Erwin G Van Meir

Erwin G Van Meir

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Erwin G Van Meir

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Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.

Oncogene 2019 Nov 1. Epub 2019 Nov 1.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41388-019-1067-0DOI Listing
November 2019

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.

Oncogene 2019 Oct 3. Epub 2019 Oct 3.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41388-019-1036-7DOI Listing
October 2019

A simple genotyping method to detect small CRISPR-Cas9 induced indels by agarose gel electrophoresis.

Sci Rep 2019 Mar 14;9(1):4437. Epub 2019 Mar 14.

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery and Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41598-019-39950-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418129PMC
March 2019

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.

Cancer Cell 2018 06;33(6):1004-1016.e5

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University, 1365C Clifton Road N.E, C5078, Atlanta, GA 30322, USA; Department of Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183022
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http://dx.doi.org/10.1016/j.ccell.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002773PMC
June 2018

Taking a HIF pill for old age diseases?

Aging (Albany NY) 2018 03;10(3):290-292

Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.18632/aging.101395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892688PMC
March 2018

Two new species of betatorqueviruses identified in a human melanoma that metastasized to the brain.

Oncotarget 2017 Dec 11;8(62):105800-105808. Epub 2017 Nov 11.

Departments of Neurosurgery and Hematology & Medical Oncology, Winship Cancer Institute and School of Medicine, Emory University, Atlanta, Georgia, USA.

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http://www.oncotarget.com/fulltext/22400
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http://dx.doi.org/10.18632/oncotarget.22400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739680PMC
December 2017

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis.

Oncotarget 2017 Nov 29;8(59):99245-99260. Epub 2017 Oct 29.

Department of Pharmaceutics and Drug Delivery, University of Mississippi, Oxford, MS, USA.

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http://dx.doi.org/10.18632/oncotarget.22104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725089PMC
November 2017

Purifying Properly Folded Cysteine-rich, Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example.

Bio Protoc 2017 Sep;7(17)

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery and Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, USA.

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http://dx.doi.org/10.21769/BioProtoc.2537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621770PMC
September 2017

Cancer therapy: Neutrophils traffic in cancer nanodrugs.

Nat Nanotechnol 2017 07 19;12(7):616-618. Epub 2017 Jun 19.

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery and Hematology &Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, 1365C Clifton Rd. N.E., C5078, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nnano.2017.82DOI Listing
July 2017

Adhesion GPCRs in Tumorigenesis.

Handb Exp Pharmacol 2016 ;234:369-396

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1007/978-3-319-41523-9_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389670PMC
June 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Overcoming therapeutic resistance in glioblastoma: the way forward.

J Clin Invest 2017 Feb 1;127(2):415-426. Epub 2017 Feb 1.

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http://dx.doi.org/10.1172/JCI89587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272196PMC
February 2017

A role for activated Cdc42 in glioblastoma multiforme invasion.

Oncotarget 2016 08;7(35):56958-56975

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, M5G 0A4, Canada.

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http://dx.doi.org/10.18632/oncotarget.10925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302965PMC
August 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
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http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

BAI1: from cancer to neurological disease.

Oncotarget 2016 Apr;7(14):17288-9

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery and Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.18632/oncotarget.8193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951211PMC
April 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.

Genome Res 2015 Mar 3;25(3):316-27. Epub 2015 Feb 3.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;

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http://dx.doi.org/10.1101/gr.180612.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352879PMC
March 2015

Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma.

Cancer Res 2014 Aug 19;74(16):4536-48. Epub 2014 Jun 19.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia. Department of Biomedical Informatics, Emory University, Atlanta, Georgia. Winship Cancer Institute, Emory University, Atlanta, Georgia.

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http://cancerres.aacrjournals.org/content/74/16/4536.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-3703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134737PMC
August 2014

P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway.

Cancer Res 2014 Mar 7;74(5):1371-8. Epub 2014 Jan 7.

Authors' Affiliations: Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery; Departments of Pathology and Laboratory Medicine and Hematology and Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947444PMC
March 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

The somatic genomic landscape of glioblastoma.

Cell 2013 Oct;155(2):462-77

Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910500PMC
October 2013

Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.

J Biol Chem 2013 Aug 19;288(31):22248-56. Epub 2013 Jun 19.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M113.489757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829316PMC
August 2013

Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.

Future Med Chem 2013 Apr;5(5):553-72

Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Room 313, Petit Science Center, 100 Piedmont Ave, Atlanta, GA, 30303-3083, USA.

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http://dx.doi.org/10.4155/fmc.13.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871878PMC
April 2013

Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.

J Med Chem 2012 Aug 24;55(15):6738-50. Epub 2012 Jul 24.

Department of Radiology and Imaging Sciences, Emory University CSI , Wesley Woods Health Center, 1841 Clifton Road, NE, Atlanta, Georgia 30329, United States.

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http://dx.doi.org/10.1021/jm300752nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756490PMC
August 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.

ACS Med Chem Lett 2012 Aug 21;3(8):620-5. Epub 2012 Jun 21.

Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States ; Emory Institute for Drug Discovery, Emory University , Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/ml300042kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056939PMC
August 2012

Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment.

Cancer J 2012 Jan-Feb;18(1):100-6

Department of Neurosurgery and Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1097/PPO.0b013e3182452e0dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269658PMC
May 2012

P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.

J Clin Invest 2012 Apr 1;122(4):1283-95. Epub 2012 Mar 1.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1172/JCI38596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314443PMC
April 2012

Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway.

J Med Chem 2011 Dec 23;54(24):8471-89. Epub 2011 Nov 23.

Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302-4098, United States.

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http://dx.doi.org/10.1021/jm201018gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292864PMC
December 2011

Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.

Cancer Res 2011 Sep 1;71(17):5859-70. Epub 2011 Jul 1.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165103PMC
September 2011

Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.

Bioorg Med Chem Lett 2011 Sep 28;21(18):5528-32. Epub 2011 Jun 28.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292863PMC
September 2011

Proteomics of gliomas: initial biomarker discovery and evolution of technology.

Neuro Oncol 2011 Sep;13(9):926-42

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery, Hematology and Medical Oncology, School of Medicine, and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1093/neuonc/nor078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158015PMC
September 2011

Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development.

J Mol Med (Berl) 2011 Aug 21;89(8):743-52. Epub 2011 Apr 21.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/s00109-011-0759-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152611PMC
August 2011

A conspiracy of glioma and endothelial cells to invade the normal brain.

Oncotarget 2011 Jan-Feb;2(1-2):1-4

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory School of Medicine, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.18632/oncotarget.219DOI Listing
July 2011

At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop.

J Mol Med (Berl) 2011 Feb;89(2):91-4

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/s00109-010-0706-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424890PMC
February 2011

Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma.

CA Cancer J Clin 2010 May-Jun;60(3):166-93

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.3322/caac.20069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888474PMC
May 2010

Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin.

Am J Pathol 2010 Apr 18;176(4):2039-50. Epub 2010 Feb 18.

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843491PMC
April 2010

Brain cancer propagating cells: biology, genetics and targeted therapies.

Trends Mol Med 2009 Nov 2;15(11):519-30. Epub 2009 Nov 2.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University, School of Medicine, Atlanta, GA. 30322, USA.

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http://dx.doi.org/10.1016/j.molmed.2009.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782740PMC
November 2009

Identification of a novel small molecule HIF-1alpha translation inhibitor.

Clin Cancer Res 2009 Oct 29;15(19):6128-36. Epub 2009 Sep 29.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-08-3180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770235PMC
October 2009

Tumor initiating cells in malignant gliomas: biology and implications for therapy.

J Mol Med (Berl) 2009 Apr 3;87(4):363-74. Epub 2009 Feb 3.

Departments of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 33022, USA.

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http://dx.doi.org/10.1007/s00109-009-0440-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693383PMC
April 2009

Stat3 activation is required for the growth of U87 cell-derived tumours in mice.

Eur J Cancer 2009 Mar 31;45(4):677-84. Epub 2008 Dec 31.

Department of Cancer Biology, NB-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.ejca.2008.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424891PMC
March 2009

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.

Cancer Res 2009 Feb 27;69(3):1212-20. Epub 2009 Jan 27.

Department of Neurosurgery, Laboratory of Molecular Neuro-Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659670PMC
February 2009

Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment.

Mol Ther 2008 Mar 29;16(3):599-606. Epub 2008 Jan 29.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Methodist Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/sj.mt.6300391DOI Listing
March 2008

Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.

Cancer Res 2007 Jul;67(14):6872-81

Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262867PMC
July 2007

Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients.

J Proteome Res 2007 Feb;6(2):559-70

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1021/pr060240zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566942PMC
February 2007

Inhibitors of hypoxia-inducible factor-1 signaling.

Curr Opin Investig Drugs 2006 Dec;7(12):1067-76

Emory University, Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA.

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December 2006

Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.

Clin Cancer Res 2006 Nov;12(21):6331-6

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1296DOI Listing
November 2006

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.

J Neuropathol Exp Neurol 2006 Jun;65(6):529-39

Department of Pathology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1097/00005072-200606000-00001DOI Listing
June 2006

Hypoxia inducible factor-1: a novel target for cancer therapy.

Anticancer Drugs 2005 Oct;16(9):901-9

Department of Neurosurgery, Hematology/Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1097/01.cad.0000180116.85912.69DOI Listing
October 2005

Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.

Oncogene 2005 May;24(22):3632-42

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery, Hematology/Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/sj.onc.1208317DOI Listing
May 2005

The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.

Neuro Oncol 2005 Apr;7(2):122-33

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1215/S1152851704001061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871893PMC
April 2005

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.

Neuro Oncol 2005 Apr;7(2):134-53

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Hematology/Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1215/S1152851704001115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871894PMC
April 2005

Cancer scene investigation: how a cold virus became a tumor killer.

Future Oncol 2005 Apr;1(2):247-58

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University School of Medicine, Emory University, 1365C Clifton Rd NE, Room C5068, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1517/14796694.1.2.247DOI Listing
April 2005

Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization.

BMC Evol Biol 2005 Feb 4;5:11. Epub 2005 Feb 4.

Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, 1365-C Clifton Road, Room C5078, Emory University, Atlanta, GA 30322, USA.

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http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2148-5-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549037PMC
February 2005

PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.

Cancer Res 2005 Feb;65(4):1406-13

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3376DOI Listing
February 2005

Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors.

Clin Cancer Res 2004 Dec;10(24):8603-12

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1432DOI Listing
December 2004

Genetic and hypoxic regulation of angiogenesis in gliomas.

J Neurooncol 2004 Nov;70(2):229-43

Laboratory of Molecular Neuro-Oncology, Department of Neuro-surgery and Hematology/Oncology, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1007/s11060-004-2752-5DOI Listing
November 2004

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.

Am J Pathol 2004 Oct;165(4):1151-61

Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Rd., NE, Atlanta, GA 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618625PMC
http://dx.doi.org/10.1016/S0002-9440(10)63376-7DOI Listing
October 2004

Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.

Clin Cancer Res 2004 Aug;10(15):5187-201

Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0360DOI Listing
August 2004

Use of replicating oncolytic adenoviruses in combination therapy for cancer.

Clin Cancer Res 2004 Aug;10(16):5299-312

Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery, Hematology/Oncology, and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-0349-03DOI Listing
August 2004

Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.

Int J Biochem Cell Biol 2004 Jun;36(6):1046-69

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Hematology/Oncology, Winship Cancer Institute and Brain Tumor Program, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.biocel.2004.01.013DOI Listing
June 2004

Opening the chamber of peer-review secrets.

Authors:
Erwin G Van Meir

Nature 2004 Jun;429(6994):803

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http://dx.doi.org/10.1038/429803cDOI Listing
June 2004

Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.

Lab Invest 2004 Apr;84(4):397-405

Department of Pathology and Laboratory Medicine, Emory University School of Medicine H-176, 1364 Clifton Road NE, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/labinvest.3700070DOI Listing
April 2004

Emerging molecular therapies for brain tumors.

Semin Oncol 2004 Apr;31(2 Suppl 4):38-46

Department of Neurosurgery, Winship Cancer Institute Brain Tumor Program, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2004.02.019DOI Listing
April 2004

Replicative oncolytic herpes simplex viruses in combination cancer therapies.

Curr Gene Ther 2004 Mar;4(1):41-51

Laboratory of Molecular Neuro-Oncology, Department of Neurology, Emory University School of Medicine, Atlanta,GA 30322, USA.

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http://dx.doi.org/10.2174/1566523044577988DOI Listing
March 2004