Erik Portelius

Erik Portelius

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Erik Portelius

Erik Portelius

Publications by authors named "Erik Portelius"

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Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.

Brain 2019 Dec 13. Epub 2019 Dec 13.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1093/brain/awz346DOI Listing
December 2019

Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.

J Neurochem 2019 Nov 12;151(4):417-434. Epub 2018 Nov 12.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1111/jnc.14594DOI Listing
November 2019

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Clin Chem Lab Med 2019 Sep;57(10):1565-1573

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1515/cclm-2019-0034DOI Listing
September 2019

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease.

Neurosci Lett 2019 05 23;701:125-131. Epub 2019 Feb 23.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2019.02.033DOI Listing
May 2019

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Brain 2019 05;142(5):1441-1457

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487330PMC
May 2019

Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke.

Neurosci Lett 2019 04 29;698:58-63. Epub 2018 Dec 29.

Department of Psychiatry & Neurochemistry, University of Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2018.12.042DOI Listing
April 2019

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.

Acta Neuropathol 2019 02 13;137(2):279-296. Epub 2018 Dec 13.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborgsvägen 31, House V3/SU, 43180, Mölndal, Sweden.

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http://dx.doi.org/10.1007/s00401-018-1948-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514201PMC
February 2019

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease.

Acta Neuropathol 2019 01 22;137(1):89-102. Epub 2018 Sep 22.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital/Mölndal, S-431 80, Mölndal, Sweden.

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http://dx.doi.org/10.1007/s00401-018-1910-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338696PMC
January 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

Cerebrospinal Fluid Concentrations of Extracellular Matrix Proteins in Alzheimer's Disease.

J Alzheimers Dis 2019 ;69(4):1213-1220

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden.

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http://dx.doi.org/10.3233/JAD-190187DOI Listing
January 2019

Biology/Disease-Driven Initiative on Protein-Aggregation Diseases of the Human Proteome Project: Goals and Progress to Date.

J Proteome Res 2018 12 28;17(12):4072-4084. Epub 2018 Sep 28.

Institute of Molecular Systems Biology, Department of Biology , ETH Zurich , Otto-Stern-Weg 3 , 8093 Zurich , Switzerland.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00401
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http://dx.doi.org/10.1021/acs.jproteome.8b00401DOI Listing
December 2018

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase.

Mol Neurodegener 2018 08 29;13(1):47. Epub 2018 Aug 29.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s13024-018-0279-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116393PMC
August 2018

Update on biomarkers for amyloid pathology in Alzheimer's disease.

Biomark Med 2018 07 15;12(7):799-812. Epub 2018 Jun 15.

Department of Psychiatry & Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.2217/bmm-2017-0433DOI Listing
July 2018

The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease.

Acta Neuropathol Commun 2018 07 20;6(1):62. Epub 2018 Jul 20.

The Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1186/s40478-018-0563-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053705PMC
July 2018

Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease.

Dement Geriatr Cogn Disord 2016 20;42(3-4):146-158. Epub 2016 Sep 20.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000449408DOI Listing
January 2018

CSF neurofilament light concentration is increased in presymptomatic mutation carriers.

Neurology 2018 01 13;90(2):e157-e163. Epub 2017 Dec 13.

From the Danish Dementia Research Centre (N.R., P.R., A.H.S., J.E.N.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark; Clinical Neurochemistry Laboratory (E.P., K.B., H.Z.), Sahlgrenska University Hospital; Institute of Neuroscience and Physiology (E.P., K.B., H.Z.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and Department of Molecular Neuroscience and UK Dementia Research Institute (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772154PMC
January 2018

Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ.

Mol Cell Neurosci 2017 12 8;85:211-219. Epub 2017 Nov 8.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, S-431 80 Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-431 80, Sweden; Institute of Neurology, Department of Molecular Neuroscience, University College London, WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10447431163024
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http://dx.doi.org/10.1016/j.mcn.2017.10.009DOI Listing
December 2017

Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an update.

Expert Rev Proteomics 2017 11 3;14(11):1007-1020. Epub 2017 Oct 3.

a Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry , The Sahlgrenska Academy at the University of Gothenburg , Mölndal , Sweden.

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http://dx.doi.org/10.1080/14789450.2017.1384697DOI Listing
November 2017

Alzheimer's disease markers in the aged sheep (Ovis aries).

Neurobiol Aging 2017 10 24;58:112-119. Epub 2017 Jun 24.

The Neurogenetics Group, School of Biological Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.020DOI Listing
October 2017

Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease.

Alzheimers Dement (N Y) 2017 Jun 17;3(2):284-290. Epub 2017 Apr 17.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.trci.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651430PMC
June 2017

CSF Aβ - an excellent but complicated Alzheimer's biomarker - a route to standardisation.

Clin Chim Acta 2017 Apr 20;467:27-33. Epub 2016 May 20.

Inst. of Neuroscience and Physiology Dept. of Psychiatry and Neurochemistry The Sahlgrenska Academy at University of Gothenburg Mölndal, Sweden; Clinical Neurochemistry LaboratorySahlgrenska University Hospital, MölndalSE-431 80 Mölndal Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.05.014DOI Listing
April 2017

Astroglial activation and altered amyloid metabolism in human repetitive concussion.

Neurology 2017 Apr 10;88(15):1400-1407. Epub 2017 Mar 10.

From the Institute of Neuroscience and Physiology (P.S., K.H., E.P., K.B., H.Z.), Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., K.H., E.P., K.B., H.Z.), Sahlgrenska University Hospital, Mölndal; Division of Medical Sciences, Department of Health Sciences (Y.T.), Luleå University of Technology; Department of Neuroscience, Neurosurgery (N.M.), Uppsala University, Uppsala, Sweden; Washington University School of Medicine (D.L.B.), St. Louis, MO; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386435PMC
April 2017

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Stem Cell Reports 2017 04 9;8(4):870-882. Epub 2017 Mar 9.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390098PMC
April 2017

Tau oligomers in cerebrospinal fluid in Alzheimer's disease.

Ann Clin Transl Neurol 2017 04 1;4(4):226-235. Epub 2017 Mar 1.

Mitchell Center for Neurodegenerative Diseases University of Texas Medical Branch Galveston Texas; Department of Neurology, and Neuroscience and Cell Biology University of Texas Medical Branch Galveston Texas.

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http://dx.doi.org/10.1002/acn3.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376754PMC
April 2017

Expanding the cerebrospinal fluid endopeptidome.

Proteomics 2017 03;17(5)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1002/pmic.201600384DOI Listing
March 2017

Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure.

J Vis Exp 2017 03 21(121). Epub 2017 Mar 21.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital.

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http://dx.doi.org/10.3791/55386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408988PMC
March 2017

Ex vivo O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway.

Mol Neurodegener 2017 02 20;12(1):18. Epub 2017 Feb 20.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1186/s13024-017-0152-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317049PMC
February 2017

Reference measurement procedure for CSF amyloid beta (Aβ) and the CSF Aβ /Aβ ratio - a cross-validation study against amyloid PET.

J Neurochem 2016 11 30;139(4):651-658. Epub 2016 Sep 30.

Department of Psychiatry & Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1111/jnc.13838DOI Listing
November 2016

Neurochemical Aftermath of Repetitive Mild Traumatic Brain Injury.

JAMA Neurol 2016 Nov;73(11):1308-1315

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2016.2038DOI Listing
November 2016

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.

EMBO Mol Med 2016 10 4;8(10):1184-1196. Epub 2016 Oct 4.

Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden Department of Neurology, Skåne University Hospital, Lund, Sweden

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http://dx.doi.org/10.15252/emmm.201606540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048367PMC
October 2016

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.

Brain 2016 09 7;139(Pt 9):2540-53. Epub 2016 Jul 7.

1 Department of Neurobiology, Care Science, and Society, Centre for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden 17 Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

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http://dx.doi.org/10.1093/brain/aww160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995359PMC
September 2016

Case Report of Complex Amyotrophic Lateral Sclerosis with Cognitive Impairment and Cortical Amyloid Deposition.

J Alzheimers Dis 2015 ;47(3):661-7

Department NVS, Centre for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-141965DOI Listing
July 2016

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis.

Lancet Neurol 2016 Jun 8;15(7):673-684. Epub 2016 Apr 8.

Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)00070-3DOI Listing
June 2016

Increased CSF neurogranin concentration is specific to Alzheimer disease.

Neurology 2016 Mar 29;86(9):829-35. Epub 2016 Jan 29.

From the Department of Molecular Neuroscience (H.W., H.Z.), UCL Institute of Neurology, Queen Square, London; Dementia Research Centre (H.W., R.W.P., N.M., N.C.F., J.M.S.), UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK; and Clinical Neurochemistry Lab (E.P., U.T., K.B., H.Z.), Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://www.neurology.org/content/early/2016/01/29/WNL.000000
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http://www.neurology.org/content/early/2016/01/29/WNL.000000
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000242
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000002423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793782PMC
March 2016

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans.

Alzheimers Res Ther 2016 Mar 7;8(1):11. Epub 2016 Mar 7.

Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Mölndal Hospital, 431 80, Mölndal, Sweden.

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http://dx.doi.org/10.1186/s13195-016-0178-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780148PMC
March 2016

Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass spectrometry.

Alzheimers Dement 2016 Jan 21;12(1):55-9. Epub 2015 Jul 21.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Salgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2015.06.1890DOI Listing
January 2016

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression.

JAMA Neurol 2016 Jan;73(1):60-7

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2015.3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624219PMC
January 2016

APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment.

Alzheimers Res Ther 2015 Dec 22;7(1):77. Epub 2015 Dec 22.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, S-431 80, Sweden.

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http://dx.doi.org/10.1186/s13195-015-0160-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687145PMC
December 2015

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease.

Alzheimers Res Ther 2015 Dec 24;7:74. Epub 2015 Dec 24.

Department of Psychiatry and Psychotherapy, University clinic Erlangen and Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1186/s13195-015-0161-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690296PMC
December 2015

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.

Alzheimers Dement 2015 Nov 4;11(11):1286-305. Epub 2015 Apr 4.

Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592782PMC
November 2015

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

Alzheimers Dement 2015 Oct 19;11(10):1180-90. Epub 2014 Dec 19.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.10.009DOI Listing
October 2015

Alzheimer's disease--Recent biomarker developments in relation to updated diagnostic criteria.

Clin Chim Acta 2015 Sep 7;449:3-8. Epub 2015 Feb 7.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.01.041DOI Listing
September 2015

Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability.

Clin Chim Acta 2015 Sep 30;449:9-15. Epub 2015 Jun 30.

Neurobiology Laboratory, Biochemistry and Molecular Biology Department, Hôpitaux de Lyon, Lyon, France; University of Lyon 1, CNRS UMR5292, INSERM U1028, BioRan, Lyon, France; Société Française de Biologie Clinique (SFBC), Alzheimer Biomarkers group co-coordination, France. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.05.024DOI Listing
September 2015

Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer's disease by hybrid immunoprecipitation mass spectrometry.

Neurodegener Dis 2015 13;15(1):50-7. Epub 2015 Jan 13.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1159/000369465DOI Listing
July 2015

Explorative and targeted neuroproteomics in Alzheimer's disease.

Biochim Biophys Acta 2015 Jul 22;1854(7):769-78. Epub 2015 Jan 22.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden; UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.01.009DOI Listing
July 2015

Biomarkers, assays, and therapies for Alzheimer disease.

Clin Chem 2015 Jul 26;61(7):903-8. Epub 2015 May 26.

Director of Neurology and the Memory and Aging Program, Butler Hospital, and Professor of Neurology and Psychiatry, the Warren Alpert Medical School of Brown University, Providence, RI.

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http://dx.doi.org/10.1373/clinchem.2015.241901DOI Listing
July 2015

Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid.

Neurodegener Dis 2014 27;14(2):98-106. Epub 2014 Jun 27.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1159/000358800DOI Listing
May 2015

APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

Cell Rep 2015 May 23;11(5):689-96. Epub 2015 Apr 23.

The Gurdon Institute, Cambridge Stem Cell Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431668PMC
May 2015

Characterization of the effect of a novel γ-secretase modulator on Aβ: a clinically translatable model.

Curr Pharm Des 2014 ;20(15):2484-90

AstraZeneca Translational Sciences Centre, Science for Life Laboratory, Box 1031, 171 65 Solna, Sweden.

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http://dx.doi.org/10.2174/13816128113199990499DOI Listing
February 2015

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage.

Alzheimers Res Ther 2014 17;6(5-8):75. Epub 2014 Nov 17.

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S-431 80 Mölndal, Sweden.

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http://dx.doi.org/10.1186/s13195-014-0075-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233234PMC
November 2014

Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal fluid.

Clin Chem 2014 Jul 19;60(7):987-94. Epub 2014 May 19.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Salgrenska Academy, University of Gothenburg, Mölndal, Sweden;

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http://dx.doi.org/10.1373/clinchem.2013.220392DOI Listing
July 2014

Altered cerebrospinal fluid levels of amyloid β and amyloid precursor-like protein 1 peptides in Down's syndrome.

Neuromolecular Med 2014 Jun 18;16(2):510-6. Epub 2014 Apr 18.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden,

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http://dx.doi.org/10.1007/s12017-014-8302-1DOI Listing
June 2014

The amyloid-β degradation pattern in plasma--a possible tool for clinical trials in Alzheimer's disease.

Neurosci Lett 2014 Jun 4;573:7-12. Epub 2014 May 4.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.04.041DOI Listing
June 2014

Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms.

J Proteome Res 2014 Feb 14;13(2):1077-87. Epub 2014 Jan 14.

Lunenfeld-Tanenbaum Research Institute, Joseph and Wolf Lebovic Health Complex, Mount Sinai Hospital , 60 Murray Street, Toronto, Ontario, M5T 3L9 Canada.

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http://dx.doi.org/10.1021/pr401060xDOI Listing
February 2014

A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.

J Alzheimers Dis 2013 ;33(4):1021-32

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JAD-2012-121471DOI Listing
October 2013

Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease.

J Alzheimers Dis 2013 ;33(1):85-93

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JAD-2012-120994DOI Listing
September 2013

Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay.

Anal Chem 2013 Sep 14;85(17):8142-9. Epub 2013 Aug 14.

LVR-Klinikum Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, D-45147 Essen, Germany.

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http://dx.doi.org/10.1021/ac401055yDOI Listing
September 2013

Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease.

J Alzheimers Dis 2012 ;31(2):335-41

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JAD-2012-120508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609706PMC
June 2013

Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease.

Brain Res 2013 Jun 27;1513:117-26. Epub 2013 Mar 27.

Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.brainres.2013.03.019DOI Listing
June 2013

Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment.

J Alzheimers Dis 2012 ;30(4):767-78

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JAD-2012-120019DOI Listing
May 2013

Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis.

Mult Scler 2013 Apr 15;19(5):543-52. Epub 2012 Oct 15.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1177/1352458512460603DOI Listing
April 2013

Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases.

Neuromolecular Med 2013 Mar 7;15(1):169-79. Epub 2012 Dec 7.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital/Mölndal, S-431 80, Mölndal, Sweden.

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http://dx.doi.org/10.1007/s12017-012-8208-8DOI Listing
March 2013

Amyloid-β metabolism in Niemann-Pick C disease models and patients.

Metab Brain Dis 2012 Dec 1;27(4):573-85. Epub 2012 Sep 1.

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Gothenburg, Sweden.

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https://www.hadleyhope.com/files/Amyloid%20NPC%20revised.pdf
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http://link.springer.com/content/pdf/10.1007/s11011-012-9332
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http://link.springer.com/10.1007/s11011-012-9332-8
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http://dx.doi.org/10.1007/s11011-012-9332-8DOI Listing
December 2012

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

J Biol Chem 2012 Sep 31;287(39):32640-50. Epub 2012 Jul 31.

Department of Neurobiology, Care Sciences and society, KI-Alzheimer's Disease Research Center, Karolinska Institutet, 14157 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M112.376541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463353PMC
September 2012

Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient.

Neurodegener Dis 2012 1;10(1-4):138-40. Epub 2012 Feb 1.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1159/000334537DOI Listing
August 2012

An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid.

J Mass Spectrom 2012 May;47(5):591-603

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1002/jms.2987DOI Listing
May 2012

The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease.

Mol Med Rep 2012 Apr 1;5(4):1111-5. Epub 2012 Feb 1.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3892/mmr.2012.774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493058PMC
April 2012

Multiplexing and multivariate analysis in neurodegeneration.

Methods 2012 Apr 25;56(4):464-70. Epub 2012 Feb 25.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.ymeth.2012.02.004DOI Listing
April 2012

Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment.

Curr Pharm Des 2011 ;17(25):2594-602

Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology Dept. of Psychiatry and Neurochemistry The Sahlgrenska Academy at the University of Gothenburg Sahlgrenska University Hospital, Mölndal SE-431 80 Mölndal, Sweden.

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http://dx.doi.org/10.2174/138161211797416039DOI Listing
March 2012

Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.

J Biol Chem 2012 Mar 20;287(11):8154-62. Epub 2012 Jan 20.

Division of Molecular Psychiatry, Georg August University Göttingen, University Medicine Göttingen, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1074/jbc.M111.308601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318696PMC
March 2012

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.

Proc Natl Acad Sci U S A 2011 Jul 28;108(29):11848-53. Epub 2011 Jun 28.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1102664108
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http://dx.doi.org/10.1073/pnas.1102664108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141957PMC
July 2011

A new member in the biomarker discovery toolbox.

Biomark Med 2011 Apr;5(2):202

Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.

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April 2011

Troponin T: more than acute myocardial infarction.

Biomark Med 2011 Apr;5(2):203

Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.

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April 2011

Growth factors in Parkinson's disease.

Biomark Med 2011 Apr;5(2):201-2

Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.

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April 2011

It is all about clearance.

Biomark Med 2011 Apr;5(2):202

Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.

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April 2011