Publications by authors named "Ersin Uysal"

23 Publications

  • Page 1 of 1

Endoscopic Sphenopalatine Ganglion Block Efficacy in the Management of Periorbital Edema and Ecchymosis After Septorhinoplasty.

J Craniofac Surg 2020 Oct 12. Epub 2020 Oct 12.

Department of Technique, Vocational High School, Dicle University, Diyarbakir, Turkey.

Aim: This study aims to evaluate the efficacy of sphenopalatine ganglion block (SPGB) on postoperative edema and ecchymosis for the patients undergoing septorhinoplasty (SRP).

Methods: In the study, a total number of 55 participant patients (40% male and 60% female, aged between 18 and 42 years) undergoing hump resection and osteotomies were allocated into 2 groups. The SPGB (+) group consisted of 27 patients who underwent SPGB, while the SPGB (-) group consisted of 28 patients who underwent SRP without SPGB. On the first, third, and seventh postoperative days (POD1, POD3, POD7), the score marks of periorbital edema and ecchymosis of the patients were evaluated. Additionally, postoperative upper eyelid edema and upper eyelid ecchymosis as well as lower eyelid edema, and lower eyelid ecchymosis on POD1, POD3, POD7 were evaluated. A comparison with regard to intraoperative bleeding, surgical field, and operation time between the 2 groups was also conducted.

Results: Upper eyelid edema, upper eyelid ecchymosis, lower eyelid edema, lower eyelid ecchymosis on POD 1, 3, 7 were found to be significantly lower in SPGB (+) group in comparison to SPGB (-) group (P < 0.001). Intraoperative blood loss and surgical field were found to be significantly lower in SPGB group (+) than in SPGB (-) group (P < 0.00). The operation time was not found statistically significant between the 2 groups (P = 0.212).

Conclusion: Sphenopalatine ganglion block is a safe and effective way of reducing postoperative edema and ecchymosis after SRP. Besides, it provides a better surgical field and reduced bleeding intraoperatively.
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http://dx.doi.org/10.1097/SCS.0000000000007189DOI Listing
October 2020

Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing.

J Craniomaxillofac Surg 2019 May 22;47(5):815-825. Epub 2019 Jan 22.

Dicle University, Diyarbakır Technical Sciences Vocational School, Diyarbakır, Turkey.

Aim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model.

Material And Methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. After PRF preparation, right defects were evaluated as empty defect or graft group, and left defects were evaluated as PRF test group. All animals were sacrificed at the end of 8 weeks and specimens were examined histopathologically and immunohistochemically.

Results: The most superior histopathological results were obtained in the autograft group. The combination of β-TCP-PRF could not provide superiority over the β-TCP group. The immunohistochemical results showed that, in the PRF/BTCP group, the expression of osteopontin and osteonectin was relatively higher compared to the only-BTCP group.

Conclusion: In terms of new bone formation, autograft combined with PRF yielded superior results but the combination of β-TCP-PRF had no effect compared to the only-BTCP group. However, further experimental and clinical studies might be beneficial to clarify the exact mechanism and results of combining PRF with bone grafts on bone healing process.
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http://dx.doi.org/10.1016/j.jcms.2019.01.023DOI Listing
May 2019

Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis.

Adv Clin Exp Med 2017 Dec;26(9):1419-1424

Vocational High School, Department of Technics Programs, Dicle University, Diyarbakır, Turkey.

Background: Tumor necrosis factor alpha (TNF-α) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis.

Objectives: The aim of this study was to determine the effect of vector ultrasonic system (VUS) on the levels of TNF-α in gingival crevicular fluid (GCF) and the clinical parameters in patients with chronic periodontitis.

Material And Methods: The study protocol was conducted using split-mouth design in 30 patients with chronic periodontitis. VUS and scaling and root planing (S/RP) were applied separately to 2 quadrants, including the upper and the lower jaws. At baseline and after 6 months, clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) were recorded, and concentrations of TNF-α in GCF were determined by enzyme-linked immunosorbent assay (ELISA). Intergroup comparisons were evaluated by the independent Students' t-test, and the Pearson correlation was used to determine the relationship between parameters. The level of significance was set at 5%.

Results: Both treatment modalities provided statistically significant improvements in clinical periodontal parameters and TNF-α levels after 6 months (p < 0.05). Also, there were no significant correlations between the TNF-α levels in GCF and the clinical parameters in both treatment group at baseline and at the end of 6 months period (p > 0.05).

Conclusions: The use of the vector ultrasonic system in the non-surgical treatment of chronic periodontitis presents beneficial improvements for the clinical attachment level and the probing pocket depth as well as TNF-α levels in GCF.
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http://dx.doi.org/10.17219/acem/65410DOI Listing
December 2017

Clinical Evaluation of Complications in Implant-Supported Dentures: A 4-Year Retrospective Study.

Med Sci Monit 2017 Dec 27;23:6137-6143. Epub 2017 Dec 27.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey.

BACKGROUND Implants that can be used in the prosthetic rehabilitation of full and partial edentulous patients are now frequently used due to advances in dentistry. Despite advanced methods of applications, failures and complications can still be seen. The aim of our study was to evaluate clinical prosthetic values and complications that occurred during 4-year follow-up in implant-supported restorations. MATERIAL AND METHODS This retrospective study included 40 patients who received oral rehabilitation with an implant-supported prosthesis. A total of 162 implants were placed: 99 in the maxilla and 63 in the mandible. The prosthetic and surgical data were recorded. Data including prosthetic complications and implant loss were recorded and statistically analyzed using Cox proportional hazard regression analysis. RESULTS In total, 159 implants (98.14%) survived, 3 implants (1.86%) failed, and 100% of the protheses were successful. There were 62 dental implants used as abutments for removable dentures and 97 for fixed dentures. The most frequent prosthetic complications after placement of an implant-supported prosthesis were loss of retention, mucositis, abutment screw loosening, and fracture. Patient satisfaction after prosthesis use was also evaluated, showing that satisfaction was systematically increased. CONCLUSIONS To minimize the frequency of complications, protocols must be established from diagnosis to the completion of treatment and follow-up of implant-supported prostheses, especially in terms of adequate technical steps and careful radiographic evaluation of the components.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751727PMC
http://dx.doi.org/10.12659/msm.907840DOI Listing
December 2017

Associations of alveolar bone loss and interleukin-1β levels in one- and two-stage surgical procedures: a randomized prospective trial.

Acta Odontol Scand 2017 Nov 21;75(8):608-615. Epub 2017 Aug 21.

h Department of Periodontology, Faculty of Dentistry , Hacettepe University , Ankara , Turkey.

Objective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1β levels in one- and two-stage surgical procedures.

Materials And Methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.

Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p < .05). There was no significant difference in other clinical parameters between the groups (p > .05). There was a significant difference between Group I ABLR values at T0 and T2 (p < .05). The PICF IL-1β levels were not significantly different between groups (p > .05).

Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.
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http://dx.doi.org/10.1080/00016357.2017.1367959DOI Listing
November 2017

Protective Effects of Caffeic Acid Phenethyl Ester on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats.

J Biochem Mol Toxicol 2015 Dec 24;29(12):559-63. Epub 2015 Jul 24.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.

We investigated the protective effect of caffeic acid phenethyl ester (CAPE) on cyclophosphamide-induced hemorrhagic cystitis in rats in comparison with 2-mercaptoethane sulfonate (MESNA). Forty male rats were randomized into four groups: group 1 (control), group 2 (cyclophosphamide), group 3 (cyclophosphamide + MESNA), group 4 (cyclophosphamide + CAPE). Cyclophosphamide injection increased malondialdehyde levels indicating oxidative stress, whereas CAPE and MESNA ameliorated malondialdehyde levels in the bladder (p < 0.05). Only catalase activities were decreased significantly in both groups (cyclophosphamide + MESNA and cyclophosphamide + CAPE, p < 0.05). Pretreatment with CAPE (p < 0.01) resulted in a significant decrease in nitric oxide levels when compared with the cyclophosphamide group. When we consider the studies that show the critical importance of increased nitric oxide levels in pathogenesis of cyclophosphamide-induced hemorrhagic cystitis, we suggest that it would be more beneficial to use MESNA with CAPE to prevent histological damage.
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http://dx.doi.org/10.1002/jbt.21728DOI Listing
December 2015

Biochemical and Histopathological Investigation of Resveratrol, Gliclazide, and Losartan Protective Effects on Renal Damage in a Diabetic Rat Model.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):187-98

Objective: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes.

Study Design: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. The other kidney was stained for histochemical and immunohistochemical markers and examined by light microscopy.

Results: Nephropathy due to diabetes was developed at the end of the third week in the diabetic group: in the glomeruli, contraction from Bowman distance, diffuse mesangial matrix increasing and tubular dilation, and cytoplasmic vacuolar changes were observed. In tubulointerstitial areas, some tubular structures, an increased expression of VEGF was observed.

Conclusion: As a result, in diabetic rats, the effects of gliclazide, resveratrol, and losartan cure were equivalent to each other according to the parameters which were followed. Resveratrol, gliclazide, and losartan significantly protected renal glomeruli and the proximal and distal tubules.
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June 2015

Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats.

Biotechnol Biotechnol Equip 2014 Jul 17;28(4):710-715. Epub 2014 Oct 17.

Faculty of Veterinary Medicine, Dicle University , Diyarbakir , Turkey.

This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups ( = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health.
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http://dx.doi.org/10.1080/13102818.2014.943558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684055PMC
July 2014

The effect of low-level laser therapy on the healing of hard palate mucosa and the oxidative stress status of rats.

J Oral Pathol Med 2014 Feb 19;43(2):103-10. Epub 2013 Aug 19.

Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey.

Objective: The biostimulation effects of low-level laser therapy (LLLT) have been demonstrated recently. This study investigated the effects of LLLT on palatal mucoperiosteal wound healing and oxidative stress status in rats.

Material And Method: Forty-two male Wistar rats weighing 250-300 g were used in this study. A standardized full-thickness wound was created in the mucoperiosteum of the hard palates of the rats using a 3-mm-diameter biopsy punch. Treatment using a GaAlAs laser at a wavelength of 940 nm and a dose of 10 J/cm(2) was initiated after surgery and repeated on the 2nd, 4th, and 6th days post-surgery. Seven animals from each group were sacrificed on the 7th, 14th, and 21st days after surgery. Total antioxidant status and total oxidative status were measured in serum.

Results: The histopathological findings revealed reduced numbers of inflammatory cells on the 7th day, increased mitotic activity of fibroblasts on the 14th and 21st day, and the same degree of collagen synthesis and vascularization on the days 7, 14, and 21 in the LLLT group compared with the control group. No significant differences in total oxidative status and total antioxidant status were observed between the groups.

Conclusion: LLLT using a GaAlAs laser at a wavelength of 940 nm and a dose of 10 J/cm(2) elicited a positive healing effect on palatal mucoperiosteal wounds likely via the induction of fibroblasts. The oxidative stress status was not affected by LLLT.
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http://dx.doi.org/10.1111/jop.12106DOI Listing
February 2014

The effects of low-level laser therapy on palatal mucoperiosteal wound healing and oxidative stress status in experimental diabetic rats.

Photomed Laser Surg 2013 Jul 21;31(7):315-21. Epub 2013 Jun 21.

Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey.

Objective: The biostimulation effects of low-level laser therapy (LLLT) have recently been demonstrated. In this study, we aimed to investigate the effects of LLLT on palatal mucoperiostal wound healing and oxidative stress status in experimental diabetic rats.

Materials And Methods: Forty-two male Wistar rats that weighed 250-300 g were used in this study. Experimental diabetes was induced in all of the rats using streptozotocin. A standardized full thickness wound was made in the mucoperiosteum of the hard palates of the rats using a 3 mm biopsy punch. The rats were divided into groups: 1 (control group, non- irradiated), and 2 (experimental group, irradiated). Treatment using a GaAlAs laser at a wavelength of 940 nm and at dose of 10 J/cm(2) began after surgery, and was repeated on the 2nd, 4th, and 6th days post-surgery. Seven animals from each group were killed on the 7th, 14th, and 21st day after surgery. Biopsies were performed for the histological analysis and blood samples were collected by cardiac puncture for biochemical analysis.

Results: The histopathological findings revealed reduced numbers of inflammatory cells, and increased mitotic activity of fibroblasts, collagen synthesis, and vascularization in rats in group 2. The total oxidative status was significantly decreased in the laser-treated group on the 21st day.

Conclusions: LLLT elicits a positive healing effect on palatal mucoperiostal wounds, and modulates the oxidative status in experimental diabetic rats.
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http://dx.doi.org/10.1089/pho.2012.3406DOI Listing
July 2013

Intra-articularly applied pulsed radiofrequency can reduce chronic knee pain in patients with osteoarthritis.

J Chin Med Assoc 2011 Aug 23;74(8):336-40. Epub 2011 Jul 23.

Department of Anesthesiology, Pain Management Center, Dicle University, Diyarbakir, Turkey.

Background: Osteoarthritis (OA) is the most widespread chronic joint disease worldwide. Symptomatic knee OA is observed in approximately 12% of individuals more than 60 years of age. Conservative treatments models may not be effective always, and that some of them have serious adverse effects that prompted the researchers to research different treatment methods. In this study, we investigated short- and mid-term effectiveness of intra-articular pulsed radiofrequency (PRF) applied in patients with chronic knee pain due to OA.

Methods: This study was carried out in the pain management center of a university hospital between January 2009 and June 2009. The patient record files of 31 patients who received intra-articular PRF were retrospectively reviewed. The antero-lateral area of the knee, where the intervention would be applied, was anesthetized with 1% lidocaine. An introducer needle was placed intra-articularly. PRF was started as 42°C at 2 Hz for 15 minutes. The pain of the patients was evaluated by 10 cm Visual Analog Scale (VAS). Furthermore, the ages, the gender, the symptom duration of the patients, the side of the knee on which the intervention was applied, and the complications were collected for statistical evaluation.

Results: Although the mean initial VAS scores of the patients were 6.1 ± 0.9 cm, it was found, respectively, to be 3.9 ± 1.9 cm and 4.1 ± 1.9 cm at the first- and sixth-month follow-ups. In general, a decrease of 32.8% in mean in the VAS scores was achieved in the last follow-up; whereas the rate of patients reporting a minimum decrease of 2 points in the VAS scores was 64.5% and the rate of patients reporting a decrease of ≥50% in their pain was calculated as 35.5%.

Conclusion: PRF applied to the knee joint appears to be an effective and safe method.
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http://dx.doi.org/10.1016/j.jcma.2011.06.004DOI Listing
August 2011

Identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement.

Eur J Orthod 2012 Jun 7;34(3):357-61. Epub 2011 Apr 7.

Department of Orthodontics, Dicle University, Diyarbakır, Turkey.

The aim of this study was to identify the levels of interleukin (IL)-2, IL-6, and IL-8 around miniscrews used for anchorage during canine distalization. Sixteen patients (eight males and eight females; mean age, 16.6 ± 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. Thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary canine distalization. Three groups were constructed. The treatment, miniscrew, and control groups consisted of upper canines, miniscrew implants, and upper second premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid (GCF) were obtained at baseline (T1) and at 1 (T2), 24 (T3), and 48 (T4) hours, 7 (T5) and 21 (T6) days, and 3 months (T7) after force application. Paired sample t-tests were used to determine within-group changes and Dunnett's t and Tukey's honestly significant difference tests for between-group multiple comparisons. During the 3 month period, IL-2 levels significantly increased (P < 0.01) but only in the treatment group after 24 hours. IL-6 levels were unchanged at all times points in the three groups. IL-8 levels increased significantly at 1 (P < 0.05), 24 (P < 0.01), and 48 (P < 0.01) hours in the treatment group and at 24 (P < 0.05) and 48 (P < 0.01) hours in the miniscrew group. It appears that miniscrews can be used for anchorage in orthodontics when correct physiological forces are applied.
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http://dx.doi.org/10.1093/ejo/cjr019DOI Listing
June 2012

Optimization of α-amylase production by Bacillus subtilis RSKK96: using the Taguchi experimental design approach.

Prep Biochem Biotechnol 2011 ;41(1):84-93

Dicle University, Diyarbakır Vocational School, Diyarbakır, Turkey.

In this study, the Taguchi experimental design was applied to optimize the conditions for α-amylase production by Bacillus subtilis RSKK96, which was purchased from Refik Saydam Hifzissihha Industry (RSHM). Four factors, namely, carbon source, nitrogen source, amino acid, and fermentation time, each at four levels, were selected, and an orthogonal array layout of L(16) (4(5)) was performed. The model equation obtained was validated experimentally at maximum casein (1%), corn meal (1%), and glutamic acid (0.01%) concentrations with incubation time to 72 h in the presence of 1% inoculum density. Point prediction of the design showed that maximum α-amylase production of 503.26 U/mg was achieved under optimal experimental conditions.
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http://dx.doi.org/10.1080/10826068.2010.534333DOI Listing
June 2011

6-month results of TransDiscal Biacuplasty on patients with discogenic low back pain: preliminary findings.

Int J Med Sci 2010 Dec 14;8(1):1-8. Epub 2010 Dec 14.

Pain Management Center, Department of Anesthesiology, Dicle University, Diyarbakir, Turkey.

Study Design: Prospective observational study.

Objective: Our aim is to investigate the efficacy and safety of TransDiscal Biacuplasty.

Summary Of Background Data: Chronic discogenic pain is one of the leading causes of low back pain; however, the condition is not helped by most non-invasive methods. The results of major surgical operations for these patients are unsatisfactory. Recently, attention has shifted to disk heating methods for treatment. TransDiscal Biacuplasty is one of the minimally invasive treatment methods. The method was developed as an alternative to spinal surgical practices and Intradiscal Electrothermal Therapy for treatment of patients with chronic discogenic pain.

Methods: The candidates for this study were patients with chronic discogenic pain that did not respond to conservative treatment. The main criteria for inclusion were: the existence of axial low back pain present for 6 months; disc degeneration or internal disc disruption at a minimum of one level, and maximum of two levels, in MR imaging; and positive discography. Physical function was assessed using the Oswestry Disability Index when measuring the pain with VAS. Patient satisfaction was evaluated using a 4-grade scale. Follow-ups were made 1, 3, and 6 months after treatment.

Results: 15 patients were treated at one or two levels. The mean patient age was 43.1 ± 9.2 years. We found the mean symptom duration to be 40.5 ± 45.7 months. At the sixth month, 57.1% of patients reported a 50% or more reduction in pain, while 78.6% of patients reported a reduction of at least two points in their VAS values. In the final check, 78.6% of patients reported a 10-point improvement in their Oswestry Disability scores compared to the initial values. No complications were observed in any of the patients.

Conclusions: TransDiscal Biacuplasty is an effective and safe method.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005544PMC
http://dx.doi.org/10.7150/ijms.8.1DOI Listing
December 2010

Relaparotomies: Why is Mortality Higher?

Eur J Trauma Emerg Surg 2009 Dec 12;35(6):547-52. Epub 2009 May 12.

Department of General Surgery, Dicle University, Diyarbakir, Turkey.

Background: Relaparotomy is sometimes required for complications that develop after abdominal surgery, but it is associated with high mortality. We aimed to investigate the independent risk factors related to mortality in patients that undergo relaparotomies.

Materials And Methods: One hundred and fourteen patients who had relaparatomies were evaluated. Risk factors studied were patient characteristics, cause of the first operation, condition of the first operation, systemic diseases, presence of peritonitis, relaparotomy interval, cause of relaparatomy, APACHE II score, transfused blood units, number of relaparatomies, length of hospital stay, and mortality. In order to determine the independent risk factors, we carried out multivariate logistic regression analysis.

Results: There were 75 male and 39 female patients with a mean age of 46.06 ± 19.98 (15-84). The most common reasons for relaparotomy were leakage from intestinal primary repair or anastomosis (29.8%). Mortality developed in 55 (48.2%) patients undergoing relaparatomy. Intestinal necrosis (p = 0038) and intraabdominal sepsis (p = 0.027) were found to be risk factors in mortality. In multivariate logistic regression analysis, advanced age (OR 0.966, p = 0. 0.017) and APACHE II score ≥ 20 (OR 0.137, p < 0.0001) were found to be independent risk factors affecting mortality.

Conclusion: Advanced age and APACHE II score ≥ 20 were found to be independent risk factors affecting relaparotomy-related mortality.
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http://dx.doi.org/10.1007/s00068-009-8221-2DOI Listing
December 2009

Management of duodenal injury: our experience and the value of tube duodenostomy.

Ulus Travma Acil Cerrahi Derg 2009 Sep;15(5):467-72

Department of General Surgery, Dicle University Faculty of Medicine, Diyarbakir, Turkey.

Background: The aim of this study was to report our experience with duodenal injuries and determine if primary repair and/or tube duodenostomy are valid options for definitive operative repair of severe duodenal injuries.

Methods: Sixty-seven patients who underwent surgery for duodenal injuries were evaluated. Management of duodenal injury was classified as primary repair and tube decompression.

Results: Fifty-nine patients were injured by a penetrating mechanism, and eight were injured by blunt mechanism. The most common injury site was in the second portion of the duodenum. There were no significant differences between the two groups with respect to morbidity and mortality rate. In 35 patients without morbidity, the mean length of hospital stay was 18.53+/-1.85 days in the tube duodenostomy group and 11.45+/-1.92 days in the primary repair group, and the difference was statistically significant. In the 32 patients with morbidity, the mean length of hospital stay was 47.05+/-10.46 days in the tube duodenostomy group and 49.86+/-10.86 days in primary repair group, but there was no statistically significant difference between the groups.

Conclusion: Primary repair is suitable in the vast majority of duodenal injuries; tube duodenostomy increases the length of hospital stay and does not improve clinical outcome.
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September 2009

Effect of nigella (Nigella sativa L.) seeds on hematological parameters in rats.

Saudi Med J 2009 Sep;30(9):1233-5

Department of Physiology, Dicle University, Diyarbakir, Turkey.

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September 2009

The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats.

Saudi Med J 2009 Jul;30(7):893-6

Department of Physiology, Medical Faculty, Dicle University Diyarbakir, Turkey.

Objective: To investigate the effect of oral treatment of Wistar albino rats with different doses of Nigella sativa L. (NS) powdered seeds on the levels of serum lipids.

Methods: This study was performed in the Medical Science Application and Research Center of Dicle University, Diyarbakir, Turkey, from February 2003 to December 2008. A total of 75 Wistar albino male rats, 60 of them with NS supplementation and 15 animals acting as controls, were included in the study. The NS groups were divided into 4 main groups of 15 each. Four doses of NS were used (100, 200, 400, and 600 mg/kg/day). Each dose group was further divided into 3 duration subgroups of 5 rats each, the feeding of NS seeds continued for one, 2, and 4 weeks. Control animals were divided into 3 main groups of 5 rats each. The rats were sacrificed at one, 2, and 4 weeks after feeding. Lipid parameters were measured.

Results: Rats treated with the 400mg dose for one week's duration showed a significant increase in high-density lipoprotein-cholesterol levels. There was a significant decrease in low density lipoprotein-cholesterol levels after one week for 400 and 600 mg doses, and all doses after 2 weeks and 4 weeks for 200 and 600 mg doses when compared to control groups. There was a significant decrease in very low-density lipoprotein-cholesterol levels after one week for 200, 400, and 600 mg doses, and all doses for 2 and 4 weeks. A 400 mg dose for 2 weeks, and all doses for 4 weeks caused a significant decrease in triglyceride levels. There was a significant decrease of total cholesterol levels in all doses after 4 weeks of NS feeding.

Conclusion: These results indicate that NS may ameliorate the alteration in the lipid levels caused by diseases or toxic agents.
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July 2009

Independent risk factors of morbidity in penetrating colon injuries.

Ulus Travma Acil Cerrahi Derg 2009 May;15(3):232-8

Department of General Surgery, Dicle University, Diyarbakir, Turkey.

Background: The present study explored the factors effective on colon-related morbidity in patients with penetrating injury of the colon.

Methods: The medical records of 196 patients were reviewed for variables including age, gender, factor of trauma, time between injury and operation, shock, duration of operation, Penetrating Abdominal Trauma Index (PATI), Injury Severity Score (ISS), site of colon injury, Colon Injury Score, fecal contamination, number of associated intra- and extraabdominal organ injuries, units of transfused blood within the first 24 hours, and type of surgery. In order to determine the independent risk factors, multivariate logistic regression analysis was performed.

Results: Gunshot wounds, interval between injury and operation > or =6 hours, shock, duration of the operation > or =6 hours, PATI > or =25, ISS > or =20, Colon Injury Score > or = grade 3, major fecal contamination, number of associated intraabdominal organ injuries >2, number of associated extraabdominal organ injuries >2, multiple blood transfusions, and diversion were significantly associated with morbidity. Multivariate logistic regression analysis showed diversion and transfusion of > or =4 units in the first 24 hours as independent risk factors affecting colon-related morbidity.

Conclusion: Diversion and transfusion of > or =4 units in the first 24 hours were determined to be independent risk factors for colon-related morbidity.
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May 2009

Dental Aesthetic Index scores and perception of personal dental appearance among Turkish university students.

Eur J Orthod 2009 Apr 6;31(2):168-73. Epub 2009 Jan 6.

Department of Orthodontics, School of Dentistry, Dicle University, Diyarbakir, Turkey.

The aim of this study was to investigate the relationship between Turkish university students' awareness of malocclusion, their satisfaction with their personal dental appearance, and the severity of their occlusal irregularities. The sample consisted of 841 randomly selected university students, 522 (62.1 per cent) males and 319 (37.9 per cent) females, aged 17-26 years (mean age, 21.91+/-1.92 years). A pre-tested questionnaire was used to assess the subjects' awareness of malocclusion and satisfaction with their personal dental appearance; the actual severity of malocclusion was determined using the Dental Aesthetic Index (DAI). Statistical analysis was carried out using chi-square for gender differences and Spearman rank-order correlation coefficients for awareness of malocclusion, satisfaction with personal dental appearance, and DAI scores. Analysis of variance and univariate analysis, with age and gender as the independent variables, were further used to analyse the data. Weak but statistically significant, negative, correlations were found between awareness of malocclusion and satisfaction at the following DAI scores: or= 36 (r= -0.477, P<0.001), and a statistically insignificant, negative correlation at a score of 31-35 (r= -0.102, P>0.05). A statistically significant association was found between DAI and awareness of malocclusion (r= -0.305) and satisfaction with dental appearance (r=0.234). There were no significant associations between the department in which the individuals studied and the investigated variables (P>0.05). DAI scores were significantly higher for females. Generally, no statistically significant gender differences were found in relation to DAI scores, awareness, or satisfaction (P>0.05). The findings of this study showed that age had a significant effect on satisfaction and gender on DAI score variation. Females had a greater need for normative treatment except in the 20- to 22-year-olds, and satisfaction decreased with age.
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http://dx.doi.org/10.1093/ejo/cjn083DOI Listing
April 2009

Levels of transaminases, alkaline phosphatase, and protein in tissues of Clarias gariepienus fingerlings exposed to sublethal concentrations of cadmium chloride.

Environ Toxicol 2008 Dec;23(6):672-8

Environmental Science and Biotechnology Research Unit, Department of Zoology, Loyola College, Chennai 600 034, Tamil Nadu, India.

The freshwater fish, Clarias gariepienus fingerlings, were exposed to sublethal concentrations (1.7 and 3.4 mg/L) of cadmium chloride for 12 days. Aspartate aminotransferase (AAT), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total protein levels were assayed in the gill, brain, and muscle of the fish at regular intervals of 6 and 12 days. The activities of AAT, ALT, and ALP of the treated fishes increased significantly in all the tissues compared with the control fish. Protein level in all the tissues showed a significant decrease in comparison to unexposed controls throughout the experimental periods. These results revealed that cadmium chloride effects the intermediary metabolism of C. gariepienus fingerlings and that the assayed enzymes can work as good biomarkers of contamination.
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http://dx.doi.org/10.1002/tox.20372DOI Listing
December 2008

Effect of storage duration on tensile bond strength of acrylic or silicone-based soft denture liners to a processed denture base polymer.

Acta Odontol Scand 2005 Feb;63(1):31-5

Dicle University, Dental Faculty, Department of Prosthodontics, Diyarbakzr, Turkey.

Objective: To investigate the effect of storage duration on the tensile bond strength of acrylic and silicone-based denture base materials with liners either heat-cured or auto-cured.

Material And Methods: The denture liners investigated were Vertex soft (acrylic-based, heat-cured), Coe soft (acrylic-based, auto-cured), Molloplast-B (silicone-based, heat-cured), and Mollosil plus (silicone-based, auto-cured). The soft liner specimens were 10 x 10 x 3 mm and were processed between two PMMA blocks. They were tested following immersion in water at 37 degrees C for 1 day, 1 week, and 1, 3, and 6 months. Tensile bond strength was measured using a universal testing machine (Testometric Micro 500) at a crosshead speed of 20 mm/min (n = 10 specimens per experimental group). Multiple ANOVA and Tukey HSD were used to analyse the data at a pre-set alpha of 0.05.

Results: The results indicate that the tensile bond strength of acrylic-based soft liners is greater than that of silicone-based materials. The bond strength of all lining materials decreases with storage duration; the decrease being greatest for the acrylic-based soft liners. The decrease in bond strength of the auto-cured materials is greater than that of the heat-cured products.

Clinical Significance: Comparison of the materials in this study indicates that the silicone-based, heat-cured soft liner is superior, based on the tensile bond strength property. Use of silicone-based, heat-cured soft liners may provide better clinical success over a long period. These laboratory results need to be verified by clinical testing.
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http://dx.doi.org/10.1080/00016350510019667DOI Listing
February 2005

Evaluation of caries risk factors and effects of a fluoride-releasing adhesive material in children with insulin-dependent diabetes mellitus (IDDM): initial first-year results.

Acta Odontol Scand 2004 Oct;62(5):289-92

Dental Faculty, Department of Pedodontics, Dicle University, Diyarbakir, Turkey.

The aims of this study were to evaluate the prevalence and risk factors of dental caries, and to determine whether there is any relationship between a fluoride-releasing adhesive material and the development of dental caries in the first year in children with insulin-dependent diabetics (IDDM). The average age of the subjects was 4-15 years, and they had been suffering from IDDM for at least 2 years. The DMF/df(t) indices of 70 patients were calculated and total HbA1 (%) (glucose levels of blood) values were recorded from the medical records after clinical examination. The mean DMF/df(t) values of poorly controlled subjects (HbA1 values over 13%) were significantly higher than those of moderately (HbA1, 10.0-12.9%) and well-controlled (HbA1 values, <10%) subjects. The levels of salivary mutans streptococci (MS) and lactobacilli (LB) and the pH of paraffin-stimulated whole saliva were measured in diabetic patients. Salivary MS and LB scores of the poorly controlled subjects were significantly higher (2.5+/-0.7 and 2.1+/-1.0) than those of the moderately (1.6+/-0.9 and 1.1+/-0.8) and well-controlled (1.2+/-1.0 and 0.8+/-0.8) subjects. The mean pH values among all subjects were not statistically significant. All dental caries were restored with a fluoride-releasing adhesive material. At the end of the first year, no new caries or lost restorations were observed in these patients. Moreover, the rate of MS in the poorly and moderately controlled subjects was considerably reduced. However, no significant statistical reduction of MS was determined in the well-controlled subjects. The level of lactobacilli in the poorly controlled, moderately controlled, and well-controlled subjects was reduced.
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http://dx.doi.org/10.1080/00016350410001766DOI Listing
October 2004
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