Publications by authors named "Ernst Lengyel"

100Publications

Are We Ready for Hyperthermic Intraperitoneal Chemotherapy in the Upfront Treatment of Ovarian Cancer?

JAMA Netw Open 2020 Aug 3;3(8):e2014184. Epub 2020 Aug 3.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.14184DOI Listing
August 2020

Healthy food for trainees: a call to action.

Postgrad Med J 2020 Aug 20. Epub 2020 Aug 20.

OB/GYN, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/postgradmedj-2020-138506DOI Listing
August 2020

Care of Transgender Persons.

N Engl J Med 2020 04;382(15):1481-1482

University of Chicago, Chicago, IL

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http://dx.doi.org/10.1056/NEJMc2000825DOI Listing
April 2020

A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.

J Pathol 2020 05;251(1):100-112

Clinical Proteomics Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/path.5420DOI Listing
May 2020

Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.

Cancer Res 2020 04 13;80(8):1748-1761. Epub 2020 Feb 13.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1999DOI Listing
April 2020

RADAR: differential analysis of MeRIP-seq data with a random effect model.

Genome Biol 2019 12 23;20(1):294. Epub 2019 Dec 23.

Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1186/s13059-019-1915-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927177PMC
December 2019

Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.

Commun Biol 2019 18;2:386. Epub 2019 Oct 18.

1Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas USA.

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http://dx.doi.org/10.1038/s42003-019-0609-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802217PMC
April 2020

Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation.

Proc Natl Acad Sci U S A 2019 10 7;116(43):21493-21500. Epub 2019 Oct 7.

Department of Chemistry, The University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.1073/pnas.1912934116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815137PMC
October 2019

New Roles for Glycogen in Tumor Progression.

Trends Cancer 2019 07 31;5(7):396-399. Epub 2019 May 31.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology/Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.05.003DOI Listing
July 2019

Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.

Sci Rep 2019 03 26;9(1):5195. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois, USA.

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http://www.nature.com/articles/s41598-019-41352-5
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http://dx.doi.org/10.1038/s41598-019-41352-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435808PMC
March 2019

Interpretation of Mismatch Repair Protein Immunohistochemistry in Endometrial Carcinoma Should Consider Both Lynch Syndrome Screening and Immunotherapy Susceptibility: An Illustrative Case Report.

Int J Gynecol Pathol 2020 May;39(3):233-237

Departments of Pathology (D.B.C., L.L.R., R.R.L.) Obstetrics and Gynecology, Section of Gynecologic Oncology (E.L.), University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1097/PGP.0000000000000594DOI Listing
May 2020

Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.

Gynecol Oncol 2019 05 20;153(2):405-415. Epub 2019 Feb 20.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486884PMC
May 2019

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.

Mol Cancer Res 2019 04 17;17(4):870-881. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445689PMC
April 2019

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.

J Exp Med 2019 01 19;216(1):176-194. Epub 2018 Dec 19.

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX

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http://dx.doi.org/10.1084/jem.20181170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314534PMC
January 2019

The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.

Gynecol Oncol 2019 02 22;152(2):228-234. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology/Center for Integrated Science, University of Chicago, Chicago, IL 60637, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.11.007DOI Listing
February 2019

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

Biomaterials 2019 01 16;190-191:63-75. Epub 2018 Oct 16.

Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia; Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane, QLD 4102, Australia; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA 30332-0405, USA; Institute for Advanced Study, Technical University Munich, Lichtenbergstr. 2a, 85748 Garching, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183072
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http://dx.doi.org/10.1016/j.biomaterials.2018.10.014DOI Listing
January 2019

The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis.

Trends Cancer 2018 08 22;4(8):517-519. Epub 2018 Jun 22.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.06.002DOI Listing
August 2018

Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.

Trends Cancer 2018 05 5;4(5):374-384. Epub 2018 Apr 5.

The Brown Foundation, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932630PMC
May 2018

Who are the long-term survivors of high grade serous ovarian cancer?

Gynecol Oncol 2018 01 8;148(1):204-212. Epub 2017 Nov 8.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.10.032DOI Listing
January 2018

High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.

Gynecol Oncol 2017 07 26;146(1):153-160. Epub 2017 Apr 26.

Department of Medicine, Section of Hematology-Oncology, The University of Chicago, Chicago, IL, United States; The University of Chicago Comprehensive Cancer Center, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955699PMC
July 2017

A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth.

SLAS Discov 2017 06 31;22(5):494-506. Epub 2017 Jan 31.

1 Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/2472555216687082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815521PMC
June 2017

Unsaturated Fatty Acids Maintain Cancer Cell Stemness.

Cell Stem Cell 2017 03;20(3):291-292

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956908PMC
March 2017

Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.

Mol Cancer Res 2017 01 6;15(1):78-92. Epub 2016 Oct 6.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0191DOI Listing
January 2017

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.

Cell Metab 2016 11 13;24(5):728-739. Epub 2016 Oct 13.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889952PMC
November 2016

Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.

Mol Cancer Ther 2016 10 27;15(10):2282-2293. Epub 2016 Jul 27.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050109PMC
http://dx.doi.org/10.1158/1535-7163.MCT-15-0986DOI Listing
October 2016

A prospective study evaluating diffusion weighted magnetic resonance imaging (DW-MRI) in the detection of peritoneal carcinomatosis in suspected gynecologic malignancies.

Gynecol Oncol 2016 07 28;142(1):169-175. Epub 2016 Apr 28.

The University of Chicago Medicine, Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, 5841 S. Maryland Avenue, MC 2050, Chicago, IL 60637, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.04.018DOI Listing
July 2016

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.

J Vis Exp 2015 12 31(106):e53541. Epub 2015 Dec 31.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago;

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http://dx.doi.org/10.3791/53541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780905PMC
December 2015

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.

Oncotarget 2015 Sep;6(27):23548-60

Department of Obstetrics and Gynecology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.18632/oncotarget.4556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695136PMC
September 2015

Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.

Gynecol Oncol 2015 Sep 24;138(3):656-62. Epub 2015 Jun 24.

Department of Medicine, The University of Chicago, Chicago, IL, United States; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556542PMC
September 2015

Whole-genome characterization of chemoresistant ovarian cancer.

Nature 2015 May;521(7553):489-94

1] Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia [3] Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia [4] Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, UK [5] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nature14410DOI Listing
May 2015

Patterns and utility of routine surveillance in high grade endometrial cancer.

Gynecol Oncol 2015 Jun 30;137(3):485-9. Epub 2015 Mar 30.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258150077
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http://dx.doi.org/10.1016/j.ygyno.2015.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484273PMC
June 2015

Molecular pathways: trafficking of metabolic resources in the tumor microenvironment.

Clin Cancer Res 2015 Feb;21(4):680-6

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333734PMC
February 2015

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.

Nat Commun 2015 Feb 5;6:6220. Epub 2015 Feb 5.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, 5841 South Maryland Avenue, MC2050, Chicago, Illinois 60637, USA.

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http://www.nature.com/articles/ncomms7220
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http://dx.doi.org/10.1038/ncomms7220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427252PMC
February 2015

Old drug, new trick: repurposing metformin for gynecologic cancers?

Gynecol Oncol 2014 Dec 23;135(3):614-21. Epub 2014 Oct 23.

Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268303PMC
December 2014

Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.

Am J Obstet Gynecol 2015 Apr 19;212(4):479.e1-479.e10. Epub 2014 Oct 19.

Department of Obstetrics and Gynecology, Gordon Center for Integrative Science, University of Chicago, Chicago, IL. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029378140108
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http://dx.doi.org/10.1016/j.ajog.2014.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387077PMC
April 2015

Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis.

PLoS One 2014 13;9(8):e104521. Epub 2014 Aug 13.

Department of Obstetrics & Gynecology/Section of Gynecologic Oncology - Center for Integrative Science, University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104521PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131884PMC
May 2015

Three-dimensional modeling of ovarian cancer.

Adv Drug Deliv Rev 2014 Dec 14;79-80:184-92. Epub 2014 Jul 14.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426864PMC
December 2014

Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.

Am J Pathol 2014 Jan;184(1):271-81

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873497PMC
January 2014

Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.

Mol Cancer Ther 2013 Dec 23;12(12):2628-39. Epub 2013 Sep 23.

Corresponding Author: Ernst Lengyel, Department of Obstetrics and Gynecology, University of Chicago, MC 2050, 5841 South Maryland Avenue, Chicago, IL 60637.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885360PMC
December 2013

Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.

Gynecol Oncol 2013 Jul;130(1):6-8

Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA.

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http://dx.doi.org/10.1016/j.ygyno.2013.05.031DOI Listing
July 2013

Adipose tissue and adipocytes support tumorigenesis and metastasis.

Biochim Biophys Acta 2013 Oct 14;1831(10):1533-41. Epub 2013 Mar 14.

Department of Obstetrics and Gynecology, Center for Integrative Science, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.bbalip.2013.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742583PMC
October 2013

Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.

Gynecol Oncol 2013 Apr 10;129(1):120-3. Epub 2012 Dec 10.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, The University of Chicago Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.ygyno.2012.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717384PMC
April 2013

MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.

Cancer Discov 2012 Dec 21;2(12):1100-8. Epub 2012 Nov 21.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685866PMC
December 2012

HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.

J Clin Invest 2012 Oct 4;122(10):3603-17. Epub 2012 Sep 4.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.

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http://dx.doi.org/10.1172/JCI62229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461910PMC
October 2012

Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.

Gynecol Oncol 2012 Nov 24;127(2):316-20. Epub 2012 Jul 24.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, USA.

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http://dx.doi.org/10.1016/j.ygyno.2012.07.105DOI Listing
November 2012

Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

Obstet Gynecol 2012 Jan;119(1):61-7

University of Chicago, Department of Obstetrics and Gynecology, 5841 South Maryland Avenue, MC 2050, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1097/AOG.0b013e3182393ab3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244683PMC
January 2012

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.

Nat Med 2011 Oct 30;17(11):1498-503. Epub 2011 Oct 30.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/nm.2492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157349PMC
October 2011

The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.

Cancer Discov 2011 Jul;1(2):100-2

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology - Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193939PMC
July 2011

The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.

Gynecol Oncol 2012 Jan 11;124(1):134-41. Epub 2011 Oct 11.

Department of Obstetrics and Gynecology, Center for Integrative Science, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ygyno.2011.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249832PMC
January 2012

FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.

Pediatr Dev Pathol 2011 Sep-Oct;14(5):391-5. Epub 2011 Jun 17.

Department of Pathology, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.2350/10-12-0943-OA.1DOI Listing
February 2012

Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.

Int J Cancer 2012 Apr 16;130(8):1787-97. Epub 2011 Aug 16.

Feinberg School of Medicine, Division Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.

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http://doi.wiley.com/10.1002/ijc.26190
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http://dx.doi.org/10.1002/ijc.26190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230767PMC
April 2012

Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.

Clin Cancer Res 2011 Jun 6;17(12):4042-51. Epub 2011 May 6.

Departments of Obstetrics and Gynecology/Section of Gynecologic Oncology-Center for Integrative Science and Pathology, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169439PMC
June 2011

Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report.

J Reprod Med 2011 Jan-Feb;56(1-2):71-4

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Maryland Women's Health, Stapa Building, 3rd Floor, 11 South Paca Street, Baltimore, MD 21201, USA.

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March 2011

The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.

Gynecol Oncol 2011 Apr 17;121(1):218-23. Epub 2010 Dec 17.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, The University of Chicago Medical Center, Chicago, IL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009082581000857
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http://dx.doi.org/10.1016/j.ygyno.2010.11.031DOI Listing
April 2011

Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.

Clin Cancer Res 2011 Feb 13;17(3):459-71. Epub 2010 Dec 13.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology-Center for Integrative Science, University of Chicago, Chicago, Illinois 60637, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-2258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073583PMC
February 2011

Ovarian cancer development and metastasis.

Authors:
Ernst Lengyel

Am J Pathol 2010 Sep 22;177(3):1053-64. Epub 2010 Jul 22.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928939PMC
September 2010

CD95 promotes tumour growth.

Nature 2010 May;465(7297):492-6

The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nature09075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879093PMC
May 2010

The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions.

Mol Cell Endocrinol 2010 Apr 29;317(1-2):112-9. Epub 2009 Dec 29.

Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA.

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http://dx.doi.org/10.1016/j.mce.2009.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814902PMC
April 2010

Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.

Cancer Prev Res (Phila) 2009 Sep 8;2(9):792-9. Epub 2009 Sep 8.

Department of Obstetrics and Gynecology-Center forIntegrative Science, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758654PMC
September 2009

The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.

Fertil Steril 2010 Sep 30;94(4):1212-1217. Epub 2009 Jul 30.

Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426869PMC
September 2010

Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.

Hum Mol Genet 2009 Oct 7;18(19):3632-44. Epub 2009 Jul 7.

Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, 81675 München, Germany.

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http://dx.doi.org/10.1093/hmg/ddp312DOI Listing
October 2009

MMP-2 functions as an early response protein in ovarian cancer metastasis.

Cell Cycle 2009 Mar 25;8(5):683-8. Epub 2009 Mar 25.

Department of Obstetrics, Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, Illinois 60637, USA.

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March 2009

A special key for unlocking the door to targeted therapies of breast cancer.

ScientificWorldJournal 2008 Sep 21;8:905-8. Epub 2008 Sep 21.

Department of Obstetrics and Gynaecology, Medical Faculty, University of Oslo, Division Akershus University Hospital, Norway.

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http://dx.doi.org/10.1100/tsw.2008.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848708PMC
September 2008

Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer.

Gynecol Oncol 2008 Nov 26;111(2):173-8. Epub 2008 Sep 26.

Department of Obstetrics and Gynecology, The University of Chicago, 5841 S Maryland Ave, MC 2050, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ygyno.2008.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612941PMC
November 2008

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

Genes Dev 2008 Apr;22(7):894-907

The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279201PMC
April 2008

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.

J Clin Invest 2008 Apr;118(4):1367-79

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267016PMC
April 2008

Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.

J Biol Chem 2008 Feb 29;283(5):2822-34. Epub 2007 Nov 29.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1074/jbc.M704855200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805198PMC
February 2008

Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.

Cell Cycle 2007 Nov 6;6(21):2585-90. Epub 2007 Aug 6.

The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.

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November 2007

Let-7 expression defines two differentiation stages of cancer.

Proc Natl Acad Sci U S A 2007 Jul 28;104(27):11400-5. Epub 2007 Jun 28.

Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.0704372104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040910PMC
July 2007

Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.

Int J Cancer 2007 Oct;121(7):1463-72

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.

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http://doi.wiley.com/10.1002/ijc.22874
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October 2007

Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.

Mol Cancer Res 2007 May;5(5):485-96

Department of Experimental Surgery Mannheim Faculty, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0211DOI Listing
May 2007

Tyrosine kinase mutations in human cancer.

Curr Mol Med 2007 Feb;7(1):77-84

University of Chicago, Department of Obstetrics and Gynecology, MC 2050, Section of Gynecologic Oncology, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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February 2007