Publications by authors named "Erik S Knudsen"

100Publications

A Phase I Study of Ribociclib Plus Everolimus in Patients with Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy.

J Pancreat Cancer 2020 22;6(1):45-54. Epub 2020 Jun 22.

Sidney Kimmel Comprehensive Cancer Center at Sibley Memorial Hospital, Johns Hopkins University School of Medicine, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1089/pancan.2020.0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337242PMC
June 2020

Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows.

Mol Cancer Ther 2020 08 16;19(8):1575-1588. Epub 2020 Jun 16.

Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473501PMC
August 2020

Selective CDK4/6 Inhibitors: Biologic Outcomes, Determinants of Sensitivity, Mechanisms of Resistance, Combinatorial Approaches, and Pharmacodynamic Biomarkers.

Am Soc Clin Oncol Educ Book 2020 May;40:115-126

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/EDBK_281085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306922PMC
May 2020

Pan-cancer molecular analysis of the RB tumor suppressor pathway.

Commun Biol 2020 Apr 2;3(1):158. Epub 2020 Apr 2.

Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.

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http://dx.doi.org/10.1038/s42003-020-0873-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118159PMC
April 2020

Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations.

Sci Rep 2019 09 4;9(1):12766. Epub 2019 Sep 4.

Department of Molecular and Cellular Biology, Roswell Park Cancer Center, Buffalo, NY, 14263, USA.

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http://dx.doi.org/10.1038/s41598-019-48967-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726654PMC
September 2019

Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy.

Trends Cancer 2019 05 30;5(5):308-324. Epub 2019 Apr 30.

Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.

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http://dx.doi.org/10.1016/j.trecan.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719339PMC
May 2019

Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer.

Clin Cancer Res 2019 04 11;25(7):2290-2304. Epub 2018 Dec 11.

Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445724PMC
April 2019

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Cancer Cell 2018 11;34(5):807-822.e7

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://www.researchgate.net/publication/325458004_KRAS_Supp
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https://linkinghub.elsevier.com/retrieve/pii/S15356108183046
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http://dx.doi.org/10.1016/j.ccell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321749PMC
November 2018

The vulnerability of RB loss in breast cancer: Targeting a void in cell cycle control.

Oncotarget 2018 Jul 24;9(57):30940-30941. Epub 2018 Jul 24.

Erik S. Knudsen: Department of Molecular and Cellular Biology, Roswell Park Cancer Center, Buffalo, New York, USA.

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http://www.oncotarget.com/fulltext/25797
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http://dx.doi.org/10.18632/oncotarget.25797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089558PMC
July 2018

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer.

Cell Rep 2018 01;22(5):1185-1199

University of Arizona Cancer Center, Tucson, AZ 85724, USA; Department of Medicine, University of Arizona, Tucson, AZ 85724, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183003
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http://dx.doi.org/10.1016/j.celrep.2018.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967622PMC
January 2018

Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors.

Bioinformatics 2018 05;34(10):1713-1718

University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946891PMC
May 2018

The transcriptome of CDK4/6 inhibition.

Aging (Albany NY) 2017 Aug;9(8):1859-1860

Department of Medicine, ,, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.18632/aging.101285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611978PMC
August 2017

Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.

Clin Cancer Res 2017 Aug 27;23(15):4429-4440. Epub 2017 Mar 27.

McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951386PMC
August 2017

The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.

Trends Cancer 2017 01;3(1):39-55

University of Arizona Cancer Center; Department of Medicine, University of Arizona; Department of Pathology, University of Arizona.

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http://dx.doi.org/10.1016/j.trecan.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347397PMC
January 2017

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential.

Oncotarget 2016 Nov;7(48):78396-78411

McDermott Center for Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.11893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346648PMC
November 2016

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer.

Oncotarget 2016 Oct;7(43):69111-69123

Department of Medicine, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.18632/oncotarget.11588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342463PMC
October 2016

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.

Cell Rep 2016 08 4;16(7):2017-31. Epub 2016 Aug 4.

McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA; Simmons Cancer Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA; University of Arizona Cancer Center, University of Arizona, 1515 N. Campbell Street, Tucson, AZ 85724, USA; Department of Medicine, University of Arizona, 1515 N. Campbell Street, Tucson, AZ 85724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287055PMC
August 2016

Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease.

Clin Cancer Res 2016 07 8;22(14):3606-17. Epub 2016 Feb 8.

McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas. Department of Pathology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947442PMC
July 2016

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities.

Cell Rep 2016 Feb 21;14(5):979-990. Epub 2016 Jan 21.

McDermott Center University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA; Simmons Cancer Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757440PMC
February 2016

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine.

Gastroenterology 2016 Jan 15;150(1):48-63. Epub 2015 Sep 15.

Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.08.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010785PMC
January 2016

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Nat Commun 2015 Apr 9;6:6744. Epub 2015 Apr 9.

1] Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncomms7744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403382PMC
April 2015

The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy.

Cell Cycle 2015 ;14(24):3812-9

a Department of Pathology ; University of Texas Southwestern Medical Center ; Dallas , TX USA.

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http://dx.doi.org/10.1080/15384101.2015.1010922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825764PMC
September 2016

The history and future of targeting cyclin-dependent kinases in cancer therapy.

Nat Rev Drug Discov 2015 Feb;14(2):130-46

Simmons Cancer Center and Department of Pathology, University of Texas Southwestern, Dallas, USA.

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http://dx.doi.org/10.1038/nrd4504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480421PMC
February 2015

MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.

Cell Rep 2014 Dec 11;9(6):2233-49. Epub 2014 Dec 11.

Department of Pathology, UT Southwestern, Dallas, TX 75390, USA; Simmons Cancer Center, UT Southwestern, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.11.025DOI Listing
December 2014

CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models.

Genes Cancer 2014 Jul;5(7-8):261-72

Department of Pathology, Simmons Cancer Center, Dalls, TX ; Department of Pathology, UT Southwestern, Dallas, TX.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162138PMC
http://dx.doi.org/10.18632/genesandcancer.24DOI Listing
July 2014

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer.

Oncotarget 2014 Aug;5(15):6512-25

Department of Pathology , UT Southwestern, Dallas TX; Simmons Cancer Center, UT Southwestern, Dallas TX.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171647PMC
http://dx.doi.org/10.18632/oncotarget.2270DOI Listing
August 2014

Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers.

Clin Cancer Res 2014 Sep 21;20(18):4837-48. Epub 2014 Jul 21.

Simmons Cancer Center and Department of Pathology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286972PMC
September 2014

Retinoblastoma protein potentiates the innate immune response in hepatocytes: significance for hepatocellular carcinoma.

Hepatology 2014 Oct 28;60(4):1231-40. Epub 2014 Aug 28.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1002/hep.27217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482134PMC
October 2014

RB tumor suppressive function in response to xenobiotic hepatocarcinogens.

Am J Pathol 2014 Jun 13;184(6):1853-9. Epub 2014 Apr 13.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044713PMC
June 2014

The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy.

Am J Pathol 2014 Mar 31;184(3):574-83. Epub 2013 Dec 31.

Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936328PMC
March 2014

Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.

Cell Cycle 2013 Jan 19;12(1):98-111. Epub 2012 Dec 19.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.4161/cc.23029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570523PMC
January 2013

RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer.

Clin Cancer Res 2012 Sep 18;18(18):5110-22. Epub 2012 Jul 18.

Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436088PMC
September 2012

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

Cell Cycle 2012 Jul 15;11(14):2756-61. Epub 2012 Jul 15.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.21195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409015PMC
July 2012

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy.

Cell Cycle 2012 Jul 15;11(14):2747-55. Epub 2012 Jul 15.

Department of Cancer Biology at Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.21127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409014PMC
July 2012

Modification of the DNA damage response by therapeutic CDK4/6 inhibition.

J Biol Chem 2012 Aug 25;287(34):29075-87. Epub 2012 Jun 25.

Kimmel Cancer Center, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1074/jbc.M112.365494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436568PMC
August 2012

Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia.

Breast Cancer Res Treat 2012 Jun 2;133(3):1009-24. Epub 2011 Dec 2.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s10549-011-1894-3DOI Listing
June 2012

The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments.

Cell Cycle 2011 Aug 1;10(15):2497-503. Epub 2011 Aug 1.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685613PMC
http://dx.doi.org/10.4161/cc.10.15.16776DOI Listing
August 2011

RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.

Mol Biol Cell 2011 Apr 2;22(7):931-9. Epub 2011 Feb 2.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1091/mbc.E10-11-0895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069018PMC
April 2011

Alternative cyclin D1 splice forms differentially regulate the DNA damage response.

Cancer Res 2010 Nov 12;70(21):8802-11. Epub 2010 Oct 12.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970762PMC
November 2010

Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.

Cancer Res 2010 Mar 23;70(5):1854-65. Epub 2010 Feb 23.

Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-1922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831128PMC
March 2010

Targeting the RB-pathway in cancer therapy.

Clin Cancer Res 2010 Feb 9;16(4):1094-9. Epub 2010 Feb 9.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822892PMC
February 2010

Regulation of RB transcription in vivo by RB family members.

Mol Cell Biol 2010 Apr 25;30(7):1729-45. Epub 2010 Jan 25.

Department of Pediatrics, Stanford Medical School, 269 Campus Drive, CCSR1215, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1128/MCB.00952-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838078PMC
April 2010

Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model.

PLoS One 2010 Jan 1;5(1):e8558. Epub 2010 Jan 1.

Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796719PMC
January 2010

The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.

Cancer Res 2010 Jan 8;70(1):212-20. Epub 2009 Dec 8.

Department of Environmental Health, University of Cincinnati Medical Center, College of Medicine, Cincinnati, Ohio 45267-0056, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939500PMC
January 2010

Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.

J Biol Chem 2010 Jan 2;285(2):1089-96. Epub 2009 Nov 2.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M109.043380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801236PMC
January 2010

Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.

J Biol Chem 2009 Jul 11;284(29):19265-71. Epub 2009 Mar 11.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M808740200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740551PMC
July 2009

Tailoring to RB: tumour suppressor status and therapeutic response.

Nat Rev Cancer 2008 09;8(9):714-24

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1038/nrc2401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914856PMC
September 2008

The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.

Mol Biol Cell 2008 Aug 4;19(8):3263-71. Epub 2008 Jun 4.

Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1091/mbc.e08-04-0359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488290PMC
August 2008

Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines.

Mol Carcinog 2009 Jan;48(1):45-55

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mc.20456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978426PMC
January 2009

RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents.

Cell Cycle 2008 Apr 11;7(8):1095-103. Epub 2008 Feb 11.

Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.4161/cc.7.8.5737DOI Listing
April 2008

Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.

Toxicology 2008 Apr 16;246(2-3):242-7. Epub 2008 Jan 16.

Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267-00567, USA.

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http://dx.doi.org/10.1016/j.tox.2008.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323453PMC
April 2008

The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.

Blood 2008 Feb 29;111(4):1894-902. Epub 2007 Nov 29.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2007-02-071746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234042PMC
February 2008

Retinoblastoma deficiency increases chemosensitivity in lung cancer.

Cancer Res 2007 Sep;67(17):8264-73

Division of Thoracic Surgery, Department of Surgery, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine and Department of Surgery, Cincinnati VA Medical Center, Cincinnati, OH 45267-0558, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-06-4753DOI Listing
September 2007

RB activity alters checkpoint response and chemosensitivity in lung cancer lines.

J Surg Res 2007 Oct 19;142(2):364-72. Epub 2007 Jul 19.

Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0558, USA.

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http://dx.doi.org/10.1016/j.jss.2007.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734970PMC
October 2007

RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.

J Biol Chem 2007 Aug 6;282(33):23867-77. Epub 2007 Jun 6.

Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, Ohio 45267, USA.

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http://dx.doi.org/10.1074/jbc.M700542200DOI Listing
August 2007

SWI/SNF activity is required for the repression of deoxyribonucleotide triphosphate metabolic enzymes via the recruitment of mSin3B.

J Biol Chem 2007 Jul 17;282(28):20116-23. Epub 2007 May 17.

Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA.

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http://dx.doi.org/10.1074/jbc.M701406200DOI Listing
July 2007

RB in breast cancer: at the crossroads of tumorigenesis and treatment.

Cell Cycle 2007 Mar 7;6(6):667-71. Epub 2007 Mar 7.

Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0521, USA.

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http://dx.doi.org/10.4161/cc.6.6.3988DOI Listing
March 2007

Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.

J Cell Physiol 2007 Apr;211(1):131-7

Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0521, USA.

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http://dx.doi.org/10.1002/jcp.20913DOI Listing
April 2007

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer.

J Clin Invest 2007 Jan 7;117(1):218-28. Epub 2006 Dec 7.

Department of Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1172/JCI28803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679964PMC
January 2007