Erik J M Toonen

Erik J M Toonen

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Erik J M Toonen

Erik J M Toonen

Publications by authors named "Erik J M Toonen"

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Oxidative Stress Increases Endogenous Complement-Dependent Inflammatory and Angiogenic Responses in Retinal Pigment Epithelial Cells Independently of Exogenous Complement Sources.

Authors:
Timon-Orest Trakkides Nicole Schäfer Maria Reichenthaler Konstanze Kühn Ricardo J M G E Brandwijk Erik J M Toonen Florian Urban Joachim Wegener Volker Enzmann Diana Pauly

Antioxidants (Basel) 2019 Nov 13;8(11). Epub 2019 Nov 13.

Experimental Ophthalmology, Eye clinic, University Hospital Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.3390/antiox8110548DOI Listing
November 2019

Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Authors:
Andreea-Manuela Mirea Erik J M Toonen Inge van den Munckhof Isabelle D Munsterman Eric T T L Tjwa Martin Jaeger Marije Oosting Kiki Schraa Joost H W Rutten Marinette van der Graaf Niels P Riksen Jacqueline de Graaf Mihai G Netea Cees J Tack Triantafyllos Chavakis Leo A B Joosten

Mol Med 2019 May 2;25(1):16. Epub 2019 May 2.

Department of Internal Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s10020-019-0084-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498541PMC
May 2019

Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice.

Authors:
Anjan K Bongoni Bo Lu Jennifer L McRae Evelyn J Salvaris Erik J M Toonen Ingela Vikstrom Adriana Baz Morelli Martin J Pearse Peter J Cowan

Transplant Direct 2019 Apr 25;5(4):e341. Epub 2019 Mar 25.

Immunology Research Centre, St. Vincent's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1097/TXD.0000000000000881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445655PMC
April 2019

Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia.

Authors:
Anne J M Loonen Sandra Leijtens Ozan Serin Mirrian Hilbink Peter C Wever Adriaan J C van den Brule Erik J M Toonen

Immunol Lett 2019 02 4;206:28-32. Epub 2018 Dec 4.

Department of R&D, Hycult Biotechnology, Uden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2018.12.001DOI Listing
February 2019

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies.

Authors:
Andreea-Manuela Mirea Cees J Tack Triantafyllos Chavakis Leo A B Joosten Erik J M Toonen

Trends Mol Med 2018 05 14;24(5):458-471. Epub 2018 Apr 14.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; R&D Department, Hycult Biotech, Uden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939989PMC
May 2018

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.

Authors:
Erik J M Toonen Andreea-Manuela Mirea Cees J Tack Rinke Stienstra Dov B Ballak Janna A van Diepen Anneke Hijmans Triantafyllos Chavakis Wim H Dokter Christine T N Pham Mihai G Netea Charles A Dinarello Leo A B Joosten

Mol Med 2016 05 24;22. Epub 2016 May 24.

Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2119/molmed.2016.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004724PMC
May 2016

Glucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoids.

Authors:
Erik J M Toonen Anke J Laskewitz Theo H van Dijk Aycha Bleeker Aldo Grefhorst Annelies E Schouten Ellen A J Bastiaanssen Dov B Ballak Marije I Koenders Cindy van Doorn Monique A J van der Vleuten Marie-Jose C van Lierop Albert K Groen Wim H A Dokter

PLoS One 2014 2;9(9):e98684. Epub 2014 Sep 2.

Department of Immune Therapeutics, MSD Research Laboratories, Oss, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151983PMC
November 2015

Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritic mice.

Authors:
Sandrine Ellero-Simatos Wilco W M Fleuren Susanne Bauerschmidt Wim H A Dokter Erik J M Toonen

Pharmacogenomics 2014 Apr;15(5):629-41

Division Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.

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https://www.futuremedicine.com/doi/10.2217/pgs.14.3
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http://dx.doi.org/10.2217/pgs.14.3DOI Listing
April 2014

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.

Authors:
Maša Umiċeviċ Mirkov Jing Cui Sita H Vermeulen Eli A Stahl Erik J M Toonen Remco R Makkinje Annette T Lee Tom W J Huizinga Renee Allaart Anne Barton Xavier Mariette Corinne Richard Miceli Lindsey A Criswell Paul P Tak Niek de Vries Saedis Saevarsdottir Leonid Padyukov S Louis Bridges Dirk-Jan van Schaardenburg Tim L Jansen Ellen A J Dutmer Mart A F J van de Laar Pilar Barrera Timothy R D J Radstake Piet L C M van Riel Hans Scheffer Barbara Franke Han G Brunner Robert M Plenge Peter K Gregersen Henk-Jan Guchelaar Marieke J H Coenen

Ann Rheum Dis 2013 Aug 11;72(8):1375-81. Epub 2012 Dec 11.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2012-202405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169706PMC
August 2013

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.

Authors:
Wilco W M Fleuren Margot M L Linssen Erik J M Toonen Gerard C M van der Zon Bruno Guigas Jacob de Vlieg Wim H A Dokter D Margriet Ouwens Wynand Alkema

Arch Physiol Biochem 2013 May 19;119(2):52-64. Epub 2013 Mar 19.

CDD, CMBI, NCMLS, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3109/13813455.2013.774022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665230PMC
May 2013

Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis.

Authors:
Erik J M Toonen Pilar Barrera Jaap Fransen Arjan P M de Brouwer Agnes M Eijsbouts Pierre Miossec Hubert Marotte Hans Scheffer Piet L C M van Riel Barbara Franke Marieke J H Coenen

Arthritis Res Ther 2012 Dec 7;14(6):R264. Epub 2012 Dec 7.

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http://dx.doi.org/10.1186/ar4110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674610PMC
December 2012

Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis.

Authors:
Erik J M Toonen Christian Gilissen Barbara Franke Wietske Kievit Agnes M Eijsbouts Alfons A den Broeder Simon V van Reijmersdal Joris A Veltman Hans Scheffer Timothy R D J Radstake Piet L C M van Riel Pilar Barrera Marieke J H Coenen

PLoS One 2012 21;7(3):e33199. Epub 2012 Mar 21.

Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033199PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310059PMC
August 2012

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells.

Authors:
Margot M L Linssen Daniel H van Raalte Erik J M Toonen Wynand Alkema Gerard C van der Zon Wim H Dokter Michaela Diamant Bruno Guigas D Margriet Ouwens

Cell Signal 2011 Nov 13;23(11):1708-15. Epub 2011 Jun 13.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cellsig.2011.06.002DOI Listing
November 2011

Prednisolone-induced changes in gene-expression profiles in healthy volunteers.

Authors:
Erik J M Toonen Wilco W M Fleuren Ulla Nässander Marie-José C van Lierop Susanne Bauerschmidt Wim H A Dokter Wynand Alkema

Pharmacogenomics 2011 Jul 2;12(7):985-98. Epub 2011 Jun 2.

MSD Research Laboratories, Oss, The Netherlands.

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http://dx.doi.org/10.2217/pgs.11.34DOI Listing
July 2011

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.

Authors:
Marieke J H Coenen Christian Enevold Pilar Barrera Mascha M V A P Schijvenaars Erik J M Toonen Hans Scheffer Leonid Padyukov Alf Kastbom Lars Klareskog Anne Barton Wietske Kievit Maarten J Rood Tim L Jansen Dorine Swinkels Piet L C M van Riel Barbara Franke Klaus Bendtzen Timothy R D J Radstake

PLoS One 2010 Dec 15;5(12):e14326. Epub 2010 Dec 15.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, Institute for Genetic and Metabolic Disease (IGMD), Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014326PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002281PMC
December 2010

Tumour necrosis factor alpha -308G->A polymorphism is not associated with response to TNFalpha blockers in Caucasian patients with rheumatoid arthritis: systematic review and meta-analysis.

Authors:
Stephan Pavy Erik J M Toonen Corinne Miceli-Richard Pilar Barrera Piet L C M van Riel Lindsey A Criswell Xavier Mariette Marieke J H Coenen

Ann Rheum Dis 2010 Jun 4;69(6):1022-8. Epub 2009 Dec 4.

Service de Rhumatologie, Hôpital Bicetre, 78 avenue du Général Leclerc, 94275 Le Kremlin Bicetre, France.

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http://dx.doi.org/10.1136/ard.2009.117622DOI Listing
June 2010

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.

Authors:
Raoul Frijters Wilco Fleuren Erik J M Toonen Jan P Tuckermann Holger M Reichardt Hans van der Maaden Andrea van Elsas Marie-Jose van Lierop Wim Dokter Jacob de Vlieg Wynand Alkema

BMC Genomics 2010 Jun 5;11:359. Epub 2010 Jun 5.

Computational Drug Discovery (CDD), Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26-28, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1186/1471-2164-11-359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895630PMC
June 2010

Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis.

Authors:
Christian Enevold Timothy R D Radstake Marieke J H Coenen Jaap Fransen Erik J M Toonen Klaus Bendtzen Piet L C M van Riel

J Rheumatol 2010 May 1;37(5):905-10. Epub 2010 Mar 1.

Institute for Inflammation Research, National University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.3899/jrheum.090775DOI Listing
May 2010

HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis.

Authors:
Frank A D T G Wagener Erik J M Toonen Lonneke Wigman Jaap Fransen Marjonne C W Creemers Timothy R D J Radstake Marieke J H Coenen Pilar Barrera Piet L C M van Riel Frans G M Russel

Arthritis Rheum 2008 Nov;58(11):3388-93

Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/art.23970DOI Listing
November 2008

The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis.

Authors:
Mieke F Roelofs Mark H Wenink Erik J M Toonen Marieke J H Coenen Leo A B Joosten Wim B van den Berg Piet L C M van Riel Timothy R D J Radstake

J Rheumatol 2008 Apr 15;35(4):558-61. Epub 2008 Mar 15.

Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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April 2008

Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis.

Authors:
Timothy R D J Radstake Jaap Fransen Erik J M Toonen Marieke J H Coenen Agnes E Eijsbouts Rachelle Donn Frank H J van den Hoogen Piet L C M van Riel

Ann Rheum Dis 2007 Nov 24;66(11):1525-30. Epub 2007 Apr 24.

Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/ard.2006.064394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111625PMC
November 2007

Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis.

Authors:
Marieke J H Coenen Erik J M Toonen Hans Scheffer Timothy R D J Radstake Pilar Barrera Barbara Franke

Pharmacogenomics 2007 Jul;8(7):761-73

Radboud University, Nijmegen Medical Centre, Department of Human Genetics, Internal Mail 855, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/14622416.8.7.761DOI Listing
July 2007