Publications by authors named "Eric T Kool"

252 Publications

OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1.

Redox Biol 2021 Apr 2;40:101848. Epub 2021 Jan 2.

Department of Radiation Oncology, University of Miami Medical School, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA. Electronic address:

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April 2021

Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions.

ACS Chem Biol 2021 01 17;16(1):45-51. Epub 2020 Dec 17.

Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.

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January 2021

Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity.

ACS Cent Sci 2020 Oct 31;6(10):1735-1742. Epub 2020 Aug 31.

Department of Chemistry, ChEM-H Institute, and Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.

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October 2020

The chemistry and applications of RNA 2'-OH acylation.

Nat Rev Chem 2020 Jan 19;4(1):22-37. Epub 2019 Nov 19.

Department of Chemistry, Stanford University, Stanford, CA, USA.

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January 2020

Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Infection.

J Immunol 2020 Oct 14;205(8):2231-2242. Epub 2020 Sep 14.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203;

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October 2020

Site-Selective RNA Functionalization via DNA-Induced Structure.

J Am Chem Soc 2020 09 14;142(38):16357-16363. Epub 2020 Sep 14.

Department of Chemistry, ChEM-H Institute and Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.

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September 2020

Trapping Transient RNA Complexes by Chemically Reversible Acylation.

Angew Chem Int Ed Engl 2020 12 28;59(49):22017-22022. Epub 2020 Sep 28.

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

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December 2020

Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1.

Cell Chem Biol 2020 Sep 11;27(9):1117-1123. Epub 2020 Aug 11.

Department of Chemistry, ChEM-H Institute, and Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA. Electronic address:

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September 2020

An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1.

Angew Chem Int Ed Engl 2020 05 17;59(19):7450-7455. Epub 2020 Mar 17.

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

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May 2020

A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.

Chem Commun (Camb) 2019 Dec;56(2):317-320

Department of Chemistry and ChEM-H Institute, Stanford University, Stanford, CA 94305, USA.

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December 2019

Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision.

J Am Chem Soc 2019 12 27;141(49):19379-19388. Epub 2019 Nov 27.

Department of Chemistry, Stanford Cancer Institute and ChEM-H Institute , Stanford University , Stanford , California 94305 , United States.

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December 2019

Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.

ACS Chem Biol 2019 12 29;14(12):2606-2615. Epub 2019 Oct 29.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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December 2019

Polymerase synthesis of four-base DNA from two stable dimeric nucleotides.

Nucleic Acids Res 2019 10;47(18):9495-9501

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

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October 2019

Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties.

Org Lett 2019 07 3;21(14):5413-5416. Epub 2019 Jul 3.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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July 2019

Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA.

Chem Sci 2019 Mar 30;10(11):3264-3270. Epub 2019 Jan 30.

Department of Chemistry , Stanford University , Stanford , CA 94305 , USA . Email:

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March 2019

Simple alkanoyl acylating agents for reversible RNA functionalization and control.

Chem Commun (Camb) 2019 Apr;55(35):5135-5138

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

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April 2019

RNA structure maps across mammalian cellular compartments.

Nat Struct Mol Biol 2019 04 18;26(4):322-330. Epub 2019 Mar 18.

MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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April 2019

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

PLoS One 2019 27;14(2):e0208341. Epub 2019 Feb 27.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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October 2019

Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA.

Org Lett 2018 10 9;20(20):6587-6590. Epub 2018 Oct 9.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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October 2018

Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.

Angew Chem Int Ed Engl 2018 09 3;57(39):12896-12900. Epub 2018 Sep 3.

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

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September 2018

Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity.

Chem Sci 2018 Jun 21;9(23):5252-5259. Epub 2018 May 21.

Department of Chemistry , Stanford University , Stanford , CA 94305 , USA . Email:

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June 2018

ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase.

Bioconjug Chem 2018 05 29;29(5):1614-1621. Epub 2018 Mar 29.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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May 2018

RNA Control by Photoreversible Acylation.

J Am Chem Soc 2018 03 1;140(10):3491-3495. Epub 2018 Mar 1.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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March 2018

Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase.

J Am Chem Soc 2018 02 5;140(6):2105-2114. Epub 2018 Feb 5.

Department of Chemistry, Stanford University , Stanford, California 94305, United States.

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February 2018

RNA Cloaking by Reversible Acylation.

Angew Chem Int Ed Engl 2018 03 22;57(12):3059-3063. Epub 2018 Feb 22.

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

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March 2018

Fluorescent Probes of DNA Repair.

ACS Chem Biol 2018 07 30;13(7):1721-1733. Epub 2017 Nov 30.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

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July 2018