Publications by authors named "Eric Statz"

5 Publications

  • Page 1 of 1

Cytokeratin 7, GATA3, and SOX-10 is a Comprehensive Panel in Diagnosing Triple Negative Breast Cancer Brain Metastases.

Int J Surg Pathol 2021 Feb 5:1066896921990717. Epub 2021 Feb 5.

5506Medical College of Wisconsin, Milwaukee, WI, USA.

Following lung cancer, breast cancer is the second most common metastatic tumor to the brain, of which triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2+ (HER2+) breast cancer are the most common subtypes. TNBC does not have standard immunoprofiles and can be difficult to distinguish from other metastases. A tissue microarray was created from 47 patients with breast cancer metastases to the brain and 12 paired breast primaries. Of 47 breast cancer metastases, 24 were HER2+, 14 were TNBC, and 9 were luminal. Forty-five were cytokeratin 7 (CK7) positive, 36 were GATA-binding protein 3 (GATA3) positive, 7 were Sry-related HMg-Box gene 10 (SOX-10) positive, 20 were mammaglobin positive, and 19 were gross cystic disease fluid protein 15 positive. At least one of the CK7, GATA3, or SOX-10 was positive in all TNBC metastases. A panel of CK7, GATA3, and SOX-10 is complementary in the diagnosis of breast cancer brain metastasis. SOX-10 appears to be a specific but not particularly sensitive marker in this context.
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http://dx.doi.org/10.1177/1066896921990717DOI Listing
February 2021

New Syphilis Serology Testing Requires New Reporting Algorithms.

J Appl Lab Med 2020 05;5(3):601-604

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1093/jalm/jfaa016DOI Listing
May 2020

Insulin resistance predicts brain amyloid deposition in late middle-aged adults.

Alzheimers Dement 2015 May 17;11(5):504-510.e1. Epub 2014 Jul 17.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

Background: Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if IR is associated with an in vivo index of amyloid in the human brain in late middle-aged participants at risk for AD.

Methods: Asymptomatic, late middle-aged adults (N = 186) from the Wisconsin Registry for Alzheimer's Prevention underwent [C-11]Pittsburgh compound B (PiB) positron emission tomography. The cross-sectional design tested the interaction between insulin resistance and glycemic status on PiB distribution volume ratio in three regions of interest (frontal, parietal, and temporal).

Results: In participants with normoglycemia but not hyperglycemia, higher insulin resistance corresponded to higher PiB uptake in frontal and temporal areas, reflecting increased amyloid deposition.

Conclusions: This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD.
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http://dx.doi.org/10.1016/j.jalz.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297592PMC
May 2015

Coherent control of phonon-polaritons in a terahertz resonator fabricated with femtosecond laser machining.

Opt Lett 2004 Nov;29(22):2671-3

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Using femtosecond laser machining, we fabricated a terahertz resonant cavity in LiNbO3. Optical pulse sequences with variable repetition rates, generated through a novel pulse-shaping method, are used for characterization of the cavity resonances and for amplification of terahertz phonon-polaritons in the cavity.
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http://dx.doi.org/10.1364/ol.29.002671DOI Listing
November 2004

Direct Visualization of a Polariton Resonator in the THz Regime.

Opt Express 2004 May;12(11):2387-96

We report fabrication of a THz phonon-polariton resonator in a single crystal of LiNbO3 using femtosecond laser machining with high energy pulses. Fundamental and overtone resonator modes are excited selectively and monitored through spatiotemporal imaging. The resonator is integrated into a single solid-state platform that can include THz generation, manipulation, readout and other functionalities.
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http://dx.doi.org/10.1364/opex.12.002387DOI Listing
May 2004