Publications by authors named "Erich Seifritz"

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Gamma-hydroxybutyrate increases brain resting-state functional connectivity of the salience network and dorsal nexus in humans.
Neuroimage 2018 Jun 7;173:448-459. Epub 2018 Mar 7.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Switzerland.

Combining actigraphy, ecological momentary assessment and neuroimaging to study apathy in patients with schizophrenia.
Schizophr Res 2018 May 11;195:176-182. Epub 2017 Oct 11.
Division of Adult Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Chemin du Petit-Bel-Air, 1225 Chêne-Bourg, Switzerland.

Social Cognition and Interaction in Chronic Users of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy").
Int J Neuropsychopharmacol 2018 Apr;21(4):333-344
Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland.

Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice.
Neurobiol Stress 2018 Feb 2;8:42-56. Epub 2018 Feb 2.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland.

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis.
Schizophr Bull 2018 Jan;44(1):147-157
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Anterior cingulate volume predicts response to psychotherapy and functional connectivity with the inferior parietal cortex in major depressive disorder.
Eur Neuropsychopharmacol 2018 Jan 1;28(1):138-148. Epub 2017 Dec 1.
Neuroscience Center, University and ETH Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland. Electronic address:

Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research.
J Psychiatr Res 2017 Sep 24;92:147-159. Epub 2017 Apr 24.
Psychiatric University Hospital, Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland. Electronic address:

Inflammatory processes and schizophrenia: two independent lines of evidence from a study of twins discordant and concordant for schizophrenic disorders.
Eur Arch Psychiatry Clin Neurosci 2017 Aug 4;267(5):377-389. Epub 2017 Apr 4.
Psychiatric University Hospital (KPPP), Institute for Response-Genetics, University of Zurich, 8032, Zurich, Switzerland.

Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation.
Psychopharmacology (Berl) 2017 Jul 7;234(13):2031-2046. Epub 2017 Apr 7.
Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032, Zurich, Switzerland.

Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers.
Psychopharmacology (Berl) 2017 Jul 20;234(13):1957-1968. Epub 2017 Apr 20.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, CH-8032, Zurich, Switzerland.

Dynamic reorganization of intrinsic functional networks in the mouse brain.
Neuroimage 2017 May 14;152:497-508. Epub 2017 Mar 14.
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Electronic address:

α -Adrenergic receptor polymorphisms and mRNA expression levels are associated with delay discounting in cocaine users.
Addict Biol 2017 Mar 8;22(2):561-569. Epub 2015 Nov 8.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland.

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation.
Curr Biol 2017 Feb 26;27(3):451-457. Epub 2017 Jan 26.
Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, Lenggstr. 31, 8032 Zurich, Switzerland.

Altered dynamics of brain connectivity in major depressive disorder at-rest and during task performance.
Psychiatry Res Neuroimaging 2017 Jan 17;259:1-9. Epub 2016 Nov 17.
Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland; Neuroscience Center, University and ETH Zurich, Switzerland; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland. Electronic address:

Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.
World J Psychiatry 2016 Dec 22;6(4):419-430. Epub 2016 Dec 22.
Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.

Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice.
Brain Behav Immun 2016 Nov 8;58:310-326. Epub 2016 Aug 8.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland. Electronic address:

Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression.
Neuroimage 2016 Nov 9;142:544-552. Epub 2016 Aug 9.
Institute for Biomedical Engineering, University and ETH Zurich, CH-8093 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, CH-8057 Zurich, Switzerland; Institute of Pharmacology and Toxicology, University and ETH Zurich, CH-8057 Zurich, Switzerland. Electronic address:

Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
Brain Behav Immun 2016 May 24;54:59-72. Epub 2015 Dec 24.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Neuroscience Center, University and ETH Zurich, Switzerland. Electronic address:

Effects of serotonin 2A/1A receptor stimulation on social exclusion processing.
Proc Natl Acad Sci U S A 2016 May 18;113(18):5119-24. Epub 2016 Apr 18.
Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, 8032 Zurich, Switzerland;

Mental Health Literacy, Attitudes to Help Seeking, and Perceived Need as Predictors of Mental Health Service Use: A Longitudinal Study.
J Nerv Ment Dis 2016 Apr;204(4):321-4
*Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zürich, Switzerland; †Institute of Psychiatry, Laboratory of Neuroscience (LIM27), University of Sao Paulo, Brazil; and ‡Department of Psychiatry II, University of Ulm and BKH Günzburg, Germany.

[Assessment of Functioning when Conducting Occupational Capacity Evaluations--What is "Evidence-Based"?].
Psychiatr Prax 2016 Mar 10;43(2):74-81. Epub 2015 Nov 10.
Gutachtenstelle für Zivil- und Öffentlichrechtliche Fragestellungen, Klinik für Psychiatrie, Psychotherapie und Psychosomatik der Psychiatrischen Universitätsklinik Zürich, Zürich, Schweiz.

Amygdala response to self-critical stimuli and symptom improvement in psychotherapy for depression.
Br J Psychiatry 2016 Feb 22;208(2):175-81. Epub 2015 Oct 22.
Nadja Doerig, PhD, Neuroscience Centre, University and ETH Zurich, and Department of Psychology, University of Zurich; Tobias Krieger, PhD, Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Bern, and Department of Psychology, University of Zurich; David Altenstein, PhD, Department of Psychology, University of Zurich; Yolanda Schlumpf, PhD, Division of Neuropsychology, Department of Psychology, University of Zurich; Simona Spinelli, PhD, Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Neuroscience Centre, University and ETH Zurich, Zurich Centre for Integrative Human Physiology, University of Zurich, Switzerland; Jakub Späti, PhD, Department of Psychophysiology, National Institute of Mental Health, National Centre of Neurology and Psychiatry, Tokyo, Japan, and Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Janis Brakowski, MD, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich; Boris B. Quednow, PhD, Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Neuroscience Centre, University and ETH Zurich, and Zurich Centre for Integrative Human Physiology, University of Zurich; Erich Seifritz, MD, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Neuroscience Centre, University and ETH Zurich, and Zurich Centre for Integrative Human Physiology, University of Zurich; Martin grosse Holtforth, PhD, Department of Psychology, University of Zurich, and Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Bern, Switzerland.

Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.
Neuropsychopharmacology 2015 Dec 27;40(13):2929-37. Epub 2015 May 27.
Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland.

Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone.
Psychoneuroendocrinology 2015 Dec 17;62:1-10. Epub 2015 Jul 17.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland.

Valence and agency influence striatal response to feedback in patients with major depressive disorder.
J Psychiatry Neurosci 2015 Nov;40(6):394-400
From the Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan (Späti); the Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Switzerland (Chumbley); the Institute of Psychology, University of Zurich, Zurich, Switzerland (Doerig, Grosse Holtforth); the Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland (Brakowski, Seifritz); the Department of Psychology, University of Bern, Bern, Switzerland (Grosse Holtforth); the Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland (Spinelli); the Neuroscience Center, University and ETH Zurich, Zurich, Switzerland ( Spinelli); and the Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland ( Seifritz, Spinelli).

CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway.
Brain Behav Immun 2015 Nov 11;50:125-140. Epub 2015 Jul 11.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy & Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Neuroscience Center, University and ETH Zurich, Switzerland. Electronic address:

Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations.
Psychopharmacology (Berl) 2015 Oct 1;232(19):3663-76. Epub 2015 Aug 1.
Neuropsychopharmacology and Brain Imaging Research Unit, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Lenggstrasse 31, CH-8032, Zurich, Switzerland,

Reward-dependent modulation of working memory is associated with negative symptoms in schizophrenia.
Schizophr Res 2015 Oct 9;168(1-2):238-44. Epub 2015 Sep 9.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology, Winterthurerstrasse 190, 8057 Zurich, Switzerland.


Pharmacological Cognitive Enhancement in Healthy Individuals: A Compensation for Cognitive Deficits or a Question of Personality?
PLoS One 2015 24;10(6):e0129805. Epub 2015 Jun 24.
Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland.

Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia.
J Psychiatry Neurosci 2016 04;41(3):152-61
From the Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, (Kirschner, Hager, Bischof, Hartmann, Kluge, Seifritz, Kaiser); and the Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich (Hager, Hartmann, Tobler), Zurich, Switzerland.

The translational study of apathy-an ecological approach.
Front Behav Neurosci 2015 9;9:241. Epub 2015 Sep 9.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich Zurich, Switzerland ; Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich Zurich, Switzerland ; Zurich Center for Integrative Human Physiology, University of Zurich Zurich, Switzerland.

Shared neural basis of social and non-social reward deficits in chronic cocaine users.
Soc Cogn Affect Neurosci 2016 06 12;11(6):1017-25. Epub 2016 Mar 12.
Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland

Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies.
Neuropharmacology 2016 10 30;109:306-319. Epub 2016 Mar 30.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland. Electronic address:

Differential effects of rumination and distraction on ketamine induced modulation of resting state functional connectivity and reactivity of regions within the default-mode network.
Soc Cogn Affect Neurosci 2016 08 13;11(8):1227-35. Epub 2016 Apr 13.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, 8032, Switzerland Department of Psychiatry, Charité, CBF, 12203 Berlin, Germany.

Cognitive and emotional impairments in adults with attention-deficit/hyperactivity disorder and cocaine use.
Drug Alcohol Depend 2016 06 7;163:92-9. Epub 2016 Apr 7.
Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital of the University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: A model for reward pathology with effects of agomelatine.
Eur Neuropsychopharmacol 2016 09 13;26(9):1448-1464. Epub 2016 Jul 13.
Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy & Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Neuroscience Center, University and ETH Zurich, Zurich, Switzerland. Electronic address:

Deficits in context-dependent adaptive coding of reward in schizophrenia.
NPJ Schizophr 2016 15;2:16020. Epub 2016 Jun 15.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Selective amotivation deficits following chronic psychosocial stress in mice.
Behav Brain Res 2017 01 28;317:424-433. Epub 2016 Sep 28.
Preclinical Laboratory for Translational Research into Affective Disorders, DPPP, Psychiatric Hospital, University of Zurich, August-Forel-Strasse 7, CH-8008, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH, Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Pesychosomatics (DPPP), Psychiatric Hospital, University of Zurich, Lengstrasse 31, CH-8032, Zurich, Switzerland. Electronic address:

Behavioural endophenotypes in mice lacking the auxiliary GABA receptor subunit KCTD16.
Behav Brain Res 2017 01 4;317:393-400. Epub 2016 Oct 4.
Preclinical Laboratory for Translational Research into Affective Disorders (PLaTRAD), Department of Psychiatry, Psychotherapy & Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Neuroscience Center, University and ETH Zurich, Switzerland. Electronic address:


Neural underpinnings of prosexual effects induced by gamma-hydroxybutyrate in healthy male humans.
Eur Neuropsychopharmacol 2017 04 8;27(4):372-382. Epub 2017 Mar 8.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Switzerland.

The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.
Behav Brain Res 2017 07 12;330:1-7. Epub 2017 May 12.
Preclinical Laboratory for Translational Research into Affective Disorders, DPPP, Psychiatric Hospital, University of Zurich, August-Forel-Strasse 7, CH-8008 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Pesychosomatics (DPPP), Psychiatric Hospital, Universit of Zurich, Lengstrasse 31, CH-8032 Zurich, Switzerland. Electronic address:

Discrete memory impairments in largely pure chronic users of MDMA.
Eur Neuropsychopharmacol 2017 10 31;27(10):987-999. Epub 2017 Aug 31.
Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital of the University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:



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