Publications by authors named "Erik Portelius"

132 Publications

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.

Authors:
Ashvini Keshavan Josef Pannee Thomas K Karikari Juan Lantero Rodriguez Nicholas J Ashton Jennifer M Nicholas David M Cash William Coath Christopher A Lane Thomas D Parker Kirsty Lu Sarah M Buchanan Sarah E Keuss Sarah-Naomi James Heidi Murray-Smith Andrew Wong Anna Barnes John C Dickson Amanda Heslegrave Erik Portelius Marcus Richards Nick C Fox Henrik Zetterberg Kaj Blennow Jonathan M Schott

Brain 2021 Jan 22. Epub 2021 Jan 22.

Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.

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January 2021

Brevican and Neurocan Peptides as Potential Cerebrospinal Fluid Biomarkers for Differentiation Between Vascular Dementia and Alzheimer's Disease.

Authors:
Karolina Minta Gunnar Brinkmalm Erik Portelius Per Johansson Johan Svensson Petronella Kettunen Anders Wallin Henrik Zetterberg Kaj Blennow Ulf Andreasson

J Alzheimers Dis 2021 ;79(2):729-741

Department of Psychiatry and Neurochemistry,Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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January 2021

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.

Authors:
Diego Sepulveda-Falla Lucia Chavez-Gutierrez Erik Portelius Jorge I Vélez Simon Dujardin Alvaro Barrera-Ocampo Felix Dinkel Christian Hagel Berta Puig Claudio Mastronardi Francisco Lopera Bradley T Hyman Kaj Blennow Mauricio Arcos-Burgos Bart de Strooper Markus Glatzel

Acta Neuropathol 2021 02 14;141(2):217-233. Epub 2020 Dec 14.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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February 2021

Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury.

Authors:
Karolina Minta Gunnar Brinkmalm Eric P Thelin Faiez Al Nimer Fredrik Piehl Mats Tullberg Anna Jeppsson Erik Portelius Henrik Zetterberg Kaj Blennow Ulf Andreasson

Clin Chim Acta 2021 Jan 2;512:74-83. Epub 2020 Dec 2.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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January 2021

Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.

Authors:
Karolina Minta Gunnar Brinkmalm Faiez Al Nimer Eric P Thelin Fredrik Piehl Mats Tullberg Anna Jeppsson Erik Portelius Henrik Zetterberg Kaj Blennow Ulf Andreasson

Sci Rep 2020 10 22;10(1):18075. Epub 2020 Oct 22.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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October 2020

First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.

Authors:
Sébastien Boulo Julia Kuhlmann Ulf Andreasson Britta Brix Iswariya Venkataraman Victor Herbst Sandra Rutz Ekaterina Manuilova Manu Vandijck Filip Dekeyser Maria Bjerke Josef Pannee Jean Charoud-Got Guy Auclair Stéphane Mazoua Gregor Pinski Stefanie Trapmann Heinz Schimmel Hendrik Emons Milena Quaglia Erik Portelius Magdalena Korecka Leslie M Shaw Mary Lame Erin Chambers Hugo Vanderstichele Erik Stoops Andreas Leinenbach Tobias Bittner Rand G Jenkins Vesna Kostanjevecki Piotr Lewczuk Johan Gobom Henrik Zetterberg Ingrid Zegers Kaj Blennow

Alzheimers Dement 2020 11 4;16(11):1493-1503. Epub 2020 Aug 4.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.

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November 2020

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Authors:
Ivan Alić Pollyanna A Goh Aoife Murray Erik Portelius Eleni Gkanatsiou Gillian Gough Kin Y Mok David Koschut Reinhard Brunmeir Yee Jie Yeap Niamh L O'Brien Jürgen Groet Xiaowei Shao Steven Havlicek N Ray Dunn Hlin Kvartsberg Gunnar Brinkmalm Rosalyn Hithersay Carla Startin Sarah Hamburg Margaret Phillips Konstantin Pervushin Mark Turmaine David Wallon Anne Rovelet-Lecrux Hilkka Soininen Emanuela Volpi Joanne E Martin Jia Nee Foo David L Becker Agueda Rostagno Jorge Ghiso Željka Krsnik Goran Šimić Ivica Kostović Dinko Mitrečić Paul T Francis Kaj Blennow Andre Strydom John Hardy Henrik Zetterberg Dean Nižetić

Mol Psychiatry 2020 Jul 10. Epub 2020 Jul 10.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.

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July 2020

Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg.

Authors:
Pawel Obrocki Ayesha Khatun Deborah Ness Konstantin Senkevich Jörg Hanrieder Federica Capraro Niklas Mattsson Ulf Andreasson Erik Portelius Nicholas J Ashton Kaj Blennow Michael Schöll Ross W Paterson Jonathan M Schott Henrik Zetterberg

Alzheimers Res Ther 2020 02 28;12(1):20. Epub 2020 Feb 28.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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February 2020

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.

Authors:
Kaj Blennow Chun Chen Claudia Cicognola Kristin R Wildsmith Paul T Manser Sandra M Sanabria Bohorquez Zhentao Zhang Boer Xie Junmin Peng Oskar Hansson Hlin Kvartsberg Erik Portelius Henrik Zetterberg Tammaryn Lashley Gunnar Brinkmalm Geoffrey A Kerchner Robby M Weimer Keqiang Ye Kina Höglund

Brain 2020 02;143(2):650-660

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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February 2020

Cerebrospinal Fluid Concentrations of Extracellular Matrix Proteins in Alzheimer's Disease.

Authors:
Karolina Minta Erik Portelius Shorena Janelidze Oskar Hansson Henrik Zetterberg Kaj Blennow Ulf Andreasson

J Alzheimers Dis 2019 ;69(4):1213-1220

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden.

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September 2020

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Authors:
Gunnar Brinkmalm Wei Hong Zemin Wang Wen Liu Tiernan T O'Malley Xin Sun Matthew P Frosch Dennis J Selkoe Erik Portelius Henrik Zetterberg Kaj Blennow Dominic M Walsh

Brain 2019 05;142(5):1441-1457

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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May 2019

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Authors:
Karolina Minta Nicholas C Cullen Faiez Al Nimer Eric P Thelin Fredrik Piehl Marcus Clarin Mats Tullberg Anna Jeppsson Erik Portelius Henrik Zetterberg Kaj Blennow Ulf Andreasson

Clin Chem Lab Med 2019 Sep;57(10):1565-1573

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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September 2019

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.

Authors:
Charles Arber Jamie Toombs Christopher Lovejoy Natalie S Ryan Ross W Paterson Nanet Willumsen Eleni Gkanatsiou Erik Portelius Kaj Blennow Amanda Heslegrave Jonathan M Schott John Hardy Tammaryn Lashley Nick C Fox Henrik Zetterberg Selina Wray

Mol Psychiatry 2020 11 12;25(11):2919-2931. Epub 2019 Apr 12.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.

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November 2020

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.

Authors:
Marianne K O Grant Maureen Handoko Malgorzata Rozga Gunnar Brinkmalm Erik Portelius Kaj Blennow Karen H Ashe Kathleen R Zahs Peng Liu

PLoS One 2019 28;14(2):e0212815. Epub 2019 Feb 28.

Department of Neurology, University of Minnesota, Minneapolis, Minnesota, United States of America.

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December 2019

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease.

Authors:
Eleni Gkanatsiou Erik Portelius Christina E Toomey Kaj Blennow Henrik Zetterberg Tammaryn Lashley Gunnar Brinkmalm

Neurosci Lett 2019 05 23;701:125-131. Epub 2019 Feb 23.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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May 2019

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

Authors:
Tanja Weiffert Georg Meisl Patrick Flagmeier Suman De Christopher J R Dunning Birgitta Frohm Henrik Zetterberg Kaj Blennow Erik Portelius David Klenerman Christopher M Dobson Tuomas P J Knowles Sara Linse

ACS Chem Neurosci 2019 05 8;10(5):2374-2384. Epub 2019 Mar 8.

Department of Biochemistry and Structural Biology , Lund University , P O box 124, 221 00 Lund , Sweden.

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May 2019

Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke.

Authors:
Fani Pujol-Calderón Erik Portelius Henrik Zetterberg Kaj Blennow Lars E Rosengren Kina Höglund

Neurosci Lett 2019 04 29;698:58-63. Epub 2018 Dec 29.

Department of Psychiatry & Neurochemistry, University of Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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April 2019

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.

Authors:
Claudia Cicognola Gunnar Brinkmalm Jessica Wahlgren Erik Portelius Johan Gobom Nicholas C Cullen Oskar Hansson Lucilla Parnetti Radu Constantinescu Kristin Wildsmith Hsu-Hsin Chen Thomas G Beach Tammaryn Lashley Henrik Zetterberg Kaj Blennow Kina Höglund

Acta Neuropathol 2019 02 13;137(2):279-296. Epub 2018 Dec 13.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborgsvägen 31, House V3/SU, 43180, Mölndal, Sweden.

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February 2019

Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.

Authors:
Bob Olsson Erik Portelius Nicholas C Cullen Åsa Sandelius Henrik Zetterberg Ulf Andreasson Kina Höglund David J Irwin Murray Grossman Daniel Weintraub Alice Chen-Plotkin David Wolk Leo McCluskey Lauren Elman Leslie M Shaw Jon B Toledo Jennifer McBride Pilar Hernandez-Con Virginia M-Y Lee John Q Trojanowski Kaj Blennow

JAMA Neurol 2019 03;76(3):318-325

Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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March 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Authors:
Åsa Sandelius Erik Portelius Åsa Källén Henrik Zetterberg Uros Rot Bob Olsson Jon B Toledo Leslie M Shaw Virginia M Y Lee David J Irwin Murray Grossman Daniel Weintraub Alice Chen-Plotkin David A Wolk Leo McCluskey Lauren Elman Vesna Kostanjevecki Manu Vandijck Jennifer McBride John Q Trojanowski Kaj Blennow

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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January 2019

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease.

Authors:
Hlin Kvartsberg Tammaryn Lashley Christina E Murray Gunnar Brinkmalm Nicholas C Cullen Kina Höglund Henrik Zetterberg Kaj Blennow Erik Portelius

Acta Neuropathol 2019 01 22;137(1):89-102. Epub 2018 Sep 22.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital/Mölndal, S-431 80, Mölndal, Sweden.

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January 2019

Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.

Authors:
Ann Brinkmalm Erik Portelius Gunnar Brinkmalm Josef Pannee Rahil Dahlén Johan Gobom Kaj Blennow Henrik Zetterberg

J Neurochem 2019 11 12;151(4):417-434. Epub 2018 Nov 12.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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November 2019

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.

Authors:
Francisco Oliveira Antoine Leuzy João Castelhano Konstantinos Chiotis Steen Gregers Hasselbalch Juha Rinne Alexandre Mendonça Markus Otto Alberto Lleó Isabel Santana Jarkko Johansson Sarah Anderl-Straub Christine Arnim Ambros Beer Rafael Blesa Juan Fortea Herukka Sanna-Kaisa Erik Portelius Josef Pannee Henrik Zetterberg Kaj Blennow Ana P Moreira Antero Abrunhosa Agneta Nordberg Miguel Castelo-Branco

Neuroimage Clin 2018 19;20:603-610. Epub 2018 Aug 19.

CiBIT, ICNAS, Institute for Biomedical Imaging in Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Portugal. Electronic address:

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January 2019

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase.

Authors:
Bruno Becker Faisal Hayat Nazir Gunnar Brinkmalm Elena Camporesi Hlin Kvartsberg Erik Portelius Martina Boström Marie Kalm Kina Höglund Maria Olsson Henrik Zetterberg Kaj Blennow

Mol Neurodegener 2018 08 29;13(1):47. Epub 2018 Aug 29.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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August 2018

Biology/Disease-Driven Initiative on Protein-Aggregation Diseases of the Human Proteome Project: Goals and Progress to Date.

Authors:
Paul J Boersema Andre Melnik Bouke P C Hazenberg Melinda Rezeli György Marko-Varga Junichi Kamiie Erik Portelius Kaj Blennow Roman A Zubarev Magdalini Polymenidou Paola Picotti

J Proteome Res 2018 12 28;17(12):4072-4084. Epub 2018 Sep 28.

Institute of Molecular Systems Biology, Department of Biology , ETH Zurich , Otto-Stern-Weg 3 , 8093 Zurich , Switzerland.

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December 2018

The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease.

Authors:
Christina E Murray Priya Gami-Patel Eleni Gkanatsiou Gunnar Brinkmalm Erik Portelius Oliver Wirths Wendy Heywood Kaj Blennow Jorge Ghiso Janice L Holton Kevin Mills Henrik Zetterberg Tamas Revesz Tammaryn Lashley

Acta Neuropathol Commun 2018 07 20;6(1):62. Epub 2018 Jul 20.

The Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.

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July 2018

Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements.

Authors:
Ulf Andreasson Julia Kuhlmann Josef Pannee Robert M Umek Erik Stoops Hugo Vanderstichele Anja Matzen Manu Vandijck Martine Dauwe Andreas Leinenbach Sandra Rutz Erik Portelius Ingrid Zegers Henrik Zetterberg Kaj Blennow

Clin Chem Lab Med 2018 11;56(12):2058-2066

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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November 2018

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Authors:
Frances K Wiseman Laura J Pulford Chris Barkus Fan Liao Erik Portelius Robin Webb Lucia Chávez-Gutiérrez Karen Cleverley Sue Noy Olivia Sheppard Toby Collins Caroline Powell Claire J Sarell Matthew Rickman Xun Choong Justin L Tosh Carlos Siganporia Heather T Whittaker Floy Stewart Maria Szaruga Michael P Murphy Kaj Blennow Bart de Strooper Henrik Zetterberg David Bannerman David M Holtzman Victor L J Tybulewicz Elizabeth M C Fisher

Brain 2018 08;141(8):2457-2474

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.

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August 2018

Update on biomarkers for amyloid pathology in Alzheimer's disease.

Authors:
Nicholas J Ashton Michael Schöll Kerstin Heurling Eleni Gkanatsiou Erik Portelius Kina Höglund Gunnar Brinkmalm Abdul Hye Kaj Blennow Henrik Zetterberg

Biomark Med 2018 07 15;12(7):799-812. Epub 2018 Jun 15.

Department of Psychiatry & Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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July 2018

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.

Authors:
Erik Portelius Bob Olsson Kina Höglund Nicholas C Cullen Hlin Kvartsberg Ulf Andreasson Henrik Zetterberg Åsa Sandelius Leslie M Shaw Virginia M Y Lee David J Irwin Murray Grossman Daniel Weintraub Alice Chen-Plotkin David A Wolk Leo McCluskey Lauren Elman Jennifer McBride Jon B Toledo John Q Trojanowski Kaj Blennow

Acta Neuropathol 2018 09 26;136(3):363-376. Epub 2018 Apr 26.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80, Mölndal, Sweden.

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September 2018