Eric Spooner

Eric Spooner

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Eric Spooner

Eric Spooner

Publications by authors named "Eric Spooner"

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Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

Proc Natl Acad Sci U S A 2016 Feb 25;113(6):E705-14. Epub 2016 Jan 25.

HKU-Pasteur Research Pole and Center for Influenza Research, School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong; Department of Cell Biology and Infection, Institut Pasteur, 75015 Paris, France;

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http://dx.doi.org/10.1073/pnas.1521763113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760780PMC
February 2016

Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.

PLoS One 2014 2;9(10):e109883. Epub 2014 Oct 2.

Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183550PMC
December 2015

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Cell Rep 2014 Oct 25;9(1):1-8. Epub 2014 Sep 25.

Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223866PMC
October 2014

Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA.

Infect Immun 2014 Feb 25;82(2):706-19. Epub 2013 Nov 25.

Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1128/IAI.01291-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911376PMC
February 2014

Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.

Cell Rep 2013 Dec 27;5(5):1302-15. Epub 2013 Nov 27.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957429PMC
December 2013

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

Mol Cell 2013 Nov 3;52(4):495-505. Epub 2013 Oct 3.

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867817PMC
November 2013

Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multiphage structures.

ACS Synth Biol 2013 Sep 28;2(9):490-6. Epub 2013 May 28.

The David H. Koch Institute for Integrative Cancer Research, ‡Department of Materials Science and Engineering, ∥Department of Biology, and ⊥Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/sb400019sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905569PMC
September 2013

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

J Biol Chem 2013 Sep 8;288(38):27019-30. Epub 2013 Aug 8.

From the Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.

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http://dx.doi.org/10.1074/jbc.M113.498055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779703PMC
September 2013

Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection.

Chembiochem 2013 Feb 18;14(3):343-52. Epub 2013 Jan 18.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/cbic.201200701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841013PMC
February 2013

Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.

Proc Natl Acad Sci U S A 2013 Jan 7;110(4):1428-33. Epub 2013 Jan 7.

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1214994110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557095PMC
January 2013

Class II MHC self-antigen presentation in human B and T lymphocytes.

PLoS One 2012 27;7(1):e29805. Epub 2012 Jan 27.

Program in Immunology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267721PMC
July 2012

M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins.

Bioconjug Chem 2012 Jul 3;23(7):1478-87. Epub 2012 Jul 3.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1021/bc300130zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564602PMC
July 2012

Protein ligation in living cells using sortase.

Traffic 2012 Jun 23;13(6):780-9. Epub 2012 Mar 23.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2012.01345.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490390PMC
June 2012

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

J Biol Chem 2011 Oct 20;286(43):37602-14. Epub 2011 Aug 20.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.284794
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http://dx.doi.org/10.1074/jbc.M111.284794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199505PMC
October 2011

Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner.

PLoS Negl Trop Dis 2011 Oct 4;5(10):e1340. Epub 2011 Oct 4.

Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186758PMC
October 2011

Sortase A as a tool for high-yield histatin cyclization.

FASEB J 2011 Aug 27;25(8):2650-8. Epub 2011 Apr 27.

Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1096/fj.11-182212DOI Listing
August 2011

Granulin is a soluble cofactor for toll-like receptor 9 signaling.

Immunity 2011 Apr 14;34(4):505-13. Epub 2011 Apr 14.

Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, South Korea.

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http://dx.doi.org/10.1016/j.immuni.2011.01.018DOI Listing
April 2011

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.

Proc Natl Acad Sci U S A 2011 Feb 5;108(5):1763-70. Epub 2011 Jan 5.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1014402108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033243PMC
February 2011

Sortase-catalyzed transformations that improve the properties of cytokines.

Proc Natl Acad Sci U S A 2011 Feb 4;108(8):3169-74. Epub 2011 Feb 4.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1016863108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044387PMC
February 2011

The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation.

J Exp Med 2010 Aug 16;207(9):2033-41. Epub 2010 Aug 16.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20091793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931171PMC
August 2010

The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.

J Biol Chem 2010 Jul 30;285(27):20732-9. Epub 2010 Apr 30.

Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1074/jbc.M110.120766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898349PMC
July 2010

Haploid genetic screens in human cells identify host factors used by pathogens.

Science 2009 Nov;326(5957):1231-5

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.1178955DOI Listing
November 2009

A straight path to circular proteins.

J Biol Chem 2009 Jun 9;284(23):16028-36. Epub 2009 Apr 9.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1074/jbc.M901752200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708896PMC
June 2009

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.

Nat Immunol 2008 Dec 19;9(12):1407-14. Epub 2008 Oct 19.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02115, USA.

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http://www.nature.com/articles/ni.1669
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http://dx.doi.org/10.1038/ni.1669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735466PMC
December 2008

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

Proc Natl Acad Sci U S A 2008 Nov 18;105(47):18255-60. Epub 2008 Nov 18.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.0808756105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584574PMC
November 2008

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12325-30. Epub 2008 Aug 18.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0805371105
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http://dx.doi.org/10.1073/pnas.0805371105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527910PMC
August 2008

Sortagging: a versatile method for protein labeling.

Nat Chem Biol 2007 Nov 23;3(11):707-8. Epub 2007 Sep 23.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://www.nature.com/articles/nchembio.2007.31
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http://dx.doi.org/10.1038/nchembio.2007.31DOI Listing
November 2007

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

J Virol 2007 Oct 18;81(19):10300-9. Epub 2007 Jul 18.

Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1128/JVI.01149-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045495PMC
October 2007

Iron load and redox stress in skeletal muscle of aged rats.

Muscle Nerve 2007 Aug;36(2):223-33

Department of Neuroscience, Karolinska Institute, Retzius väg 8, 171 77 Stockholm, Sweden.

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http://doi.wiley.com/10.1002/mus.20808
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http://dx.doi.org/10.1002/mus.20808DOI Listing
August 2007

Sequence and structure evolved separately in a ribosomal ubiquitin variant.

EMBO J 2007 Jul 28;26(14):3474-83. Epub 2007 Jun 28.

Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933403PMC
July 2007

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Mol Cell 2007 Mar;25(6):903-15

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.03.003DOI Listing
March 2007

Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.

ACS Chem Biol 2006 Dec;1(11):713-23

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://pubs.acs.org/doi/abs/10.1021/cb600431a
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http://dx.doi.org/10.1021/cb600431aDOI Listing
December 2006

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.

Mol Microbiol 2006 Sep;61(5):1187-95

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05307.xDOI Listing
September 2006

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.

Mol Microbiol 2006 Jul;61(1):142-50

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2006.05199.x
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http://dx.doi.org/10.1111/j.1365-2958.2006.05199.xDOI Listing
July 2006

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.

Nature 2006 Jun 31;441(7095):894-7. Epub 2006 May 31.

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature04830
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http://dx.doi.org/10.1038/nature04830DOI Listing
June 2006

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

Cell 2006 May 6;125(3):467-81. Epub 2006 Apr 6.

Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2006.03.028DOI Listing
May 2006

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae.

Mol Cell 2005 Aug;19(4):547-57

Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.07.003DOI Listing
August 2005

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

J Biol Chem 2004 Nov 13;279(48):50110-9. Epub 2004 Sep 13.

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M409226200
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http://dx.doi.org/10.1074/jbc.M409226200DOI Listing
November 2004