listing
September 2018

Association of esophageal dilatation in chest CT scan with gastroesophageal reflux disease: A case control study.

Monaldi Arch Chest Dis 2018 Jul 2;88(2):914. Epub 2018 Jul 2.

Ahvaz Jundishapur University of Medical Sciences, Alimentary Tract Research Center.

The presence of increased air bubble in the lumina of esophagus on a chest CT scan may be associated with esophageal disorders. The purpose of this study was to determine the association between the appearance of air bubbles on chest CT scan and gastroesophageal Reflux Disease (GERD). In this case-control study, thirty-two patients with endoscopically proved GERD and 32 subjects without GERD underwent chest computed tomography (CT) scanning. Esophageal dilatation (ED) was defined as the presence of air bubbles greater than 10 mm in the supra ventricle (SV) and ventricle (CV), and air bubbles >15 mm in the ventricle to the lower esophageal sphincter (V-LES). The results were compared between the two groups. The GERD patients included 16 (50%) males with a mean age of 58.5±11.2 years and the control group included 17 (54.8%) males and 14 (45.1%) females with a mean age of 66.7±10.5 years. There was a significant relationship between the presence of GERD and esophageal dilation (ED) in the V-LES sections on the CT scan (P=0.002). The mean size of the air bubbles in the V-LES section was 11.73 mm in the case group in comparison to 4.32 mm in the control group (P<0.001).  The size and location of the air bubbles in the esophagus can vary and be important. The possibility of GERD increases in the presence of esophageal dilation on CT scan.
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http://dx.doi.org/10.4081/monaldi.2018.914DOI Listing
July 2018

Association between cancer risk and polycyclic aromatic hydrocarbons' exposure in the ambient air of Ahvaz, southwest of Iran.

Int J Biometeorol 2018 Aug 29;62(8):1461-1470. Epub 2018 Jun 29.

Rehabilitation Management, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.

Nowadays, a large number of health endpoints such as disease rates, treatment costs, and death, by air pollutants, have been a serious health problem for humans. One of the most hazardous air pollutants, which is highly dangerous for human health, is polycyclic aromatic hydrocarbons (PAHs). The existence of the emission of industries' pollutants and seasonal variations are the primary agents affecting PAHs' concentration. The purposes of this study were to calculate the cancer risk and measure PAHs' exposure in the ambient air of Ahvaz, southwest of Iran, during 2017. Three distinct areas ((S1) industrial, (S2) high traffic, and (S3) residential) of Ahvaz metropolitan were selected. Omni sampler equipped with polytetrafluoroethylene (PTFE) filters were used for active sampling of PAHs. To detect the level of PAHs, gas chromatography with mass spectrometry (GC/MS) was used. Incremental lifetime cancer risk (ILCR) and lifetime average daily dose (LADD) were used to estimate the health risk caused by PAHs. The results showed that the residential and industrial areas had the lowest and highest level of PAHs. Moreover, the average levels of PAHs in industrial, high traffic, and residential areas were 8.44 ± 3.37, 7.11 ± 2.64, and 5.52 ± 1.63 ng m, respectively. Furthermore, ILCR in autumn and winter was higher than EPA standard, 0.06307 and 0.04718, respectively. In addition, ILCR in different areas was significantly higher than standard. Research findings imply that the levels of exposure to PAHs can increase ILCR and risk of health endpoint. The cancer risk attributed to PAHs should be further investigated from the perspective of the public health in metropolitans.
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http://dx.doi.org/10.1007/s00484-018-1543-1DOI Listing
August 2018

Lag time structure of cardiovascular deaths attributed to ambient air pollutants in Ahvaz, Iran, 2008-2015.

Int J Occup Med Environ Health 2018 Jul 15;31(4):459-473. Epub 2018 Mar 15.

Kerman University of Medical Sciences, Kerman, Iran (Physiology Research Center).

Objectives: There are few studies about the association between breathing polluted air and increased risk of cardiovascular diseases and cardiac death in the Middle East. This study aimed to investigate the relation between air pollutants and cardiovascular mortality (based on ICD-10) in Ahvaz.

Material And Methods: In this ecological study, the data about cardiovascular disease mortality and air pollutants from March 2008 until March 2015 was inquired from the Ahvaz City Authority and the Khuzestan Province Environmental Protection Agency. The quasi-Poisson, second degree polynomial constrained, distributed lag model; using single and cumulative lag structures, adjusted by trend, seasonality, temperature, relative humidity, weekdays and holidays was used for the data analysis purposes.

Results: Findings indicated a direct significant relation between an interquartile range (IQR) increase in ozone and cardiovascular deaths among men after 3 days' lag. There was also a significant relation between an IQR increase in particulate matter below 10 μm and cardiovascular deaths for all people, over 60 years old and under 18 years old after 3 and 13 days' lags. There was a significant relation between an IQR increase in nitrogen dioxide and carbon monoxide, and cardiovascular deaths in the case of under 18-year-olds (in the lag 11) and over 60-year-olds (in the lag 9), respectively. We finally found a significant association between an IQR increase in sulfur dioxide and cardiovascular deaths in the case of men, under 18-year-olds and from 18- to 60-year-olds in the lag 9, 0, and 11, respectively (p-values < 0.05).

Conclusions: It appears that air pollution is significantly associated with cardiovascular deaths in Ahvaz City. Int J Occup Med Environ Health 2018;31(4):459-473.
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http://dx.doi.org/10.13075/ijomeh.1896.01104DOI Listing
July 2018

Health risk assessment on human exposed to heavy metals in the ambient air PM in Ahvaz, southwest Iran.

Int J Biometeorol 2018 Jun 20;62(6):1075-1083. Epub 2018 Feb 20.

Department of Environmental Health Engineering, School of Public Health AND Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Heavy metals (HM) are one of the main components of urban air pollution. Today, megacities and industrial regions in southwest of Iran are frequently suffering from severe haze episodes, which essentially caused by PM-bound heavy metals. The purpose of this study was to evaluate the health risk assessment on human exposed to heavy metals (Cr, Ni, Pb, and Zn) in the ambient air PM in Ahvaz, southwest Iran. In this study, we estimated healthy people from the following scenarios: (S3) residential site; (S2) high-traffic site; (S1) industrial site in Ahvaz metropolitan during autumn and winter. In the current study, high-volume air samplers equipped with quartz fiber filters were used to sampling and measurements of heavy metal concentration. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was utilized for detection of heavy metal concentration (ng m). Also, an estimate of the amount of health risk assessment (hazard index) of Cr, Ni, Pb, and Zn of heavy metal exposure to participants was used. Result of this study showed that the residential and industrial areas had the lowest and the highest level of heavy metal. Based on the result of this study, average levels of heavy metal in industrial, high-traffic, and residential areas in autumn and winter were 31.48, 30.89, and 23.21 μg m and 42.60, 37.70, and 40.07 μg m, respectively. Based on the result of this study, the highest and the lowest concentration of heavy metal had in the industrial and residential areas. Zn and Pb were the most abundant elements among the studied PM-bound heavy metals, followed by Cr and Ni. The carcinogenic risks of Cr, Pb, and the integral HQ of metals in PM for children and adults via inhalation and dermal exposures exceeded 1 × 10 in three areas. Also, based on the result of this study, the values of hazard index (HI) of HM exposure in different areas were significantly higher than standard. The health risks attributed to HM should be further investigated from the perspective of the public health in metropolitans. The result of this study showed increasing exposure concentrations to heavy metal in the studied scenarios have a significant potential for generating different health endpoints, while environmental health management in ambient air can cause disorders in citizenship and causing more spiritual and material costs.
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http://dx.doi.org/10.1007/s00484-018-1510-xDOI Listing
June 2018

Acute effects of air pollution on spontaneous abortion, premature delivery, and stillbirth in Ahvaz, Iran: a time-series study.

Environ Sci Pollut Res Int 2018 Feb 6;25(6):5447-5458. Epub 2017 Dec 6.

Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Living in areas with high air pollution may have adverse effects on human health. There are few studies about the association between breathing polluted air and adverse pregnancy outcomes in the Middle East. The aim of this study was to determine the relationship between air pollution and spontaneous abortion, premature birth, and stillbirth in Ahvaz. A time-series study was conducted. Data about spontaneous abortion, premature deliveries, and stillbirth was collected from Ahvaz Imam Khomeini Hospital. Air pollution data including NO, CO, NO, PM, SO, O, and climate data were, respectively, collected from the Environmental Protection Agency and the Khuzestan Province Meteorology Office from March 2008 until March 2015. The relationship between air pollutants with the number of abortions, premature births, and stillbirths was found using a quasi-Poisson distributed lag model, adjusted by trend, seasonality, temperature, relative humidity, weekdays, and holidays. The average daily dust in Ahvaz on 7.2% days of the year was higher than 500 μg/m (very dangerous). Findings from this study indicate a significant association between each 10-unit increase in SO and spontaneous abortion in lag 0 and 9 days. There was a significant relation between each 10-unit increase in NO and CO, and premature birth in lag 0. Also, we found a significant association between each 10-unit increase in CO and premature delivery in lag 1; PM and premature delivery in lags 10, 11, and 12; and NO and premature delivery in lags 3, 4, 10, 11, 12, and 13 (p value < 0.05). Contact with polluted air during pregnancy may increase adverse pregnancy outcomes and stillbirth. Pregnant women should avoid polluted air.
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http://dx.doi.org/10.1007/s11356-017-0692-9DOI Listing
February 2018

Comparison of normal and dusty day impacts on fractional exhaled nitric oxide and lung function in healthy children in Ahvaz, Iran.

Environ Sci Pollut Res Int 2017 May 29;24(13):12360-12371. Epub 2017 Mar 29.

Master of Environmental Engineering, School of Science Water Engineering, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Children are the vulnerable group at risk of adverse health effects related to air pollution due to dust storm in Ahvaz. The purpose of this study was to compare the values of fractional exhaled nitric oxide (FENO) and lung functions as parameters of adverse health effects of particulate matter (PM) in dusty and normal (non-dusty) days in elementary schoolchildren. The study was conducted among elementary school students in Ahvaz. The healthy elementary schoolchildren (N = 105) were selected from different districts for FENO and lung function sampling during the dusty and normal days. The values of PM and PM during dusty days were higher than during normal days. Mean values of FENO during the normal and dusty days were 14.23 and 20.3 ppb, respectively, and the difference between these values was statistically significant (p < 0.05). Lung function results showed a statistically significant difference between the mean values of forced vital capacity during the dusty and normal days (p < 0.05). The results revealed a significant difference both in the values of inflammatory biomarker and in the lung function tests in dusty and normal days. Based on our results, fractional exhaled nitric oxide could be a useful short-term biomarker of particulate pollution effect coupled with spirometry.
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http://dx.doi.org/10.1007/s11356-017-8853-4DOI Listing
May 2017

Relationship Between Air Pollution, Weather, Traffic, and Traffic-Related Mortality.

Trauma Mon 2016 Sep 22;21(4):e37585. Epub 2016 Aug 22.

Modeling in Health Research Center, Institute for Futures Studies in Health, Department of Biostatistics and Epidemiology, Faculty of Health Kerman Univesity of Medical Sciences Kerman, IR Iran.

Background: Air pollution and weather are just two of many environmental factors contributing to traffic accidents (RTA).

Objectives: This study assessed the effects of these factors on traffic accidents and related mortalities in Ahvaz, Iran.

Methods: In this ecological study, data about RTA, traffic-related mortalities, air pollution (including NO, CO, NO, NO PM, SO, and O rates) and climate data from March 2008 until March 2015 was acquired from the Khuzestan State Police Force, the Environmental Protection Agency and the State Meteorological Department. Statistical analysis was performed with STATA 12 through both crude and adjusted negative binomial regression methods.

Results: There was a significant positive correlation between increase in the monthly average temperature, the number of rainy days, and the number of frost days with the number of RTA (P < 0.05). Increased monthly average relative humidity, evaporation, and number of sunny days were negatively correlated with the frequency of RTA (P < 0.05). We also observed an inverse significant correlation between monthly average relative humidity, evaporation, and wind speed with traffic accident mortality (P < 0.05). Some air pollutants were negatively associated with the incidence rate of RTA.

Conclusions: It appears that some weather variables were significantly associated with increased RTA. However, increased levels of air pollutants were not associated with increased rates of RTA and/or related mortalities. Additional studies are recommended to explore this topic in more detail.
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http://dx.doi.org/10.5812/traumamon.37585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282930PMC
September 2016

An evaluation of hospital admission respiratory disease attributed to sulfur dioxide ambient concentration in Ahvaz from 2011 through 2013.

Environ Sci Pollut Res Int 2016 Nov 18;23(21):22001-22007. Epub 2016 Aug 18.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

There is no doubt that air pollutants have adverse impacts on human health. The main objective of this study was to evaluate hospital admission respiratory disease (HARD) attributed to sulfur dioxide levels in Ahvaz during three successive years. Data was taken from Iranian Environmental Protection Agency (EPA). The AirQ2,2,3 model is used to quantify the impact of SO on inhabitants of Ahvaz and in terms of hospital admission respiratory diseases. This is a kind of statistical model which is based on some epidemiological indices such as relative risk, baseline incidence, and attributable proportion. Sampling was already performed for 24 h in four stations during 2011-2013. Four stations are good representative for residential, high traffic, industry, and background sites which cover the whole area of the Ahvaz city. Regarding to gravimetric scale, raw data of sulfur dioxide was processed using Excel software. Encoding, filtering, and processing were conducted to prepare input file for the Air Q model. After running model, outputs presented in term of hospital admissions respiratory cases. Based on our result, the highest mean and maximum of seasonal and annual levels for sulfur dioxide were observed in 2013. We concluded that obnoxious quality of fuel and some deficiencies in maintenance and operation of industries lead to worse quality of ambient air especially in 2013. Cumulative cases of HARD attributed to sulfur dioxide level at central of relative risk (RR) were estimated 24, 25, and 30 persons for 2011, 2012, and 2013, respectively. The finding of this study showed that total mean of sulfur dioxide was higher than standard concentration. We also noticed that wintertime concentrations of sulfur dioxide during three successive years were higher than of those levels in summer.
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http://dx.doi.org/10.1007/s11356-016-7447-xDOI Listing
November 2016

The prevalence of Pneumocystis jirovecii among patients with different chronic pulmonary disorders in Ahvaz, Iran.

Iran J Microbiol 2015 Dec;7(6):333-7

Department of Internal Medicine, Division of Pulmonology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Objectives: Pneumocystis jirovecii pneumonia (PJP) is a chronic fungal infection that caused by P. jirovecii. Disease is more prevalent among the HIV-infected patients. The colonization of pneumocystis in human respiratory system is associated with the airway inflammation and obstruction. The current study was conducted to identify the prevalence of P. jirovecii among the patients with chronic pulmonary disorders in Ahvaz, Iran.

Materials And Methods: In the present study, 115 bronchoalveolar lavage (BAL) specimens were collected from patients. Samples were subjected to Nested-PCR with specific primers. The second PCR products were used for sequencing analysis.

Results: Our findings demonstrated that 31(27.0%) of samples were positive for P. jirovecii. Nine patients (29%) have tuberculosis (TB) followed by, 1(3.2%) HIV positive and 21(67.7%) miscellaneous pulmonary disorders. Our results show that there was no significant differences between sex (male:female ratio, 17:14), TB, HIV and P. jirovecii in BAL samples (P>0.05).

Conclusion: The current study is the first report from Ahvaz and it showed a relatively high frequency (27%) of P. jirovecii among patients with different pulmonary disorders. In addition Nested-PCR might be reliable technique for diagnosis of P. jirovecii, while the Grocott's methenamine silver (GMS) have a low sensitivity, which only two positive patients were identified.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752688PMC
December 2015

Chemical composition of PM10 and its in vitro toxicological impacts on lung cells during the Middle Eastern Dust (MED) storms in Ahvaz, Iran.

Environ Pollut 2016 Apr 15;211:316-24. Epub 2016 Jan 15.

Environmental Technologies Research Center (ETRC), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Environmental Health Engineering, Health Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Reports on the effects of PM10 from dust storm on lung cells are limited. The main purpose of this study was to investigate the chemical composition and in vitro toxicological impacts of PM10 suspensions, its water-soluble fraction, and the solvent-extractable organics extracted from Middle Eastern Dust storms on the human lung epithelial cell (A549). Samples of dust storms and normal days (PM10 < 200 μg m(-3)) were collected from December 2012 until June 2013 in Ahvaz, the capital of Khuzestan Province in Iran. The chemical composition and cytotoxicity were analyzed by ICP- OES and Lactase Dehydrogenase (LDH) reduction assay, respectively. The results showed that PM10 suspensions, their water-soluble fraction and solvent-extractable organics from both dust storm and normal days caused a decrease in the cell viability and an increase in LDH in supernatant in a dose-response manner. Although samples of normal days showed higher cytotoxicity than those of dust storm at the highest treated dosage, T Test showed no significant difference in cytotoxicity between normal days and dust event days (P value > 0.05). These results led to the conclusions that dust storm PM10 as well as normal day PM10 could lead to cytotoxicity, and the organic compounds (PAHs) and the insoluble particle-core might be the main contributors to cytotoxicity. Our results showed that cytotoxicity and the risk of PM10 to human lung may be more severe during dust storm than normal days due to inhalation of a higher mass concentration of airborne particles. Further research on PM dangerous fractions and the most responsible components to make cytotoxicity in exposed cells is recommended.
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http://dx.doi.org/10.1016/j.envpol.2016.01.006DOI Listing
April 2016

Oxygen therapy for corneal edema after cataract surgery.

J Cataract Refract Surg 2015 Jul 29;41(7):1370-5. Epub 2015 Jul 29.

From the Department of Ophthalmology (Sharifipour, Panahi-Bazaz, Hajizadeh), Department of Pulmonology (Idani), and Department of Biostatics and Epidemiology (Saki), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Purpose: To evaluate the effects of oxygen therapy on corneal edema after cataract surgery.

Setting: Imam Khomeini Hospital, Ahvaz, Iran.

Design: Randomized controlled trial.

Methods: Patients with severe corneal edema were randomized into 3 groups. Group 1 (control) received conventional therapy including topical sodium chloride, timolol, and betamethasone. Group 2 received the same therapy in addition to systemic normobaric oxygen at a flow rate of 10 L/min for 1 hour twice daily for 3 weeks. Group 3 received conventional therapy and transcorneal oxygen at a flow rate of 5 L/min for 1 hour twice daily for 3 weeks. Preoperative pachymetry and specular microscopy were performed. Pachymetry was performed 1, 3, 5, 7, 10, and 14 days postoperatively. At 1, 3 and 12 months, pachymetry and specular microscopy were performed.

Results: The study enrolled 45 patients. Preoperatively, there was no significant difference between the groups. Pachymetry was more than 1000 μm 1 day postoperatively in all patients. The preoperative pachymetry was restored in 14 days in Group 3 only. After 1 year, the endothelial cell count (ECC) was 1603 cells/mm(2), 1693 cells/mm(2), and 1911 cells/mm(2) with a loss of 37%, 32%, and 25% in Group 1, Group 2, and Group 3, respectively (P = .034, Groups 1 and 3). Group 3 had a higher ECC than the control group at 3 months (P = .037) and 1 year (P = .025). One patient in Group 1 and 1 patient in Group 2 developed bullous keratopathy.

Conclusion: Transcorneal oxygen decreased corneal edema more rapidly than conventional and systemic oxygen therapies and preserved more endothelial cells than conventional therapy.

Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.
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http://dx.doi.org/10.1016/j.jcrs.2014.10.033DOI Listing
July 2015

An overview of thunderstorm-associated asthma outbreak in southwest of Iran.

J Environ Public Health 2014 29;2014:504017. Epub 2014 Jun 29.

Department of Emergency Medicine, Imam Khomeini Hospital, Azadegan Avenue, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61936-73116, Ahvaz, Iran.

The aim of this study was to report the characteristics and treatment strategies of all patients with acute bronchospasm who were presented to the emergency departments of Ahvaz, Iran, following the occurrence of a thunderstorm on November 2, 2013. A total of 2000 patients presenting with asthma attacks triggered by thunderstorm were interviewed and an initial questionnaire was completed for each individual. After twenty days, patients were asked to complete a supplementary questionnaire, but only 800 of them accepted to do so. The majority of subjects was aged 20-40 years (60.5%) and had no history of asthma in most cases (60.0%). The symptoms had started outdoors for 60.0% of the participants. In most patients, the onset of the condition was on November 2. Short-acting β 2-agonist (salbutamol) and aminophylline were the most commonly prescribed medications in the emergency department. Upon the second interview, 85.3% of the patients were still symptomatic. Overall, 63.6% did not have a follow-up visit after hospital discharge, although all of them were referred to the specialist. The findings of the present study suggest that thunderstorm-associated asthma could affect young adults with no gender priority, with or without asthma history, which put a strain on emergency medical services.
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http://dx.doi.org/10.1155/2014/504017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100362PMC
March 2015

Children with asthma and their families' viewpoints on spiritual and psychological resources in adaptation with the disease.

J Relig Health 2014 Aug;53(4):1176-89

Faculty of Nursing and Midwifery, Nursing and Midwifery School, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran,

Recognition of the spiritual and psychological needs of children and their families with chronic asthma disease may be helpful in a successful coping with their problems in order to control over the condition. In a qualitative content analysis study, nine children with moderate to severe asthma and 10 parents were studied in order to discover the resources of compatibility of them. The participants were chosen purposefully and they were asked some semi-structure questions about their experiences. The spiritual and psychological experiences of the participants were divided into two main categories as follows: (1) contrive to religious-belief consisting of three sub-categories known as "religious rituals, believe in a divine predestination, and Islamic-based patience," and (2) psycho-intellectual management that includes the five sub-categories of "psycho-intellectual attention, maintaining family's mental peace, reduction in negative burden of disease, satisfaction from optimal treatment, and matching internal desires with disease conditions." It is recommended that heath care providers by reinforcing parent's and children's religious and spiritual backgrounds and according to child's cognitive development at this age provide a suitable foreground through necessary instructions for children and their families in order to spiritual growth and suitable adaptation with disease.
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http://dx.doi.org/10.1007/s10943-013-9782-2DOI Listing
August 2014

In response.

J Glaucoma 2013 Oct-Nov;22(8):e24-6

Departments of *Ophthalmology ‡Pulmonology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz †Ophthalmic Research Center Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences Tehran, Iran.

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http://dx.doi.org/10.1097/IJG.0b013e3182a4a029DOI Listing
May 2014

Oxygen Tension in the Aqueous Humor of Human Eyes under Different Oxygenation Conditions.

J Ophthalmic Vis Res 2013 Apr;8(2):119-25

Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Purpose: To measure oxygen tension in the aqueous humor of human eyes under different oxygenation conditions.

Methods: This prospective comparative interventional case series consisted of two parts. In the first part, 120 consecutive patients scheduled for cataract surgery were randomized into group I (control group) in which surgery was performed under local anesthesia inhaling 21% oxygen; group II in whom general anesthesia using 50% oxygen was employed; and group III receiving general anesthesia with 100% oxygen. After aspirating 0.2 ml aqueous humor under sterile conditions, the aqueous sample and a simultaneously drawn arterial blood sample were immediately analyzed using a blood gas analyzer. In part II the same procedures were performed in 10 patients after fitting a contact lens and patching the eye for 20 minutes (group IV) and in 10 patients after transcorneal delivery of oxygen at a flow rate of 5 L/min (group V).

Results: Mean aqueous PO2 in groups I, II and III was 112.3±6.2, 141.1±20.4, and 170.1±27 mmHg, respectively (P values <0.001) and mean arterial PO2 was 85.7±7.9, 184.6±46, and379.1±75.9 mmHg, respectively (P values <0.001). Aqueous PO2 was 77.2±9.2 mmHg in group IV and 152.3±10.9 mmHg in group V (P values <0.001). There was a significant correlation between aqueous and blood PO2 (r=0.537, P<0.001). The contribution of atmospheric oxygen to aqueous PO2 was 23.7%.

Conclusion: Aqueous oxygen tension is mostly dependent on the systemic circulation and in part on the atmosphere. Increasing inspiratory oxygen and transcorneal oxygen delivery both increase aqueous PO2 levels.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740463PMC
April 2013

Remission of childhood asthma after entering the second decade of life: a hospital based cohort.

Iran J Allergy Asthma Immunol 2013 May 15;12(2):124-8. Epub 2013 May 15.

Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Asthma is the most common chronic disease in children. The natural history of asthma is often characterized by periods of remission and relapse. The aim of this study was to determine the remission rate of asthmatic children after entering the second decade of life and remission related factors in a hospital-based cohort.The study population was asthmatic children who were diagnosed, registered and followed up in outpatient pediatric clinic of a university hospital in Ahvaz, Iran. Remission was assessed in the age of 11 to 15 years-old if ≥ 5 years passed from the time of diagnosis. Clinical remission was defined as the absence of asthma symptoms for at least one year without the use of inhaled corticosteroids and short acting β2 agonists.In the cases with clinical remission, spirometry and exercise tests were conducted to document complete remission. The study included 197 adolescents (mean age of 13.1±1.9 years). Clinical remissions were found in 71 cases (%36) but according to spirometry criteria, 65 children (33%) were in complete remission. There was no significant difference between the genders. The remission rate was positively correlated with age of onset, and inversely correlated with family history of asthma, atopic dermatitis, hospitalization due to asthma, passive smoking and the need to use long-term inhaled corticosteroid.Based on this study, approximately one third of asthmatic children showed remission up to 15 years of age which is a moderate rate compared to other studies.
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May 2013

Normobaric oxygen therapy for scleral ischemia or melt.

J Ophthalmic Vis Res 2012 Oct;7(4):275-80

Department of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Purpose: To investigate the efficacy of normobaric oxygen (NBO) therapy for treatment of scleral ischemia or melt.

Methods: This prospective interventional case series includes 9 eyes of 8 patients with scleral ischemia or melt of diverse etiologies. Following the failure of conventional medical and/or surgical therapy to improve ischemia or upon clinical deterioration, NBO was initiated. All patients received 100% NBO at flow rate of 10 liters/minute by face mask for 1 hour, twice daily until complete vascularization of ischemic areas. Main outcome measures were improvement of scleral ischemia and healing of conjunctival epithelial defects.

Results: NBO therapy led to epithelialization and vascularization of the ischemic sclera in all eyes; the repair process began 3-4 days after NBO had been initiated and was completed in 18.1±4.7 (range, 10-25) days. All patients remained stable over a 9-month follow-up period.

Conclusion: NBO therapy seems effective for treatment of scleral ischemia or melt, and hence can be considered as a non-invasive alternative to surgical intervention in these conditions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595579PMC
October 2012

Clinical, high resolution computed tomography and pulmonary function in sulphur mustard victims.

Acta Med Iran 2012 ;50(9):603-8

Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.

We aimed to evaluate clinical, high resolution computed tomography (HRCT) and pulmonary function test (PFT) findings after 18-23 years of exposure in veterans of sulphur mustard (SM) exposure. We performed a cross-sectional study of 106 patients. Inclusion criteria were 1: documented exposure to SM as confirmed by toxicological analysis of their urine and vesicular fluid after exposure 2: single exposure to SM that cause skin blisters and subsequent transient or permanent sequel. Cigarette smoking and pre-exposure lung diseases were of exclusion criteria. After taking history and thorough respiratory examination, patients underwent high resolution computed tomography and spirometry. Clinical diagnoses were made considering the findings. More than 85% of the patients were complaining of dyspnea and cough. Obstructive pattern (56.6%) was main finding in spirometry followed by restrictive and normal patterns. HRCT revealed air trapping (65.09%) and mosaic parenchymal attenuation patterns (58.49%) as most common results. Established diagnoses mainly were chronic obstructive pulmonary disease (COPD) (54.71%), bronchiolitis obliterans (27.35%) and asthmatic bronchitis (8.49%). There were not any significant association between the clinical findings and results of PFT and HRCT imaging and also between PFT and HRCT findings (P-values were more than 0.05). Considering debilitating and progressive nature of the respiratory complications of SM exposure, attempts are needed for appropriate diagnosis and treatment.
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April 2013

Aqueous oxygen tension in glaucomatous and nonglaucomatous eyes.

J Glaucoma 2013 Oct-Nov;22(8):608-13

Departments of *Ophthalmology ‡Pulmonology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz †Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical, Sciences, Tehran, Iran.

Purpose: To compare aqueous oxygen tension in eyes with primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), and neovascular glaucoma (NVG), with normal eyes with senile cataracts.

Patients And Methods: This study included 82 eyes of 82 patients with POAG (22 eyes), PXG (20 eyes), NVG (18 eyes), and cataracts (22 eyes). Before initiating surgery and while breathing room air, 0.2 mL of aqueous humor and 1 mL of arterial blood were aspirated in heparinized syringes under sterile conditions. Partial pressures of oxygen (PO2), carbon dioxide (PCO2), and pH of the samples were measured using a blood-gas analyzer.

Results: Overall, aqueous PO2 was comparable among the study groups (P=0.202). After repeating the analysis in eyes with controlled and high intraocular pressure (IOP), a significant difference was observed in POAG eyes with high IOP (post-hoc test, P=0.046). Overall, a significant negative correlation (r=-0.184, P=0.045) was observed between IOP and aqueous PO2. The strongest correlation was observed in the POAG group (r=-0.507, P=0.016). Aqueous PO2 was higher than arterial PO2 in all study groups except POAG eyes, significantly so in the cataract and PXG groups (P=0.013 and P<0.001, respectively), implying a contribution of atmospheric oxygen to aqueous PO2. This contribution was lower in POAG eyes but the difference failed to reach statistical significance (P=0.262).

Conclusions: Aqueous oxygen tension was lower in POAG eyes with high IOP. A significant negative correlation was observed between IOP and aqueous PO2. Aqueous PO2 was higher than arterial PO2 suggesting a contribution by atmospheric oxygen.
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http://dx.doi.org/10.1097/IJG.0b013e318255bc62DOI Listing
May 2014

Histologic evaluation of normobaric oxygen therapy safety in an animal model.

Jundishapur J Nat Pharm Prod 2012 25;7(3):97-9. Epub 2012 Aug 25.

Department of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.

Background: Oxygen therapy, as a therapeutic modality, can be used for long periods of times. However, it may be accompanied by potential complications and side effects.

Objectives: To evaluate the side effects of normobaric oxygen therapy in rabbits.

Materials And Methods: In a double-blind experiment, 28 white New Zealand rabbits were randomized into an oxygen treatment group (n = 14) and a control group (n = 14). The oxygen treatment group received 100% oxygen at a flow rate of 5 L/min for 1 h daily, for 1 month. The animals were euthanized at the end of the study, and following autopsy a histological evaluation was carried out to detect levels of oxygen toxicity in their; lungs, liver, brain, heart, kidney, eyes and spleen.

Results: Histological evaluation revealed no evidence of toxicity in the examined tissues, compared with the control group.

Conclusions: Oxygen therapy at a flow rate of 5 L/min for 1 h daily for 1 month had no systemic toxicity and it appears to be safe in rabbits.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941851PMC
March 2014

Oxygen therapy for acute ocular chemical or thermal burns: a pilot study.

Am J Ophthalmol 2011 May 18;151(5):823-8. Epub 2011 Feb 18.

Department of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Purpose: To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns.

Design: Prospective, nonrandomized, comparative, interventional case series.

Methods: Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns received conventional medical therapy. The oxygen therapy group (13 eyes) additionally received 100% oxygen using a simple mask at a flow rate of 10 L/minute for 1 hour twice daily. Main outcome measures were time for healing of the corneal epithelial defect and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency and vascularization, and complications.

Results: Corneal epithelial defects healed within 15.23 ± 3.94 days (range, 10 to 21 days) in the oxygen group versus 59.9 ± 23.33 days (range, 28 to 95 days) in controls (P < .001). Vascularization of ischemic areas was complete in 14.54 ± 2.70 days (range, 10 to 21 days) in the oxygen group versus 45.09 ± 22.20 days (range, 25 to 105 days) in controls (P = .001). In the oxygen group, the cornea was more transparent and less vascularized 3 and 6 months after injury. Mean final visual acuity (logarithm of the minimal angle of resolution) was 0.40 ± 0.52 (range, 0 to 1.3) versus 1.11 ± 0.83 (range, 0.1 to 3) in the oxygen and control groups, respectively (P = .018). In the oxygen group, symblepharon or corneoscleral melting did not develop in any patient; however, in the control group, symblepharon developed in 3 eyes and corneoscleral melting developed in 1 patient.

Conclusions: In the acute phase of ocular chemical or thermal burns, oxygen therapy improves limbal ischemia, accelerates epithelialization, increases corneal transparency, and decreases corneal vascularization. It also may improve visual acuity and reduce complications.
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http://dx.doi.org/10.1016/j.ajo.2010.11.005DOI Listing
May 2011

Oxygen therapy for diabetic macular ischemia: a pilot study.

Retina 2011 May;31(5):937-41

Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Purpose: To evaluate the structural and functional effects of systemic oxygen therapy in patients with diabetic macular ischemia.

Methods: This interventional case series was performed on 20 eyes from 13 consecutive diabetic patients with macular ischemia. For each patient, baseline optical coherence tomography and electroretinography were obtained before and after administration of 100% oxygen by face mask at a flow rate of 10 L/minute for 1 hour. Central macular thickness and b-wave amplitude were measured before and after oxygen therapy.

Results: The patients included 9 women and 4 men with mean (SD) age of 63.38 (7.34) years. Central macular thickness decreased from 358.55 ± 96.27 μm before to 326.55 ± 84.11 μm after the oxygen therapy (P < 0.001). A reduction of >10% was observed in 55% of the eyes. In dark-adapted combined response electroretinography, the amplitude of b-wave increased from 227.76 ± 105.66 μV before to 264.35 ± 128.48 μV after the oxygen therapy (P < 0.001), representing a 16% increase. More than a 10% increase in b-wave amplitude occurred in 60% of the eyes.

Conclusion: Oxygen therapy seems to have beneficial effects on the structural and functional changes of the retina in patients with diabetic macular ischemia. It may decrease central macular thickness and improve electrophysiologic function of the retina.
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http://dx.doi.org/10.1097/IAE.0b013e3181f57e4dDOI Listing
May 2011

Oxygen therapy for severe corneal alkali burn in rabbits.

Cornea 2007 Oct;26(9):1107-10

Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.

Purpose: To evaluate the efficacy of oxygen therapy in the treatment of severe corneal alkali injury in rabbits.

Methods: In a double-blind experiment, 28 white New Zealand rabbits were randomized into an oxygen treatment group (n = 14) and a control group (n = 14). Under general anesthesia, severe corneal alkali injuries were induced by application of 1 N sodium hydroxide to the right eye of each rabbit. The oxygen treatment group was treated with oxygen 100% at a flow of 5 L/min for 1 hour daily for 1 month. Daily photographs were taken of the rabbits' eyes, and the sizes of the epithelial defect in the 2 groups were compared. The principal endpoint was descemetocele and perforation of the cornea. The animals were euthanized at the end of the study or earlier if corneal perforation had occurred, and the corneas were excised and fixed in 10% neutral-buffered formalin for histologic examination.

Results: Experimentally induced severe eye burns gave similar opacity of the cornea in both groups. Three eyes in the oxygen group and 9 eyes in the control group developed descemetocele and perforation (P = 0.022). Mean time to beginning of ulceration was 13.45 days in the control group and 18.11 days in the oxygen treatment group (P = 0.032). There was no other significant difference between the 2 groups.

Conclusions: Oxygen therapy at a flow of 5 L/min for 1 hour daily reduces the possibility of corneal perforation in rabbits and may delay ulceration of the cornea compared with the control group.
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http://dx.doi.org/10.1097/ICO.0b013e31813349d2DOI Listing
October 2007