Publications by authors named "Erita Filipek"

14 Publications

  • Page 1 of 1

Success rates of probing for congenital nasolacrimal duct obstruction at various ages.

BMC Ophthalmol 2020 Oct 8;20(1):403. Epub 2020 Oct 8.

Departament of Pediatric Ophthalmology, School of Medicine in Katowice, Medical University in Katowice, Katowice, Poland.

Background: Although nasolacrimal duct probing is the standard treatment for congenital nasolacrimal duct obstruction (CNLDO) among children, the optimal timing of this procedure has been a topic of debate. The aim of the study was to analyze the clinical efficacy of nasolacrimal duct probing among patients with CNLDO symptoms at various ages.

Methods: An 8-year retrospective study involved 2434 patients (3009 eyes), who underwent nasolacrimal duct probing conducted under topical anesthesia in the operating theatre. The study group consisted of 1148 girls (47.2%) and 1286 boys (52.8%) from 2 weeks to 41 months (average age was 8 ± 5.6 months). The participants were divided into nine age groups: 0-2 months, 3-6 months, 7-9 months, 10-12 months, 13-15 months, 16-18 months, 19-21 months, 22-24 months and over 24 months.

Results: Bilateral obstruction was present among 575 (23.6%) children and was associated with a higher percentage of unsuccessful procedures compared to patients with unilateral obstruction (16.9% vs 10.2%, p < 0.001 Chi-square test). The success rate of the initial probing was 87.2% for all children and it was shown that it decreased with age. In the above age groups, it was 87.9%; 91.4%; 89.6%; 86%; 76.3%; 71.3%; 70.3%; 70.2%; 65.4%, respectively.

Conclusions: Probing is a safe and effective procedure. However, age at the time of the initial intervention and bilateral surgery constitute significant risk factors for failed probing. Probing between 7 and 9 months appears to be reasonable treatment strategy for children without recurrent infections. Early surgical intervention may be considered for patients with additional signs.
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http://dx.doi.org/10.1186/s12886-020-01658-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542772PMC
October 2020

Contribution of a Novel Variant to Peters Plus Syndrome Discovered by a Combination of Next-Generation Sequencing and Automated Text Mining.

Int J Mol Sci 2019 Nov 28;20(23). Epub 2019 Nov 28.

Center for Medical Genomics-OMICRON, Jagiellonian University Medical College, ul. Kopernika 7c, 31-034 Krakow, Poland.

Anterior segment dysgenesis (ASD) encompasses a spectrum of ocular disorders affecting the structures of the anterior eye chamber. Mutations in several genes, involved in eye development, are implicated in this disorder. ASD is often accompanied by diverse multisystemic symptoms and another genetic cause, such as variants in genes encoding collagen type IV. Thus, a wide spectrum of phenotypes and underlying genetic diversity make fast and proper diagnosis challenging. Here, we used AMELIE, an automatic text mining tool that enriches data with the most up-to-date information from literature, and wANNOVAR, which is based on well-documented databases and incorporates variant filtering strategy to identify genetic variants responsible for severely-manifested ASD in a newborn child. This strategy, applied to trio sequencing data in compliance with ACMG 2015 guidelines, helped us find two compound heterozygous variants of the gene, of which c.660+1G>A (rs80338851) was previously associated with the phenotype of Peters plus syndrome (PPS), while the second, NM_194318.3:c.755delC (p.T252fs), in exon 9 of the same gene was noted for the first time. PPS, a very rare subtype of ASD, is a glycosylation disorder, where the dysfunctional gene product, O-fucose-specific β-1,3-glucosyltransferase, is ineffective in providing a noncanonical quality control system for proper protein folding in cells. Our study expands the mutation spectrum of the gene related to PPS. We suggest that the implementation of automatic text mining tools in combination with careful variant filtering could help translate sequencing results into diagnosis, thus, considerably accelerating the diagnostic process and, thereby, improving patient management.
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http://dx.doi.org/10.3390/ijms20236006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928627PMC
November 2019

Nonpenetrating very deep sclerectomy with hyaluronic acid implant vs trabeculectomy--a 2-year follow-up.

Graefes Arch Clin Exp Ophthalmol 2012 Dec 9;250(12):1835-41. Epub 2012 May 9.

Department of Ophthalmology, Medical University of Silesia, Katowice, Poland.

Objective: To study and compare the efficacy and safety of nonpenetrating very deep sclerectomy (NPVDS) with the use of hyaluronic acid implant (SKGEL) to trabeculectomy (TB) in patients with with medically uncontrolled glaucoma.

Methods: Prospective, controlled study of patients with open-angle glaucoma was designed. Seventy-eight eyes of 68 patients with medically uncontrolled glaucoma were assigned either to the NPVDS or to the TB group of trial. Examinations were applied before and 7 days, 1, 3, 6, 12, 18, and 24 months after surgery.

Main Outcome Measure: Best-corrected logMAR visual acuity, intraocular pressure, number of additional procedures, antiglaucoma medications, number of complications.

Results: At 24 months, success rate defined as IOP ≤ 21 mmHg with medication and additional procedures in NPVDS group was 92.31 %, and 94.88 % in control group (p = 0.64). There was no statistically significant difference between intraocular pressure in NPVDS (14.56 ± 4.07 mmHg ) and control (TB) (15.38 ± 3.38 mmHg) group (p = 0.34). Number of glaucoma mediations decreased from 2.18 ± 0.56 to 0.54 ± 0.56 in NPVDS and from 2.28 ± 1.41 to 0.61 ± 0.03 in TB group (p = 0.71). Early and late postoperative complications included two cases of hyphema, two of choroidal detachment, two of filtering bleb fibrosis, four of cataract progression in the NPVDS group; and five cases of hyphema, four of choroidal detachment, one of filtering bleb fibrosis, one of blebitis, and 12 of cataract progression in the control group.

Conclusions: NPVDS is an effective surgical option for patients with medically uncontrolled glaucoma. NPVDS is associated with a lower risk of complications, and in particular cataract progression, compared to TB.

Application To Clinical Practice: NPVDS is a modification of NPDS devised for patients with medically uncontrolled open-angle glaucoma.
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http://dx.doi.org/10.1007/s00417-012-1985-9DOI Listing
December 2012

Quantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataracts.

Mol Vis 2011 18;17:3025-33. Epub 2011 Nov 18.

Division of Pediatric Ophthalmology, Department of Ophthalmology, Medical University of Silesia, Katowice, Poland.

Purpose: The aim of this study was to determine differences in the expression profiles of transforming growth factor (TGF) β isoforms in the fragments of anterior lens capsules (ALCs) and peripheral blood mononuclear cells (PBMCs) of pediatric patients with congenital and traumatic cataracts.

Methods: Forty children with congenital cataracts (19 girls and 21 boys) and 22 children with traumatic cataracts (six girls and 16 boys) participated in the study. Fragments of ALCs obtained during cataract surgery and whole blood samples were analyzed. Quantification of TGFβ1, TGFβ2, and TGFβ3 mRNA was performed by real-time quantitative reverse transcription (QRT)-PCR using SYBR Green I chemistry.

Results: TGFβ1, TGFβ2, and TGFβ3 mRNA was detected in all the studied samples. Significant differences were found for TGFβ1 and TGFβ2 expression profiles in PBMCs between the patients with congenital and traumatic cataracts. The expression profiles of TGFβ isoforms in ALCs did not differ significantly between the groups.

Conclusions: Overexpression of TGFβ1 and TGFβ2 in the PBMCs of patients with congenital cataracts might indicate that these cytokines are involved in the development of lens opacity.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224844PMC
April 2012

Etiopathogenesis and management of high myopia. Part II.

Med Sci Monit 2009 Nov;15(11):RA252-5

Department and Clinic of Opthalmology, Medical University of Silesia, Katowice, Poland.

High myopia (HM) is defined as refractive error above -6.0 D (-8.0 diopters) with axial eyeball length above 26 mm, and is connected with the process of excessive myopisation. HM is not a homogenous disease. HM is considered to be inherited in 3 different patterns: dominant, autosomal recessive, and X-linked. Many genetic mutations linked to the development of HM have been described, including high grade myopia, and MYP1-16; different patterns of inheritance may reflect different types of HM. Over 150 genetic syndromes are associated with HM. The clinical state of the HM eyeball may also depend on environmental risk factors influencing the progression of refractive error. The complexity of etiopathogenesis makes it difficult to distinguish to what extent the development of HM is related to genetics versus exposure to environmental factors. HM remains a leading cause of visual loss. HM and its complications are considered to be one of the most significant causes of blindness and visual impairment in young, professionally active people, becoming an important social problem. Contemporary data concerning genetic factors, family aggregation, and epidemiological data of visual impairment connected with HM are presented in this paper. Therapeutic options for this refractive error are presented as well.
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November 2009

Etiopathogenesis and management of high-degree myopia. Part I.

Med Sci Monit 2009 Sep;15(9):RA199-202

Department and Clinic of Opthalmology, Medical University of Silesia, Katowice, Poland.

High-degree myopia (HM) is defined as a refractive error above -6 D (-8 diopters). An axial eyeball length above 26 mm and is also connected with excessive myopisation. Mechanical stretching and thinning of the choroids may lead to the development of irreversible degenerative changes in the eyeball and visual impairment. HM prevalence varies significantly by geographical area, ranging from 1.7-3.3%, while in highly urban regions of South-East Asia it affects up to 24% of university students. HM is not a homogenous disease. It is considered to be inherited in different patterns: dominant, autosomal recessive, and X-linked. Many genetic mutations linked to HM development have been described and the different patterns of inheritance may reflect different types of HM. Moreover, the clinical state of the HM eyeball may result from both genetic and environmental risk factors influencing the progression of the refractive error. The development and progression of HM is connected with sustained prolonged near work involving accommodation-convergence imbalance leading to retinal blur, the years spent at school, the amount of near work, especially writing and reading, which is related to slight chronic under-accommodation, and improper light stimuli in early childhood. Contemporary definitions of HM, views on etiopathogenesis, excessive axial elongation, and pathological changes within the eyeball in the course of HM leading to visual impairment are presented here. Genetic and environmental risk factors influencing the progression of HM, its significantly different prevalence in various geographical areas, and therapeutic options for the refractive error are also presented.
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September 2009

[Gaucher's disease--ocular manifestation and treatment].

Klin Oczna 2006 ;108(7-9):357-60

Katedry i Kliniki Okulistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.

Gaucher's disease is the most common lysosomal storage disorder due to a deficiency of glukocerebrosidase activity. It leads to an accumulation of glukosylceramide within the cells of the the reticuloendothelial system. Gaucher's disease is divided into three subtypes based on clinical symptoms. Type I--nonneuronopathic--chronically progressive in adulthood, type II--acute neuronopathic--infantile form lead up to the difficult damage nervous system, and type III--juvenile form--subacute neuronopathic. The aim of this paper is to present the typical ocular symptoms which occured in the disease. Gaucher's disease is the lysosomal storage disorder which is treated by enzyme replacement therapy.
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March 2007

[Variability of the eyeballs axial length in children with pseudophakia].

Klin Oczna 2006 ;108(7-9):301-5

Katedry i Kliniki Okulistyki, Dzieciecej SIaskiej Akademii Medycznej w Katowicach.

Purpose: The aim of the study is to evaluate the dynamics of axial elongation of pseudophakic eyes and changes in refraction pseudophakic eyes in children after monocular or binocular cataract surgery.

Material And Methods: the observations of 79 children (158 eyes) aged from 4 to 18 years (mean 9.7 +/- 0.55) after cataract surgery were conducted. The examined group consisted of 105 pseudophakic eyes, the comparative group consisted of 53 eyes without surgery in the same observed group of children. Moreover, the patients were evaluated in the following group: moncular - binocular cataract, primary or secondary IOL implantation, the age in groups were between 4-7 and between 8-18 years. Analysis statistically: STATGRAPHICS and SIMSTAT programs, p (alpha) = 0.05.

Results: In the examined group (105 eyes) the mean follow-up time was 4.2 years (+/- 0.3), the average age of patients was 9.7 years (+/- 0.7). Improvement of visual acuity was achieved mean 0.5 in 52.4% post operative eyes observed, myopic shift was -0.7D (+/- 0.52). The anatomic eyeball length increased up to 0.5mm (+/- 0.27). The average age of patients of the control group was 9.7 years (+/- 0.83), follow-up 4.3 years (+/- 0.44), visual acuity 0.8 (+/- 0.03). Mean elongation of the axial length was 0.56 mm(+/- 0.26), mean refraction of the eyeball was +0.38 D (+/- 0.54). The difference of the changes of refraction between examined and control group was statistically significant. The comparison of final refraction in optical pathway (p = 0.32) and the growth of anatomic eyeball length (p = 0.14), proved no significant differences in the group with monocular and binocular IOL. The comparative analysis of final refraction in optical pathway (p1 = 0.36), and the growth of anatomic eyeball length (p2 = 0.26) in the group with primary or secondary IOL and in the younger or older children (p1 = 0.52; p = 0.98) in the both groups, did not significantly differ.

Conclusions: The dynamics of axial elongation of pseudophakic and phakic eyes in children is similar. The myopic shift of pseufophakic eyes is bigger than in phakic eyes. It should be undertaken in calculation of the refractive power of intraocular lenses.
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March 2007

[Vernal keratoconjunctivitis in children].

Klin Oczna 2005 ;107(1-3):86-9

Z Katedry i Kliniki Okuliistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.

Purpose: To evaluate the course of palpebral type of vernal keratoconjunctivitis (VKC) and relation of the number of recurrences per year, to patients age and to estimate the frequency of irreversible corneal transparency changes and visual acuity decrease.

Material And Methods: There were 34 eyes of 17 children, 13 boys (76.4%) included 2 brothers and 4 girls. The age of patients was from 5 to 14 years, mean 9.1. All patients were hospitalized because of pathological corneal changes. Follow up from 2 to 13 years (mean 8.4). The number of recurrences ranged from 2 to 5 per year and there was not correlation between age of children and frequency of episodes.

Results: We have observed punctate keratopathy (79.14% of cases) and corneal ulcers (26.5% of cases). In 25 eyes of 13 patients cryocoagulation and/or excision of giant palpebral papillae were done. Visual acuity ranged from 0.01 to 1.0 and mean value before treatment was 0.879 +/- 0.09 and after 0.884 +/- 0.10. The difference was not statistically significant (p = 0.878).

Conclusions: (1) The course of VKC is recurrent, the number of recurrences per year does not depend on the age of patients, but is correlated with giant papillae of palpebral conjunctiva presence. (2) Large papillae should be excised, in order to make the healing of cornea quicker. (3) Permanent visual function decreasing is not frequent because partial leucoma is localized at the periphery of cornea.
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September 2005

[Central corneal thickness and intraocular pressure in the youth].

Klin Oczna 2004 ;106(1-2 Suppl):234-5

Kliniki Okulistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.

Purpose: To estimate the central corneal thickness in young patients and to evaluate the relationship between the intraocular pressure (IOP) and pachometry.

Patients And Methods: Eighty eyes of 40 children at the age from 9-18 years, mean 13.75 were examined. The applanation tonometry, pachometry, refraction and examination of corneal diameter were done. To statistical purpose t-Student test was used alpha = 0.05.

Results: IOP ranged from 12 to 24 mmHg, in 32 eyes was above 17 mmHg, mean 20.2 +/- 1.46 mmHg (I group) and in 48 eyeballs ranged from 12 to 17 mmHg, mean 15.6 +/- 0.96 mmHg (II group), p = 0. In the I group pachometry was from 480 to 591 microm, mean 542 +/- 11.1 and in the II group from 451 to 570 microm mean 521.7 +/- 9.39 p = 0.006. Mean refractive error in the I group was -0.4 D (from -5.0 to +4.0 D) and in the II group mean -0.8 (from -6.25 to +4.75), p = 0.45. In the both groups corneal diameter was from 11.5 to 12.5 mm. Comparing eyeballs of patients at similar age, refraction and corneal diameter, it was shown that central corneal thickness in the group with higher IOP was statistically significantly bigger than in the group II.

Conclusion: Measuring IOP in children we have to take into account the corneal thickness.
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March 2005

[Heparin-surface-modified PMMA intraocular lenses in children in early and late follow-up].

Klin Oczna 2003 ;105(5):273-6

Katedra i Klinika Okulistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.

Purpose: To compare anatomical and functional state of eyeballs after congenital cataract extraction and heparin-surface-modified PMMA (HSM-PMMA) or PMMA implanted lenses and to conclude, which type of implants is more advantageous in young patients.

Materials And Methods: 42 eyes of 30 children at the age of 3-16 years with congenital or developmental cataract after extraction and IOL implantation: I group--HSM-PMMA lenses in 24 eyes, and PMMA lenses in 18 eyes--II group. Mean age in the I group was 6 years and in the II group 8 years, p = 0.07. The presence of cellular and pigment deposits on the IOL surface as a sign of postoperative inflammation was examined by slit-lamp within 1 month after surgery. We have compared the results of visual acuity (V/A), corneal endothelium cell density and posterior capsule state. The examination were done in the short-term follow-up mean 14.1 months (4-24 months) in the I group and mean 32.1 months (16-48 months) in the II group. In the long-term follow-up mean 38 months (30-44 months) in the I group, and mean 56.1 months (40-72 months) in the II group.

Results: Within first month after operation cellular and pigment deposits on the IOL surface were seen more often in the II group, p = 0.03. Best corrected V/A was comparable in both groups in the short-term and the long-term follow-up. At last visit, mean value of V/A was 0.54 (I group) and 0.42 (II group), p = 0.37. There was no significant difference between central corneal endothelial cell density in both groups: before (2893 +/- 261/mm2 and 2821 +/- 217/mm2, p = 0.143) and after operation (2371 +/- 202/mm2 and 2361 +/- 299/mm2, p = 0.428). In the short-term follow-up, but not longer than within first 12 months after surgery the frequency of clinically significant posterior capsule opacification (PCO) was less in the HSM-PMMA group (8%), than in the PMMA group (33%), p = 0.006. In the long-term follow-up there was no statistically significant difference in PCO appearance between these groups (44% and 50%, p = 0.27).

Conclusions: Heparin-surface-modified intraocular lenses reduced postoperative inflammation and delayed the incidence of PCO in children. Heparin-surface-modified intraocular lenses are more advantageous, than PMMA lenses in young patients.
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April 2004

[Optic nerve disc in unilateral myopia in children].

Klin Oczna 2002 ;104(2):119-21

Katedry i Kliniki Okulistyki Dzieciecej Slaskiej Akademii Medycznej, Katowicach.

Purpose: The evaluation of biomorphometric parameters of optic nerve head of the eyes in myopic anisometropia, to state if glaucoma similar changes described in adults were present.

Material And Methods: 17 children, 14 girls and 3 boys at the age from 7-18 years, mean 12.6 years with unilateral myopia of mean value 8.6 D. The parameters of optic nerve disc: total contour area (TCA), cup/disc ratio (C/D), neuroretinal rim area (Rim), volume of neuroretinal rim (Vol. A), cup volume (Vol. B), maximum slope (MSL) and average slope angle (ASL) were examined using laser scanning ophthalmoscope in the TopSS system of Laser Diagnostic Technologies Inc. The I group consists of myopic eyes, in the II group there were emmetropic eyes of the same children.

Results: Refraction in the I group ranged from -4.5 to -12 D, mean -8.6 D, in the II group from 0 to + 1.0 D, mean 0.07 D. The mean axial length of eyeballs was 25.57 SD 1.9 mm in the I and 22.47 SD 1.09 mm in II group--the difference was significant. There was not statistically significant difference between TCA in the I (mean 1.19 SD 0.75 mm2) and II group (mean 2.13 SD 0.49 mm2). Mean C/D ratio and cup volume were significantly smaller in myopic (C/D 0.23 SD 0.16 Vol. B -0.06 SD 0.05) than in emmetropic eyes (C/D 0.33 SD 0.11 mm3, Vol. B -0.18 SD 0.14 mm3).

Conclusions: Optic nerve disc images in myopic and glaucomatous eyes in children are different. Smaller optic disc cup in myopic than in emmetropic eyes can show, that children myopic eyeballs enlarged without nerve fibers atrophy.
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October 2002

[Prognosis in juvenile glaucoma after trabeculectomy].

Klin Oczna 2002 ;104(2):115-8

Katedry i Kliniki Okulistyki Dzieciecej Slaskiej Akademii Medycznej, Katowicach.

Purpose: To evaluate the efficacy of trabeculectomy in the patients with juvenile glaucoma in the long-term follow-up.

Material And Methods: In 22 of 37 patients--41 trabeculectomies with basal iridectomy were performed. The age of children ranged from 6 to 18 years, mean 12.4 years. In one eye of 15-year-old boy we used Mitomycin C during reoperation. The follow-up period ranged from 2 to 14 years, mean 8 years. Patients were divided into 2 groups depending on the follow-up: I group (19 eyes) was observed 2-6 years, mean 5.1 years, II group (18 eyes) 7-14 years, mean 11.1 years. In the I group 57.9% and in the II group 61% of children were myopic.

Results: Intraocular pressure lower or equal to 21 mmHg with no glaucoma medication was obtained in 79% of eyes in the I group and 66.7% of eyes in the II group. The difference was not statistically significant. In other eye local application of B-blockers and dorzolamid decreased intraocular pressure to values safe for the optic nerve, what was monitored by visual acuity and laser scanning tomography.

Conclusion: Prognosis of juvenile glaucoma patients treated with trabeculectomy is satisfactory but the effectiveness of this procedure decreases together with the elongation of the follow-up period.
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October 2002

[Image of optic nerve disc with laser scanning tomography and results of static perimetry in children with juvenile glaucoma].

Klin Oczna 2002 ;104(1):37-40

Katedry i Kliniki Okulistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.

Unlabelled: The aim of our research was to estimate the correlation between optic nerve head parameters examined with laser scanning ophthalmoscope and results of central, visual field (MD and PSD) in the youth and the evaluation the role of this correlation in juvenile glaucoma early diagnosis.

Material: Three groups of patients. Group I consisted of 32 eyes (16 children) with juvenile glaucoma in which trabeculectomy was performed. There were 72 eyes of 32 children with glaucoma juvenile suspect in the group II. Control group (III) contained 20 eyes of 10 children without glaucoma. The age of patients ranged from 9 to 18 years. The mean intraocular pressure was 16 mmHg in the I group, 18 mmHg in the II group and 15.6 mmHg in the III group. Simple Regression Analysis of mean values of biomorphometric parameters of optic nerve head for Mean Defect of central visual field was used in all three groups.

Results: The statistically significant correlation between Vol. B and MD was observed in the I group. There was no such correlation in the II group, but correlation between Av. Sl. and MD was presented. In the III group mean value of MD was the smallest one and correlated with Vol. B. Statistically significant correlation between mean values of PSD and Vol. B was observed in the I and II group, between PSD and Vol. A in group III.

Conclusion: There was the correlation between optic nerve head parameters and mean deviation of retinal sensitivity of central visual field in the youth. This examination can be helpful in early diagnosis of primary juvenile glaucoma.
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June 2002