Publications by authors named "Ernesto Guccione"

77Publications

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Cell 2020 Oct;183(3):786-801.e19

BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Laboratory of Chemical Biology, Department of Biochemical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.09.059DOI Listing
October 2020

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.

J Med Chem 2020 Sep 21;63(17):9977-9989. Epub 2020 Aug 21.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c01111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486226PMC
September 2020

Global translation during early development depends on the essential transcription factor PRDM10.

Nat Commun 2020 07 17;11(1):3603. Epub 2020 Jul 17.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1038/s41467-020-17304-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368010PMC
July 2020

Discovery of a first-in-class EZH2 selective degrader.

Nat Chem Biol 2020 02 9;16(2):214-222. Epub 2019 Dec 9.

Mount Sinai Center for Therapeutics Discovery, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41589-019-0421-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982609PMC
February 2020

Identification of Quinolinols as Activators of TEAD-Dependent Transcription.

ACS Chem Biol 2019 12 2;14(12):2909-2921. Epub 2019 Dec 2.

Department of Multi-Modal Molecular (M3) Biology , Institute of Molecular and Cell Biology , 61 Biopolis Drive , 138673 Singapore.

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http://dx.doi.org/10.1021/acschembio.9b00786DOI Listing
December 2019

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer Cell 2019 08;36(2):194-209.e9

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194031PMC
August 2019

Author Correction: The regulation, functions and clinical relevance of arginine methylation.

Nat Rev Mol Cell Biol 2019 Sep;20(9):567

Segal Cancer Center, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital and Gerald Bronfman Department of Oncology and Departments of Medicine, Biochemistry and Human Genetics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/s41580-019-0166-7DOI Listing
September 2019

The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.

Commun Biol 2019 24;2:272. Epub 2019 Jul 24.

1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599 Singapore.

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http://dx.doi.org/10.1038/s42003-019-0506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656769PMC
May 2020

The regulation, functions and clinical relevance of arginine methylation.

Nat Rev Mol Cell Biol 2019 10 26;20(10):642-657. Epub 2019 Jul 26.

Segal Cancer Center, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital and Gerald Bronfman Department of Oncology and Departments of Medicine, Biochemistry and Human Genetics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/s41580-019-0155-xDOI Listing
October 2019

Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma.

Cancer Res 2019 05 4;79(9):2232-2243. Epub 2019 Mar 4.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2676DOI Listing
May 2019

Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

Gastroenterology 2019 05 31;156(6):1862-1876.e9. Epub 2019 Jan 31.

Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; Singapore Immunology Network, Agency for Science and Technology (A*STAR), Singapore. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.251DOI Listing
May 2019

MBNL1 alternative splicing isoforms play opposing roles in cancer.

Life Sci Alliance 2018 Oct 7;1(5):e201800157. Epub 2018 Sep 7.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.26508/lsa.201800157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238595PMC
October 2018

PRMT5-mediated regulation of developmental myelination.

Nat Commun 2018 07 19;9(1):2840. Epub 2018 Jul 19.

Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of The City University of New York, 85 St. Nicholas Terrace, New York, NY, 10031, USA.

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http://www.nature.com/articles/s41467-018-04863-9
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http://dx.doi.org/10.1038/s41467-018-04863-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053423PMC
July 2018

Chromatin dependencies in cancer and inflammation.

Nat Rev Mol Cell Biol 2018 04 29;19(4):245-261. Epub 2017 Nov 29.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos Building #3-06, 138673 Singapore.

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http://www.nature.com/doifinder/10.1038/nrm.2017.113
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http://dx.doi.org/10.1038/nrm.2017.113DOI Listing
April 2018

PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.

Nat Genet 2017 Sep 24;49(9):1354-1363. Epub 2017 Jul 24.

Methyltransferases in Development and Disease Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1038/ng.3922DOI Listing
September 2017

Emi2 Is Essential for Mouse Spermatogenesis.

Cell Rep 2017 07;20(3):697-708

Institute of Molecular and Cell Biology (IMCB), A(∗)STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos #3-09, Singapore 138673, Republic of Singapore; Department of Biochemistry, National University of Singapore (NUS), Singapore 117597, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.033DOI Listing
July 2017

[Androgen receptors in breast cancer: Expression, value and therapeutic prospects].

Bull Cancer 2017 Apr 16;104(4):363-369. Epub 2017 Feb 16.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 138673 Singapour, Singapour.

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http://dx.doi.org/10.1016/j.bulcan.2017.01.005DOI Listing
April 2017

Discovery and characterisation of the automethylation properties of PRDM9.

Biochem J 2017 03 7;474(6):971-982. Epub 2017 Mar 7.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos 03-01, Singapore 138669

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http://dx.doi.org/10.1042/BCJ20161067DOI Listing
March 2017

Loss of maternal Trim28 causes male-predominant early embryonic lethality.

Genes Dev 2017 01 23;31(1):12-17. Epub 2017 Jan 23.

Developmental Epigenetics and Disease Group, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology, and Research (A*STAR), Singapore 138673.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.291195.116
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http://dx.doi.org/10.1101/gad.291195.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287108PMC
January 2017

The role of PRDMs in cancer: one family, two sides.

Curr Opin Genet Dev 2016 02 7;36:83-91. Epub 2016 May 7.

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos Building #3-06, 138673 Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.03.009DOI Listing
February 2016

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Sci Rep 2016 Feb 18;6:19943. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore 117599.

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http://dx.doi.org/10.1038/srep19943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757891PMC
February 2016

Targeting MYC in cancer therapy: RNA processing offers new opportunities.

Bioessays 2016 Mar 18;38(3):266-75. Epub 2016 Jan 18.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1002/bies.201500134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819695PMC
March 2016

Transcription and imprinting dynamics in developing postnatal male germline stem cells.

Genes Dev 2015 Nov;29(21):2312-24

Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA;

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.261925.115
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http://dx.doi.org/10.1101/gad.261925.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647563PMC
November 2015

Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress.

Sci Rep 2015 May 29;5:9737. Epub 2015 May 29.

1] Division of Cancer Genetics and Therapeutics, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), 138673, Singapore [2] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore.

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http://dx.doi.org/10.1038/srep09737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448690PMC
May 2015

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.

Nature 2015 Jul 11;523(7558):96-100. Epub 2015 May 11.

1] Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore [2] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore [3] Cancer Science Institute of Singapore (CSI), National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.

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http://dx.doi.org/10.1038/nature14351DOI Listing
July 2015

Trained immunity in newborn infants of HBV-infected mothers.

Nat Commun 2015 Mar 25;6:6588. Epub 2015 Mar 25.

1] Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Singapore [2] Emerging Infectious Diseases (EID) Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore [3] School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/ncomms7588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389241PMC
March 2015

Modeling cerebrovascular pathophysiology in amyloid-β metabolism using neural-crest-derived smooth muscle cells.

Cell Rep 2014 Oct 2;9(1):391-401. Epub 2014 Oct 2.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore.

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http://dx.doi.org/10.1016/j.celrep.2014.08.065DOI Listing
October 2014

Multiplexed analysis of protein-ligand interactions by fluorescence anisotropy in a microfluidic platform.

Anal Chem 2014 Oct 25;86(19):9901-8. Epub 2014 Sep 25.

Microfluidics Systems Biology Lab, Institute of Molecular and Cell Biology (IMCB), A*STAR , 138673, Singapore.

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http://dx.doi.org/10.1021/ac502605fDOI Listing
October 2014

NUCKS is a positive transcriptional regulator of insulin signaling.

Cell Rep 2014 Jun 12;7(6):1876-86. Epub 2014 Jun 12.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.030DOI Listing
June 2014

Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis.

Cell Stem Cell 2014 Aug 15;15(2):239-53. Epub 2014 May 15.

Howard Hughes Medical Institute, Department of Oncological Sciences, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.04.006DOI Listing
August 2014

The core and conserved role of MAL is homeostatic regulation of actin levels.

Genes Dev 2014 May;28(10):1048-53

Institute of Molecular and Cell Biology, Singapore 138673, Singapore.

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http://dx.doi.org/10.1101/gad.237743.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035534PMC
May 2014

Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.

Sci Rep 2014 Mar 6;4:4289. Epub 2014 Mar 6.

1] Institute of Molecular and Cell Biology, Singapore [2] Department of Biological Sciences, National University of Singapore, Singapore.

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http://www.nature.com/articles/srep04289
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http://dx.doi.org/10.1038/srep04289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944368PMC
March 2014

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.

Biol Open 2013 9;2(11):1203-13. Epub 2013 Sep 9.

Institute of Molecular and Cell Biology , 61 Biopolis Drive , Singapore 138673 ; Present address: High Throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, China.

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http://dx.doi.org/10.1242/bio.20136262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828767PMC
November 2013

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

Cell Rep 2013 Nov 31;5(3):687-701. Epub 2013 Oct 31.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM U964, Université de Strasbourg, F-67404 Illkirch, CU de Strasbourg, France.

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http://dx.doi.org/10.1016/j.celrep.2013.09.044DOI Listing
November 2013

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.

Genes Dev 2013 Sep;27(17):1903-16

Division of Cancer Genetics and Therapeutics, Laboratory of Chromatin, Epigenetics, and Differentiation, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology, and Research), Singapore 138673, Singapore;

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.219899.113
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http://dx.doi.org/10.1101/gad.219899.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778243PMC
September 2013

PRMT5 modulates the metabolic response to fasting signals.

Proc Natl Acad Sci U S A 2013 May 13;110(22):8870-5. Epub 2013 May 13.

The Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1304602110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670393PMC
May 2013

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.

Nucleic Acids Res 2012 Oct 16;40(19):9534-42. Epub 2012 Sep 16.

Division of Cancer Genetics and Therapeutics, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore 138673.

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http://dx.doi.org/10.1093/nar/gks858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479215PMC
October 2012

On WD40 proteins: propelling our knowledge of transcriptional control?

Epigenetics 2012 Aug 19;7(8):815-22. Epub 2012 Jul 19.

Institute of Molecular and Cell Biology, Singapore, Singapore.

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http://dx.doi.org/10.4161/epi.21140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427277PMC
August 2012

miR-Sens--a retroviral dual-luciferase reporter to detect microRNA activity in primary cells.

RNA 2012 May 14;18(5):1091-100. Epub 2012 Mar 14.

Department of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

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http://dx.doi.org/10.1261/rna.031831.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334695PMC
May 2012

Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a.

EMBO J 2010 Apr 18;29(7):1215-24. Epub 2010 Feb 18.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan, Italy.

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http://dx.doi.org/10.1038/emboj.2010.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857460PMC
April 2010

Arginine/lysine-methyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation.

Epigenomics 2010 Feb;2(1):119-37

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.2217/epi.09.39DOI Listing
February 2010

Analysis of Myc-induced histone modifications on target chromatin.

PLoS One 2008 5;3(11):e3650. Epub 2008 Nov 5.

Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003650PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574517PMC
February 2009

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.

Nature 2007 Oct 26;449(7164):933-7. Epub 2007 Sep 26.

Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Milan 20139, Italy.

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http://www.nature.com/doifinder/10.1038/nature06166
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http://dx.doi.org/10.1038/nature06166DOI Listing
October 2007

Myc-binding-site recognition in the human genome is determined by chromatin context.

Nat Cell Biol 2006 Jul 11;8(7):764-70. Epub 2006 Jun 11.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan 20139, Italy.

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http://www.nature.com/articles/ncb1434
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http://dx.doi.org/10.1038/ncb1434DOI Listing
July 2006

HPV-18 E6*I modulates HPV-18 full-length E6 functions in a cell cycle dependent manner.

Int J Cancer 2004 Jul;110(6):928-33

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy.

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http://doi.wiley.com/10.1002/ijc.20184
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http://dx.doi.org/10.1002/ijc.20184DOI Listing
July 2004

The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.

J Mol Biol 2004 May;339(2):313-25

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1016/j.jmb.2004.03.071DOI Listing
May 2004

HPV E6 proteins interact with specific PML isoforms and allow distinctions to be made between different POD structures.

Oncogene 2004 Jun;23(27):4662-72

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1038/sj.onc.1207631DOI Listing
June 2004

Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.

Oncogene 2002 Aug;21(33):5088-96

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1038/sj.onc.1205668DOI Listing
August 2002

Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteins.

Virology 2002 Feb;293(1):20-5

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1006/viro.2001.1290DOI Listing
February 2002