Erin G Schuetz

Erin G Schuetz

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Erin G Schuetz

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Role of Vitamins A and D in BCR-ABL Arf Acute Lymphoblastic Leukemia.

Sci Rep 2020 Feb 11;10(1):2359. Epub 2020 Feb 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41598-020-59101-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012907PMC
February 2020

Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo.

Drug Metab Dispos 2018 11 15;46(11):1725-1733. Epub 2018 Aug 15.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (K.Y., S.G., E.G.S.); and Cancer and Developmental Biology Track, University of Tennessee Health Science Center, Memphis, Tennessee (S.G.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0835
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http://dx.doi.org/10.1124/dmd.118.083584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199625PMC
November 2018

Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.

Drug Metab Dispos 2018 07 19;46(7):1014-1022. Epub 2018 Apr 19.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, (S.G., J.C.P., J.K.R., E.G.S.); and Cancer and Developmental Biology Track, University of Tennessee Health Science Center, Memphis, Tennessee (S.G.)

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http://dx.doi.org/10.1124/dmd.117.078360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992966PMC
July 2018

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Drug Metab Dispos 2018 06 30;46(6):888-896. Epub 2018 Mar 30.

Departments of Pharmaceutics (D.K.B., A.B., H.Z., K.G.C., A.M., B.P.), Genome Sciences (S.L., D.A.N.), Biostatistics (T.A.T.), and Medicine (J.K.A.), University of Washington, Seattle, Washington; Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://dx.doi.org/10.1124/dmd.118.080952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938891PMC
June 2018

Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions.

Drug Metab Dispos 2018 05 7;46(5):567-580. Epub 2018 Mar 7.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/dmd.118.080663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896366PMC
May 2018

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.

Hepatology 2018 04 23;67(4):1531-1545. Epub 2018 Feb 23.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1002/hep.29632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480337PMC
April 2018

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D-3--Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Drug Metab Dispos 2018 04 17;46(4):367-379. Epub 2018 Jan 17.

Departments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.)

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http://dx.doi.org/10.1124/dmd.117.078428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829543PMC
April 2018

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

J Pharmacol Exp Ther 2017 Jan 4;360(1):129-139. Epub 2016 Nov 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada (J-A.T., R.F.T.); Department of Pharmacology and Toxicology (J-A.T., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; Department of Pharmaceutics (B.P., K.G.C, K.E.T.) and Center for Exposures, Diseases, Genomics, and Environment (P.S.), University of Washington, Seattle, Washington; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.C., E.G.S.)

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http://dx.doi.org/10.1124/jpet.116.237594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193072PMC
January 2017

Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.

Drug Metab Dispos 2016 07 20;44(7):999-1004. Epub 2016 Apr 20.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee (M.M.S.T., B.M.); Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (R.N.H.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital Memphis, Tennessee (E.G.S.)

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http://dx.doi.org/10.1124/dmd.115.069252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931892PMC
July 2016

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.

Drug Metab Dispos 2016 Mar 17;44(3):343-51. Epub 2015 Dec 17.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.S.T.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., K.E.T., L.M.S., J.T.-S., Y.S.L.); Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (X.Z., Y.-C.T); and Departments of Pharmacy Practice and Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois (H.J., X.P.).

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http://dx.doi.org/10.1124/dmd.115.067900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767386PMC
March 2016

In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.

Drug Metab Dispos 2015 Nov 17;43(11):1646-54. Epub 2015 Aug 17.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)

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http://dx.doi.org/10.1124/dmd.115.065078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613952PMC
November 2015

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.

Drug Metab Dispos 2015 Aug 28;43(8):1226-35. Epub 2015 May 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.064428
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http://dx.doi.org/10.1124/dmd.115.064428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518065PMC
August 2015

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.

Biochem Pharmacol 2015 Aug 25;96(4):357-68. Epub 2015 Jun 25.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526351PMC
August 2015

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

Endocrinology 2014 Jun 18;155(6):2052-63. Epub 2014 Mar 18.

Departments of Pharmaceutics (Z.W., T.W., K.E.T.) and Medicinal Chemistry (M.S.), University of Washington, Seattle, Washington 98195-7610; Faculty of Pharmacy (T.H.), Osaka Ohtani University, Tondabayashi, Osaka 584-8540, Japan; Department of Pharmacokinetics and Drug Metabolism (L.Z.D.), Amgen, Seattle, Washington 98119; Department of Biomedical Sciences (N.J.K., J.P.G.), College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011; Heartland Assays, LLC (R.L.H.), Ames, Iowa 50010; and Department of Pharmaceutical Sciences (A.S.C., E.G.S.), St Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1210/en.2013-2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020929PMC
June 2014

Why do most human liver cytosol preparations lack xanthine oxidase activity?

Drug Metab Dispos 2014 Apr 15;42(4):695-9. Epub 2014 Jan 15.

Department of Chemistry, Washington State University, Pullman, Washington (J.T.B., K.V.C., S.N., C.A.J.-J., J.P.J.); Department of Pharmaceutics, University of Washington, Seattle, Washington (K.E.T., T.W.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden (S.C.S.); and Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Inc., La Jolla, California (M.Z.).

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http://dx.doi.org/10.1124/dmd.113.056374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965898PMC
April 2014

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.

Toxicol Appl Pharmacol 2013 Oct 22;272(1):96-107. Epub 2013 May 22.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.taap.2013.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775940PMC
October 2013

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.

Drug Metab Dispos 2013 Aug 23;41(8):1538-47. Epub 2013 May 23.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1124/dmd.113.051672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162005PMC
August 2013

Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.

J Steroid Biochem Mol Biol 2013 Jul 15;136:54-8. Epub 2012 Sep 15.

Department of Pharmaceutics, University of Washington, Seattle, WA 98195,, United States.

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http://dx.doi.org/10.1016/j.jsbmb.2012.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549031PMC
July 2013

Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.

Drug Metab Dispos 2013 Apr 8;41(4):923-31. Epub 2013 Jan 8.

Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1124/dmd.112.050344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608452PMC
April 2013

The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.

Drug Metab Dispos 2013 Mar 13;41(3):575-81. Epub 2012 Dec 13.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, CB #7569, Kerr Hall Rm 3310, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.112.048108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162003PMC
March 2013

Ontogeny and sorafenib metabolism.

Clin Cancer Res 2012 Oct 27;18(20):5788-95. Epub 2012 Aug 27.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490489PMC
October 2012

PharmGKB summary: very important pharmacogene information for CYP3A5.

Pharmacogenet Genomics 2012 Jul;22(7):555-8

Department of Experimental and Clinical Pharmacology, College of Pharmacy, Institute of Human Genetics, University of Minnesota, Minnesota, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FPC.0b013e328351d47fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738061PMC
July 2012

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

Hepatology 2010 Nov;52(5):1797-807

Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/hep.23876DOI Listing
November 2010

Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2.

Ann Pharmacother 2010 Nov 19;44(11):1709-17. Epub 2010 Oct 19.

Clinical Pharmacology Program, Medical Oncology Branch, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1345/aph.1P354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100585PMC
November 2010

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

J Pharmacol Exp Ther 2010 Mar 24;332(3):1088-99. Epub 2009 Nov 24.

Department of Pharmaceutical Sciences, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/content/332/3/1088.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.16080
Publisher Site
http://dx.doi.org/10.1124/jpet.109.160804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835441PMC
March 2010

Etoposide pathway.

Pharmacogenet Genomics 2009 Jul;19(7):552-3

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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https://insights.ovid.com/crossref?an=01213011-200907000-000
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http://dx.doi.org/10.1097/FPC.0b013e32832e0e7fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164627PMC
July 2009

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.

Drug Metab Dispos 2009 Apr 26;37(4):719-30. Epub 2009 Jan 26.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.024695
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http://dx.doi.org/10.1124/dmd.108.024695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680541PMC
April 2009

The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans.

Drug Metab Dispos 2008 Aug 19;36(8):1465-9. Epub 2008 May 19.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1124/dmd.107.020065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770345PMC
August 2008

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

J Pharmacol Exp Ther 2007 Dec 12;323(3):935-45. Epub 2007 Sep 12.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.107.12859
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http://dx.doi.org/10.1124/jpet.107.128595DOI Listing
December 2007

Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor.

Mol Pharmacol 2007 Sep 14;72(3):734-43. Epub 2007 Jun 14.

Department of Pharmaceutical Sciences, the State University of New York at Buffalo, Buffalo, New York 14260-1200, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.03
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http://dx.doi.org/10.1124/mol.107.035550DOI Listing
September 2007

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.

Mol Endocrinol 2007 Aug 22;21(8):1769-80. Epub 2007 May 22.

Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario, London Health Sciences Centre, University Hospital, London, Ontario, Canada N6A 5A5.

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http://dx.doi.org/10.1210/me.2007-0025DOI Listing
August 2007

Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.

J Clin Invest 2006 Jun 11;116(6):1703-12. Epub 2006 May 11.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195-7610, USA.

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http://dx.doi.org/10.1172/JCI27793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459072PMC
June 2006

Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.

Pharmacogenet Genomics 2006 Jun;16(6):415-27

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1097/01.fpc.0000194421.35641.70DOI Listing
June 2006

Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.

Mol Pharmacol 2006 Jan 5;69(1):56-65. Epub 2005 Oct 5.

Department of Pharmaceutics, Box 357610, University of Washington, Seattle, WA 98195-7610, USA.

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http://dx.doi.org/10.1124/mol.105.017392DOI Listing
January 2006

Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5.

Clin Pharmacol Ther 2005 Dec;78(6):605-18

General Clinical Research Center, School of Pharmacy, and Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.clpt.2005.08.014DOI Listing
December 2005

Tandem machine learning for the identification of genes regulated by transcription factors.

BMC Bioinformatics 2005 Aug 22;6:204. Epub 2005 Aug 22.

School of Computing and Engineering, University Of Missouri-Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1186/1471-2105-6-204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208855PMC
August 2005

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts.

Mol Endocrinol 2005 Jul 17;19(7):1720-39. Epub 2005 Feb 17.

University of Pittsburgh, Department of Pathology, 200 Lothrop, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1210/me.2004-0427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238640PMC
July 2005

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.

Drug Metab Dispos 2004 Sep;32(9):930-6

University of Chicago, Department of Medicine, Section of Hematology-Oncology, 5841 S. Maryland Avenue, MC2115, Chicago, IL 60637, USA.

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September 2004

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators.

Toxicol Appl Pharmacol 2004 Sep;199(3):251-65

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.taap.2003.12.027DOI Listing
September 2004

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.

J Biol Chem 2004 May 5;279(21):22250-7. Epub 2004 Mar 5.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M314111200DOI Listing
May 2004

Lessons from the CYP3A4 promoter.

Authors:
Erin G Schuetz

Mol Pharmacol 2004 Feb;65(2):279-81

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1124/mol.65.2.279DOI Listing
February 2004

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

J Pharmacol Exp Ther 2003 Dec 9;307(3):906-22. Epub 2003 Oct 9.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.103.05486
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http://dx.doi.org/10.1124/jpet.103.054866DOI Listing
December 2003

Structural determinants of P-glycoprotein-mediated transport of glucocorticoids.

Pharm Res 2003 Nov;20(11):1794-803

Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1023/b:pham.0000003377.39548.f6DOI Listing
November 2003

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.

J Appl Physiol (1985) 2003 Sep 16;95(3):1297-300. Epub 2003 May 16.

General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA.

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http://dx.doi.org/10.1152/japplphysiol.00322.2003DOI Listing
September 2003

Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.

Clin Pharmacol Ther 2003 Mar;73(3):209-22

Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1067/mcp.2003.29DOI Listing
March 2003

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

Nat Med 2003 Feb 6;9(2):220-4. Epub 2003 Jan 6.

Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/nm815DOI Listing
February 2003

Polarized cell cultures for integrated studies of drug metabolism and transport.

Methods Enzymol 2002 ;357:321-9

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)57690-4DOI Listing
January 2003

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons.

Hum Mol Genet 2003 Jan;12(2):99-109

St Jude Children's Research Hospital, Department of Pharmaceutical Sciences, Memphis, TN, USA.

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http://dx.doi.org/10.1093/hmg/ddg011DOI Listing
January 2003

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

Pharmacogenetics 2003 Jan;13(1):19-28

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, and Department of Pharmaceutical Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1097/00008571-200301000-00004DOI Listing
January 2003

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta.

Pharm Res 2002 Dec;19(12):1788-800

Concurrent Pharmaceuticals Inc., Fort Washington, Pennsylvania 19034, USA.

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http://dx.doi.org/10.1023/a:1021429105173DOI Listing
December 2002

Genetic contribution to variable human CYP3A-mediated metabolism.

Adv Drug Deliv Rev 2002 Nov;54(10):1271-94

St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/s0169-409x(02)00066-2DOI Listing
November 2002

Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.

J Pharmacol Exp Ther 2002 Oct;303(1):323-32

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.102.03754
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http://dx.doi.org/10.1124/jpet.102.037549DOI Listing
October 2002

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.

Mol Pharmacol 2002 Jul;62(1):162-72

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1124/mol.62.1.162DOI Listing
July 2002

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Mol Pharmacol 2002 May;61(5):964-73

Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1124/mol.61.5.964DOI Listing
May 2002

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.

Pharmacogenetics 2002 Mar;12(2):121-32

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1097/00008571-200203000-00006DOI Listing
March 2002