Ernesto Canalis

Ernesto Canalis

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Ernesto Canalis

Publications by authors named "Ernesto Canalis"

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Antisense oligonucleotides targeting ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome.

J Biol Chem 2020 Mar 28;295(12):3952-3964. Epub 2020 Jan 28.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030.

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http://dx.doi.org/10.1074/jbc.RA119.011440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086019PMC
March 2020

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice.

J Cell Physiol 2020 Jan 12;235(1):210-220. Epub 2019 Jun 12.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcp.28960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778702PMC
January 2020

The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α.

J Biol Chem 2019 Sep 1;294(39):14203-14214. Epub 2019 Aug 1.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030

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http://dx.doi.org/10.1074/jbc.RA119.009824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768656PMC
September 2019

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment.

Eur J Endocrinol 2019 Aug;181(2):R45-R56

Departments of Orthopaedic Surgery and Medicine, The UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1530/EJE-19-0184DOI Listing
August 2019

Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo.

J Cell Biochem 2018 11 16;119(11):9334-9345. Epub 2018 Jul 16.

Department of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcb.27212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195439PMC
November 2018

The lateral meningocele syndrome mutation causes marked osteopenia in mice.

J Biol Chem 2018 09 24;293(36):14165-14177. Epub 2018 Jul 24.

From the Departments of Orthopaedic Surgery.

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http://dx.doi.org/10.1074/jbc.RA118.004242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130932PMC
September 2018

Glucocorticoids inhibit notch target gene expression in osteoblasts.

J Cell Biochem 2018 07 25;119(7):6016-6023. Epub 2018 Mar 25.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcb.26798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830575PMC
July 2018

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

Am J Pathol 2018 06 12;188(6):1430-1446. Epub 2018 Mar 12.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut; Department of Medicine, UConn Health, Farmington, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971225PMC
June 2018

Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders.

Authors:
Ernesto Canalis

Metabolism 2018 03 24;80:48-56. Epub 2017 Aug 24.

Department of Orthopaedic Surgery, the UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030, USA; Department of Medicine, the UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00260495173020
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http://dx.doi.org/10.1016/j.metabol.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818282PMC
March 2018

MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

Authors:
Ernesto Canalis

Eur J Endocrinol 2018 Feb 7;178(2):R33-R44. Epub 2017 Nov 7.

Departments of Orthopaedic Surgery and Medicine, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1530/EJE-17-0920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819362PMC
February 2018

The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.

Am J Pathol 2018 01 14;188(1):149-159. Epub 2017 Oct 14.

Department of Orthopaedic Surgery, UConn Musculoskeletal Institute, Farmington, Connecticut; Department of Medicine, UConn Musculoskeletal Institute, Farmington, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745525PMC
January 2018

Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.

Bone 2017 Oct 1;103:159-167. Epub 2017 Jul 1.

Departments of Orthopaedic Surgery and Medicine, UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030-5456, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282173022
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http://dx.doi.org/10.1016/j.bone.2017.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568480PMC
October 2017

Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice.

J Cell Biochem 2017 07 9;118(7):1819-1826. Epub 2017 Mar 9.

Departments of Orthopaedic Surgery and Medicine, and the UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, 06030-5456.

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http://doi.wiley.com/10.1002/jcb.25859
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http://dx.doi.org/10.1002/jcb.25859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424199PMC
July 2017

An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice.

Endocrinology 2017 04;158(4):730-742

Departments of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, CT, USA.

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http://dx.doi.org/10.1210/en.2016-1787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460801PMC
April 2017

Effects of Sex and Notch Signaling on the Osteocyte Cell Pool.

J Cell Physiol 2017 Feb 7;232(2):363-370. Epub 2016 Jun 7.

Department of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcp.25433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325059PMC
February 2017

Hajdu Cheney Syndrome; report of a novel NOTCH2 mutation and treatment with denosumab.

Bone 2016 11 31;92:150-156. Epub 2016 Aug 31.

Department of Orthopaedic Surgery, the UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056853PMC
http://dx.doi.org/10.1016/j.bone.2016.08.025DOI Listing
November 2016

Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations.

Curr Osteoporos Rep 2016 08;14(4):126-31

Departments of Orthopaedic Surgery and Medicine, and the UConn Musculoskeletal Institute, UConn Health, Farmington, CT, 06030-5456, USA.

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http://dx.doi.org/10.1007/s11914-016-0311-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927394PMC
August 2016

Notch Signaling and the Skeleton.

Endocr Rev 2016 06 13;37(3):223-53. Epub 2016 Apr 13.

Departments of Orthopaedic Surgery and Medicine and the UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.

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http://dx.doi.org/10.1210/er.2016-1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890266PMC
June 2016

The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.

J Cell Biochem 2016 May 20;117(5):1222-32. Epub 2015 Oct 20.

Departments of Orthopaedic Surgery and Medicine, and The UConn Musculoskeletal Institute, UConn Health, Farmington, 06030, Connecticut.

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http://dx.doi.org/10.1002/jcb.25405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777692PMC
May 2016

Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice.

PLoS One 2015 17;10(3):e0120164. Epub 2015 Mar 17.

New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut, United States of America; Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120164PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363701PMC
February 2016

Canonical Notch activation in osteocytes causes osteopetrosis.

Am J Physiol Endocrinol Metab 2016 Jan 17;310(2):E171-82. Epub 2015 Nov 17.

Department of Orthopedic Surgery and the University of Connecticut Musculoskeletal Institute, Farmington, Connecticut; and Department of Medicine, University of Connecticut Health, Farmington, Connecticut.

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http://ajpendo.physiology.org/content/ajpendo/early/2015/11/
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.003
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http://dx.doi.org/10.1152/ajpendo.00395.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719030PMC
January 2016

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption.

J Biol Chem 2016 Jan 1;291(4):1538-51. Epub 2015 Dec 1.

From the Departments of Orthopaedic Surgery, Medicine.

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http://dx.doi.org/10.1074/jbc.M115.685453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722436PMC
January 2016

Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.

Endocrinology 2015 Nov 31;156(11):4129-40. Epub 2015 Jul 31.

Maine Medical Center Research Institute (V.E.M., P.T.L., A.R.G., D.E.M., C.J.R.), Scarborough, Maine 04074; Departments of Orthopedic Surgery and Medicine (E.C.), University of Connecticut Health Center, Farmington, Connecticut 06032; Department of Medicine (K.N., R.B.), Harvard Medical School and Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, Massachusetts 02115; and University of North Carolina (D.R.C.), Chapel Hill, North Carolina 27514.

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http://dx.doi.org/10.1210/en.2014-1452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606757PMC
November 2015

Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.

Eur J Endocrinol 2015 Sep 13;173(3):R131-51. Epub 2015 May 13.

Division of Endocrinology and MetabolismDepartments of MedicineOrthopaedic SurgeryUConn Musculoskeletal Institute, UConn Health, 263 Farmington Avenue, Farmington, Connecticut 06030-5456, USA Division of Endocrinology and MetabolismDepartments of MedicineOrthopaedic SurgeryUConn Musculoskeletal Institute, UConn Health, 263 Farmington Avenue, Farmington, Connecticut 06030-5456, USA.

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http://dx.doi.org/10.1530/EJE-15-0118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534332PMC
September 2015

Activation of Nfatc2 in osteoblasts causes osteopenia.

J Cell Physiol 2015 Jul;230(7):1689-95

Departments of Orthopaedic Surgery and Medicine, UConn Health Center, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcp.24928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380686PMC
July 2015

Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.

J Bone Miner Res 2014 ;29(5):1217-31

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA.

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http://dx.doi.org/10.1002/jbmr.2114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984377PMC
December 2014

Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.

PLoS One 2014 28;9(1):e86757. Epub 2014 Jan 28.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States of America ; University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086757PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904935PMC
December 2014

Hajdu-Cheney syndrome: a review.

Orphanet J Rare Dis 2014 Dec 10;9:200. Epub 2014 Dec 10.

Departments of Orthopaedic Surgery and Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1186/s13023-014-0200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269900PMC
December 2014

Nemo-like kinase regulates postnatal skeletal homeostasis.

J Cell Physiol 2014 Nov;229(11):1736-43

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut; The University of Connecticut School of Medicine, Farmington, Connecticut.

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http://dx.doi.org/10.1002/jcp.24625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117815PMC
November 2014

Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage.

Bone 2014 Jul 2;64:273-80. Epub 2014 May 2.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT, 06105. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069863PMC
July 2014

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.

Bone 2014 May 4;62:22-8. Epub 2014 Feb 4.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT, USA; University of Connecticut School of Medicine, Farmington, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970724PMC
May 2014

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

Am J Physiol Lung Cell Mol Physiol 2014 Apr 7;306(8):L786-96. Epub 2014 Feb 7.

109 Zina Pitcher Place, BSRB 4061, Ann Arbor, MI 48109.

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http://dx.doi.org/10.1152/ajplung.00243.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989723PMC
April 2014

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches.

Authors:
Ernesto Canalis

Nat Rev Endocrinol 2013 Oct 13;9(10):575-83. Epub 2013 Aug 13.

Department of Research, Saint Francis Hospital and Medical Centre, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://www.nature.com/articles/nrendo.2013.154
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http://dx.doi.org/10.1038/nrendo.2013.154DOI Listing
October 2013

Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling.

J Biol Chem 2013 Aug 24;288(35):25614-25. Epub 2013 Jul 24.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1074/jbc.M113.470492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757222PMC
August 2013

Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice.

J Biol Chem 2013 Jul 19;288(30):21547-57. Epub 2013 Jun 19.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1074/jbc.M113.489435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724615PMC
July 2013

Notch signaling in skeletal health and disease.

Eur J Endocrinol 2013 Jun 8;168(6):R95-103. Epub 2013 May 8.

Department of Research, , Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1530/EJE-13-0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501254PMC
June 2013

Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes.

Endocrinology 2013 Feb 21;154(2):762-72. Epub 2012 Dec 21.

PhD, Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2012-1925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548184PMC
February 2013

Osteoblast lineage-specific effects of notch activation in the skeleton.

Endocrinology 2013 Feb 28;154(2):623-34. Epub 2012 Dec 28.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2012-1732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548181PMC
February 2013

Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts.

J Biol Chem 2013 Jan 19;288(1):624-32. Epub 2012 Nov 19.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA.

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http://dx.doi.org/10.1074/jbc.M112.340455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537061PMC
January 2013

Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.

Endocrinology 2012 Apr 14;153(4):1616-26. Epub 2012 Feb 14.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://endo.endojournals.org/content/153/4/1616.full.pdf
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http://press.endocrine.org/doi/10.1210/en.2011-1604
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http://dx.doi.org/10.1210/en.2011-1604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320258PMC
April 2012

Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling.

J Cell Biochem 2012 Feb;113(2):449-56

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1002/jcb.23365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253257PMC
February 2012

Notch regulation of bone development and remodeling and related skeletal disorders.

Calcif Tissue Int 2012 Feb 16;90(2):69-75. Epub 2011 Oct 16.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105, USA.

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http://dx.doi.org/10.1007/s00223-011-9541-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272107PMC
February 2012

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.

J Cell Physiol 2012 Jan;227(1):269-77

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://doi.wiley.com/10.1002/jcp.22730
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http://dx.doi.org/10.1002/jcp.22730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132213PMC
January 2012

Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice.

Biol Reprod 2011 Dec 10;85(6):1175-82. Epub 2011 Aug 10.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1095/biolreprod.111.091728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223251PMC
December 2011

Glucocorticoid-induced osteoporosis in rheumatic diseases.

Clinics (Sao Paulo) 2010 ;65(11):1197-205

Rheumatology Division, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999719PMC
http://dx.doi.org/10.1590/s1807-59322010001100024DOI Listing
October 2011

New treatment modalities in osteoporosis.

Authors:
Ernesto Canalis

Endocr Pract 2010 Sep-Oct;16(5):855-63

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299 , USA.

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http://dx.doi.org/10.4158/EP10048.RADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278773PMC
June 2011

Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts.

J Biol Chem 2011 Feb 3;286(6):4576-88. Epub 2010 Dec 3.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA.

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http://dx.doi.org/10.1074/jbc.M110.161893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039329PMC
February 2011

Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms.

J Cell Biochem 2011 Feb;112(2):715-22

Department of Research, Saint Francis Hospital, Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1002/jcb.22985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059361PMC
February 2011

HES1 (hairy and enhancer of split 1) is a determinant of bone mass.

J Biol Chem 2011 Jan 17;286(4):2648-57. Epub 2010 Nov 17.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA.

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http://dx.doi.org/10.1074/jbc.M110.183038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024760PMC
January 2011

Drug-induced osteoporosis: mechanisms and clinical implications.

Am J Med 2010 Oct;123(10):877-84

Department of Medical and Surgical Sciences, University of Brescia, Montichiari, Italy.

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http://dx.doi.org/10.1016/j.amjmed.2010.02.028DOI Listing
October 2010

Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation.

Bone 2010 Sep 9;47(3):573-82. Epub 2010 Jun 9.

Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.bone.2010.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926146PMC
September 2010

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice.

Endocrinology 2010 Aug 9;151(8):3490-501. Epub 2010 Jun 9.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2010-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940511PMC
August 2010

Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage.

J Cell Biochem 2010 May;110(2):477-83

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1002/jcb.22561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008370PMC
May 2010

Update in new anabolic therapies for osteoporosis.

Authors:
Ernesto Canalis

J Clin Endocrinol Metab 2010 Apr;95(4):1496-504

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/jc.2009-2677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853988PMC
April 2010

Notch and the skeleton.

Mol Cell Biol 2010 Feb 7;30(4):886-96. Epub 2009 Dec 7.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1128/MCB.01285-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815558PMC
February 2010

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis.

Endocrinology 2010 Jan 24;151(1):221-33. Epub 2009 Nov 24.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2009-0574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803142PMC
January 2010

Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss.

Curr Osteoporos Rep 2009 Dec;7(4):118-26

The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1007/s11914-009-0021-4DOI Listing
December 2009

Growth factor control of bone mass.

Authors:
Ernesto Canalis

J Cell Biochem 2009 Nov;108(4):769-77

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1002/jcb.22322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004749PMC
November 2009

Transgenic overexpression of gremlin results in developmental defects in enamel and dentin in mice.

Connect Tissue Res 2008 ;49(6):391-400

Department of Periodontics, School of Dentistry, [corrected] University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1080/03008200802325060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852574PMC
August 2009

Misexpression of CCAAT/enhancer binding protein beta causes osteopenia.

J Endocrinol 2009 May 13;201(2):263-74. Epub 2009 Feb 13.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1677/JOE-08-0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674520PMC
May 2009

Treatment of glucocorticoid-induced osteoporsis.

Ther Adv Musculoskelet Dis 2009 Feb;1(1):27-34

Department of Internal Medicine, University of Brescia, Italy.

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http://dx.doi.org/10.1177/1759720X09343222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382670PMC
February 2009

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

Endocrinology 2008 Sep 5;149(9):4374-81. Epub 2008 Jun 5.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2008-0254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553373PMC
September 2008

Notch inhibits osteoblast differentiation and causes osteopenia.

Endocrinology 2008 Aug 17;149(8):3890-9. Epub 2008 Apr 17.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2008-0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488209PMC
August 2008

Growth hormone, insulin-like growth factors, and the skeleton.

Endocr Rev 2008 Aug 24;29(5):535-59. Epub 2008 Apr 24.

Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1210/er.2007-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726838PMC
August 2008

Connective tissue growth factor enhances osteoblastogenesis in vitro.

J Biol Chem 2008 Aug 25;283(33):22690-9. Epub 2008 Jun 25.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1074/jbc.M710140200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504891PMC
August 2008

Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2.

J Cell Biochem 2008 Jul;104(4):1421-6

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1002/jcb.21715DOI Listing
July 2008

Gene delivery by retroviruses.

Methods Mol Biol 2008 ;455:157-62

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT, USA.

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http://dx.doi.org/10.1007/978-1-59745-104-8_12DOI Listing
June 2008

Notch signaling in osteoblasts.

Authors:
Ernesto Canalis

Sci Signal 2008 Apr 29;1(17):pe17. Epub 2008 Apr 29.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA.

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http://dx.doi.org/10.1126/stke.117pe17DOI Listing
April 2008

Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist.

Authors:
Ernesto Canalis

Ann N Y Acad Sci 2007 Nov;1116:50-8

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105-1299, USA.

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http://doi.wiley.com/10.1196/annals.1402.055
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November 2007

Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects.

Arq Bras Endocrinol Metabol 2007 Nov;51(8):1404-12

Department of Internal Medicine, University of Brescia, Italy.

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http://dx.doi.org/10.1590/s0004-27302007000800028DOI Listing
November 2007

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass.

J Biol Chem 2007 Oct 4;282(43):31549-57. Epub 2007 Sep 4.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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October 2007

Age-related changes in trabecular architecture differ in female and male C57BL/6J mice.

J Bone Miner Res 2007 Aug;22(8):1197-207

Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://doi.wiley.com/10.1359/jbmr.070507
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August 2007

Mechanisms of anabolic therapies for osteoporosis.

N Engl J Med 2007 Aug;357(9):905-16

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1056/NEJMra067395DOI Listing
August 2007

Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.

J Biol Chem 2007 Jul 10;282(27):19762-72. Epub 2007 May 10.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA.

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http://dx.doi.org/10.1074/jbc.M700212200DOI Listing
July 2007

CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia.

Bone 2007 Mar 7;40(3):619-26. Epub 2006 Nov 7.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT, USA.

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http://dx.doi.org/10.1016/j.bone.2006.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850334PMC
March 2007

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.

Bone 2006 Dec 24;39(6):1252-60. Epub 2006 Aug 24.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1016/j.bone.2006.06.028DOI Listing
December 2006

Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage.

J Bone Miner Res 2006 Aug;21(8):1317-26

Department of Research Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://doi.wiley.com/10.1359/jbmr.060505
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August 2006

Glucocorticoid-induced osteoporosis: an update.

Trends Endocrinol Metab 2006 May-Jun;17(4):144-9

Department of Internal Medicine, Spedali Civili, University of Brescia, 25125 Brescia, Italy.

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http://dx.doi.org/10.1016/j.tem.2006.03.009DOI Listing
July 2006

Bone morphogenetic proteins and their antagonists.

Rev Endocr Metab Disord 2006 Jun;7(1-2):51-65

Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, Genoa, Italy.

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http://dx.doi.org/10.1007/s11154-006-9000-6DOI Listing
June 2006

Expression and regulation of CCN genes in murine osteoblasts.

Bone 2006 May 28;38(5):671-7. Epub 2005 Nov 28.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA.

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http://dx.doi.org/10.1016/j.bone.2005.10.005DOI Listing
May 2006

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling.

J Biol Chem 2006 Mar 6;281(10):6203-10. Epub 2006 Jan 6.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1074/jbc.M508370200DOI Listing
March 2006

C/EBP homologous protein is necessary for normal osteoblastic function.

J Cell Biochem 2006 Feb;97(3):633-40

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1002/jcb.20660DOI Listing
February 2006

Skeletal actions of insulin-like growth factors.

Expert Rev Endocrinol Metab 2006 Jan;1(1):47-56

b

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http://dx.doi.org/10.1586/17446651.1.1.47DOI Listing
January 2006

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.

Endocrinology 2005 Sep 26;146(9):3875-82. Epub 2005 May 26.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2005-0053DOI Listing
September 2005

Mechanisms of glucocorticoid action in bone.

Authors:
Ernesto Canalis

Curr Osteoporos Rep 2005 Sep;3(3):98-102

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299, USA.

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http://dx.doi.org/10.1007/s11914-005-0017-7DOI Listing
September 2005

The fate of circulating osteoblasts.

Authors:
Ernesto Canalis

N Engl J Med 2005 May;352(19):2014-6

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http://dx.doi.org/10.1056/NEJMe058080DOI Listing
May 2005

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.

Endocrinology 2005 Feb 11;146(2):655-65. Epub 2004 Nov 11.

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1210/en.2004-0766DOI Listing
February 2005