Erin K Linehan

Erin K Linehan

UNVERIFIED PROFILE

Are you Erin K Linehan?   Register this Author

Register author
Erin K Linehan

Erin K Linehan

Publications by authors named "Erin K Linehan"

Are you Erin K Linehan?   Register this Author

15Publications

254Reads

18Profile Views

Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.

PLoS One 2015 12;10(8):e0134397. Epub 2015 Aug 12.

Department of Microbiology and Physiological Systems, Univ. of Massachusetts Medical School, Worcester, MA, 01605, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534307PMC
May 2016

Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.

PLoS Genet 2015 Aug 11;11(8):e1005438. Epub 2015 Aug 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532491PMC
August 2015

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

J Immunol 2014 Jul 16;193(2):931-9. Epub 2014 Jun 16.

Department of Molecular and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105697PMC
July 2014

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9217-22. Epub 2014 Jun 9.

Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1405590111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078814PMC
June 2014

ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

J Immunol 2014 May 11;192(10):4887-96. Epub 2014 Apr 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1303481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049217PMC
May 2014

DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

DNA Repair (Amst) 2013 Dec 29;12(12):1087-93. Epub 2013 Sep 29.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000569PMC
December 2013

The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.

PLoS One 2012 20;7(4):e36061. Epub 2012 Apr 20.

Department of Microbiology and Physiological Systems, Medical School, University of Massachusetts, Worcester, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334981PMC
August 2012

AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

J Immunol 2011 Sep 29;187(5):2464-75. Epub 2011 Jul 29.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1101406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159830PMC
September 2011

p53 represses class switch recombination to IgG2a through its antioxidant function.

J Immunol 2010 Jun 5;184(11):6177-87. Epub 2010 May 5.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0904085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235438PMC
June 2010

Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

J Immunol 2008 Dec;181(12):8450-9

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656362PMC
http://dx.doi.org/10.4049/jimmunol.181.12.8450DOI Listing
December 2008

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

J Immunol 2007 Nov;179(9):6064-71

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.179.9.6064DOI Listing
November 2007

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

J Exp Med 2007 Nov 19;204(12):3017-26. Epub 2007 Nov 19.

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20071289
Publisher Site
http://dx.doi.org/10.1084/jem.20071289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118529PMC
November 2007

Inducible DNA breaks in Ig S regions are dependent on AID and UNG.

J Exp Med 2005 Aug;202(4):561-8

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20050872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212854PMC
August 2005