Eric W F W Alton

Eric W F W Alton

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Eric W F W Alton

Eric W F W Alton

Publications by authors named "Eric W F W Alton"

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Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.

J Cyst Fibros 2019 Jun 5. Epub 2019 Jun 5.

Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2019.05.017DOI Listing
June 2019

Children with cystic fibrosis demonstrate no respiratory immunological, infective or physiological, consequences of vitamin D deficiency.

J Cyst Fibros 2018 Sep 7;17(5):657-665. Epub 2018 Apr 7.

National Heart and Lung Institute, Imperial College, London, United kingdom; Department of Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jcf.2018.02.011DOI Listing
September 2018

Genetic medicines for CF: Hype versus reality.

Pediatr Pulmonol 2016 Oct;51(S44):S5-S17

Department of Pediatrics I - Pediatric Infectiology and Immunology - Translational Genomics and Gene Therapy, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1002/ppul.23543DOI Listing
October 2016

Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells.

Curr Gene Ther 2015 ;15(6):581-90

National Heart and Lung Institute, Imperial College, London, United Kingdom, Emmanuel Kaye Building 1b, Manresa Rd, London, SW3 6LR. UK.

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September 2016

Does mass spectrometric breath analysis detect Pseudomonas aeruginosa in cystic fibrosis?

Eur Respir J 2016 Mar 4;47(3):994-7. Epub 2016 Feb 4.

National Heart and Lung Institute, Imperial College, London, UK Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1183/13993003.00944-2015DOI Listing
March 2016

Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung.

Antimicrob Agents Chemother 2016 Feb 16;60(2):744-51. Epub 2015 Nov 16.

National Heart and Lung Institute, Imperial College London, London, United Kingdom Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom

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http://dx.doi.org/10.1128/AAC.01426-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750668PMC
February 2016

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

September 2015

Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction.

F1000Prime Rep 2015 27;7:64. Epub 2015 May 27.

Department of Gene Therapy and the UK Cystic Fibrosis Gene Therapy Consortium, Imperial College London SW3 6LR UK.

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http://dx.doi.org/10.12703/P7-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447040PMC
June 2015

Cystic Fibrosis Gene Therapy in the UK and Elsewhere.

Hum Gene Ther 2015 May;26(5):266-75

Department of Gene Therapy and the U.K. Cystic Fibrosis Gene Therapy Consortium, Imperial College, London SW3 6LR, United Kingdom.

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http://dx.doi.org/10.1089/hum.2015.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442579PMC
May 2015

Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function.

Eur Respir J 2014 Nov 3;44(5):1253-61. Epub 2014 Sep 3.

Dept of Life Sciences, Imperial College, London, UK Joint senior authors

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http://dx.doi.org/10.1183/09031936.00097014DOI Listing
November 2014

Gene therapy in cystic fibrosis.

Arch Dis Child 2014 May 24;99(5):465-8. Epub 2014 Jan 24.

UK CF Gene Therapy Consortium.

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http://dx.doi.org/10.1136/archdischild-2012-302158DOI Listing
May 2014

Moving forward: cystic fibrosis gene therapy.

Hum Mol Genet 2013 Oct 4;22(R1):R52-8. Epub 2013 Aug 4.

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http://dx.doi.org/10.1093/hmg/ddt372DOI Listing
October 2013

Expert opinion in biological therapy: update on developments in lung gene transfer.

Expert Opin Biol Ther 2013 Mar 5;13(3):345-60. Epub 2013 Jan 5.

National Heart and Lung Institute, Imperial College London, Department of Gene Therapy, and The UK Cystic Fibrosis Gene Therapy Consortium, London, UK.

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http://dx.doi.org/10.1517/14712598.2013.735656DOI Listing
March 2013

Oral contraceptives do not appear to affect cystic fibrosis disease severity.

Eur Respir J 2013 Jan 3;41(1):67-73. Epub 2012 May 3.

Dept of Gene Therapy, Imperial College London, London, UK.

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http://dx.doi.org/10.1183/09031936.00018712DOI Listing
January 2013

Progress in gene and cell therapy for cystic fibrosis lung disease.

Curr Pharm Des 2012 ;18(5):642-62

Department of Gene Therapy, Imperial College London, Emmanuel Kaye Building, Manresa Road, London.

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June 2012

Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis.

Thorax 2012 Feb 18;67(2):164-70. Epub 2011 Oct 18.

Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2011-200585DOI Listing
February 2012

Design of gene therapy trials in CF patients.

Methods Mol Biol 2011 ;741:55-68

Department of Gene Therapy, Imperial College London, SW3 6LR, London, UK.

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http://link.springer.com/10.1007/978-1-61779-117-8_5
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http://dx.doi.org/10.1007/978-1-61779-117-8_5DOI Listing
September 2011

Airway remodelling and its relationship to inflammation in cystic fibrosis.

Thorax 2011 Jul 1;66(7):624-9. Epub 2010 Oct 1.

Division of Paediatric Respiratory Medicine, University Children's Hospital, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1136/thx.2009.134106DOI Listing
July 2011

Current status and future directions of gene and cell therapy for cystic fibrosis.

BioDrugs 2011 Apr;25(2):77-88

Department of Gene Therapy, Imperial College London, London, UK.

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http://dx.doi.org/10.2165/11586960-000000000-00000DOI Listing
April 2011

Gene therapy for cystic fibrosis.

Proc Am Thorac Soc 2010 Nov;7(6):408-14

Department of Gene Therapy, Imperial College London, Manresa Road, London SW3 6LR, UK.

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http://pats.atsjournals.org/cgi/doi/10.1513/pats.201004-029A
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http://dx.doi.org/10.1513/pats.201004-029AWDOI Listing
November 2010

Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.

Acta Biochim Biophys Sin (Shanghai) 2010 Jan;42(1):45-51

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1093/abbs/gmp100DOI Listing
January 2010

Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.

Mol Ther 2009 Nov 16;17(11):1897-903. Epub 2009 Jun 16.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/mt.2009.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835029PMC
November 2009

Cystic fibrosis gene therapy: successes, failures and hopes for the future.

Expert Rev Respir Med 2009 Aug;3(4):363-71

Department of Gene Therapy, Faculty of Medicine at the National Heart and Lung Institute, Imperial College London, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1586/ers.09.25DOI Listing
August 2009

The role of doxorubicin in non-viral gene transfer in the lung.

Biomaterials 2009 Apr 18;30(10):1971-7. Epub 2009 Jan 18.

Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, Manresa Road, London SW36LR, UK.

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http://dx.doi.org/10.1016/j.biomaterials.2008.12.037DOI Listing
April 2009

Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.

Adv Drug Deliv Rev 2009 Feb 24;61(2):128-39. Epub 2008 Dec 24.

Department of Gene Therapy, Faculty of Medicine at the National Heart and Lung Institute, Imperial College London, Manresa Road, London SW36LR, UK.

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http://dx.doi.org/10.1016/j.addr.2008.09.010DOI Listing
February 2009

Validation of nasal potential difference measurements in gut-corrected CF knockout mice.

Am J Respir Cell Mol Biol 2008 Oct 5;39(4):490-6. Epub 2008 May 5.

Department of Gene Therapy, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2007-0385OCDOI Listing
October 2008

Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid.

J Cyst Fibros 2008 Sep 1;7(5):352-8. Epub 2008 Feb 1.

School of Molecular and Clinical Medicine, University of Edinburgh, EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1016/j.jcf.2007.12.005DOI Listing
September 2008

Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation.

Am J Respir Cell Mol Biol 2008 Jul 31;39(1):19-25. Epub 2008 Jan 31.

Department of Gene Therapy, Emmanuel Kaye Building, 1b Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1165/rcmb.2007-0284OCDOI Listing
July 2008

Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.

Mol Ther 2008 Jul 20;16(7):1283-90. Epub 2008 May 20.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/mt.2008.96DOI Listing
July 2008

Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice.

Mol Ther 2008 May 11;16(5):812-8. Epub 2008 Mar 11.

Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/mt.2008.25DOI Listing
May 2008

In vivo imaging of gene transfer to the respiratory tract.

Biomaterials 2008 Apr 21;29(10):1533-40. Epub 2007 Dec 21.

Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1016/j.biomaterials.2007.11.017DOI Listing
April 2008

Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis.

Am J Respir Crit Care Med 2008 Apr 24;177(8):837-43. Epub 2008 Jan 24.

Department of Gene Therapy, National Heart and Lung Institute, 1B Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1164/rccm.200707-977OCDOI Listing
April 2008

Airway remodelling in children with cystic fibrosis.

Thorax 2007 Dec 25;62(12):1074-80. Epub 2007 May 25.

Department of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1136/thx.2006.074641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094274PMC
December 2007

Cystic fibrosis.

BMJ 2007 Dec;335(7632):1255-9

Department of Gene Therapy, Imperial College, London.

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http://www.bmj.com/lookup/doi/10.1136/bmj.39391.713229.AD
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http://dx.doi.org/10.1136/bmj.39391.713229.ADDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137053PMC
December 2007

Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis.

Chest 2007 Jun 22;131(6):1710-7. Epub 2007 Feb 22.

Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1378/chest.06-2666DOI Listing
June 2007

Biomarkers for cystic fibrosis: are we progressing?

Am J Respir Crit Care Med 2007 Apr;175(8):750-1

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http://dx.doi.org/10.1164/rccm.200702-226EDDOI Listing
April 2007

Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies.

Endothelium 2006 Jan-Feb;13(1):25-33

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1080/10623320600660128DOI Listing
September 2006

Nondisruptive, sequence-specific coupling of fluorochromes to plasmid DNA.

Anal Biochem 2006 May 9;352(2):169-75. Epub 2006 Mar 9.

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LR, UK.

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http://dx.doi.org/10.1016/j.ab.2006.02.021DOI Listing
May 2006

Exploring the mechanisms of macrolides in cystic fibrosis.

Respir Med 2006 Apr 26;100(4):687-97. Epub 2005 Sep 26.

Department of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.rmed.2005.07.016DOI Listing
April 2006

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

J Negat Results Biomed 2005 Dec 7;4. Epub 2005 Dec 7.

Institute of Genetics, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/1477-5751-4-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1318481PMC
December 2005

Use of nonviral vectors for cystic fibrosis gene therapy.

Proc Am Thorac Soc 2004 ;1(4):296-301

Imperial College London, National Heart & Lung Institute, Department of Gene Therapy, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1513/pats.200404-031MSDOI Listing
October 2005

Airway gene therapy.

Adv Genet 2005 ;54:291-314

Department of Gene Therapy, Imperial College London, London SW3 6LR, United Kingdom.

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http://dx.doi.org/10.1016/S0065-2660(05)54012-4DOI Listing
September 2005

Sendai virus for gene therapy and vaccination.

Curr Opin Mol Ther 2005 Aug;7(4):346-52

Imperial College London, NHLI, UK.

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August 2005

The efficacy of a 'master switch gene' HIF-1alpha in a porcine model of chronic myocardial ischaemia.

Eur Heart J 2005 Jul 8;26(13):1327-32. Epub 2005 Apr 8.

Department of Gene Therapy, Faculty of Medicine, The National Heart and Lung Institute, Imperial College London, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1093/eurheartj/ehi223DOI Listing
July 2005

Vascular oligonucleotide transfer facilitated by a polymer-coated stent.

Hum Gene Ther 2005 Jun;16(6):734-40

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, SW3 6LR, UK.

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http://dx.doi.org/10.1089/hum.2005.16.734DOI Listing
June 2005

Potential difference measurements in the lower airway of children with and without cystic fibrosis.

Am J Respir Crit Care Med 2005 May 7;171(9):1015-9. Epub 2005 Jan 7.

Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1164/rccm.200408-1116OCDOI Listing
May 2005

The effect of varying tonicity on nasal epithelial ion transport in cystic fibrosis.

Am J Respir Crit Care Med 2005 Apr 23;171(7):760-3. Epub 2004 Dec 23.

Department of Gene Therapy, Faculty of Medicine, Imperial College at the National Heart and Lung Institute, London SW3 6LR, UK.

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http://dx.doi.org/10.1164/rccm.200310-1423OCDOI Listing
April 2005

Advances in cystic fibrosis gene therapy.

Curr Opin Pulm Med 2004 Nov;10(6):542-6

Department of Gene Therapy, Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK.

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November 2004

Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators.

J Cyst Fibros 2004 Aug;3 Suppl 2:171-6

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 GLR, UK.

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http://dx.doi.org/10.1016/j.jcf.2004.05.036DOI Listing
August 2004

Critical appraisal of the mouse model of myocardial infarction.

Exp Physiol 2004 Jul 6;89(4):497-505. Epub 2004 May 6.

Department of Gene Therapy, Faculty of Medicine at the National Heart & Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1113/expphysiol.2004.027276DOI Listing
July 2004

Emerging significance of plasmid DNA nuclear import in gene therapy.

Adv Drug Deliv Rev 2003 Jun;55(6):749-60

Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK.

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June 2003

Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.

Adv Drug Deliv Rev 2002 Dec;54(11):1373-93

Department of Gene Therapy, National Heart and Lung Institute, Imperial College Faculty of Medicine, UK Cystic fibrosis Gene Therapy Consortium, Edinburgh-London-Oxford, UK, London SW3 6LR, UK.

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December 2002

Bone marrow stem cells do not repopulate the healthy upper respiratory tract.

Pediatr Pulmonol 2002 Oct;34(4):251-6

Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK.

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http://dx.doi.org/10.1002/ppul.10163DOI Listing
October 2002

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.

Hum Mol Genet 2002 May;11(9):1059-67

Institute for Molecular Biosciences, Imperial College of Medicine at the National Heart and Lung Institute, Manresa Road, London SW3 6LR, UK.

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http://dx.doi.org/10.1093/hmg/11.9.1059DOI Listing
May 2002

The nasal epithelium as a factory for systemic protein delivery.

Mol Ther 2002 Feb;5(2):98-103

Department of Gene Therapy, Imperial College School of Medicine at the National Heart and Lung Institute, London, SM5 1RU, UK.

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http://dx.doi.org/10.1006/mthe.2002.0524DOI Listing
February 2002