Ernesto Carafoli

Ernesto Carafoli

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Ernesto Carafoli

Ernesto Carafoli

Publications by authors named "Ernesto Carafoli"

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Editorial.

Neurosci Lett 2018 01 13;663. Epub 2017 Oct 13.

Department of Biomedical Sciences, University of Padova, Italy.

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http://dx.doi.org/10.1016/j.neulet.2017.10.017DOI Listing
January 2018

The PMCA pumps in genetically determined neuronal pathologies.

Neurosci Lett 2018 01 17;663:2-11. Epub 2017 Nov 17.

Venetian Institute of Molecular Medicine, Via G. Orus, 2, 35129 Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2017.11.005DOI Listing
January 2018

The plasma membrane calcium pumps: focus on the role in (neuro)pathology.

Biochem Biophys Res Commun 2017 02 29;483(4):1116-1124. Epub 2016 Jul 29.

Dept. of Biomedical Sciences, University of Padova, 35131 Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.117DOI Listing
February 2017

Misery loves company - shared features of neurodegenerative disorders.

Biochem Biophys Res Commun 2017 02;483(4):979-980

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http://dx.doi.org/10.1016/j.bbrc.2017.01.099DOI Listing
February 2017

Historical perspective: An interview of Vladimir Skulachev by Ernesto Carafoli.

Authors:
Ernesto Carafoli

Biochem Biophys Res Commun 2016 10 2;479(3):411-416. Epub 2016 Sep 2.

Venetian Institute of Molecular Medicine, University of Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.08.177DOI Listing
October 2016

The Plasma Membrane Ca(2+) ATPase: Purification by Calmodulin Affinity Chromatography, and Reconstitution of the Purified Protein.

Methods Mol Biol 2016 ;1377:57-70

VIMM, Venetian Institute of Molecular Medicine, University of Padova, Padova, 35129, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3179-8_7DOI Listing
September 2016

Why Calcium? How Calcium Became the Best Communicator.

J Biol Chem 2016 Sep 26;291(40):20849-20857. Epub 2016 Jul 26.

the Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany.

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http://dx.doi.org/10.1074/jbc.R116.735894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076498PMC
September 2016

Research funding: Reform oversight of Italy's science funds.

Nature 2016 05;533(7602):179

University of Padua, Italy.

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http://dx.doi.org/10.1038/533179cDOI Listing
May 2016

Intracellular calcium homeostasis and signaling.

Met Ions Life Sci 2013 ;12:119-68

Department of Comparative Biomedicine and Food Sciences, University of Padova, Viale G. Colombo 3, I-35131, Padova, Italy,

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http://link.springer.com/content/pdf/10.1007%2F978-94-007-55
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http://link.springer.com/10.1007/978-94-007-5561-1_5
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http://dx.doi.org/10.1007/978-94-007-5561-1_5DOI Listing
April 2016

Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli.

Biochem Biophys Res Commun 2015 Nov 24;467(4):612-6. Epub 2015 Oct 24.

Venetian Institute of Molecular Medicine, Via G.Orus, 2, 35129, Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.046DOI Listing
November 2015

For love of metals.

Biochem Biophys Res Commun 2015 Nov;467(4):611

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http://dx.doi.org/10.1016/j.bbrc.2015.09.134DOI Listing
November 2015

Meeting report: BBRC Symposium on Trends in Biochemistry and Biophysics.

Biochem Biophys Res Commun 2015 Sep;465(1):v-vii

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http://dx.doi.org/10.1016/s0006-291x(15)01126-2DOI Listing
September 2015

Historical perspective: An interview with renowned Immunologist Dr. Michael Sela.

Biochem Biophys Res Commun 2015 Aug 20;464(2):376-8. Epub 2015 May 20.

Venetian Institute of Molecular Medicine, via G.Orus, 2, 35129 Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.05.039DOI Listing
August 2015

Neuronal calcium signaling: function and dysfunction.

Cell Mol Life Sci 2014 Aug 19;71(15):2787-814. Epub 2014 Jan 19.

Department of Biology, University of Padova, Via U.Bassi, 58/b, 35131, Padua, Italy,

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http://link.springer.com/10.1007/s00018-013-1550-7
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http://dx.doi.org/10.1007/s00018-013-1550-7DOI Listing
August 2014

Discussion forum on mitochondrial calcium. Historical introduction.

Authors:
Ernesto Carafoli

Biochem Biophys Res Commun 2014 Jul 30;449(4):365-6. Epub 2014 Apr 30.

Venetian Institute of Molecular Medicine, University of Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.04.145DOI Listing
July 2014

Calcium in health and disease.

Met Ions Life Sci 2013 ;13:81-137

Department of Biology, University of Padova, Via U. Bassi 58/B, I-35131, Padova, Italy,

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http://link.springer.com/10.1007/978-94-007-7500-8_4
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http://dx.doi.org/10.1007/978-94-007-7500-8_4DOI Listing
June 2014

The plasma membrane calcium pump: new ways to look at an old enzyme.

J Biol Chem 2014 Apr 25;289(15):10261-8. Epub 2014 Feb 25.

From the Department of Biomedical Sciences, University of Padova, 35121 Padova and.

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http://dx.doi.org/10.1074/jbc.O114.555565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036151PMC
April 2014

The plasma membrane calcium pump in health and disease.

FEBS J 2013 Nov 11;280(21):5385-97. Epub 2013 Mar 11.

Department of Comparative Biomedicine and Food Science, University of Padova, Italy.

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http://dx.doi.org/10.1111/febs.12193DOI Listing
November 2013

A bizarre case of scientific fraud.

Authors:
Ernesto Carafoli

Biochem Biophys Res Commun 2013 Nov;441(3):529-30

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http://dx.doi.org/10.1016/j.bbrc.2013.11.049DOI Listing
November 2013

Amarcord: I remember.

Authors:
Ernesto Carafoli

J Biol Chem 2013 Sep 8;288(36):25668-82. Epub 2013 Jul 8.

Venetian Institute of Molecular Medicine, University of Padova, 35129 Padova, Italy.

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http://dx.doi.org/10.1074/jbc.X113.497966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764775PMC
September 2013

Neuronal Ca(2+) dyshomeostasis in Huntington disease.

Prion 2013 Jan-Feb;7(1):76-84. Epub 2013 Jan 1.

University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.4161/pri.23581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609054PMC
August 2013

Plasma membrane calcium ATPases and related disorders.

Int J Biochem Cell Biol 2013 Mar 4;45(3):753-62. Epub 2012 Oct 4.

Venetian Institute of Molecular Medicine, University of Padova, Padua, Italy.

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http://dx.doi.org/10.1016/j.biocel.2012.09.016DOI Listing
March 2013

Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice.

Front Mol Neurosci 2012 3;5:58. Epub 2012 May 3.

Genomic Regulation Center, Parc de Recerca Biomèdica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras Barcelona, Spain.

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http://dx.doi.org/10.3389/fnmol.2012.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342529PMC
October 2012

Pitfalls in the detection of cholesterol in Huntington's disease models.

PLoS Curr 2012 Oct 11;4:e505886e9a1968. Epub 2012 Oct 11.

Centre for Stem Cell Research, Università degli Studi di Milano, 20133 Milan, Italy.

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http://dx.doi.org/10.1371/505886e9a1968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493072PMC
October 2012

Introduction to thematic minireview series on calcium.

J Biol Chem 2012 Sep 20;287(38):31623. Epub 2012 Jul 20.

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0509, USA.

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http://dx.doi.org/10.1074/jbc.R112.402354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442495PMC
September 2012

Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis.

Proc Natl Acad Sci U S A 2012 Sep 21;109(36):14514-9. Epub 2012 Aug 21.

Unit of Molecular Medicine for Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, 00165 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1207488109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437887PMC
September 2012

Bill Lennarz. Foreword.

Authors:
Ernesto Carafoli

Biochem Biophys Res Commun 2012 Aug;425(3):493

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http://dx.doi.org/10.1016/j.bbrc.2012.08.035DOI Listing
August 2012

The interplay of mitochondria with calcium: an historical appraisal.

Authors:
Ernesto Carafoli

Cell Calcium 2012 Jul 15;52(1):1-8. Epub 2012 May 15.

Venetian Institute of Molecular Medicine, University of Padova, Italy.

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http://dx.doi.org/10.1016/j.ceca.2012.02.007DOI Listing
July 2012

Hair cells, plasma membrane Ca²⁺ ATPase and deafness.

Int J Biochem Cell Biol 2012 May 13;44(5):679-83. Epub 2012 Feb 13.

Venetian Institute of Molecular Medicine, Via G. Orus, 2, 35129 Padua, Italy.

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http://dx.doi.org/10.1016/j.biocel.2012.02.006DOI Listing
May 2012

Crystal structure of sarcoplasmic reticulum Ca2+-ATPase (SERCA) from bovine muscle.

J Struct Biol 2012 Apr 24;178(1):38-44. Epub 2012 Feb 24.

Department of Experimental Veterinary Sciences, Viale dell'Università 16, 35020 Legnaro, Padua, Italy.

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http://dx.doi.org/10.1016/j.jsb.2012.02.008DOI Listing
April 2012

Calcium pumps: why so many?

Compr Physiol 2012 Apr;2(2):1045-60

Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro Padova, Italy.

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http://dx.doi.org/10.1002/cphy.c110034DOI Listing
April 2012

Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.

Cell Calcium 2011 Dec 1;50(6):569-76. Epub 2011 Nov 1.

Venetian Institute of Molecular Medicine (VIMM), Padua, Italy.

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http://dx.doi.org/10.1016/j.ceca.2011.09.004DOI Listing
December 2011

Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease.

Biofactors 2011 May-Jun;37(3):189-96

Department of Biochemistry, University of Padova, Italy.

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http://dx.doi.org/10.1002/biof.157DOI Listing
October 2011

The plasma membrane calcium pump in the hearing process: physiology and pathology.

Authors:
Ernesto Carafoli

Sci China Life Sci 2011 Aug 24;54(8):686-90. Epub 2011 Jul 24.

Venetian Institute of Molecular Medicine, University of Padova, Padua, Italy.

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http://dx.doi.org/10.1007/s11427-011-4200-zDOI Listing
August 2011

The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium.

Cold Spring Harb Perspect Biol 2011 Feb 1;3(2). Epub 2011 Feb 1.

Department of Biological Chemistry, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy.

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http://dx.doi.org/10.1101/cshperspect.a004168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039526PMC
February 2011

The fateful encounter of mitochondria with calcium: how did it happen?

Authors:
Ernesto Carafoli

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):595-606. Epub 2010 Apr 10.

Department of Biochemistry and Venetian Institute of Molecular Medicine, University of Padova, Italy.

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http://dx.doi.org/10.1016/j.bbabio.2010.03.024DOI Listing
January 2011

A proteomic study of calpain-3 and its involvement in limb girdle muscular dystrophy type 2a.

Cell Calcium 2009 Nov-Dec;46(5-6):356-63. Epub 2009 Nov 18.

Department of Biochemistry University of Padova, and Venetian Institute of Molecular Medicine, Padova, Italy.

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http://dx.doi.org/10.1016/j.ceca.2009.10.003DOI Listing
July 2010

Calcium pumps in health and disease.

Physiol Rev 2009 Oct;89(4):1341-78

Department of Biochemistry, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1152/physrev.00032.2008DOI Listing
October 2009

Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling.

J Biol Chem 2008 Oct 29;283(41):27494-503. Epub 2008 Jul 29.

Department of Biochemistry, University of Padova, Padova 35131, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M804152200
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http://dx.doi.org/10.1074/jbc.M804152200DOI Listing
October 2008

The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation.

Arch Biochem Biophys 2008 Aug 4;476(1):65-74. Epub 2008 Mar 4.

Department of Biochemistry, University of Padova, Viale G. Colombo, 3 35131 Padova, Italy.

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http://dx.doi.org/10.1016/j.abb.2008.02.026DOI Listing
August 2008

Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.

Cell Calcium 2008 Jun 29;43(6):550-61. Epub 2007 Oct 29.

Venetian Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.

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http://dx.doi.org/10.1016/j.ceca.2007.09.003DOI Listing
June 2008

Exporting calcium from cells.

Cell Calcium 2005 Sep-Oct;38(3-4):281-9

Novartis Pharma AG, 4002 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S014341600500119
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http://dx.doi.org/10.1016/j.ceca.2005.06.032DOI Listing
May 2008

Calcium and signal transduction.

Biochem Mol Biol Educ 2008 May;36(3):175-80

Department of Biochemistry, University of Padova, 35131 Padova, Italy.

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http://dx.doi.org/10.1002/bmb.20187DOI Listing
May 2008

A tribute to Dr. Setsuro Ebashi.

Biochem Biophys Res Commun 2008 Apr 7;369(1):28-9. Epub 2008 Jan 7.

Universitá degli Studi di Padova, Dipartimento di Chimica Biologica, Viale Giuseppe Colombo, 3 I-35121 Padova, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2007.12.080DOI Listing
April 2008

Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease.

J Biol Chem 2008 Feb 21;283(9):5780-9. Epub 2007 Dec 21.

Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy.

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http://dx.doi.org/10.1074/jbc.M704704200DOI Listing
February 2008

The role of phosphorylation on the structure and dynamics of phospholamban: a model from molecular simulations.

Proteins 2007 Mar;66(4):930-40

Venetian Institute of Molecular Medicine (VIMM),Via Orus 2, 35129, Padova, Italy.

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http://dx.doi.org/10.1002/prot.21239DOI Listing
March 2007

Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.

J Biol Chem 2006 Jul 5;281(28):19645-54. Epub 2006 May 5.

Venetian Institute of Molecular Medicine, and Department of Biochemistry, University of Padova, 35100 Padova, Italy.

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http://dx.doi.org/10.1074/jbc.M602033200DOI Listing
July 2006

Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pump.

J Biol Chem 2005 Nov 26;280(44):37195-203. Epub 2005 Aug 26.

Department of Biochemistry, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.

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http://dx.doi.org/10.1074/jbc.M504921200DOI Listing
November 2005

Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.

J Neurosci 2005 Nov;25(47):10822-30

Department of Molecular and Cellular Biology, National Centre of Biotechnology, Consejo Superior de Investigaciones Científicas, E-28049 Madrid, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3912-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725879PMC
November 2005

Calcium signaling: a historical account.

Authors:
Ernesto Carafoli

Biol Res 2004 ;37(4):497-505

Department of Biochemistry, University of Padova, Venetian Institute of Molecular Medicine (VIMM), 35121 Padova, Italy.

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http://dx.doi.org/10.4067/s0716-97602004000400002DOI Listing
October 2005

Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations.

J Biol Chem 2005 Apr 2;280(15):15380-9. Epub 2005 Feb 2.

Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council (CNR), University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.

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http://dx.doi.org/10.1074/jbc.M410421200DOI Listing
April 2005

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity.

Cell 2005 Jan;120(2):275-85

MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road LE1 9HN, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.cell.2004.11.049DOI Listing
January 2005

Calcium-mediated cellular signals: a story of failures.

Authors:
Ernesto Carafoli

Trends Biochem Sci 2004 Jul;29(7):371-9

Department of Biochemistry, University of Padova, Viale G. Colombo 3, 35121 Padua, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S096800040400126
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http://dx.doi.org/10.1016/j.tibs.2004.05.006DOI Listing
July 2004

Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity.

J Biol Chem 2003 Oct 8;278(40):38141-8. Epub 2003 Jul 8.

Institute of Biochemistry, Swiss Federal Institute of Technology, CH-8092 Zürich, Switzerland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302400200
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http://dx.doi.org/10.1074/jbc.M302400200DOI Listing
October 2003

A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells.

J Biol Chem 2003 Jul 25;278(27):24500-8. Epub 2003 Apr 25.

Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council (CNR), University of Padova, Viale G. Colombo 3, Italy.

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http://dx.doi.org/10.1074/jbc.M300784200DOI Listing
July 2003

The calcium-signalling saga: tap water and protein crystals.

Authors:
Ernesto Carafoli

Nat Rev Mol Cell Biol 2003 04;4(4):326-32

Department of Biochemistry, University of Padova, 35121 Padova, Italy.

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http://dx.doi.org/10.1038/nrm1073DOI Listing
April 2003

Historical review: mitochondria and calcium: ups and downs of an unusual relationship.

Authors:
Ernesto Carafoli

Trends Biochem Sci 2003 Apr;28(4):175-81

Department of Biochemistry, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.

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http://dx.doi.org/10.1016/S0968-0004(03)00053-7DOI Listing
April 2003

Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons.

J Neurochem 2003 Jan;84(2):282-93

Department of Biological Chemistry, University of Padova, Italy.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01511.xDOI Listing
January 2003

The gene promoter of human Na+/Ca2+ exchanger isoform 3 (SLC8A3) is controlled by cAMP and calcium.

Ann N Y Acad Sci 2002 Nov;976:282-4

Department of Biological Chemistry, University of Padua, 35121 Padua, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04750.xDOI Listing
November 2002

A study of the activity of the plasma membrane Na/Ca exchanger in the cellular environment.

Ann N Y Acad Sci 2002 Nov;976:376-81

Department of Biochemistry and Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04764.xDOI Listing
November 2002

Recombinant expression of the plasma membrane Na(+)/Ca(2+) exchanger affects local and global Ca(2+) homeostasis in Chinese hamster ovary cells.

J Biol Chem 2002 Oct 26;277(41):38693-9. Epub 2002 Jul 26.

Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M206075200
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http://dx.doi.org/10.1074/jbc.M206075200DOI Listing
October 2002

The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms.

Gene 2002 Sep;298(1):1-7

Department of Biological Chemistry, University of Padova, Via G. Colombo, 3, 35121 Padua, Italy.

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http://dx.doi.org/10.1016/s0378-1119(02)00982-4DOI Listing
September 2002

Ca2+ on the move: ways and means to translate a multifarious signal.

Trends Pharmacol Sci 2002 Aug;23(8):348-50

Dept of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/s0165-6147(02)02063-1DOI Listing
August 2002

Signalling takes control of nucleo-cytoplasmic trafficking. Workshop on signal-regulated nuclear transport.

EMBO Rep 2002 May;3(5):410-4

University of Zürich, Institute of Zoology, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1093/embo-reports/kvf093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084106PMC
May 2002

Differential membrane targeting of the SERCA and PMCA calcium pumps: experiments with recombinant chimeras.

FASEB J 2002 Apr;16(6):519-28

Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), 8092 Zurich, Switzerland.

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http://dx.doi.org/10.1096/fj.01-0362comDOI Listing
April 2002

Calcium signaling: a tale for all seasons.

Authors:
Ernesto Carafoli

Proc Natl Acad Sci U S A 2002 Feb;99(3):1115-22

Department of Biochemistry, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.

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http://dx.doi.org/10.1073/pnas.032427999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122154PMC
February 2002